NUIG 053-17 Postdoctoral Researcher, In 3D Printing/Micro Processing of Electrically Active Materials, Centre for Research in Medical Devices (CÚRAM), NUI Galway

Applications are invited from suitably qualified candidates for a full-time, fixed term contract research position at the Centre for Research in Medical Devices (CÚRAM), National University of Ireland, Galway. The position is available for a 24 month period initially, with a possibility for extension, subject to successful project outcomes and funding acquisition. This position is funded by Science Foundation Ireland (SFI) and The Biotechnology and Biological Sciences Research Council (BBSRC) and is available from June 2017.   

Organisation:  The Centre for Research in Medical Devices (CÚRAM) is a national, SFI funded, €49.6m research centre that brings together researchers from NUI Galway, University College Dublin, Dublin City University, University of Limerick, University College Cork, Trinity College Dublin and Royal College of Surgeons Ireland. The prime objective for CÚRAM is to radically improve health outcomes for patients by developing innovative implantable ‘smart’ medical devices to treat major unmet medical needs. Implants will be designed and manufactured to respond to the body’s environment and to deliver therapeutic agents, such as drugs, exactly where needed. Cutting-edge science will develop devices using the very latest research from electrically active materials, biomaterials, stem cells and drug delivery and the support of strong clinical collaborations, industry partners and hospital groups to enable rapid translation to the clinic. The centre will include almost 40 industry partners and support product development and the creation of new spin-out companies. This project will also be conducted in conjunction with the Centre for Cell Engineering at the University of Glasgow through an SFI-BBSRC joint funding grant.   

Job Description: The Postdoctoral Researcher will be responsible for the microfabrication, characterization and analysis of novel electrically active materials. Candidates with expertise in 3D printing, modeling of piezoelectric processes and laser processing or 2-photon lithography are particularly sought.   

Duties and Responsibilities:

  • Perform extensive 3D design, fabrication and electrochemical analysis of polymeric materials.

  • Analyze data in an accurate and precise manner;

  • Actively participate in international conferences and meetings;

  • Publish data in high impact factor journals;

  • Closely work with postdoctoral scientists within CÚRAM, the University of Glasgow and associated institutes within and outside NUI Galway. 

Qualifications:

  • Candidates must have a PhD, or a PhD in prospect, in a relevant science or engineering subject, and a proven track record in a research and development environment.

  • Candidates must be highly motivated and passionate about developing new products.

  • Previous experience in 3D modeling; optical processing, lithography or 3D printing is essential.

  • In addition, the successful candidate should also have expertise in as many of the following areas as possible: 2-photon lithography; piezoelectric material formulation and characterization; electrochemistry; biomaterials fabrication and functionalization. 

Salary: €37,750 - €38,860 per annum.    Start date: June 2017.   

Continuing Professional Development/Training:Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.   

For informal enquiries about this post, please contact contact Dr Manus Biggs (manus.biggs@nuigalway.ie)  

Further information on research and working at NUI Galway is available on Research at NUI Galway. 

For information on moving to Ireland please see www.euraxess.ie

To Apply:  Applications to include a covering letter, CV,and the contact details of three referees should be sent, via e-mail (in word or PDF only) to Tara Cosgrave (curam@nuigalway.ie).   Please put reference number NUIG 053-17 in subject line of e-mail application.   

Closing date for receipt of applications is 5.00 pm on 1st May 2017.   

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment.

National University of Ireland, Galway is an equal opportunities employer.

 

Closing Date: Monday, 01 May 2017

Application: NUIG 053-17 Postdoctoral Researcher

NUIG 052-17 Research Performance Engineer Irish Centre for High-End Computing, NUI Galway

Applications are invited from suitably qualified candidates for a full-time, fixed term position as a Research Performance Engineer with the Irish Centre for High End Computing (ICHEC) at the National University of Ireland, Galway.  The successful candidate can choose to be based in ICHEC’s offices in either Dublin or Galway.  The position is available immediately to contract end date of 31st December 2020, subject of one year probationary period.  

Job Description:

ICHEC is the national High-Performance Computing (HPC) in Ireland and is a centre of domain, systems and software expertise that provides high performance software solutions to academia, industry and state bodies, through partnership, knowledge transfer, project delivery and service provision. ICHEC operates the national HPC service providing compute resources and software expertise for the research communities across all the main science disciplines through collaborative partnerships and programmes of education and outreach.  

Working with industry partners, the job will focus on investigating new approaches, developing new software, as well as refactoring/optimizing existing software (performance engineering), with the general goal of increasing the performance and energy efficiency of software applications on a range of emerging many-core platforms, including emerging extreme scale systems.  

Qualifications:

Applicants must have a Ph.D. or equivalent experience (min. 4+ yrs.) in computational science/computer science, or a related discipline. In particular the candidate should be able to demonstrate a track record in an R&D environment, with strong software development experience in C/C++, CUDA, OpenMP, OpenCL being highly desirable. The ideal candidate would have; in-depth knowledge of parallel programming and performance analysis at node and cluster levels, as well as scaling and optimising applications on at least one of the following platforms (GPU, Xeon Phi, FPGA). Experience in scaling applications on large-scale clusters as well as development experience in a technical computing domain (e.g., oil & gas, finance, weather, machine learning). Candidates should also have excellent communication and organisational skills; be highly motivated to develop and enhance software; and have strong documentation, oral and interpersonal skills.   

Salary: €51,716 per annum        Start date: Post is open, Immediate.   

Continuing Professional Development/Training:  Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.   

For information on moving to Ireland please see www.euraxess.ie

Further information on NUI Galway is available at http://www.nuigalway.ie/our-research/

Informal enquiries concerning the post may be made to Dr Michael Lysaght, michael.lysaght@ichec.ie 

To Apply:

Applications to include a covering letter, CV,and the contact details of three referees should be sent, via e-mail (in word or PDF only) to recruit@ichec.ie Please put reference number NUIG 052-17 in subject line of e-mail application. 

Closing date for receipt of applications is 4.00 pm Tuesday 2nd May 2017. 

National University of Ireland, Galway is an equal opportunities employer.

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment.

 

Closing Date: Tuesday, 02 May 2017

Application: NUIG 052-17 Research Performance Engineer

NUIG 071-17 Part-time Research Assistant (0.4FTE) - Centre for Research in Medical Devices (Cúram), NUI Galway.

 Applications are invited from suitably qualified candidates for part-time (40%), fixed term position for 18 months, subject to an initial one year probationary period as a Research Assistant with CÚRAM at the National University of Ireland, Galway. The project represents a Science Foundation Ireland-facilitated collaboration between NUI Galway and an industrial partner.         

Organisation: CÚRAM is a partnership of scientists, engineers and clinicians, who all share a common vision of developing the next generation of medical devices in order to provide solutions for current clinical needs. The University provides a research-friendly social and cultural environment. Galway is also one of the key cities in Europe with a significant presence of the medical device industry sector. For more information on CÚRAM please refer to http://www.curamdevices.ie/ 

Job Description:  The part-time, fixed term Research Assistant position is designed for assisting in research into the mechanism of action of Mesenchymal Stem/Stromal Cells in modulation of Osteoarthritis and development of therapeutic agents from the data generated.  These agents will ultimately be delivered using medical devices. The successful candidate will work in a strongly-team oriented environment in the Orthobiology /Immunology groups at the Regenerative Medicine Institute (REMEDI, www.remedi.ie) within CÚRAM.    

Duties and Responsibilities:

The successful candidate will:

  • Assist in all areas associated the ABBVIE/CÚRAM project at REMEDI to ensure research programme requirements in terms of documentation of the project activities, milestones and major key deliverables are implemented and adhered to

  • Assist in the implementation of the research programme in vivo and in vitro work

  • Assist in collecting, recording and processing clinical trial samples

  • Record and validate assigned experimental work

  • Assist in dissemination of project results and outcomes

  • Assist in the preparation of periodic scientific reports to the funders

  • Maintain confidentiality of background IP, foreground IP and research results.  

Essential Criteria for the post:

  • BSc or equivalent experience in a relevant area of Biomedical Science.

  • Pre-clinical experience with relevant training/licensing.

  • A minimum of 2 years relevant research experience in an academic and/or industry R&D environment.

  • Problem solving experience in a research laboratory environment.

  • Excellent communication and interpersonal skills. 

Desirable Criteria:

  • Experience in a stem cell laboratory environment.

  • Knowledge of clinical trial methodology.

  • Team player with good organisational skills.

  • Good initiative and flexibility.

  • Evidence of understanding of the entrepreneurial, commercialisation process and IP generation and protection.

  • High level of IT skills: proficiency in the full Microsoft Office package and use of the Internet. 

Salary: €23,181 – €31,083 PA/Pro-rata for this part-time post (40% or 15.6 hrs. per week) 

Start date: June/July 2017 

NB: work permit restrictions apply to this category of post. 

Continuing Professional Development/Training:  Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.   

Further information on research and working at NUI Galway is available on Research at NUI Galway 

For information on moving to Ireland please see www.euraxess.ie 

For informal enquiries about these posts please contact Dr. Mary Murphy at mary.murphy@nuigalway.ie 

To Apply: Applications to include a cover letter, CV, and the contact details of three referees should be sent, via e-mail (in word or PDF only) to mary.murphy@nuigalway.ie.    Please put reference number NUIG 071-17 in the subject line of the e-mail application. 

Closing date for receipt of applications is 5pm on Friday May 12, 2017. 

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment.

National University of Ireland, Galway is an equal opportunities employer.

 

Closing Date: Friday, 12 May 2017

Application: NUIG 071-17 Research Assistant (part-time) CURAM

NUIG 068-17 Postdoctoral Researcher/Research Fellow in Signal Processing for Driver Monitoring Electrical and Electronic Engineering, College of Engineering & Informatics, NUI Galway.

Applications are invited from suitably qualified candidates for a full-time, fixed term (18 month) position as a Postdoctoral Researcher/Research Fellow in Electrical & Electronic Engineering at NUI Galway.   

The position is funded by a Horizon 2020 Research and Innovation project titled “ADAS&ME” (http://www.adasandme.com) which aims to develop and trial technology for managing the interface between humans and vehicles in the context of development of autonomous and semi-autonomous cars. The position is available from June 1st 2017.   

The postholder will work on the development and prototyping of a radar-based sensor for non-contact monitoring of vehicle occupants. The radar sensor will be used as part of a larger system used to monitor the overall state of the person, e.g. fatigued, anxious, stressed etc.   

The successful candidate will be based in the Electrical & Electronic Engineering discipline at NUI Galway, and will work as an integral part of an international consortium of around 30 organisations across Europe, including industry, academic, research institutes and user group partners.

Job Description: The postholder will be responsible for the specification and design of a radar-based system for driver monitoring, for working with an industry partner on prototyping and testing, and development of signal processing algorithms for the system. The successful candidate will also be expected to take responsibility for meeting appropriate milestones, timelines and deliverables as part of the overall ADAS&ME project.

Duties and Responsibilities:

  • Carry out high-level design, simulation and characterisation of a microwave radar-based monitoring system;

  • Develop signal processing algorithms for radar signals in driver monitoring applications;

  • Support industry partner on system hardware design;

  • Contribute to prototype development and system integration;

  • Actively participate in international conferences and meetings as required;

  • Publish in high-impact journals as appropriate;

  • Participate in consortium meetings and workshops as appropriate, including travel to other countries within Europe;

  • Provide project management support e.g. budgetary management and reporting;

  • Provide support and mentoring to post-graduate research students in the host research group;

  • Engage in appropriate continuing professional development activities to support their own career development plans, and to support the development of the host research group through e.g. development of research proposals. 

    Essential Requirements:

  • An honours BE degree (or equivalent) in Electrical/Electronic/Computer Engineering, or Biomedical Engineering with a strong electronics background.

  • A PhD, or equivalent experience** in a relevant research environment.

  • Significant experience in the development of radar-based or other RF systems for non-contact monitoring applications, ideally in biomedical or related applications.

  • Experience in development of signal processing algorithms and embedded software.

  • Knowledge of Matlab or other signal processing development tools.

  • Evidence of primary/senior authorship of peer-reviewed publications in relevant areas, or other equivalent output e.g. patents.

  • Excellent written and spoken English communication skills. 

    ** Minimum 4 years for appointment at Postdoctoral level, minimum 6 years for appointment at Research Fellow level. 

    Desirable Skills:

  • Experience of RF simulation/modelling.
  • Expertise in issues relating to medical device regulation. 

Salary: €42,394 to €46,255 per annum – Postdoctoral Researcher.

            €51,716 per annum – Research Fellow. 

Start Date: The position is available from 1st June 2017, and no later than 1st August 2017.  

Continuing Professional Development/Training:  Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.   

Further information on research and working at NUI Galway is available on Research at NUI Galway 

For information on moving to Ireland please see www.euraxess.ie 

Informal enquiries concerning the post may be made to Dr Edward Jones (edward.jones@nuigalway.ie). 

Applications: Candidates are requested to submit a cover letter, CV (Word or PDF format only) and the names and addresses of three referees via e-mail to Dr Edward Jones (edward.jones@nuigalway.ie)   Please ensure to put the reference number NUIG-068-17in subject line of e-mail application.

                                                                                        The closing date for receipt of applications is 5pm on 30th April 2017. 

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment. 

National University of Ireland, Galway is an equal opportunity employer.

 

Closing Date: Sunday, 30 Apr 2017

Application: NUIG 068-17 Postdoctoral / Research Fellow

13 PhD Fellowship positions available in the Marie Skłodowska-Curie Actions, Innovative Training Network, "PATHSENSE" (H2020-MSCA-ETN-721456) Ref. No. NUIG 072-17

13 PhD Fellowship positions available in the

 Marie Skłodowska-Curie Actions

Innovative Training Network

"PATHSENSE"

(H2020-MSCA-ETN-721456)

 

Ref. No. NUIG 072-17

 

Training Network to Understand and Exploit Mechanisms of Sensory Perception in Bacteria

 

Located in Ireland, Germany, Netherlands, Spain, Sweden, Switzerland and UK.

 

Project background and goal: The PATHSENSE (Pathogen Sensing) ETN investigates the molecular mechanisms of sensory perception in bacterial pathogens. Rapid and sensitive systems to sense and respond to environmental changes are a cornerstone of a bacterium’s survival apparatus, and understanding these sensory systems is central to predicting their behaviour. The success of bacterial pathogens is underpinned by their ability to sense their environment in order to protect themselves and then to deploy their virulence mechanisms at the appropriate time. A deep knowledge of how their first line of defence (sensory perception) functions is a vital step in developing strategies to subvert their survival apparatus, and ultimately to preventing human, animal and plant infections.

The overall objective of this project is to focus on understanding a highly sophisticated but poorly understood sensory organelle called the “stressosome”. The relationship between molecular structures and biological function is central to understanding any living system; however the research methodologies required to unravel these relationships are often complex and fast-changing. The team participating in the PATHSENSE Network will recruit and train 13 early stage researchers (ESRs) in state-of-the art methodologies, including structural biology, proteomics & protein biochemistry, molecular biology, bacterial genetics, food microbiology, mathematical modelling, cell biology, microscopy and comparative genomics. This inter-sectoral Network comprises 8 leading Universities, 1 public research institution, 4 companies (from spin-off to large multi-national) and 1 governmental agency. A major objective of this Network will be to exploit the fundamental research to develop novel antimicrobial treatments that have applications in the food and public health sectors.

 

Career Stage

Early Stage Researcher (ESR):

ESR are those who, at the time of recruitment, are in the first four years (full-time equivalent) of their research careers. This time is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged. Qualifications required for entry into the PhD program in each partner country can be found on each partner’s website or by contacting the partner by email (see links in the project descriptions section).

 

Benefits and salary

The MSCA-ITN programme offers a highly competitive and attractive salary and working conditions. The successful candidates will receive a salary in accordance with the MSCA regulations for early stage researchers. Exact salary will be confirmed upon offer and will be based on a Living Allowance of €3110/month to be paid in currency of country where based and with a correction factor to be applied per country + mobility allowance of €600/month. Additionally researchers may also qualify for a family allowance of €500/month depending on family situation. Taxation and Social Contribution deductions based on National and Institutional regulations will apply and will be deducted from the gross payment highlighted above. In addition to their individual scientific projects, all fellows will benefit from further continuing education, which includes the opportunity to register for a PhD degree, scientific skills courses, transferable skills courses, active participation in workshops and conferences, and secondments to partner labs.

 

Applicants need to fully comply with the three eligibility criteria:

  1. Early-stage researchers (ESR) are those who are, at the time of recruitment by the host, in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the research training is provided, irrespective of whether or not a doctorate was envisaged. Please note applicants cannot already hold a PhD.

  2. Conditions of international mobility of researchers: Researchers are required to undertake trans-national mobility (i.e. move from one country to another) when taking up the appointment. At the time of appointment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to their recruitment. Short stays, such as holidays, are not taken into account.

  3. English language: Network fellows (ESRs) must demonstrate that their ability to understand and express themselves in both written and spoken English is sufficiently high for them to derive the full benefit from the network training. Non-native English speakers are required to provide evidence of English language competency before the appointment is made. An IELTS score of 6.5, or equivalent, is the minimum requirement.

 

 

PhD Projects

 

ESR1: Stressosome expression, localisation and diffusion in response to osmotic stress in Listeria monocytogenes

Objectives: The biochemical processes that characterize all living cells, such as energy provision, gene expression, and cell division, take place in a confined and highly crowded space. The reaction conditions in the cytoplasm are very different from those in the test tube. The high concentration of macromolecules impacts individual proteins and provides a unique environment for catalysis and the co-evolution of cell components. We will study the formation of protein complexes and the structure of the cytoplasm, using state-of-the-art super-resolution fluorescence microscopy (http://www.membraneenzymology.com/our-equipment/). We will track the activity, localization and mobility of individual protein complexes (e.g. the stressosome) in cells perturbed by osmotic stress. In parallel, we will use recently developed biosensors for crowding, ionic strength, pH and ATP to probe the physicochemistry of the cytoplasm.

Expected Results: A quantitative description of the physical biology of the cell, and a comparison of the reaction environment of pathogenic and non-pathogenic bacteria. A model of the structure of the bacterial cytoplasm, which clearly is not a bag of randomly organized enzymes.

 

Host: University of Groningen – RUG (Groningen, Netherlands)

Supervisor: Prof Bert Poolman (For information on this lab and more detail of the project please see www.membraneenzymology.com or contact b.poolman@rug.nl)

 

 

ESR2: Structural analysis of Listeria monocytogenes and Vibrio vulnificus stressosomes

Objectives: To: (1) establish the architecture of the core L. monocytogenes stressosome (comprising RsbR, S, T) using cryo-electron microscopy; (2) characterise the influence of RsbR paralogues and sensing defective mutants of RsbR on the overall structure of the stressosome; (3) compare the structures of the V. vulnificus and L. monocytogenes stressosomes.

Expected Results: A model describing the stoichiometry and structure of the L. monocytogenes stressosome, incorporating both core stressosome subunits and paralogues of RsbR. An understanding of how sensing defective stressosome mutants influence the overall structure. A comparative model of stressosomes from distantly related food-borne pathogenic bacteria.

 

Host: Universität Regensburg – UR (Regensburg, Germany)

Supervisor: Prof Christine Ziegler (For information on this lab and more detail of the project please see http://www.biologie.uni-regensburg.de/Biophysik2/Ziegler/ or contact christine.ziegler@ur.de)

 

 

ESR3: Genetic characterisation of the Listeria monocytogenes stressosome and role in virulence and food survival

Objectives: In L. monocytogenes the stressosome contributes to sB activation in response to different environmental stimuli (e.g. acidic pH, visible light, osmotic stress) but the molecular mechanisms of stress sensing are largely not understood. In this project the sensory components of the stressosome, thought to involve RsbR and its paralogues, will be dissected genetically. Mutants lacking these components will be phenotypically characterised to determine the role of each in stress sensing. The possibility that the stressosome may interact with other regulatory elements will be investigated by screening a transposon library for mutants that fail to induce sB in response to stress. The contribution of stress sensing to virulence and survival in the food chain will be investigated using established food and animal model systems.

Expected Results: This project will define the sensory elements of the stressosome in L. monocytogenes and establish what role these play in the saprophytic and host-associated phase of this pathogen’s life cycle. The project will also give new insights into the mechanisms underpinning stress sensing, which in the long term should help devise new control measures for this important pathogen. 

 

Host: National University of Ireland Galway – NUIG (Galway, Ireland)

Supervisor: Dr Conor O’Byrne (For information on this lab and more detail of the project please see http://www.nuigalway.ie/microbiology/cpoblab/ or contact conor.obyrne@nuigalway.ie).

 

 

ESR4: Role of the Listeria monocytogenes stressosome during intracellular pathogenesis

Objectives: To: (1) determine the role played by stressosome components in the invasion and intracellular life cycle of L. monocytogenes; (2) measure the influence of the stress sensing via the stressosome on the L. monocytogenes proteome in the vacuole and cytoplasm of the host cell; (3) determine the influence of the stressosome on the cell envelope structure of L. monocytogenes (protein and glycolipid).

Expected Results: A comprehensive understanding of the role of stress sensing via the stressosome on the intracellular behaviour of L. monocytogenes. A full description of the role of the stressosome in regulating the proteome and cell surface properties during the intracellular stage of infections.  

 

Host: Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas - CNB-CSIC (Madrid-Spain)

Supervisor: Prof Francisco Garcia del Portillo (For information on this lab and more detail of the project please see http://www.cnb.csic.es/index.php/es/investigacion/departamentos-de-investigacion/biotecnologia-microbiana/laboratorio-de-patogenos-bacterianos-intracelulares or contact fgportillo@cnb.csic.es)

 

 

ESR5: The design principles of the stressosome signalling module at the single-cell level

Objectives: Gene expression is noisy; single cells often display dynamic and heterogeneous gene expression, even in an isogenic population under uniform environmental conditions. This variability can be obscured by traditional 'bulk' approaches that average away dynamics over 1000's of cells. To tackle this in this project we will combine single-cell time-lapse microscopy, synthetic biology approaches, and mathematical modelling to understand the design principles of the stressosome signalling module. Broadly, the project goals will involve: (1) Perform  single-cell time lapse microscopy on B. subtilis cells carrying a fluorescent reporter of σB activity and measure σB activity in response to acid pH, osmotic stress and ethanol; (2) measure the effects of stressosome mutants with impaired sensing ability on the activation of σB at the single cell level; (3) produce a mathematical model describing the sensory behaviour of B. subtilis and test this model by re-wiring the stressosome circuit based on model predictions.

Expected Results: A systems level understanding of how stressosome-mediated stress sensing and signal transduction influences the σB activation in B. subtilis in response to stress. A mathematical model that predicts the sensory behaviour of bacteria that has the potential to be validated in a food-related setting.

 

Host: University of Cambridge - UC (Cambridge, UK).

Supervisor: Dr James Locke (For information on this lab and more detail of the project please see http://www.slcu.cam.ac.uk/directory/locke-james or contact james.locke@slcu.cam.ac.uk).

 

 

ESR6: Structure and role of the Vibrio vulnificus stressosome

Objectives: Due to its oxygen-sensing activity, the V. vulnificus stressosome is an excellent model system to explore the structure-function relationship of this macromolecular signalling hub. In this project, and in a joint effort with ESR7, a series of mutants within the stressosome genes and downstream encoded signalling proteins will be constructed to a) establish the stressosome-dependent signalling pathway and b), using a gel-free proteomic approach, to identify proteins expressed in a stressosome dependent manner in V. vulnificus. Based on these results, reporter systems for stressosome activity in V. vulnificus will be generate, which will allow the investigation of stressosome signalling and phosphorylation in a variety of in vitro and in vivo contexts. In addition, proteins that constitute the stressosome signalling pathway will be overexpressed and purified for structural analysis in close collaboration with ESR2. Results from structural analysis will guide genetic work in order to evaluate predicted mechanisms of stressosome activation.

Expected Results: A structural model of the V. vulnificus stressosome including a predicted sensory mechanism. A detailed understanding of the role of the stressosome in modulating the V. vulnificus proteome in response to stress. Elucidation of the downstream signalling events triggered by the stressosome in V. vulnificus.

 

Host: Universität Greifswald - UG (Greifswald, Germany)

Supervisor: Dr Jan Pané-Farré (For information on this lab and more detail of the project please see https://mikrobiologie.uni-greifswald.de/staff/pane-farre/ or contact janpf@uni-greifswald.de)

 

 

ESR7: Genetic characterisation of the Vibrio vulnificus stressosome and role in virulence

Objectives: V. vulnificus is a bacterial pathogen that possesses the core stressosome components, but the downstream targets of the stress sensing module are unknown. ESR7 will determine the role of the stressosome in controlling the key virulence characteristics of this bacterium. In collaboration with ESR6, ESR7 will first construct a series of defined stressosome mutants in V. vulnificus and then characterise these mutants in terms of stress resistance, biofilm formation, surface properties and virulence. Virulence functions that will be assessed include cell adhesion, cell cytotoxicity, resistance to serum and induction of host inflammatory response.

Expected Results: A defined set of mutants that allow the role of the V. vulnificus stressosome to be elucidated. A detailed understanding of the contribution of the stressosome to stress tolerance, biofilm and virulence in V. vulnificus.

 

Host: National University of Ireland Galway – NUIG (Galway, Ireland)

Supervisor: Dr Aoife Boyd (For information on this lab and more detail of the project please see http://www.nuigalway.ie/science/school-of-natural-sciences/disciplines/microbiology/stafflist/aoifeboyd/ or contact Aoife.Boyd@nuigalway.ie).

 

 

ESR8: Identification of sensory elements of the Listeria monocytogenes stressosome and elucidation of role in virulence

Objectives: RsbR and its paralogues are believed to constitute the sensory part of the stressosome in Listeria monocytogenes. To identify interacting partners of RsbR (and its paralogues) a bacterial two-hybrid system approach together with a genetic screen will be undertaken. Mutants lacking these novel partners will be phenotypically characterised to determine their role in stress sensing/tolerance and in virulence, using both human cell lines and a chicken embryo model. Also, a genetic approach will be undertaken to elucidate the mechanistic basis for the overlap between PrfA-controlled virulence gene expression and the σB-regulated stress response in L. monocytogenes.

Expected Results: This project will identify novel interaction partners to the L. monocytogenes stressosome and give a further understanding of these interactions in the physiology and virulence of this pathogen. The project will also give a comprehensive model explaining the overlap between virulence and the general stress response in L. monocytogenes.

 

Host: Umeå Universitet - UmU (Umeå, Sweden)

Supervisor: Dr Jörgen Johansson (For information on this lab and more detail of the project please see http://www.molbiol.umu.se/english/research/researchers/jorgen-johansson/ or contact jorgen.johansson@umu.se)

 

 

ESR9: Identification and characterisation of novel antimicrobial plant extracts using stress-sensing biosensors

Objectives: To: (1) exploit stress-sensing biosensors to screen plant extracts and an existing compound library for antimicrobial activity against L. monocytogenes and B. subtilis; (2) extract, purify and chemically characterise novel plant compounds that have antimicrobial activity; (3) characterise the effects of the newly isolated antimicrobial compounds on cell physiology and virulence; (4) examine the effectiveness of the novel antimicrobials in food trials.

Expected Results: Development of a new stress-sensing biosensor screen for antimicrobial compounds. Isolation of novel antimicrobial plant extracts and characterisation of their effects on bacterial cells. Validation of the new antimicrobial compounds in a food trial.

 

Host: Natac Biotech – Natac (Madrid, Spain)

Supervisor: Dr José Carlos Quintela (For information on this lab and more detail of the project please see http://www.natac.es/?lang=en or contact jcquintela@natac.es)

 

 

ESR10: Comparative and functional genomics of the general stress response in genus Bacillus

Objectives: Bacillus species form resistant spores that are ubiquitously present in the environment. Spores often survive heating processes and can lead to spoilage or food safety issues in foods upon germination and outgrowth. To prevent outgrowth, multiple hurdles can be applied in foods, but some Bacillus species are better adapted to overcome such stress factors than others. NIZO has an extensive collection of species that have led to spoilage in foods. The objective of this project is to: (1) perform an extensive comparative genomic study of the σB operon and regulon in the genus Bacillus using a large collection of newly available genomes sequences from wild isolates; (2) use σB reporters to correlate genotypic differences with altered σB activity and stress tolerance phenotypes; (3) perform proteomic comparisons on wild isolates with altered stress responses.

Expected Results: A model describing the evolution of the general stress response within the Bacillus genus. An understanding of how genetic changes in the σB regulon influence the sensory properties and phenotype of the organism, ultimately leading to improved control and prevention of outgrowth in foods.

 

Host: NIZO food research – NIZO (Ede, Netherlands)

Supervisor: Dr Marjon Wells-Bennik (For information on this lab and more detail of the project please see https://www.nizo.com/ https://www.nizo.com/food-safety-spoilage/ or contact marjon.wells-bennik@nizo.com)

 

ESR11: Use stress biosensors to develop a predictive model based on pathogen behaviour during food processing

 

Objectives: Quantitation of growth and survival of pathogens and spoilage organisms in food process environments is challenging. ESR11 will begin by developing a σB-based stress reporter system, and then using this system to correlate biosensor measurements with observed growth and survival behaviour. The student will then develop a predictive mathematical model based on these data, which will be validated in novel food systems to help develop new preservation regimes.

Expected Results: A predictive model that uses stress response measurements as an indicator of behaviour in food processing environments, and development of innovative preservation regimes that have applications in real food products. 

 

Host: Nestlé Research Konolfingen - Nestlé (Konolfingen, Switzerland )

Supervisor: Dr Nicholas Johnson (For information on this lab and more detail of the project please see http://www.nestle.com/jobs or contact NicholasBrian.Johnson@rdko.nestle.com)

 

 

ESR12: Genetic study of the molecular mechanisms of sensory perception in B. subtilis

Objectives: The stressosome contributes to sB activation in response to different environmental stimuli but the molecular mechanism of stress sensing are largely not understood. The goal of this project is to (1) generate σB reporter fusions that allow the quantification of stressosome-dependent stress sensing in B. subtilis; (2) use random transposon mutagenesis and targeted mutagenesis of RsbR and its paralogues to identify mutants with defective stress sensing, revealing either locked-on or signal blind variants; and (3) in collaboration with Dr. James Locke to develop single-cell and population based mathematical models that account for the stress sensing behaviour of B. subtilis.

Expected Results: The development of stress-sensing biosensors for B. subtilis. Identification of novel factors influencing stressosome-mediated sensing in B. subtilis and a genetic definition of residues important for sensing in RsbR and its paralogues. A model describing the molecular mechanisms of stress sensing in Bacillus.   

 

Host: University of Dundee - UD (Dundee, UK)

Supervisor: Prof Nicola Stanley-Wall (For information on this lab and more detail of the project please see http://www.lifesci.dundee.ac.uk/people/nicola-stanley-wall contact N.R.Stanleywall@dundee.ac.uk)

 

 

ESR13: Structure-function relationships within the sensory domains of the Listeria monocytogenes stressosome

Objectives: To: (1) determine the x-ray crystal structure of the amino terminal domains of L. monocytogenes RsbRA and its paralogues (Lmo0161, Lmo1642, Lmo1842); (2) to solve the structure of mutant variants with altered sensory functions; (3) perform domain-swap experiments combined with proteomics to determine the capacity for functional interspecies exchange of the sensory subunit.

Expected Results: Structural models of the sensory domains of the L. monocytogenes stressosome. A testable mechanistic model explaining the sensory capacity of the stressosome (using data from mutant analysis). An understanding of the structural constraints within the system and between species based on the domain swap studies. 

 

Host: Newcastle University - NU (Newcastle, UK)

Supervisor: Dr Richard Lewis (For information on this lab and more detail of the project please see http://sbl.ncl.ac.uk/  or contact rick.lewis@newcastle.ac.uk )

 

 

Application procedure:

 

All applications must be made on the PATHSENSE APPLICATION FORM which is included in advertisement and available to download here. 

 

The form should be completed and e-mailed to PATHSENSE@nuigalway.ie by 5.00 pm (GMT) on 12th May 2017.

 

Recruitment process information: Eligible applications will be forwarded to the relevant partners in charge of each project and each partner will shortlist their applicants. Shortlisted candidates will be invited for interview with the PATHSENSE team at a central location in June. Applicants will be informed of the outcome by end of June 2017. Successful applicants will need to prove that they are eligible (three aspects: respect ESR definition, mobility criteria, and English language proficiency). The formal enrolment of the successful applicant as a PhD student will be taken by the Host Institution. The selected ESRs are expected to start 1st September 2017.

 

Closing date for receipt of applications is 5pm (GMT) on Friday 12th May 2017.

 

Closing Date: Friday, 12 May 2017

Application: NUIG 072-17 Pathsense application form

NUIG 073-17 Computational Scientist / Researcher Irish Centre for High-End Computing, NUI Galway.

Applications are invited from suitably qualified candidates for a full-time, fixed term position as a Computational Scientist with the Irish Centre for High End Computing (ICHEC) at the National University of Ireland, Galway.  The successful candidate can choose to be based in ICHEC’s offices in either Dublin or Galway.  The position is available immediately to the contract end date of 31st December 2020, subject to a one year probationary period. 

Job Description:  ICHEC is the national High-Performance Computing (HPC) in Ireland with domain, systems and software expertise. It provides high performance software solutions to academia, industry and state bodies, through partnership, knowledge transfer, project delivery and service provision. ICHEC operates the national HPC service providing compute resources and software expertise for the research communities across all the main science disciplines, including collaborative partnerships and programmes of education and outreach. The ideal candidate will join a dynamic and enthusiastic team of expert computational scientists and systems administrators and contribute to ICHEC’s ambitious programmes of industry engagement and applied computational research. The job’s main focus is placed on developing state of the art high performance software through innovative algorithms capable of leveraging cutting-edge hardware (e.g. many-core, FPGA, etc.) The role involves close interaction with other ICHEC staff and with industry partners in a stimulating work environment.   

Qualifications:  Applicants must have a Ph.D. (or in process of finalising/submitting) or equivalent experience (min. 4+ yrs. beyond undergraduate degree) in computational science, software engineering, computational physics, applied mathematics or a related discipline. The candidate should demonstrate a track record of working in a R&D environment, with strong software development experience in C/C++, OpenMP, MPI, OpenCL, CUDA, Spark, R, Pearl, and Python, ideally within the Prince2/Agile framework. The ideal candidate would have in-depth knowledge of parallel programming and I/O, and experience working on emerging many-core platforms, performance analysis, modelling at node and cluster levels, and scaling applications on large-scale HPC systems, as well as exposure to industry domains such as; oil & gas, finance, weather and machine learning. Candidates should also have excellent communication and organisational skills; be highly motivated to develop and enhance software; and have strong documentation, oral and interpersonal skills. 

Salary: €37,750 - €46,255 per annum      Start date: Post is open, Immediate. 

Continuing Professional Development/Training:  Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.  

For information on moving to Ireland please see www.euraxess.ie 

Further information on NUI Galway is available at http://www.nuigalway.ie/our-research/

Informal enquiries concerning the post may be made to Dr Michael Lysaght, michael.lysaght@ichec.ie 

To Apply:

Applications to include a covering letter, CV,and the contact details of three referees should be sent, via e-mail (in word or PDF only) to recruit@ichec.ie Please put reference number NUIG 073-17 in subject line of e-mail application. 

Closing date for receipt of applications is 4.00 pm Wednesday 31st May 2017. 

National University of Ireland, Galway is an equal opportunities employer. 

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment.

 

Closing Date: Wednesday, 31 May 2017

Application: NUIG 073-17 Computational Scientist / Researcher

NUIG 074-17 Research Associate – Communications and Dissemination Irish Centre for High-End Computing, NUI Galway.

Applications are invited from suitably qualified candidates for a full-time, fixed term position as a Research Associate – Communications and Dissemination with the Irish Centre for High End Computing (ICHEC) at the National University of Ireland, Galway.  The successful candidate can choose to be based in ICHEC’s offices in either Dublin or Galway.  The position is available immediately to contract end date of 31st December 2020, subject to a one-year probationary period. 

Job Description:  ICHEC is a vibrant, dynamic and agile organisation composed of computational scientists, scientific domain experts, project managers and system administrators that operate in cross-functional teams to provide high performance software solutions to academia, industry and state bodies. ICHEC operate the national high-performance computing service providing compute resources and software expertise for research communities across the main science disciplines, through collaborative partnerships and programmes of education and outreach.   

ICHEC are seeking an energetic team-player to join this diverse group and to translate often complex scientific and technological concepts into digestible and informative communication and dissemination material, across a range of media. Working with multi-disciplinary teams at ICHEC the job will focus on designing, implementing and delivering a tailored communication strategy, targeted to ICHEC’s diverse stakeholders, and aligned with ICHEC’s strategic objectives. The successful candidate will co-ordinate the Centre’s communication activities, and assist in conducting awareness raising campaigns, events, and information dissemination workshops, etc. for wide target audiences. The successful candidate will also manage the Centre’s events and conference participation, website (webmaster), and have an active part in managing ICHEC’s social media presence.   

Qualifications:  Applicants must have a BSc or equivalent experience (min. 2+ yrs.) in Communications, Media or Social Science. The ideal candidate would have at least 2 years professional work experience in designing dissemination programmes, and in executing communication strategies, preferably in scientific environment. Applicants must demonstrate excellent writing skills through published press releases, articles or blog posts examples of which should be submitted with cover letter. Experience in media production (webmaster, graphic design and social media) and event management is highly desirable. Candidates must also have excellent oral presentation, communication and organisational skills.   

Salary: €37,750 - €46,255 per annum      Start date: Post is open, Immediate.  

Continuing Professional Development/Training:  Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.    

For information on moving to Ireland please see www.euraxess.ie

Informal enquiries concerning the post may be made to Sufian Al Aswad, sufian.alaswad@ichec.ie

Further information on NUI Galway is available at http://www.nuigalway.ie/our-research/  

NB: Gárda vetting is a requirement for this post. 

To Apply:  Applications to include a covering letter, CV, writing samplesand the contact details of three referees should be sent, via e-mail (in word or PDF only) to recruit@ichec.ie Please put reference number NUIG 074-17 in subject line of e-mail application.   

Closing date for receipt of applications is 4.00 pm Wednesday 31st May 2017.  

National University of Ireland, Galway is an equal opportunities employer.

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment.

Closing Date: Wednesday, 31 May 2017

Application: NUIG 074-17 Research Associate – Communications and Dissemination

NUIG 075-17 Systems Administrator /Research Associate Irish Centre for High-End Computing, NUI Galway.

Applications are invited from suitably qualified candidates for a full-time, fixed term position as a Systems Administrator with The Irish Centre for High-End Computing (ICHEC) at the National University of Ireland, Galway. This position is based at ICHEC’s Dublin office. This position is available from 1st April 2017 to contract end date of 31st December 2020. 

ICHEC is the national High-Performance Computing (HPC) centre in Ireland and is a centre of domain, systems and software expertise that provides high performance solutions to industry, state bodies, academia and research centres through partnership, knowledge transfer, project delivery and service provision. With its 28 staff, including 15 research-active application engineers, ICHEC has an active and highly regarded commercial services program, both partnering with and servicing industry, with an extensive portfolio of industry and public service clients and partners including Tullow Oil plc, Intel, Xilinx, DataDirect Networks, CADFEM, Met Éireann and the Central Statistics Office of Ireland. 

Job Description:  The successful candidate will join a team of experienced system administrators to help support the national supercomputing infrastructure, as well as the organisation’s internal IT requirements and other external facing operational services. This will require activities in a diverse range of technical domains such as networking, server virtualization and administration, and user level services such as AAA, monitoring and technical support. The role will involve close interaction with other ICHEC staff and with end users in a dynamic and stimulating work environment. 

Duties:   Assisting ICHEC’s team of system administrators in supporting the national supercomputing infrastructure, and the organisation’s internal IT requirements and other external facing operational services. Working on activities with diverse range of technical domains such as networking, server virtualization and administration, and user level services such as AAA, monitoring and technical support. The role will involve close interaction with other ICHEC staff, and with end users in a dynamic and stimulating work environment. 

Qualifications/Skills required:   The ideal candidate should have 2+ years of Linux server system administration experience and a solid understanding of the fundamentals of server and network administration. Applicants must have a good working knowledge of local area networking and network services such as DNS, email and web server configuration, etc. as well as a thorough understanding of security principles and practices. Experience of supporting OS X and Windows systems is also highly desirable, as is experience with the Python scripting language, configuration management and deploying services on public cloud IaaS. Candidates should have excellent communication and organizational skills; be highly motivated and committed to enabling high quality services; and have strong documentation and interpersonal skills. 

Essential Requirements:

  • Min 2+ years’ experience of Linux server system administration.
  • Solid understanding of the fundamentals of server and network administration.
  • Good working knowledge and experience of local area networking, and network services such as DNS, email and web server configurations.
  • Understanding of security principles and practices.
  • Excellent communication, organisational and interpersonal skills.
  • Highly motivated and committed to enabling high quality services. 

Desirable Requirements:

  • Experience of supporting OS X and windows systems is highly desirable.

  • Practical experience with Python scripting language.

  • Experience using configuration management tools such as Puppet or Salt.

  • Experience deploying services on public cloud IaaS such as AWS or Azure. 

    Salary: €37,750 - €46,255 per annum           Start date: Position is available immediately. 

Continuing Professional Development/Training:  Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.   

For information on moving to Ireland please see www.euraxess.ie

Further information about our centre is available at www.ichec.ie and http://www.nuigalway.ie/our-research/ 

Informal enquiries concerning the post may be made to Mr Niall Wilson, niall.wilson@ichec.ie  

To Apply:  Applications to include a covering letter, CV, and the contact details of three referees should be sent, via e-mail (in word or PDF only) to Ms Lisa Walkin: recruit@ichec.ie   Please put reference number NUIG 075-17 in subject line of e-mail application.   

Closing date for receipt of applications is 4.00 pm Wednesday 31st May 2017.   

National University of Ireland, Galway is an equal opportunities employer.           

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment.

Closing Date: Wednesday, 31 May 2017

Application: NUIG 075-17 Systems Administrator /Research Associate

NUIG 076-17 Research Associate/ Clinical Trials Biostatistics Programmer HRB Clinical Research Facility, Galway (CRFG) National University of Ireland, Galway

Applications are invited from suitably qualified candidates for a fixed-term contract position as a Research Associate/ Clinical Trials Biostatistics Programmer to join the CRFG team at the National University of Ireland, Galway. The position is available immediately and the contract is for 1 year initially, with potential to extend subject to project success and funding acquisition.

The HRB Clinical Research Facility, Galway’s remit is to increase the amount of clinical research currently happening in Ireland. Clinicians undertaking research require clinical support e.g. nursing or physician resources, study advice, biostatisticial advice and data management. Biostatistics will be one of the key selling features to clinical researchers, biomedical companies and pharmaceutical companies. Additional information on the CRFG can be found at www.crfg.ie 

Job Description:  The candidate will be responsible for the statistical programming aspects of clinical trials, including creating and validating analysis datasets, tables, listings and figures for the statistical report. The candidate may also be required to coordinate programming efforts across multiple research projects. 

Main Duties

  • Statistical programming aspects of projects, including the execution and validation of high-quality analysis datasets, tables, listings and figures, whilst adhering to the Standard Operating Procedures (SOPs) and international regulatory standards.

  • Liaise with data management team to perform data validation and cleaning of clinical database.

  • Review and implementation of study documents (i.e. Protocol / statistical analysis plan etc.)

  • Collaborate closely with investigators, sponsors, and other study leadership to ensure that high-quality deliverables adhere to study guidelines, are delivered on time, and study/project results and conclusions are presented accurately and without bias.

  • Carry out other appropriate and relevant duties under the direction of the Principal Investigator. 

Essential Qualifications and requirements:

  • MSc or higher in biostatistics or related field. 

  • Evidence of strong numerate/programming background (ability to program in statistical software such as SAS, R or Stata required)

  • Ability to work with complex data

  • Excellent attention to detail (will be responsible for discovering data issues etc.)

  • Ability to work as part of a team and clearly communicate statistical issues and methods to both statisticians and non-statisticians.

  • Ability to work on own initiative

  • Strong problem solving skills

  • Excellent oral and written communication skills. 

Desirable Criteria:

  • Analytic background

  • Previous experience working in clinical trials, within academia or industry

  • Experience in/knowledge of SDTM/ADaM/CDISC terminology. 

Salary: €37,750-€40,003 per annum.            Start date: Position is available immediately. 

Continuing Professional Development/Training: Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.  

Further information on research and working at NUI Galway is available on Research at NUI Galway

For information on moving to Ireland please see www.euraxess.ie

Further information about HRB Clinical Research Facility is available at www.crfg.ie

NB: Gárda vetting is a requirement for this post. 

Application Procedure: Applicants should send a covering letter, detailed CV and the names and addresses of at least three referees via e-mail (in Word or PDF format only) to: grainne.macnamara@nuigalway.ie. Applicants must put Ref. No. NUIG-076-17 in subject line of e-mail application. 

The closing date for receipt of applications is 5pm Friday 12th May 2017. 

A panel of successful reserve candidates may be formed for future similar posts. 

National University of Ireland, Galway is an equal opportunities employer. 

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment

Closing Date: Friday, 12 May 2017

Application: NUIG 076-17 Clinical Trials Biostatistics Programmer

NUIG 077-17 Research Associate / Nurse HRB-Clinical Research Facility, National University of Ireland, Galway.

Applications are invited from suitably qualified candidates for a full-time fixed term position as a Research Associate/Nurse with the HRB Clinical Research Facility (CRFG) at the National University of Ireland, Galway.  This position, funded by the EU, is available immediately for a period of one year, with potential to renew thereafter subject to project success and funding acquisition.   

The HRB Clinical Research Facility, Galway’s (CRFG) remit is to increase the amount of clinical research currently happening in Ireland. Medical doctors and nurses will work with other scientists to improve our understanding of a variety of diseases and to develop new tests and treatments to help tackle these diseases. The Centre aims to provide patients with the latest advances in areas such as cancer, obstetrics and gynaecology, diabetes, inflammatory diseases, critical illness, cystic fibrosis and cardiovascular disease.   

Job Description:  The Research Associate/Nurse will work under the direction of the Research Nurse Coordinator of the CRFG and as part of a multidisciplinary clinical research team. Within the remit of this post, the successful individual will have responsibility for a caseload of patients on clinical trials and research projects across a variety of therapeutic areas as listed above. This encompasses dietary interventions, clinical trial of IMPs and medical devices in addition to observational studies. The individual will be expected to lead under the direction of CRFG clinical managers on areas such as contribution to individual research projects, engage in nurse led research, audit and education, contribute to papers that arise from the studies undertaken, and attend relevant national and international meetings. The Research Associate/Nurse will support the ongoing development of the CRFG.   

The post holder will:-

  • ·         Adhere to protocol, SOP and regulations in place for clinical research studies.
  • ·         Participate in the implementation of delegated CRFG protocols
  • ·         Plan and conduct clinical research activities to ensure the smooth operation CRFG studies.
  • ·         Effectively plan clinical research and estimate the time and resources required to complete it, and deliver on schedule as set out in the milestones for the research project
  • ·         Inform patients of details pertaining to clinical study prior to their recruitment
  • ·         Screen participants for CRFG studies
  • ·         Keep up to date with research related methods and techniques, in particular, developments in the clinical research area.
  • ·         Have knowledge and understanding of the policy, practices and procedures, relevant to the role, including those of the broader sector, external sponsor or funder (e.g. Research Ethics, Health and Safety).
  •  Ensure patient confidentiality and dignity is maintained at all times during CRFG activities.
  •  Upkeep and input of research documentation including but not limited to site files, case report forms, monitoring actions and data entry.
  •  Facilitate the ongoing education of multi-disciplinary teams with respect to ICH-GCP, specific protocol and research requirements.
  •  Promote a safe clinical environment for patients, visitors and staff to CRFG.
  •   Undertake further education and professional development as appropriate to develop their own career reputation and career development as outlined, discussed and agreed with PI without adversely impacting the primary research role.
  • Build up collaborative links and networks with other schools, disciplines, organisations and keep up to date with research in their own area and what is happening in the international research community by attending investigator meetings and conferences as applicable
  • Collaborate with colleagues on areas of shared clinical research interest and communicate their research with their peers

The post holder will display the following competencies:

  • Planning and Organising
  • Patient/Customer Focus
  • Communication and Interpersonal Skills
  • Leadership
  • Evidence of good IT computer skills including familiarity with the integrated Clinical Information Systems utilised by various departments in the hospital. 

Essential criteria:

  • Current registration with An Bórd Altranais.
  • Have a minimum of 3 years Clinical experience as a qualified Nurse.
  • Candidates must have a proven track record of the research process and regulation requirements for clinical research. 

Desirable criteria:

  • Experience of working in an Irish hospital is an advantage.
  • An understanding of Research and the Research process
  • Have an excellent working knowledge of ICH-GCP.
  • Evidence of undertaking or participation in research projects
  • Proven track record in Information Technology and data base management including electronic Case Report Form (eCRF) usage
  • Experience in working on lifestyle interventions. 

Salary: €37,750-40,003 per annum     Start date: Position is available immediately.   

Continuing Professional Development/Training:  Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.    

Further information on research and working at NUI Galway is available on Research at NUI Galway 

For information on moving to Ireland please see www.euraxess.ie 

Further information about HRB CRFG is available at http://www.nuigalway.ie/hrbcrfg/ 

NB: Gárda clearance is a requirement for this post. 

To Apply:  Applications to include a covering letter, CV,and the contact details of three referees should be sent, via e-mail (in word or PDF only) to Gráinne: grainne.macnamara@nuigalway.ie    Please put reference number NUIG-077-17in subject line of e-mail application.   

Closing date for receipt of applications is 5.00 pm Tuesday 16th May 2017.   

A panel of successful reserve candidates may be formed for future similar posts.  

National University of Ireland, Galway is an equal opportunities employer.   

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment

Closing Date: Tuesday, 16 May 2017

Application: NUIG 077-17 Research Associate/Nurse

NUIG 079-17 D1 Now Study Programme Manager/Research Associate School of Psychology and School of Medicine, National University of Ireland, Galway.

Applications are invited from suitably qualified candidates for a full-time fixed term position for 40 months as the D1 Now Study Programme Manager that spans the Schools of Psychology and Medicine at the National University of Ireland, Galway. This position is funded by Health Research Board (HRB) and is available from July 2017 to contract end date (approx 40 months).   

Prof Sean Dinneen, School of Medicine, is Lead Applicant of the D1 Now Study (https://d1now.ie/). He is seeking to recruit an enthusiastic and committed Programme Manager who will assist in leading a programme of research in designing and refining a health behaviour intervention that will be initially tested in a feasibility study before proceeding to a cluster randomised pilot study. The Programme Manager will report directly to Prof Dinneen. She/ he will also work closely with Dr Molly Byrne, Health Research Board Research Leader and Director of the Health Behaviour Change Research Group, School of Psychology (http://www.nuigalway.ie/hbcrg/), other Co-applicants, Collaborators, members of the Young Adult Panel and other study sites across Ireland and Northern Ireland.   

The Programme Manager will have an office in either the School of Psychology, NUI Galway or in the Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals, in agreement with Professor Dinneen and Dr Byrne.   

D1 Now Study

From January 2014 until January 2017, the study team, that spans NUI Galway and the Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals campuses, have been working on a HRB-funded study to develop a new intervention to improve outcomes for young adults with type 1 diabetes. The team used both the Medical Research Council (MRC) guidelines for developing and evaluating complex interventions (2010) and the Behaviour Change Wheel (BCW) for characterising and designing behaviour change interventions (Michie and colleagues, 2011). The team have established an evidence base from a systematic review, a Patient and Public Involvement (PPI) panel (Young Adult Panel) and a qualitative engagement study with key stakeholders to develop a new intervention called D1 Now. D1 Now emphasises better engagement between young adults and their diabetes team. It includes a key worker, a Young Adult Service Portal and an agenda setting tool. 

The D1 Now Study team have recently received funding from the HRB through their Definitive Intervention and Feasibility Award to test the feasibility and acceptability of the D1 Now intervention in a multi-centre, cluster randomised pilot in advance of a definitive cluster randomised controlled trial. The team will continue to adhere to the MRC and BCW guidelines in all 4 work packages:

  1. Developing, modelling and refining the D1 Now intervention

  2. Feasibility of the D1 Now intervention

  3. Cluster randomised pilot of the D1 Now intervention

  4. Formation of Patient and Public Involvement (PPI) in research: our Young Adult Panels. 

    The study team will use the findings from the feasibility and pilot phases to publish a protocol for a future definitive trial. 

Job Description:  The successful candidate will oversee, manage and lead on all work packages of the D1 Now feasibility and pilot study. She/ he will specifically focus on the day-to-day management of the study and delivery of the study in line with study objectives and timelines. They will lead out of some of the work packages and will oversee data entry, quality assurance, data management and analysis, financial management, meeting schedules, preparation of manuscripts and reports to the funding agency and study management. The postholder should have strong experience in testing, modeling, refining and evaluating health behavioural change intervention and randomised controlled trials. Ideally they should be familiar with the Medical Research Council for developing and evaluating complex interventions and the Behaviour Change Wheel. The postholder should have a strong track record of publishing in peer reviewed journals and at presenting at scientific conferences. Experience working with young adults would be desirable.   

Duties/ Key Responsibilities:

  •   To work closely with Prof Dinneen and Dr Byrne on all aspects on the D1 Now Study
  •   Assist with the supervision of D1 Now Study Postdoctoral Researchers
  •  To work collaboratively with other study Co-applicants and Collaborators
  •  To continue to develop the study’s Young Adult Panel in Galway and lead on the formation of similar panels in Dublin and Belfast
  •   To work closely with the Young Adult Panel to co-design all aspects of the D1 Now intervention as required
  •  To prepare scientific and financial reports
  •  To organise and host study meetings and conferences as required
  •   Lead on the qualitative and quantitative data collection, collation, cleansing and analysis where appropriate
  •  To lead on the SWAT (Study Within A Trial) – assessing if involving the Young Adult Panel in the pilot improves recruitment and retention
  •  Build collaborative relationships with other Diabetes Centres in Ireland and Northern Ireland
  •  To maintain (and develop where appropriate) the D1 Now website and social media accounts
  •  To work with the Qualitative and Behaviour/ Health Psychology Postdoctoral Researchers on the testing, modelling and refining of the D1 Now intervention
  • To assist in testing the feasibility and acceptability of the entire D1 Now intervention package and make appropriate refinements
  •  To lead and assist in the preparation of all manuscripts associated with the D1 Now Study for publication in high quality, peer-reviewed journals and for presentation at scientific conferences
  • To lead on the preparation of D1 Now intervention reports where required, e.g., annual reports for ethics committees and funding agency
  • To drive, develop, lead and coordinate the preparation and submission of grant proposals to funding agencies
  • Liaise with the Research Office, Research Accounts Office, Human Resources and Communications Office in NUI Galway
  • Identify opportunities for academic collaboration in the area of type 1 diabetes (in particular structured education and young adults)
  • Personnel and performance management - staff supervision and research team management
  • Support and deputise as required by Prof Sean Dinneen at local, national and international meetings
  •   Write job descriptions, recruit, advertise and interview potential postdoctoral researchers. 

Qualifications/Skills required:

Essential Requirements:

  • Education to the level of Masters degree or equivalent degree in Psychology, Social Science, Health Service Research or related discipline
  • Population Health and Health Services Research
  • Experience in programme management
  • Proficiency with computer systems including Word, Excel, PowerPoint and statistical and database software, e.g., SPSS and NVivo
  • Experience with managing budgets and in preparing financial reports
  • Experience of qualitative, quantitative and mixed methods research
  • Evidence of publication in peer reviewed journals
  • Evidence of the ability to work independently and collaboratively
  • Evidence of excellent oral and written communication skills
  • Highly motivated, with excellent organisation skills.

Desirable Requirements:

  • Research in the area of health behaviour change intervention development and/ or evaluation
  • Experience working with young adults
  • Research in the area of chronic disease, in particular diabetes
  • Experience of randomised controlled trials, in particular in the area of health behaviour change interventions
  • Experience in applying for research funding
  • Familiarity with key framework/ guideline documents such as the Medical Research Council for developing and evaluating complex interventions and the Behaviour Change Wheel
  • Experience of co-ordinating multi-disciplinary, multi-site programmes and of inter-agency working
  • Experience in testing, modeling, refining and evaluating health behavioural change interventions
  • Experience maintaining websites and social media accounts, such as Facebook, Twitter and Snapchat
  • Flexibility in attending national and international meetings and conferences
  • Experience in research ethics
  • Awareness of Irish Health Services. 

Salary: €46,250 fixed, per annum.     Start date: As soon as possible. 

Continuing Professional Development/Training:  Researchers at NUI Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.   

Further information on research and working at NUI Galway is available on Research at NUI Galway 

For information on moving to Ireland please see www.euraxess.ie 

Informal enquiries concerning this position may be made to Prof Seán Dinneen, sean.dinneen@nuigalway.ie, telephone +353 (0)91 495290. 

To Apply:  Applications to include a covering letter, CV,and the contact details of three referees should be sent, via e-mail (in word or PDF only) to Sean Dinneen at Sean.Dinneen@nuigalway.ie   Please put reference number NUIG-079-17 in subject line of e-mail application.  

Closing date for receipt of applications is 5.00pm, Wednesday 31st May 2017. 

Interviews are planned to be held on Thursday 22nd June 2017. 

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment.

                                                                                          National University of Ireland, Galway is an equal opportunities employer

Closing Date: Wednesday, 31 May 2017

Application: NUIG 079-17 D1 Now Study Programme Manager/Research Associate

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Human Resources

Quick facts

The Quadrangle at NUI Galway

NUI Galway Has Over:

  • 18,000 students.
  • 3,000 international students from 115 countries.
  • 2,500 staff members.
  • 120 links with universities across the globe.
  • 90,000 alumni in 107 countries.
  • 170 years experience providing university education.

NUI Galway Is:

  • Irelands's top University for graduate employability with 96% of our graduates employed or in further study within six months of graduating.
  • The largest and oldest university in the west of Ireland.

NUI Galway is world leading for research in:

  • Biomedical Science and Engineering
  • Web Science
  • Human Rights
  • Marine Science, Energy and Environmental Science
  • Applied Social Sciences and Public Policy
    Humanities, in particular literature, Theatre and Irish Studies