Numerous scientists around the world are working to better understand the complex sugars, or glycans, which coat every living cell in our bodies. Glycans are involved in the interactions between cells and physiological processes, such as fertilisation, cancer, and stem-cell differentiation. Some of the leading experts in this field will convene at NUI Galway from August 6-9, 2014.
The goal of the 5th Warren Workshop will be to highlight the capabilities and limitations that exist in the detection, identification, and quantification of these carbohydrates.
Professor Rob Woods, School of Chemistry, NUI Galway, explains the complexities involved in understanding the chemistry involved in glycosience: “Glycans are very complex and each one is unique. It’s almost like our cells are covered in snowflakes, each having its own unique fluctuating shape. So how do proteins or anitbodies identify and bind to glycans? If we could better understand this, we could use this this knowledge to develop carbohydrate-specific biosensors for use in disease diagnosis and treatment”.
The driving force for the Warren Workshop series is the need for detailed structural analysis of glycans in the context of complex biological systems. The workshop will bring together experts from around the globe in the discipline to establish workflows for tackling these huge challenges. Speakers will be coming from Ireland, the US, Switzerland, England, Japan, Australia, Sweden, Taiwan, the Czech Republic, Germany, the Netherlands, and Israel.
Professor Pauline Rudd, National Institute for Bioprocessing Research and Training (NIBERT) notes that NUI Galway, DCU, UCD, TCD and NIBRT all have strong programmes in applied glycoscience, especially in technology development, analytics, molecular modelling, carbohydrate recognition, oligosaccharide synthesis and glycan pathway modelling. In addition, bioinformatics programmes have been pioneered by Irish scientists. This meeting focuses on many of these topics, and particularly on new technologies of direct relevance to Pharmaceutical companies.
In light of the 2013 Nobel Prize in Chemistry being awarded for Computational Simulations, the 5th Warren Workshop will also include a session on computational glycoscience.
Professor Woods’ research group at NUI Galway is supported by Science Foundation Ireland and closely integrates strong computational and experimental skill sets: “Because of the mind-blowing complexities involved, we need the most advanced computational simulations to help us better understand how glycans are interacting and communicating within our bodies”.
The team in Professor Wood’s lab is investigating antiviral agents to block viral infections and applying their findings to influenza; chosen because of the potential for a pandemic. The group is also working on the development of diagnostics for cancer markers with a focus on pancreatic cancer, one of the more virulent forms of cancer with a mortality rate of over 90%. Early detection of all cancers, preferably by non-invasive surveillance, is needed for all cancers, but particularly for the most aggressive forms.
For further information on the 5th Warren Workshop visit http://glycomics.ccrc.uga.edu/warren-workshop/