RESEARCH STRANDS

Basic Scientific Research

Investigation of the therapeutic potential of Hypercapnic Acidosis in Acute Lung Injury.

Objective:

The objective of this work is to determine the therapeutic potential, mechanisms of action, and characterise the safety and efficacy, of hypercapnic acidosis in the setting of Acute Respiratory Distress Syndrome.
Collaborators:  Prof P McLoughlin, University College Dublin

Ongoing Laboratory Projects at NUI Galway

1. Investigation of the effects of Hypercapnia and Acidosis in Acute Lung Injury induced by Systemic Sepsis.

2. Investigation of the effects and mechanisms of action of hypercapnic acidosis in Acute Lung Injury induced by Ventilation induced Lung Injury.

3. Investigation of the effects and mechanisms of action of hypercapnic acidosis on the repair process following in Acute Lung Injury.

Recently Completed Laboratory Projects at NUI Galway

4. Investigation of the effects and mechanisms of action of Hypercapnic Acidosis in Acute Lung Injury induced by early and established severe Pulmonary Sepsis.

5. Investigation of the potential effects and mechanisms of hypercapnic acidosis in evolving and established systemic sepsis.

Collaborative Laboratory Projects (with University College Dublin)

6. Investigation of the effect of buffering on the effects of Hypercapnia in sepsis Induced Lung Injury.

7. Investigation of the effects and mechanisms of action of Hypercapnic Acidosis in Acute Lung Injury induced by Pulmonary Sepsis.

8. Investigation of the effects and mechanisms of action of Hypercapnic Acidosis in Acute Lung Injury induced by Endotoxin.

Selected Recent Publications

(1) Costello J, Higgins B, Contreras M, Ni Chonghaile M,  Hassett P, O’ Toole D, Laffey JG. Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis. Critical Care Med 2009 (in press).

(2) Nichol A, O’ Croinin D, Howell K, Naughton F, O’Brien S, Boylan J, O’Connor CM, O’Toole D, Laffey JG, McLoughlin P. Infection induced lung injury is worsened following renal buffering of hypercapnic acidosis Critical Care Medicine 2009 (in press). (Note: Joint Publication with Conway Institute, UCD)

(3) Ni Chonghaile M, Higgins B, Costello J, Laffey JG. Hypercapnic Acidosis Attenuates Lung Injury Induced by Established Bacterial Pneumonia. Anesthesiology 2008; 109(5):837-848.

(4) Ni Chonghaile M, Higgins B, Costello J, Laffey JG. Hypercapnic acidosis attenuates the severity of severe pulmonary sepsis by a neutrophil independent mechanism. Critical Care Medicine 2008 Dec;36(12):3135-44.

(5) Kennedy M, Higgins B Laffey JG. Hypertonic Saline reduces inflammation and enhances the resolution of Oleic Acid induced Acute Lung Injury. BMC Pulmonary Medicine 2008 Jul 8;8(1):9. [PMID: 18611275]

(6) O'Croinin DF, Nichol AD, Hopkins N, Boylan J, O'Brien S, O'Connor C, Laffey JG, McLoughlin P. Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury* Crit Care Med. 2008 Jul;36(7):2128-35. PMID: 18552698 (Note: Joint Publication with Conway Institute, UCD)

(7) O' Croinin DF, Hopkins NO, Moore MM, Boylan JF, McLoughlin P, Laffey JG. Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury. Crit Care Med. 2005 Nov;33(11):2606-2612 [PMID: 16276187]. (Note: Joint Publication with Conway Institute, UCD)

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