Fabio Quondamatteo

Email Tel: +353 (0)91 492161 

Fabio Quondamatteo studied Medicine from 1985-1992 at the Medical School of the University of Bari, Italy. In 1992 he was awarded of the title Dottore in Medicina e Chirurgia from the University of Bari and in the same year he successfully completed the State Examination for the Italian licence to practice Medicine. In 1992 he was also at the Dept. of Neurobiology of the German Primate Centre, Goettingen, Germany. In January 1993 he was appointed a position at the Department of Histology of the University of Goettingen ( wissenschaftlicher Mitarbeiter and then from 1998 wissenschaftlicher Assistent, i.e. the equivalent of researcher/lecturer at different levels) which he held up to 2002. During this period, he obtained the German licence to practice Medicine (1995); he was awarded of the title Dr. Med. from the University of Goettingen (1997) and in 1998 he qualified as Facharzt fuer Anatomie (formal recognition as Specialist in Anatomy) from the  Aerztekammer Niedersachsen (Medical Council of Lower Saxony). In 2001 he obtained the Venia legendi in Anatomy (Habilitation in Anatomy, i.e. formal qualification to teach Anatomy at the University level) from the University of Goettingen and was conferred the title Privatdozent. Following Habilitation, in 2002 he was appointed a position as wissenschaftlicher Oberassistent (i.e. researcher position at more senior level) in the Dept of Histology of the University of Goettingen which he held up to 2006. In 2006 he received a prize as Best lecturer in Anatomy of the year awarded by the Medical Students Association of the University of Goettingen among about 20 Anatomy teachers. In January 2007 Fabio Quondamatteo has been appointed as Senior Lecturer in Anatomy at the NUI Galway. Between 2008 and September 2009 he served as a pre-clinical Vice-Dean of Medicine, and from October 2009 to June 2010 he served as Vice-Head of the School of Medicine at NUIG. Principle Investigator - Among this research activities he is Principle Investigator in SAAL(Smart Ambient Assisted Living). This is a community of researchers aiming at producing innovative and person-centred scientific and technological solutions for the improvement of health and wellness management (www.saal.ie)

Research Interests:

1. Study of the cell biological role of basement membrane and extracellular matrix components in vivo . This also includes cell-matrix interactions and the biology of their receptors as well as intracellular events that may be related to their signallilng pathway (e.g. cytoskeleteal organization and Rho GTPase function).

2. Glycoscience. The glycosylation of proteins is an important post-translational process that may influence the function of proteins in several settings. Thus changes in the pattern of distribution of carbohydrate moieties in the tissue may reflect functional changes happening in the tissue. In this context, the in situ detection of carbohydrate moeities is a useful tool for exploring functional changes in the tissue related to a number of processes such as development or malignant transformation.

3. Development. Cell biological aspects of normal and pathological development.

4. Clinical Anatomy. Within this field, my interest is to provide gross anatomical expertise to the solution of clinical problems and in particular to projects that relate to the development of therapeutic devices for neuromuscular stimulations.

Research techniques:

• Histology
• Electron microscopy
• Immunohistochemistry
• In situ localization of mRNA expression
• Lectin histochemistry

Current Collaborations:

• Universty of Copenhagen
• University of Cologne
• University of Rome Tor Vergata
• Electronic Engineering - NUI Galway
• REMEDI - Galway
• NCBES - Galway
• Pathology - NUI Galway
• ENT - NUI Galway
• Anaesthesia - NUI Galway

Scientific Membership:

• Anatomische Gesellschaft (German speaking Anatomical Society)
• Anatomical Society of Great Britain and Ireland 
• German Connective Tissue Society
• International Society of Matrix Biology
• Society for Histochemistry
  

Current Postgraduate Student

Alanna Stanley

Scientific Activity

Forty-nine publications listed in Pubmed as well as numerous abstracts of conferences published.

• Over 30 conferences attended at national and international level with podium presentation and/or poster as a first/last author: these include Gordon Conferences for Basement Membranes, Anatomical Society of Great Britain and Ireland, Anatomische Gesellschaft (German speaking Anatomical Society), Italian Society for Anatomy, FECTS meeting, Society for Histochemistry, Teratology meetings
• Referee for various peer reviewed journals such as Matrix Biology, Journal of Anatomy, Histology and Histopathology, Cell and Tissue Research, Journal of Neurochemistry
• Invited lectures at various internationally recognized Universities such as Lund (Sweden), Greifswald, Hamburg, Luebeck or Goettingen (Germany), Catholic University Rome (Italy), University of Copenhagen (Denmark).
• Supervision of research students at the University of Goettingen (medical/dental students in their doctoral thesis) and NUI Galway (summer exchange students, Ureka program, research assistant program and/or postgraduate thesis
• Referee/examiner for doctoral thesis of own supervised students and students from other supervisor

Publication list (since 2004)

T Lefever, E Pedersen, A Basse, R Paus,  F Quondamatteo, AC Stanley, L Langbein, X Wu, J Wehland, S Lommel, C Brakebusch 2009. N-WASP as a novel regulator of hair follicle cycling that controls antiproliferative TGF beta pathways. J Cell Science In Press. 

GJ Corley, BJ Broderick, SM Nestor, PP Breen, PA Grace, F Quondamatteo, G Olaighin 2009. The Anatomy and Physiology of the Venous Foot Pump. Anat Rec. 2009 Dec 2. [Epub ahead of print]

SI Birlea, GJ Corley, NM Birlea, PP Breen, F Quondamatteo, G Olaighin. 2009 Detecting electroporation by assessing the time constants in the exponential response of human skin to voltage controlled impulse electrical stimulation. Conf Proc IEEE Eng Med Biol Soc;1:1355-1358.

B.J. Broderick, G.J. Corley, F. Quondamatteo, P.A. Grace, P.P. Breen, G. Olaighin. 2008 A haemodynamic study of the physiological mechanisms of the venous pump in the healthy human foot. Conf Proc IEEE Eng Med Biol Soc 2008: 1411-1414.

M. Fricke, C. Langer, E. Brunner, L.Y. Sakai, L. Fuezesi, D.P. Reinhardt, F. Quondamatteo. 2008 Fibrillin-1 in incisional hernias: an immunohistochemical study in scar and non-scar regions of human skin and muscle fasciae. J Anat 212: 674-685.

J. van Hengel, P. D Hooge, X. Wu, L. Libbrecht, R. De Vos, F. Quondamatteo,M. Klempt,  C. Brakebusch, F. Van Roy. 2008 Continuous cell injury promotes hepatic tumorigenesis in Cdc42-deficient mouse liver. Gastroenterology 134 : 781-792.

M.C. Zweers, J. M. Davidson, A. Pozzi, R. Hallinger, K. Janz, F. Quondamatteo, B. Leutgeb, T. Krieg, B. Eckes. 2007
Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization J Invest Dermatol 127: 467-478.
 
A. Diedrich, H.C. Bock, F. Koenig, T.G. Schulz, H.C. Ludwig, R. Herken, F. Quondamatteo. 2006
Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours. Histol Histopathol 21: 1199-1207.

X. Wu, F. Quondamatteo, C. Brakebusch 2006 Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin Matrix Biol 25: 466-474.

A. Chrostek, X.Wu, F. Quondamatteo, R. Hu, A. Sanecka, C. Niemann, L. Langbein, I. Haase, C. Brakebusch. 2006
Rac-1 is crucial for hair follicle integrity but is not essential for the maintainance of the epidermis Mol Cell Biol 26: 6957-6970.

F. Quondamatteo, W. Krick, Y. Hagos , M.H. Kruger, K. Neubauer-Saile, R. Herken , G. Ramadori, G. Burckhardt, B.C. Burckhardt. 2006 Localization of the sulfate-anion exchanger (sat-1) in rat liver. Am J Physiol Gastrointest Liver Physiol 290: G1075-1081.

L.T. Tomte, Y. Annatshah, N.K. Schlueter, N. Miosge, R. Herken, F. Quondamatteo. 2006 Hematopoietic cells are a source of nidogen-1 and nidogen-2 during mouse liver development  J Histochem Cytochem 54: 593-604.

M. Ellies, S. Schuetz, F. Quondamatteo, R. Laskawi. 2006 Immunohistochemical investigations on the influence of botulinum toxin A on the immunoreactivity of nNOS in the parotid gland of the rat. J Oral Maxillofac Surg  64: 397-401.

X. Wu, F. Quondamatteo, T. Lefever, A. Czuchra, H. Meyer, A.Chrostek, R. Paus, L. Langbein, C. Brakebusch. 2006
Cdc 42 controls progenitor cell differentiation and beta-catenin turnover in skin.  Genes and Development  20: 571-585.

M. Ellies, S. Schuetz, F. Quondamatteo, R. Laskawi. 2006 The effect of local injection of botulinum toxin A on the immunoreactivity of nNOS in the rat submandibular gland: An immunohistochemical study.  Int J Pediatr Otorhinolaryngol 70: 59-63.

M. Mueller, J. Berger, N. Gersdorf, F. Cecconi, R. Herken, F. Quondamatteo. 2005 Localization of gene expression of the apoptotic protein activating factor 1 (apaf-1) in the early development of the mouse using in-situ RT-PCR.  Dev Dyn 234: 215-221.

M. Cozzolino, E. Ferraro, A. Ferri, D. Rigamonti, F. Quondamatteo, H. Ding, ZS Xu, F. Ferrari, D.F. Angelini, G. Rotilio, E. Cattaneo, M.T. Carri, F. Cecconi. 2004 Apoptosome inactivation rescues proneural and neural cells from neurodegeneration. Cell Death Differ 11: 1179-1191.

F. Quondamatteo, C. Kempkensteffen, N. Miosge, A. Sonnenberg, R. Herken. 2004 Ultrastructural localization of integrin subunits alpha3 and alpha6 in capillarized sinusoids of the human cirrhotic liver.  Histol Histopathol 19: 799-806.

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