Dr. Andrew Flaus

• Career History:
  
  College Lecturer at NUI Galway, since May 2006. Member of Centre for Chromosome Biology. Responsible for BSc Biotechnology, since 2009.
  Postdoc with Dr Tom Owen-Hughes at University of Dundee, Scotland, 1999-2006 (HFSP, EMBO, Wellcome funded)
  PhD and Postdoc with Prof Tim Richmond at ETH Zurich, Switzerland, 1990-1998 (SNF funded)
  BSc(hons) including research with Drs Chris Moore and Gill Norris at Massey University, New Zealand, 1986-1989.
  
  
  
• Research Interests 
  Dynamic structure of chromosomes at the molecular level;
  Mechanism of ATP-dependent chromatin remodelling enzymes.
  
  Chromatin is the substrate for processes occuring in eukaryotic cell nuclei through its role in packaging the genome. The nucleosome is the fundamental repeating subunit of chromatin. We are interested in the principles underlying the structure and function of the nucleosome, and how this enables molecular processes such as repair, replication and transcription.
  
  
• Key Recent Publications
  Pinto DM, Flaus A, "Structure and function of histone H2AX", Subcell Biochem 50:55-78(2010) [ pubmed]
  
  Engeholm M, de Jager M, Flaus A, Brenk R, van Noort J, Owen-Hughes T, "Nucleosomes can invade DNA territories occupied by their neighbors.", Nat Struct Mol Biol. 16:151-8 (2009). [ pubmed]
  
  Ferreira H, Flaus A, Owen-Hughes T, "Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms", J Mol Biol. 374:563-79 (2007) [ pubmed]
  
  Flaus A, Martin DMA, Barton GJ and Owen-Hughes T, "Multiple distinct subfamilies within the Snf2 family", Nucl. Acids Res. 34:2887-2905 (2006) [ pubmed] 
  
  Flaus A and Owen-Hughes T, "Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?", Curr. Opin. Genet. Dev. 14: 165-173 (2004) [pubmed]
  
  Flaus A, Rencurel C, Ferreira H, Wiechens N, Owen-Hughes T, "Sin mutations alter inherent nucleosome mobility", EMBO J. 23: 343-353 (2004) [pubmed]
  
  Bruno M, Flaus A, Stockdale C, Rencurel C, Ferreira H and Owen-Hughes T, "Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodelling activities", Mol. Cell 12: 1599-1606 (2003) [pubmed]
  
  Havas K, Flaus A, Phelan M, Kingston R, Wade PA, Lilley DM and Owen-Hughes T, "Generation of superhelical torsion by ATP-dependent chromatin remodelling activities", Cell 103: 1133-1142 (2000) [pubmed]
  
  
  Full Publication list
  
  
• PhD and MSc Opportunities
  Please contact me for information about opportunities for postgraduate research projects.
  Email: andrew.flausnuigalway.ie
  
  
• Teaching Interests
  Use of personal response systems (clickers) in biochemistry teaching.
  Application of multimedia resources to support learning.
  Molecular model building as a tool for kinesthetic learning.
  
  My main role is in teaching protein structure and function across 2nd, 3rd and 4th year Biochemistry courses. I also teach a number of techniques and molecular biology topics, and am responsible for the BSc Biotechnology degree programme. I am interested in introducing new teaching methods to improve student engagement and provide realistic opportunities to learn in biochemistry.

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