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Prof. Bob Lahue

Career history:
1979 B.A. (Chemistry), University of Virginia
1984 Ph.D. (Biochemistry), University of California, Berkeley
1984-89 Postdoctoral Research Fellow, Department of Biochemistry,Duke University Medical Center. Laboratory of Dr. Paul Modrich
1989-1996 Assistant Professor, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical Center
1997-2005 Associate Professor, Eppley Institute for Cancer Research, University of Nebraska Medical Center
2005-2007 Professor, Eppley Institute for Cancer Research, and Associate Director for Education and Training, UNMC Eppley Cancer Center, University of Nebraska Medical Center
2007-present SFI Professor of Molecular Genetics, Department of Biochemistry, NUI Galway

Research Interests
DNA mutagenesis and repair
Trinucleotide repeat instability
Yeast genetics

Key Recent Publications
Daee, D.L., Mertz, T. and Lahue, R. S. Mol. Cell. Biol. 27 102-110 (2007). Post-replication repair inhibits CAG·CTG repeat expansions in Saccharomyces cerevisiae.

Claassen, D. A. and Lahue, R. S. Human Molecular Genetics 16 3088-3096 (2007). Expansions of CAG·CTG repeats in immortalized human astrocytes.

Razidlo, D. F. and Lahue, R. S. DNA Repair 7 633-640 (2008). Mrc1, Tof1 and Csm3 inhibit CAG_CTG repeat instability by at least two mechanisms.

Dhar, A. and Lahue, R. S. Nucleic Acids Research 36 3366-3373 (2008). Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae.

Sommer, D., Stith, C.M., Burgers, P.M.J. and Lahue, R. S. Nucleic Acids Res. 36 4699-4707 (2008). Partial reconstitution of DNA large loop repair and purified protiens from Saccharomyces cerevisiae.

Erlich, R.L., Fry, R.C., Begley, T.J., Daee, D.L., Lahue, R.S., and Samson, L.D. PLoS ONE 3 e3717 (2008). Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathways in S. cerevisiae.

Gellon, L., Razidlo, D.F., Gleeson, O., Verra, L., Schulz, D, Lahue, R.S., and Freudenreich, C.H. PLoS Genetics In press. New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

Full Publication List

Lab members
Dr. Elaine Lahue
Dr. Kim Debacker
Aisling Frizzell
Dr. Jennifer Stevens
Dr. Anne Marie Gannon
Lucy Kirkham
Claire Concannon
Dr. Olive Gleeson

Contact details
Bob.Lahuenuigalway.ie
353 91 49 5756 voice
353 91 49 5504 fax
Room 143a, Lower Corrib Wing, Discipline of Biochemistry

Positions available
Please contact Prof. Lahue directly for information.

Biochemistry, School of Natural Science.
National University of Ireland, Galway, University Road, Galway, Ireland.
Phone: +353 (0)91 492420
E-mail: Biochemistry
This page was last updated Thursday, January 13, 2011