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Prof. Bob Lahue

Scientific publications (excluding abstracts)

Original Research Articles

1.    DeJersey, J. D., Lahue, R. S. , and Martin, R. B. Arch. Biochem. Biophys. 205 536-542 (1980). Terbium luminescence as a probe of the calcium binding site of trypsin and alpha -chymostrypsin.
2.    Lahue, R. S. , and Schachman, H. K. J. Biol. Chem . 259 13906-13913 (1984). The influence of quaternary structure on the active site of an oligomeric enzyme, catalytic subunit of aspartate transcarbamoylase.
3. Lahue, R. S. , and Schachman, H. K. J. Biol. Chem. 261 3079-3084 (1986). Communication between polypeptide chains in aspartate transcarbamoylase: conformational changes at the active sites of unliganded chains resulting from ligand binding to other chains.
4.    Lahue, R. S. , Su, S-s., and Modrich, P. Proc. Natl. Acad. Sci. 84 1482-1486 (1987).    Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction.
5.    Lahue, R. S. , Su, S-s., Welsh, K. W., and Modrich, P. UCLA Symp. Mol. Cell. Biol. 125-134 (1987). Analysis of methyl-directed mismatch repair in vitro .
6.    Su, S-S., Lahue, R. S. , Au, K. G., and Modrich, P. J. Biol. Chem. 263 6829-6835 (1988). Mispair specificity of methyl-directed mismatch correction in vitro .
7.    Lahue, R. S. , Au, K. G., and Modrich, P. Science (Research Article) 245 160-164 (1989). DNA mismatch correction in a defined system.
8.    Miret, J. J., Milla, M., and Lahue, R. S. J. Biol. Chem.    268 3507-3513 (1993). Characterization of a DNA mismatch binding activity from yeast.
9. Cooper, D. L., Lahue, R. S. , and Modrich, P. J. Biol. Chem. 268 11823-11829 (1993).    Methyl-directed mismatch repair is bidirectional.
10. Selva, E. M., New, L., Crouse, G. F., and Lahue, R. S. Genetics 139 1175-1188 (1995) Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae .
11.    Miret, J. J., Parker, B. O. and Lahue, R. S. Nucleic Acids Research 24 721-729 (1996). Recognition of DNA insertion/deletion mismatches by an activity in S. cerevisiae.
12. Alani, E., Sokolsky, T., Studamire, B., Miret, J. J. and Lahue, R S.    Mol. Cell. Biol . 17 2436-2447 (1997). Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.
13. Miret, J. J., Pessoa-Brandao, L., and Lahue, R. S.    Mol. Cell. Biol. 17 3382-3387 (1997) Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae .
14. Selva, E. M., Maderazo, A. B., and Lahue, R. S. Mol. Gen. Genet. 257 71-82 (1997) Differential effects of the mismatch repair genes MSH2 and MSH3 on homeologous recombination in Saccharomyces cerevisiae .
15. Miret, J. J., Pessoa-Brandao, L., and Lahue, R. S. Proc. Natl. Acad. Sci. 95 12438-12443 (1998). Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae .
16. Corrette-Bennett, S. E., Parker, B. O., Mohlman, N. L., and Lahue, R. S. J. Biol. Chem . 274 17605-17611 (1999). Correction of large mispaired DNA loops by extracts of Saccharomyces cerevisiae .
17. Spiro, C., Pelletier, R., Rolfsmeier, M. L., Dixon, M. J., Lahue, R. S. , Gupta, G., Park, M. S., Chen, X., Mariappan, S. V. S., and McMurray, C. T. Molec. Cell    4 1079-1085 (1999). Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats.
18. Rolfsmeier, M. L., and Lahue, R. S. Mol. Cell. Biol. 20 173-180 (2000).    Stabilizing effects of interruptions on trinucleotide repeat expansions in Saccharomyces cerevisiae.
19. Rolfsmeier, M. L., Dixon, M. J., and Lahue, R. S. Molec. Cell    6 1501-1507 (2000). Mismatch repair blocks expansions of interrupted trinucleotide repeats in yeast.
20. Rolfsmeier, M. L., Dixon, M. J., Pessoa-Brandao, L., Pelletier, R., Miret, J. J. and Lahue, R. S . Genetics 157 1569-1579 (2001) . Cis -elements regulating trinucleotide repeat instability in Saccharomyces cerevisiae.
21. Corrette-Bennett, S. E., Mohlman, N. L., Rosado, Z., Miret, J. J., Hess, P. M., Parker, B. O., and Lahue, R. S. Nucleic Acids Research 29 : 4134-4143 (2001). Efficient repair of large DNA loops in Saccharomyces cerevisiae .
22. Dixon, M. J. and Lahue, R. S. DNA Repair 1 :765-773 (2002). Examining the potential role of DNA polymerases eta and zeta in triplet repeat instability in yeast.
23. Bhattacharyya, S., Rolfsmeier, M. L., Dixon, M. J., Wagoner, K. and Lahue, R. S. Genetics . 162 :579-589 (2002). Identification of RTG2 as a modifier gene for CTG·CAG repeat instability in Saccharomyces cerevisiae.
24. Pelletier, R., Krasilnikova, M. M., Samadashwily, G. M., Lahue, R. , and Mirkin, S. M. Mol. Cell. Biol. 23 1349-1357 (2003). Replication and expansion of trinucleotide repeats in yeast.
25. Dixon, M. J. and Lahue, R. S. Nucleic Acids Res . 32 :1289-1297 (2004). DNA elements important for CAG·CTG repeat thresholds in Saccharomyces cerevisiae .
26. Bhattacharyya, S. and Lahue, R. S. Mol. Cell. Biol. 24 7324-7330 (2004). Yeast Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.
27. Corrette-Bennett, S. E., Borgeson, C., Sommer, D., Burgers, P. M. J., and Lahue, R. S. Nucleic Acids Res. 32:6268-6275 (2004). DNA Polymerase d , RFC, and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae .
28. Bhattacharyya, S. and Lahue, R. S. J. Biol. Chem . 280 33311-33317 (2005). Srs2 helicase of Saccharomyces cerevisiae selectively unwinds triplet repeat DNA.
29. Pelletier, R., Farrell, B. T., Miret, J. J., and Lahue, R. S. Nucleic Acids Res. 33 5667-5676 (2005). Mechanistic features of CAG·CTG repeat contractions in cultured cells revealed by a novel genetic assay.
30. Farrell, B.T. and Lahue, R.S. Nucleic Acids Res. 34 4495-4505 (2006) . CAG·CTG repeat instability in cultured human astrocytes.
31. Collins, N.S, Bhattacharyya, S. and Lahue, R. S . DNA Repair 6 38-44 (2007). Rev1 enhances CAG·CTG repeat stability in Saccharomyces cerevisiae.
32. Daee, D.L., Mertz, T. and Lahue, R. S. Molecular and Cellular Biology 27 102-110 (2007). Post-replication repair inhibits CAG•CTG repeat expansions in Saccharomyces cerevisiae.
33. Claassen, D. A. and Lahue, R. S. Human Molecular Genetics 16 3088-3096 (2007). Expansions of CAG·CTG repeats in immortalized human astrocytes.
34. Razidlo, D. F. and Lahue, R. S. DNA Repair 7 633-640 (2008). Mrc1, Tof1 and Csm3 inhibit CAG_CTG repeat instability by at least two mechanisms.
35. Dhar, A. and Lahue, R. S. Nucleic Acids Research 36 3366-3373 (2008). Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae.
36. Sommer, D., Stith, C.M., Burgers, P.M.J. and Lahue, R. S. Nucleic Acids Res. 36 4699-4707 (2008). Partial reconstitution of DNA large loop repair and purified protiens from Saccharomyces cerevisiae.
37. Erlich, R.L., Fry, R.C., Begley, T.J., Daee, D.L., Lahue, R.S., and Samson, L.D. PLoS ONE 3 e3717 (2008). Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathways in S. cerevisiae.
38. Gellon, L., Razidlo, D.F., Gleeson, O., Verra, L., Schulz, D, Lahue, R.S., and Freudenreich, C.H. PLoS Genetics In press. New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

Solicited Reviews and Commentaries

39. Lahue, R. S. , and Modrich, P. Mutation Research 207 37-43 (1988). Methyl-directed mismatch correction in vitro .
40. Modrich, P., and Lahue, R. S. Annu. Rev. Biochemistry 65 101-133 (1996). Mismatch repair in replication fidelity, genetic recombination and cancer biology.
41. Lahue, R. S. and Slater, D. L. Frontiers in Bioscience . 8 s553-565 (2003). DNA repair and trinucleotide repeat instability.
42. Lahue, R. S. ChemTracts - Biochemistry and Molecular Biology. 17 :677-681 (2004). DNA mismatch repair and trinucleotide repeat instability: the expansion connection .

Methods Papers

43. Corrette-Bennett, S. E., and Lahue, R. S. Methods Mol. Biol. 113 121-132 (1999). Mismatch repair assay.
44. Bhattacharyya, S., Dixon, M. D., and Lahue, R. S. Methods Mol. Biol. 277 29-45 (2004). Genetic assays for triplet repeat instability in yeast.

Biochemistry, School of Natural Science.
National University of Ireland, Galway, University Road, Galway, Ireland.
Phone: +353 (0)91 492420
E-mail: Biochemistry
This page was last updated Thursday, January 13, 2011