Genome Stability Laboratory

• FULL PUBLICATION LIST.

  Dobbie IM, Lowndes NF , Sullivan KF (2008) Autofluorescent proteins. Methods Cell Biol. 2008;85:1-22.

  Roche KC and Lowndes NF (2007) An investigation into 53BP1 complex formation. Adv Exp Med Biol. 604:47-57.

  Rossignol T, Logue ME, Reynolds K, Grenon M, Lowndes NF and Butler G (2007) Transcriptional response of Candida parapsilosis following exposure to farnesol. Antimicrob Agents Chemother. 51(7):2304-12.

  Bree RT, Lai XY, Canavan LE, Lowndes NF (2007) Comparisons Between DT40 Wildtype and Cre1 cells as suitable model systems for studying the DNA Damage Response. Cell Cycle. 10;6(18) [Epub ahead of print]

  Lowndes NF (2007) Chaperoning the Cln3 cyclin prevents promiscuous activation of start. Mol Cell. 27(1):1-2.

  Braet C, Stephan H, Dobbie IM, Togashi DM, Ryder AG, Foldes-Papp Z, Lowndes N, Nasheuer HP (2007) Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy. Exp Mol Pathol. 82(2):156-62.

  Grenon M, Costelloe T, Jimeno S, O’Shaughnessy A, FitzGerald J, Zgheib O, Degerth L and Lowndes NF (2007) Docking onto chromatin via the S. cerevisiae Rad9 Tudor domain. Yeast. 24(2):105-19

  Friedberg EC, Aguilera A, Gellert M, Hanawalt PC, Hays JB, Lehmann AR, Lindahl T, Lowndes N, Sarasin A, Wood RD. (2006) DNA repair: from molecular mechanism to human disease. DNA Repair (Amst). 5(8):986-96.

  Costelloe T, Fitzgerald J, Murphy NJ, Flaus, A & Lowndes, NF Chromatin modulation and the DNA damage response. (2006).Exp Cell Res 312, 2677-86

  Toh GW-L, O'Shaughnessy A, Jimeno S, Dobbie I, Grenon M, Maffini S, O' Rork A and Lowndes, NF (2006) Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation. DNA Repair. 5: 693-703

  Grenon M, Magill CP, Lowndes NF and Jackson SP (2006) Double-Strand Breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint Activation. FEMS Yeast Research, 6: 836-847

  O’Shaughnessy AM, Grenon M, Gilbert C, Toh GW-L, Green CM and Lowndes NF (2006) Multiple approaches to study S. cerevisiae Rad9, a prototypical checkpoint protein. Meths. Enzym. 409: 131-150

  Nakamura K, Sakai W, Kawamoto T, Bree RT, Lowndes NF, Takeda S, Taniguchi Y. (2006) Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks. DNA Repair 10;5(6):741-9.

  Lowndes NF and Toh GW-L (2005) DNA repair: the importance of phosphorylating histone H2AX. Curr Biol. 15:R99-R102

  Bree R, Neary C, Samali A and Lowndes NF (2004) The switch from survival responses to apoptosis after chromosomal breaks. DNA Repair, 3: 989-995

  Toh GW-L and Lowndes NF. (2004). DNA Damage Surveillance in Saccharomyces cerevisiae. In Eukaryotic DNA Damage Surveillance and Repair, ed. Caldecott, K., Landes Bioscience. ISBN: 1-58706-227-5

  Green CM and Lowndes NF (2004) Purification and analysis of checkpoint protein complexes from Saccharomyces cerevisiae. Methods Mol Biol.;280:291-306

  van den Bosch M and Lowndes NF. (2003) Remodelling the Rad9 checkpoint complex. Cell Cycle 3: 1-4

  Gilbert C, van den Bosch M. Green CM, Vialard JE, Grenon M, Erdjument-Bromage H, Tempst P and Lowndes NF (2003). The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function. EMBO Reports, 4: 953-958

  van den Bosch M, Bree RT and Lowndes NF.(2003) The MRN complex: coordinating and mediating the response to broken chromosomes.EMBO Reports, 4: 844-849

  Toh GW-L and Lowndes NF. (2003). Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem Soc Trans., 31: 242-6.

  Redon C, Pilch DR, Rogakou EP, Orr AH, Lowndes NF, Bonner WM. (2003) Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage. EMBO Rep. 4:678-684

  de la Torre-Ruiz MA, Toh GW-L and Lowndes, NF. (2002) Budding yeast as a eukaryotic model for understanding the mechanisms of cellular responses to DNA damage. Recent Research Developments in DNA repair and Mutagenesis. Research Signpost, India 67-80 Eds: Ruiz-Rubio, Alejandre-Buran, E and Roldan-Arjona, T.

  Chakraverty RK, Kearsey JM, Oakley TJ, Grenon M, de La Torre Ruiz MA, Lowndes NF, Hickson ID. (2001). Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint. Mol Cell. Biol., 21: 7150-7162

  Gilbert C, Green CM and Lowndes NF (2001). Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol. Cell, 8:129-136

  Grenon M, Gilbert C, Lowndes NF. (2001) Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex. Nat. Cell Biol., 3: 844-847

  Yu S, Teng Y, Lowndes NF and Waters R. (2001). Inducible nucleotide excision repair of UV induced cyclobutane pyrimidine dimers in the Saccharomyces cerevisiae MFA2 gene. Mutat. Res., 485: 229-236

  Lowndes NF. (2001). DNA-damage signaling and apoptosis. Genome Biol., 2: 4028-4029

  Downs JA, Lowndes NF and Jackson, SP. (2000). A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature, 408: 1001-1004

  de la Torre-Ruiz MA and Lowndes NF. (2000). DUN1 defines one branch downstream of RAD53 for transcription and DNA damage repair in Sacharomyces cerevisiae. FEBS Letts, 485: 205-206

  Lowndes NF and Murguia, JR. (2000) Sensing and responding to DNA damage. Curr. Opin. Genet. & Dev. 10: 17-25

  de la Torre-Ruiz MA and Lowndes NF. (2000) The S. cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non-homologous end joining. FEBS Letts 467: 311-315

  Green CM, Erdjument-Bromage H, Tempst P and Lowndes NF. (2000) A Novel Rad24 checkpoint Protein complex closely related to Replication Factor C. Curr. Biol. 10: 39-42.

  Soulier J and Lowndes NF. (1999) The BRCT domain of the S. cerevisiae Rad9 checkpoint protein mediates Rad9/Rad9 interaction after DNA damage. Curr. Biol. 9: 551-554

  Lowndes NF. (1999). DNA damage-dependent checkpoints in yeasts and human cells. Eur J. Cancer 35: 1573-1574

  Vialard JE, Gilbert CS, Green, CM and Lowndes NF. (1998). The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J. 17: 5679-5688

  Freire R, Murguia JR, Tarsounas M, Lowndes NF, Moens PB and Jackson, SP. (1998). Human and mouse homologues of S. pombe rad1 and S. cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. Genes & Dev.; 12: 2560-2573

  de la Torre-Ruiz, MA, Green CM and Lowndes NF. (1998) RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation. EMBO J, 17: 2687-2698

  Aboussekhra A., Vialard JE, Morrison DE, de la Torre-Ruiz MA, Cernakova, L., Fabre, F and Lowndes, NF (1996). The RAD9 checkpoint gene of Saccharomyces cerevisiae controls a DNA damage-specific transcriptional response. EMBO J. 15: 3912-3922

  Merrill G, Morgan B, Lowndes NF and Johnston LH (1992). Periodic transcription during the late G1 phase of the budding yeast cell cycle. BioEssays, 14: 823-830

  Lowndes NF, Johnson AL, Breeden L and Johnston LH. (1992) SWI6 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeast. Nature, 357:505-508

  Johnston LH, Lowndes NF, Johnson AL and Sugino A. (1991) A cell-cycle-regulated trans-factor, DSC1, controls expression of DNA synthesis genes in yeast. Cold Spring Harb Symp Quant Biol. 56:169-176

  Johnston LH and Lowndes NF. (1992) Cell cycle control of DNA synthesis in budding yeast. Nucleic Acids Res. 20(10): 2403-2410

  Lowndes, N.F. and Johnston, L.H. (1992). Parallel pathways of cell cycle-regulated gene expression. Tr. Genet. 8: 79-81

  Lowndes NF, McInerny CJ, Johnson AL, Fantes PA, Johnston LH. (1992)Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10 . Nature, 355: 449-453

  Lowndes NF, Johnson AL, Johnston LH. (1991) Coordination of expression of DNA synthesis genes in budding yeast by a cell-cycle regulated trans factor. Nature, 350: 247-250

  White JH, Johnson AL, Lowndes NF, Johnston LH. (1991) The yeast DNA ligase gene CDC9 is controlled by six orientation specific upstream activating sequences that respond to cellular proliferation but which alone cannot mediate cell cycle regulation. Nucleic Acids Res, 19: 359-364

  Lowndes NF, Bushel P, Mendelsohn L, Wu J, Yen MY, Allan M. (1990) A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional read-through by a viral promoter. Mol. Cell. Biol., 10: 4990-4995

  Lowndes NF, Paul J, Wu J, Allan M. (1998) c-Ha-ras bidirectional promoter expressed in vitro: location and regulation. Mol. Cell. Biol., 9: 3758-3770

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