Prof. brian mcstay

Scientific publications

LaVolpe, A., Taggart, M., McStay, B., and Bird, A.P. (1983) DNaseI Hypersensitive sites at promoter like sequences in the spacer of X.laevis and X. borealis. Nucl. Acids Res. 11, 5361- 5380.  

McStay, B. and Bird, A.P. (1983) The origin of the rRNA precursor from X.borealis analysed in vivo and in vitro. Nucl. Acids Res. 11, 8167-8181.

McStay, B. and Reeder, R.H. (1986) A termination site for Xenopus RNA polymerase I also acts as an element of an adjacent promoter. Cell 47, 913-920.

Reeder, R.H., Labhart, P.L. and Mc Stay, B. (1987) Processing and termination of RNA polymerase I transcripts. BioEssays 6, 108-112.

Reeder, R.H., Pennock, D., McStay, B., Roan, J., Tolentino, E. and Walker, P. (1987) Linker scanner mutagenesis of the Xenopus laevis ribosomal gene promoter. Nucl. Acids Res. 15, 7429-7441.

Pikaard, C.S., McStay, B.M., Schultz, M.C., Bell, S.P. and Reeder, R.H. (1989) The Xenopus ribosomal gene enhancers bind an essential polymerase I transcription factor. Genes and Development 3, 1779-1788.

McStay, B. and Reeder, R.H. (1990) A DNA-binding protein is required for termination of transcription in Xenopus laevis. Mol.Cell.Biol. 10, 2793-2800.

McStay, B. and Reeder, R.H. (1990) An RNA polymerase I termination site can stimulate the adjacent ribosomal gene promoter by two distinct mechanisms in Xenopus laevis. Genes and Development. 4, 1240-1252.

McStay, B., Hu C. H., Pikaard, C.S. and Reeder, R.H. (1991) xUBF and Rib I are both required for formation of a stable RNA polymerase I promoterv complex in X.laevis.  EMBO journal . 10,  2297-2303

McStay, B., Frazier, M. W. and Reeder, R.H. (1991). xUBF contains a novel dimerization domain essential for RNA polymerase I transcription.  Genes and Development 5, 1957-1968

Palmer, T., Miller, A.D., Reeder, R.H. and McStay, B.M. (1993) Efficient expression of a protein coding gene under the control of an RNA polymerase I promoter. Nucleic Acids Res. 21.3451-3457

Hu,C.H., McStay B.M. and Reeder, R.H. (1994)  xUBF, an RNA polymerase I transcription factor, crosslinks DNA. Mol. Cell. Biol.    14, 2871-2882.

Cairns, C. and McStay, B. (1995) Identification and cDNA cloning of a xenopus nucleolar phosphoprotein xNopp180, that is the homolog of the rat nucleolar protein Nopp140. J. Cell Science 108, 3339-3347

Cairns, C. and McStay, B. (1995) HMG box 4 is the principal determinant of species psecificity in the RNA polymerase I transcription factor UBF. Nuc. Acids Res. 22, 4583-4590.

Reeder, R.H., Pikaard, C.S. and McStay, B. (1995) UBF an architectural element for RNA polymerase I promoters. Nucleic Acids and Molecular Biology, Vol9  251-263.

Bodeker, M., Cairns,C and McStay,B. (1996)  Upstream Binding Factor stabilizes Rib1, the TATA-binding-protein-containing RNA Polymerase I transcription factor, by multiple protein interactions in a DNA-independent manner. Mol. Cell. Biol., 16, 5572-5578.

McStay, B., Sullivan, G.J. and Cairns C. (1997) The Xenopus RNA polymerase I transcription factor, UBF, has a role in transcriptional enhancement distinct from that at the promoter. EMBO Journal 16, 396-405.

Bell, P., Mais, C., McStay, B. and Scheer, U. (1997). Association of the nucleolar transcription factor UBF with the transcriptionally inactive rRNA genes of pronuclei and early Xenopus embryos. J.Cell Science 110, 2053-2063 

Sullivan, G.J. and McStay B. (1998). Dimerisation and HMG box 1-3 domains present in xUBF are sufficient for its role in RNA polymerase I transcriptional enhancement. Nuc. Acids Res. 26, 3555-3561. 

Sullivan, G.J. Bridger, J.M., Cuthbert, A.P., Newbold, R.. Bickmore, W.A. and McStay B. (2001) Human acrocentric chromosomes with transcriptionally silent nucleolar organiser regions can associate with heterologous nucleoli. EMBO Journal  20, 2867-77.

Audrey C. O'Sullivan, Gareth J. Sullivan and Brian McStay (2002) UBF binding in vivo is not restricted to regulatory sequences within the vertebrate rDNA repeat. Mol.Cell.Bio 22, 657-668 

Mais C, McStay B, Scheer U. (2002) On the formation of amplified nucleoli during early Xenopus oogenesis. J Struct Biol. 140, 214-26.

McStay B, Paule M, Schultz MC, Willis I, Pikaard CS (2002) Oddpols united: new insights into transcription by RNA polymerases I and III. Gene Expr. 10, 263-9. 

Mais, C., Wright, J.E., Prieto, J.L., Raggett, S.L. and McStay B. (2005) UBF Binding Site Arrays Form Pseudo-NORs and Sequester the RNA Pol I Transcription Machinery. Genes and Development 19, 50-64 

Prieto, J.L. and McStay B (2005) Nucleolar biogenesis; the first small steps  Biochemical Society Transactions 2005 Dec;33(Pt 6):1441-3 

Wright, J.E., Mais, C., Prieto, J.L. and McStay B (2006) A role for UBF in organising ribosomal gene chromatin. Biochem Soc Symp 2006;(73):77-84.

McStay, B. (2006) Nucleolar dominance: a model for rRNA gene silencing. Genes and Development. 20, 1207-1214

F. J. Lawrence, B. McStay and D. A. Matthews (2006) Nucleolar protein Upstream Binding Factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis. J. Cell. Sci 119, 2621-2631 

Prieto, J.L. and McStay B (2007) Factors linking transcription and processing of pre-rRNA in human cells are recruited to nucleolar organiser region chromatin independent of transcription. Genes and Development 21, 2041-2054

McStay, B and Grummt, I (2008) The epigenetics of rRNA genes: from molecular to chromosome biology. Annual Review of Cell and Developmental Biology 24

Prieto, J.L. and McStay, B. (2008) Pseudo-NORs a novel model for studying nucleoli. BBA - Molecular Cell Research, Special Issue (in press).

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