Chromosome Biology Laboratory

• Scientific publications (Ciaran Morrison)
  
  
• Research papers
  1. Morrison, C. and Gannon, F. (1994) The impact of the PCR plateau phase on quantitative PCR. Biochim. Biophys. Acta 1219: 493-498.
  2. Morrison, C. and Wagner, E. (1996) Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems. Nucleic Acids Res. 24: 2053-2058.
  3. Wang, Z.Q., Stingl, L., Morrison, C., Jantsch, M., Los, M., Schulze-Osthoff, K. and Wagner, E.F. (1997) PARP is important for genomic stability but dispensable in apoptosis. Genes Dev. 11: 2347-2358.
  4. Morrison, C., Smith G.C.M., Stingl, L., Jackson, S.P., Wagner, E.F. and Wang, Z.Q. (1997) Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat. Genet. 17: 479-482.
  5. Takata, M., Sasaki, M.S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi-Iwai, Y., Shinohara, A. and Takeda, S. (1998) Homologous recombination and nonhomologous end-joining pathways of double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17: 5497-5508
  6. Yamaguchi-Iwai, Y., Sonoda, E., Buerstedde, J.-M., Bezzubova, O., Morrison, C., Takata, M., Shinohara, A. and Takeda, S. (1998) Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52. Mol. Cell. Biol., 18: 6430-6435.
  7. Sonoda, E., Sasaki, M.S., Morrison, C., Yamaguchi-Iwai, Y., Takata, M. and Takeda, S. (1999) Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol. Cell. Biol., 19: 5166-5169.
  8. Morrison, C., Shinohara, A., Sonoda, E., Yamaguchi-Iwai, Y., Takata, M., Weichselbaum, R.R. and Takeda, S. (1999) The essential functions of human Rad51 do not require ATP hydrolysis. Mol. Cell. Biol., 19: 6891-6897.
  9. Yamaguchi-Iwai, Y., Sonoda, E., Sasaki, M.S., Morrison, C., Haraguchi, T., Hiraoka, Y., Yamashita, Y.M., Takata, M., Price, C., Kakazu, N. and Takeda, S. (1999) Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J., 18: 6619-6629.
  10. Takao, N., Kato, H., Mori, R., Morrison, C., Sonoda, E., Sun, X., Shimizu, H., Yoshioka, K., Takeda, S. and Yamamoto, K. (1999) Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation. Oncogene, 18: 7002-7009.
  11. Morrison, C., Sonoda, E., Takao, N., Shinohara, A., Yamamoto, K. and Takeda, S. (2000) The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J., 19: 463-471.
  12. Takata, M., Sasaki, M.S., Sonoda, E., Fukushima, T., Morrison, C., Albala, J., Swagemakers, S.M.A., Kanaar, R., Thompson, L.H. and Takeda, S. (2000) The Rad51 paralog Rad51B promotes homologous recombinational repair. Mol. Cell. Biol., 20: 6476-6482.
  13. Fukushima, T., Takata, M., Morrison, C., Araki, R., Fujimori A., Abe, M., Tatsumi, K., Jasin, M., Dhar, P.K., Sonoda, E., Chiba, T. and Takeda, S. (2001) Ku impedes homologous DNA recombination: competition between the major DNA double-strand break repair pathways. J. biol. Chem., 276:44413-44418.
  14. Sonoda, E., Matsusaka, T., Morrison, C., Vagnarelli, P., Hoshi, O.,Ushiki, T., Nojima, K., Fukugawa, T., Waizenegger, I.C., Peters, J.-M., Earnshaw, W.C. and Takeda, S. (2001) Scc1/ Rad21/ Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells. Dev. Cell, 1: 759-770.
  15. Morrison, C., Henzing, A.J., Jensen, O.N., Osheroff, N., Kandels-Lewis, S.E., Dodson, H., Adams, R.R. and Earnshaw, W.C. (2002) Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res., 30: 5318-5327.
  16. Vagnarelli, P., Morrison C. , Dodson, H., Sonoda, E., Takeda, S. and Earnshaw, W.C. (2003) Cohesin-independent metaphase alignment and spindle assembly checkpoint silencing following topoisomerase II inhibition. EMBO Rep., 5 : 167-171.
  17. Dodson, H., Vagnarelli, P., Sonoda, E., Takeda, S., Earnshaw, W.C., Merdes, A. and Morrison, C. (2004) Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J., 23: 3864-3873.
  18. Hochegger, H., Dejsuphong, D., Fukushima, T., Morrison, C ., Sonoda, E., Schreiber, V., Zhao, G.Y., Saberi, A., Masutani, M., de Murcia, G. and Takeda, S. (2006) Parp-1 protects homologous recombination from interference by Ku in vertebrate cells. EMBO J. , 25:1305-1314 .
  19. Dodson, H, Wheatley, S.P. and Morrison, C.G. (2007) Involvement of centrosome amplification in radiation-induced mitotic catastrophe. Cell Cycle 6: 364-70.
  20. Bourke, E., Merdes, A., Cuffe, L., Dodson, H., Zachos, G., Walker, M., Gillespie, D. and Morrison, C.G. (2007) DNA damage induces Chk1-dependent centrosome amplification. EMBO Rep. 8 : 603-609.
  21. Jeffers, L.J., Coull, B.J., Stack, S.J. and Morrison, C.G. (2007) Distinct BRCT domains in Mcph1/Brit1 mediate ionising radiation-induced focus formation and centrosomal localisation. Oncogene, 27:139-44. 
22. Faure, V., Wenner, T., Cooley, C., Bourke, E., Farr, C.J., Takeda, S. and Morrison, C.G. (2008) Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line. DNA Repair 7: 713-724.
23. Saladino, C., Bourke, E., Conroy, P.C. and Morrison, C.G. (2009) Centriole separation in DNA damage-induced centrosome amplification. Environ. Mol. Mutagen., 50:725-732.
24. Cooley, C., Baird, K.M., Faure, V., Wenner, T., Stewart, J.L., Modino, S., Slijepcevic, P., Farr, C.J. and Morrison, C.G. (2009) Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells. Mol. Biol. Cell. 20: 2653-2571.
25. Dodson, H and Morrison, C.G. (2009) Increased sister chromatid cohesion and DNA damage response factor localization at an enzyme-induced DNA double-strand break in vertebrate cells. Nucleic Acids Res. 37: 6054-6063.
26. Bourke, E., Brown, J.A., Takeda, S., Hochegger, H. and Morrison, C.G. (2009) DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2. Oncogene, in press.


• Reviews and invited papers
  1. Kichler, A., Zauner, W., Morrison, C. and Wagner, E. (1996) 'Ligand-polylysine mediated gene transfer' in Felgner, P.L. et al. (eds.) Artificial self-assembling systems for gene delivery. ACS Conference Proceedings series, American Chemical Society. 190pp.
  2. Morrison, C. and Takeda, S. (2000) Genetic analysis of homologous DNA recombination in vertebrate somatic cells. Int. J. Biochem. Cell Biol. 32: 817-831.
  3. Sonoda, E., Morrison, C., Yamashita, Y.M, Takata, M. and Takeda, S. (2001) Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40. Phil. Trans. Roy. Soc. Lond. 356: 111-117.
  4. Morrison, C. (2001) The same, only different: postdoctoral experience in Japan- an alternative worth considering. EMBO Rep. 2: 265-266.
  5. Sonoda, E., Takata, M., Yamashita, Y.M., Morrison, C. and Takeda, S. (2001) Homologous DNA recombination in vertebrate cells. Proc. Natl. Acad. Sci. U.S.A. 98: 8388- 8394.
  6. Hudson, D.F., Morrison, C., Ruchaud, S. and Earnshaw, W.C. (2002) Reverse genetics of essential genes in tissue culture cells: 'dead cells talking' Trends Cell Biol., 12: 281-287.
  7. Morrison, C., Vagnarelli, P., Sonoda, E., Takeda, S. and Earnshaw, W.C. (2003) Biochem. Soc. Trans. 31:263-5.
  8. Morrison, C. and Rieder, C.L. (2004) Chromosome damage and progression into and through mitosis in vertebrates . DNA Repair 3: 1133-1139.

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