Dr. Stephen Rea

Career history:
SFI Investigator (PIYRA recipient) and lecturer at the NUI Galway Biochemistry Dept. (since December 2007).
Postdoc with Asifa Akhtar at EMBL, Heidelberg 2003-2007 (HFSP and EMBO funded).
Scientific Consultant, Boehringer Ingelheim, Connecticut (2002).
Postdoc and Ph.D. with Thomas Jenuwein at the Research Institute of Molecular Pathology (IMP), Vienna, 1998-2002.
B.Sc. (Hons) Biotechnology at NUI Galway (1994-1998).

Research interests
Epigenetic regulation of gene expression.
Histone modifications in normal development and disease.

Key recent publications:

Pfister, S., Rea, S., Taipale M., Mendrzyk, F., Straub, B., Ittrich, C., Thuerigen, O., Sinn, H.P., Lichter, P. and Akhtar, A. (2007): The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma. Int J. Cancer 122(6):1207-13.

Rea, S., Xouri, G., Akhtar, A., (2007): Males absent on the first (MOF): from flies to humans. Oncogene 26 (37), 5385-94.

Taipale, M., Rea, S., Richter, K., Vilar, A., Lichter, P., Imhof, A., and Akhtar, A. (2005): hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol 25, 6798-6810.

Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., and Jenuwein, T. (2001): Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-20.

Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z. W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., and Jenuwein, T. (2000): Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593-9.

Full publication list

Positions available:
Please contact me directly for information.

Contact details:
Stephen Rea Ph.D.
Department of Biochemistry
National University of Ireland Galway
University Road
Galway
Ireland

Phone: 353 91 495750
Fax: 353 91 495504

Email: stephen.reanuigalway.ie 

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