Dr.Maria Tuohy

• Career history
  
  B.Sc. (Hons) 1986, National University of Ireland, Galway;
  Ph.D. 1986-1991, NUI, Galway;
  Visiting researcher RUGhent, 1989, 1990, BSH Institut fur Holzchemie, Hamburg, 1990,1991 (funded by EU Cost Ter and Bis fellowships);
  Post-doctoral researcher 1991-1993 (RUGhent, BSH Institut fur Holzchemie & NUI, Galway);
  Research Group Leader, NUI, Galway 1993-1997;
  Lecturer and Head of the Molecular Glycobiotechnology Group, NUI, Galway 1997-present .
  
  

• Research interests
  
  1. Production, characterization, molecular genetics and biotechnological application of eukaryotic glycoproteins and novel biocatalysts, with emphasis on glycosyl hydrolases, oxidoreductases and proteases .
  2. Proteomics, structure-function analysis and cell biology of important cell-surface lectins/glycoproteins and enzymes.
  3. Regulation of gene expression and glycoprotein secretion in filamentous fungi.
  

• Key publications
  

  Grassick, A., Murray, P. G., Thompson, R., Collins, C. M., Byrnes, L. , Birrane, G., Higgins, T. M. & Tuohy, M. G.(2004). Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii. Eur. J. Biochem. 271 : 4495-4506

  
  Maloney, A.P., Callan, S.M., Murray, P.G. & Tuohy, M.G. (2004) Mitochondrial malate dehydrogenase from the thermophilic, filamentous fungus Talaromyces emersonii. Purification of the native enzyme, cloning and overexpression of the corresponding gene. Eur. J. Biochem. 271 : 3115-3126.

  
  Murray, P.G., Aro, N., Collins, C., Grassick, A., Penttilä, M., Saloheimo, M. & Tuohy, M. (2004) Expression in Trichoderma reesei and characterisation of a thermostable family 3 b -glucosidase from the moderately thermophilic fungus Talaromyces emersonii. Prot. Expr. Purif. 38 : 248-257.

  
  Reen, F.J., Murray, P.G. & Tuohy, M.G. (2003) Cloning and transcriptional analysis of the first hemicellulase gene ( bxl1 ) encoding b -xylosidase from the thermophilic fungus Talaromyces emersonii. Biochem. Biophys. Res. Commun. 305 : 579-585.

  
  Murray, P.G., Collins, C.M., Grassick, A. & Tuohy, M.G. (2003) Molecular cloning, transcriptional and expression analysis of the first cellulose gene ( cbh2), encoding cellobiohydrolase II, from the moderately thermophilic fungus Talaromyces emersonii and structure prediction of the gene product. Biochem. Biophys. Res. Commun. 301 : 280-286.

• Lab members
  

  Dr. Patrick Murray (Senior Research Scientist)
  Dr. Charles Piggott (Post-doctoral researcher)
  Franck Hennequart (Researcher)
  
  Postgraduate Students
  
  Alan Hernon
  Anthonia O’Donovan
  Pauline Walsh
  Regina O’Sullivan
  Elaine O’Connell
  Sara Fernandes
  Deborah Waters
  Sarah Foley
  Bosilijka Kovacevic
  Frantisek Apfelbeck
  Janika Simila (Visiting Erasmus Thesis Student)
  Ashish Rawson (with Teagasc)
  
  Summer research students (2005)
  
  Jonathon Nestor
  Adrian Fahey
  David Loftus
  
  Visiting (Erasmus) students (2005)
  
  Sara Fernandes
  Annelies van Hoorebeke
  
  Former Team Members
  
  Dr. Alice Grassick
  Dr. Lassarina McLoughlin
  Dr. Catherine Collins
  Dr. Jerry Reen
  Dr. Roisin Thompson
  Dr. Mary Heneghan
  Dr. Caroline Gilleran
  Dr. Liam Loftus (Former Graduate student, with Dr. T. Griffin)
  Dr. Alan Maloney
  Dr. Stephanie Ryan
  Dr. Denise Gallagher
  Dr. William (Liam) Duggan
  Dr. Susan Callan
  Dr. Christopher Laffey
  Dr. Tracey McCarthy
  Dr. Daniel Walsh
  
  

• Lectures/ courses
  

  Course co-ordinator (1998-2004) of 3rd Year Biochemistry degree programme (B.Sc. Undenominated degree programme; BI314, BI315 and BI316; co-coordinator in 1997-1998 and 2004-2005);
  

  Co-ordinator of 3rd Year Biotechnology programme (3BY221 and 3BY121: 2000-present).

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