This project focuses on research at the frontiers of knowledge of enzymes, mediators, surfaces and immobilisation strategies aimed at improving enzymatic electron transfer reactions for application towards integrated bio-powered biosensing systems for diagnosis and healthcare.

Some of the main achievements to date include:
• The kinetic and electrochemical characterisation, and improved immobilization, of various redox enzymes.
• An instrument for signal collection has been developed and tested.
• A library of Os/Ru-based redox mediator complexes has been compiled.
• Investigation of methods for enzyme immobilisation.
• Preparation of protein mutants, engineered to allow for chemical immobilisation.
• A method of template assembly for production of macroporous gold electrodes.
• Improvements in thick film technology for mass-production of structured electrodes.
• Immobilisation of enzymes within conducting polymer matrices on high-surface area carbon foams.
• Use of carbon nanotube-modified surfaces as glucose biosensors.
• Improved stability of power output obtained from combining mediators and enzymes with inks.
• Optimisation of methods for co-immobilization of enzymes and mediators at surfaces.

For further details of these and other key research findings please download our Dissemination Brochure.

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