Patrick O’Leary is a native of Cork, Ireland and has been working in the School of Chemistry as a lecturer since September 2004.   

His Previous studies include a Bachelors of Science (B.Sc, 1995) degree and a Ph.D from University College Cork.  His Ph.D Research concentrated on the Rhodium (II) Catalysed Buchner reactionOn completion of his Ph.D he was awarded the inaugural Post Doctoral Fellowship in The Sciences from the National University of Ireland in 1999.  This Fellowship is awarded after an open competition among scientists throughout Ireland and only one is awarded  every two years.  This fellowship allowed Patrick to study the use of the Buchner reaction as the key step in a challenging natural product synthesis.

On completion of the NUI-postdoctoral fellowship Patrick moved to Utrecht to work in the Department of Metal Mediated Synthesis with Prof. Gerard van Koten and Dr. Bert Klein Gebbink.  During the following two years he worked on immobilisation and recycling techniques for chiral homogeneous catalysts. This was achieved via the non-covalent immobilisation of homogeneous transition metal to silica materials.

During his time in Utrecht Patrick also acted as expert editor of a  published report on the activity in the area of chemistry of the COST funding body over the years 1999-2001. 

Publications:

 

2014

 

Catalyst and substituent effects on the rhodium(II)-catalysedintramolecular Buchner reaction.

Orla A. McNamara , N. Rachael Buckley , Patrick O’Leary, Francis Harrington ,Norma Kelly Sarah O’Keeffe, Angela Stack, Shane O’Neill Simon E. Lawrence,Catherine N. Slattery, Anita R. Maguire

Tetrahedron 70 (2014) 6870e6878

 

2013

AraBOX and XyliBOX based catalysts for cyclopropanations, Diels Alder cycloadditions and allylic additions.

David Kellehan , Fiona Kirby , David Frain , Antonio M. Rodríguez-García , José I. García ,Patrick O’Leary

Tetrahedron Asymmetry 24 (2013), pp. 750-757                  

DOI information: 10.1016/j.tetasy.2013.04.020

 

 

 

Synthetic approaches to the daucanesesquiterpene derivatives employing the intramolecular Buchner cyclisation of α-diazoketones
Tetrahedron, 69 (2013, pp 1778-1794)
David A. Foley, Patrick O’Leary, N. Rachael Buckley, Simon E. Lawrence, Anita R. Maguire

 

 

 

2012

Hydroxyamide-Based Ligands and Their Use in the Asymmetric Catalysis of Key Organic Transformations

Paul Geoghegan and Patrick O'Leary*

ACS Catalysis 2012, 2, 573591

'Preparation and Structure of Novel Chiral 4,6-Disubstituted Tetrahydropyrimidinones'

 David Frain, Fiona Kirby, Patrick McArdle, and Patrick O'Leary
Organic chemistry International Volume 2012 (2012), Article ID 293945
 

Asymmetric Synthesis of cis-7-Methoxycalamenene via the Intramolecular Buchner Reaction of an α-Diazoketone.

Paul A. McDowell,David A. Foley,Patrick OLeary,,§ Alan Ford,and Anita R. Maguire*,

J. Org. Chem. 2012, 77, 20352040

 

2010

'Preparation, structure and catalytic activity of copper(II) complexes of novel 4,4'-BOX ligands' David Frain, Fiona Kirby, Patrick McArdle and Patrick O'Leary*                                             Tetrahedron Letters 51 2010 4103–4106

'Pyroglutamate-derived hydroxyamide ligands: synthesis and application to asymmetric catalysis'             Paul Geoghegan, Patrick O'Leary*                                                                                        Tetrahedron Asymmetry 21 2010 867–870

'4,4BOX based catalysts: Synthesis, structure and catalytic application' Fiona Kirby,David Frain,  Patrick McArdle and Patrick O'Leary*                                                                                     Catalysis Communications 11 2010 1012–1016

  

2009
 

'Efficient construction of novel carbocyclic frameworks via intramolecular aromatic addition of diazoketones followed by Diels-Alder cycloaddition.'
Patrick O'Leary* and Anita R. Maguire*
ARKIVOC 2009, Accepted, In Press.

 

'The Synthesis of AraBOX, a New 4,4’-bis(oxazoline), from Novel Pentitol-Derived Bis β-Aminoalcohol'
David frain, Fiona Kirby, Patrick McArdle and Patrick O'Leary*

Synlett 2009,1261 .

 

'Enzymatic immobilization of organometallic species: Biosilification of NCN- and PCP-pincer metal species using demosponge

axial filaments'

Patrick O’Leary, C. van Walree, Nilesh C. Mehendale, Jan Summerel, Daniel E. Morse, William C. Kaska, Gerard van Koten and Robertus J.M. Klein Gebbink

Dalton Transactions 2009, 4289-4291. DOI: 10.1039/b900341j

 

'Electrostatically immobilised BOX and PYBOX metal catalysts: Application to ene reactions'
Chiara McDonagh and Patrick O'Leary*

Tetrahedron letters 50, 2009 979-982.

 

2008

'New chiral diamide ligands: synthesis and application in allylic alkylation'
Lorraine Batema, Simon W. Breeden and Patrick O'Leary*
Tetrahedron: Asymmetry 2008 391-396.

2007

'Electrostatic immobilisation of copper(I) and copper(II) bis(oxazolinyl)pyridine catalysts on silica: application to the synthesis of propargylamines via direct-addition of terminal alkynes to imines.'
Chiara McDonagh, Peter O’Conghaile, Robertus J. M. Klein Gebbink and Patrick O'Leary*
Tetrahedron letters 48, 2007 4387-4390.

 

'Arenediazonium Salts' Chapter 31.23 Science of Synthesis series Thieme Verlag 2007.

Patrick O'Leary

2005

Activity Report 1999-2001 COST CHEMISTRY ACTION D8-D29 Edited by P de Bergeyck, D Neibecker, Patrick O'Leary (Expert), L Petrus and G Van Koten.  Issued online 2005.

2004

Facile and rapid immobilization of copper(II) bis(oxazoline) catalysts on silica: application to Diels-Alder reactions, recycling and unexpected effects on enatioselectivity.

Patrick O’Leary, N.P. Krosveld, K.P. de Jong, G. van Koten and R.J.M. Klein Gebbink, Tetrahedron Lett. 2004, 45(16), 3177-3180.

Pre 2004

Dynamic equilibria in the products of intramolecular Buchner additions of diazoketones to aryl rings bearing methoxy substituents

A.R. Maguire, P. O'Leary, F. Harrington, S.E. Lawrence, A.J. Blake

J. Org. Chem., 2001, 66 (21), 7166-7177. 

 

Stereocontrol in the intramolecular Buchner Reaction of Diazoketones

A.R. Maguire, N.R. Buckley, P.O’Leary and G. Ferguson, J. Chem. Soc., Perkin Trans., 1998, 4077. 

 

Excellent Stereocontrol in Intramolecular Buchner Cyclizations and Subsequent Cycloadditions; construction of polycyclic systems

A.R. Maguire, N.R. Buckley, P.O’Leary and G. Ferguson, Chem. Commun., 1996, 2595. 

 

Presentations:

 

Design, Synthesis and Catalytic Activity of Novel Oxazoline Based Ligands

Nadine Mc Cleary (Presenter)

66th Irish Universities Chemistry Research Colloquium
19th June 2014
 

 

Design, Synthesis and Catalytic Activity of Novel 4,4’-Bis(Oxazoline) Ligands

Nadine Mc Cleary (Presenter)
Eli Lilly Symposium NUI Galway
2nd November 2012
 

Simple Idea made complex

A talk presented to the RSC Organic Chemistry Regional Meeting & Awards Symposium
April 19th 2012 NUI Galway Patrick O'Leary

 

Selective Catalysts for green oxidation: upping performance reducing waste
A Flash presentation to the annual EPA conference

Davina Flanagan (presenter)

 

Novel ARABOX ligands: Synthesis and Enantioselective Catalytic Application

David Frain (presenter), Fiona Kirby, and Patrick O'Leary

A Talk presented to the Irish Universities Chemistry Research Colloquium June 2009

 

Applications of a Simple Immobilisation Technique for metal Bisoxazolines

P. O'Leary, C. McDonagh, P. O' Conghaile

A talk presented to the 'Magic of Metals' Conference NUI, Maynooth , Ireland, 8th November 2007

 

 

Expanding the scope of established homogeneous catalysts

P. O’Leary, N. P. Krosveld, K. de Jong and G. van Koten and R.J.M. Klein Gebbink. A talk presented to the Netherlands Research School Combination-Catalysis workshop October 31st 2003, Hoog Brabant, Utrecht

  

Silica immobilised homogeneous catalysts: Preparation and use

P. O’Leary, R.J.M. Klein Gebbink, K. de Jong and G. van Koten. A Talk presented at the Netherlands' Catalysis and Chemistry Conference

NCCC IV March 10-12, 2003, Noordwijkerhout, The Netherlands

 

 

Selected Poster Presentations

 

Design and synthesis of novel 4, 4’ BOX ligands

Davina Flanagan, David Frain , Fiona Kirby, and Patrick O'Leary
European Symposium in Organic Chemistry in Crete July 2011, poster presentation

The Novel AraBOX ligands:Synthesis and enantioselective catalytic application.
David Frain , Fiona Kirby, and Patrick O'Leary
European Symposium in Organic Chemistry in Prague July 2009, poster presentation

Enantioselective Synthesis of Diamino Dialcohols key Bioactive Building Blocks
Fiona Kirby, David Frain and Patrick O'Leary
European Symposium in Organic Chemistry in Prague July 2009, poster presentation

Synthetic applications of electrostatically immobilised bisoxazoline and bis(oxazolinyl)pyridine catalysts on silica.
Chiara McDonagh, Peter O’Conghaile and Patrick O'Leary.
Poster presentation  15th European Symposium in Organic Chemistry July 2007 UCD.

 

Chiral Induction in the Tandem Aldol-Tischenko Reaction

Blaithín Sweeney, Simon W. Breeden, Patrick O'Leary.

Poster presentation 58th Irish Chemistry Research Colloquium June 2006.

 

Silica immobilised homogeneous catalysts: Expanding the scope of established homogeneous  catalysts to multi componant reactions. P. O’Leary, R.J.M. Klein Gebbink, K. de Jong and G. van Koten

A poster presented to 2nd International Conference on Multi Component Reactions, Combinatorial and Related Chemistry, April 14-16, 2003, Genoa, Italy.

 

Enantioselective Synthesis of Sesquiterpenoid Natural Products: CAF-603 and Related Analogues. P.O’Leary, A.R. Maguire, N.R. Buckley and S.E.Lawrence

Poster presented at 17th International Symposium in Organic Synthesis in Oxford 23-26 July 2001

 

Rhodium Catalyzed Carbenoid Cyclizations: Influence of Catalyst on Diastereoselectivity. P.O’Leary, A.R. Maguire, N.R. Buckley and F. Harrington

Poster presented at Transition Metals 4 in Leeds 5-7 September 2000

 

Approaches to the Synthesis of CAF-603, a Potent Modulator of the Calcium Activated Potassium channel

P.O’Leary and A.R. Maguire. Poster presented at Annual Medical Research Day at University College Hospital, Cork Ireland, 1999 

 

Rhodium Catalyzed Carbenoid Cyclizations: Stereospecific Construction of Polycyclic Systems. P.O’Leary, A.R. Maguire and N.R. Buckley,

Poster presented at the Royal Society of Chemistry Drugs From Natural Products conference at Trinity College Dublin 5-7 July 1998.

                                                                            

 







 



To contact us:
Phone: +353 (0)91 492476
Email: patrick.oleary at nuigalway.ie
School of Chemistry
National University Of Ireland, Galway
University Road
Galway