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School of Chemistry
Dr. Peter B. Crowley - Lecturer |
Check out our latest paper published in Nature Chemistry. Nature Chemistry 2012, doi:10.1038/nchem.1342 |
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2002 PhD Leiden University, The Netherlands
1998 BSc University College Dublin Phone: + 353 91 49 2480 Email: peter.crowley-at-nuigalway.ie | |
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After graduating with first class honours in chemistry Peter joined the laboratory of Prof. G. W. Canters at Leiden University, The Netherlands. Working with his advisor Prof. M. Ubbink, he used NMR spectroscopy to study transient protein interactions involved in electron transport. This research was summarized in an invited paper in Accounts of Chemical Research. From the Netherlands Peter headed south for sunnier climes. With a Marie Curie Postdoctoral fellowship he joined the lab of Prof. M. A. Carrondo at Universidade Nova de Lisboa, Portugal. During this time he further developed his interest in molecular recognition. In particular, he demonstrated the importance of cation-pi interactions in protein interfaces. In 2006, Peter returned to Ireland, working as a lecturer in Biochemistry at UCD, and since 2008 as a lecturer in Chemistry at NUI Galway. Current interests include protein self assembly and interactions under physiological conditions. For more information see publications below. The lab gratefully acknowledges funding from Science Foundation Ireland. November 19th 2012: Congratulations to Roise who won the NUI Galway - 2012 Roche Research Award in Life Sciences and Bioengineering. On Friday 13th April 2012 the School of Chemistry hosted the symposium 'From Alchemy to Chemistry'. Three excellent speakers, Peter Forshaw, John Perkins & William Brock presented their research. NUI Galway Millennium Fund is acknowledged for supporting this event. In November 2011 Peter organized 'Distill Life' an exhibition of chemically inspired art. This multi-media exhibition showcased the work of about twenty artists. Check out this video made by James Ward and Will Smith. Here's a molecular dynamics animation made with the 4th year students in 2010. | |
Research Interests- Molecular Recognition
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Group | |
| PhD Students:
Roise Mc Govern BSc, funded by NUI Galway college fellowship - Calixarene Mediated Protein Assembly Giada Cattani MSc, funded by Science Foundation Ireland - Thiol Conjugates for Protein Assembly Ciara Kyne BSc, funded by NUI Hardiman Fellowship and NUI Travelling Studentship - In-cell NMR studies of GB1 Pawel Antonik MSc, funded by Teagasc Walsh Fellowship and NUI Galway Millennium Fund - Structural Characterisation of a Fucose-binding Lectin Madeleine Mallon BSc, funded by NUI Hardiman Fellowship - Protein Surface Recognition - Ligands for Lysine Undergraduate Project Students: Aishling Doolan Shane Moran Group Photo 2012 
From left to right: Peter, Ciara, Madeleine, Roise, Giada and Pawel. Group Photo 2011 | |
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Roise
Ciara Peter Giada Ronan
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Publications | |
| 24. Crowley PB*, Kyne C, Monteith WB
Simple and inexpensive incorporation of 19F-tryptophan for protein NMR spectroscopy. Chemical Communications 2012, 48, 10681-3 23. McGovern RE, Fernandes H, Khan AR, Power NP, Crowley PB* Protein camouflage in cytochrome c–calixarene complexes. Nature Chemistry 2012, 4, 527-33 22. Crowley PB,* Chow E, Papkovskaia T. Protein interactions in the Escherichia coli cytosol: An impediment to in-cell NMR Spectroscopy. ChemBioChem 2011, 12, 1043-1048. 21. Farrell D, Sá-Miranda E, Webb H, Georgi N, Crowley PB, McIntosh LP, Nielsen JE. Titration_DB: Storage and analysis of NMR-monitored protein pH titration curves Proteins 2010, 78, 843-857. 20. Crowley PB,* Matias PM, Khan AR, Roessle M, Svergun DI. Metal-mediated self-assembly of a beta-sandwich protein. Chemistry 2009, 15, 12672-12680. 19. Yanagisawa S, Crowley PB, Firbank SJ, Lawler AT, Hunter DM, McFarlane W, Li C, Kohzuma T, Banfield MJ, Dennison C. pi-interaction tuning of the active site properties of metalloproteins. J. Am. Chem. Soc. 2008, 130, 15420-15428. 18. Petoukhov MV, Vicente JB, Crowley PB, Carrondo MA, Teixeira M, Svergun DI. Quaternary structure of flavorubredoxin as revealed by synchrotron radiation small-angle X-ray scattering. Structure 2008, 16, 1428-1436. 17. Crowley PB,* Matias PM, Mi H, Firbank SJ, Banfield MJ, Dennison C. Regulation of Protein Function: Crystal Packing Interfaces and Conformational Dimerization. Biochemistry 2008, 47, 6583–6589. 16. Crowley PB,* Ganji P, Ibrahim H. Protein surface recognition: structural characterisation of cytochrome c-porphyrin complexes. Chembiochem 2008, 9, 1029-33. 15. Crowley PB,* Brett K, Muldoon J. NMR spectroscopy reveals cytochrome c-poly(ethylene glycol) interactions. ChemBioChem 2008, 9, 685-8. 14. Sato K, Crowley PB, Dennison C. Transient protein interactions between cytochrome f and the phytocyanin umecyanin. ChemBioChem 2007, 8, 732-5. 13. Sato K, Crowley PB,* Dennison C.* Transient homodimer interactions studied using the electron self-exchange reaction. J. Biol. Chem. 2005, 280, 19281-8. 12. Díaz-Moreno I, Díaz-Quintana A, De la Rosa MA, Crowley PB, Ubbink M. Different modes of interaction in cyanobacterial complexes of plastocyanin and cytochrome f. Biochemistry 2005, 44, 3176-83. 11. Crowley PB,* Golovin A. Cation-pi interactions in protein-protein interfaces. Proteins 2005, 59, 231-9. 10. Crowley PB,* Carrondo MA. The architecture of the binding site in redox protein complexes: implications for fast dissociation. Proteins 2004, 55, 603-12. 9. Crowley PB, Hunter DM, Sato K, McFarlane W, Dennison C. The parsley plastocyanin-turnip cytochrome f complex: a structurally distorted but kinetically functional acidic patch. Biochem. J. 2004, 378, 45-51. 8. Crowley PB, Ubbink M. Close encounters of the transient kind: protein interactions in the photosynthetic redox chain investigated by NMR spectroscopy. Acc. Chem. Res. 2003, 36, 723-30. 7. Crowley PB, Vintonenko N, Bullerjahn GS, M Ubbink. Plastocyanin-cytochrome f interactions: The influence of hydrophobic patch mutations studied by NMR spectroscopy. Biochemistry 2002, 41, 15698-705. 6. Crowley PB, Díaz-Quintana A, Molina-Heredia F, Nieto P, Sutter M, Haehnel W, de la Rosa M, Ubbink M. The interactions of cyanobacterial cytochrome c6 and cytochrome f, characterized by NMR. J. Biol. Chem. 2002, 277, 48685-89. 5. Crowley PB, Rabe KS, Worrall JAR, Canters GW, Ubbink M. The ternary complex of cytochrome f and cytochrome c: Identification of a second binding site and competition for plastocyanin binding. ChemBioChem 2002, 3, 526-33. 4. Worrall JAR, Liu YJ, Crowley PB, Nocek JM, Hoffman BM, Ubbink M. Myoglobin and cytochrome b5: A nuclear magnetic resonance study of a highly dynamic protein complex. Biochemistry 2002, 41, 11721-30. 3. Dunne EC, Coyne EJ, Crowley PB, Gilheany DG. Co-operative ortho-effects on the Wittig reaction. Interpretation of stereoselectivity in the reaction of ortho-halo-substituted benzaldehydes and benzylidenetriphenyl-phosphoranes. Tetrahedron Lett. 2002, 43, 2449-53. 2. Crowley PB, Otting G, Schlarb-Ridley BG, Canters GW, Ubbink M. Hydrophobic interactions in a cyanobacterial plastocyanin-cytochrome f complex. J. Am. Chem. Soc. 2001, 123, 10444-53. 1. Crowley P, Ubbink M, Otting G. Phi angle restraints in protein backbones from dipole-dipole cross-correlation between 1HN-15N and 1HN-1Halpha vectors. J. Am. Chem. Soc. 2000, 122, 2968-69. | |
School of Chemistry
National University of Ireland, Galway, University Road, Galway, Ireland.
Head of School: Prof. Paul Murphy, B.Sc., Ph.D.
Phone: +353 (0)91 492460
E-mail: karen.kelly
nuigalway.ie
This page was last updated Wednesday, February 13, 2013
National University of Ireland, Galway, University Road, Galway, Ireland.
Head of School: Prof. Paul Murphy, B.Sc., Ph.D.
Phone: +353 (0)91 492460
E-mail: karen.kelly
nuigalway.ie
This page was last updated Wednesday, February 13, 2013