SCHOOL OF CHEMISTRY

Research Interests

Current research interests include (1) design and development of smart stimulus-responsive biomaterials for cytotechnology and drug delivery; (2) characterization of biomaterials and medical devices at the nano- and micro-scale level; (3) cell-biomaterial interactions, fundamental aspects of biocompatibility. I have co-authored more than 120 journal articles, book chapters, conference and workshops abstracts and papers. I am actively involved in several national and international collaborative research projects in biomaterials and tissue engineering. I am also heavily involved in a number of industrial research collaborations, including a major collaborative research program with Boston Scientific Ireland. 

Recent Publications

1. Maria E. Nash, Deirdre Healy, William M. Carroll, Carlos Elvira and Yury A. Rochev. Cell and cell sheet recovery from pNIPAm coatings; motivation and history to present day approaches J. Mater. Chem., 2012.
2. O' Connor, P., Yang, R., Carroll, W.M., Rochev, Y., Aldabbagh, F. Facile synthesis of thermoresponsive block copolymers of N-isopropylacrylamide using heterogeneous controlled/living nitroxide-mediated polymerizations in supercritical carbon dioxide, European Polymer Journal, 2012, 48(7), 1279-1288.
3. Maria E. Nash, William M. Carroll,  Diego Velasco, Javier Gomez,  Alexander V. Gorelov,  Dmitry Elezov,  Alberto Gallardo,  Yury A. Rochev,  Carlos Elvira. Synthesis and Characterization of a Novel Thermoresponsive Copolymer Series and their Application in Cell and Cell Sheet Regeneration. Journal of Biomaterials Science: Polymer Edition (In Press), 2012.
4. Maria E. Nash, William M. Carroll,a Padraic J. Foley, Garrett Maguire, Claire O’ Connell, Alexander Gorelov, Sergey Beloshapkin  and Yury Rochev, Ultra-thin Spin Coated Crosslinkable Hydrogels for use in Cell Sheet Recovery - Synthesis, Characterization to Application, Soft Matter. 2012, 8, 3889-3899.
5. Rongbing Yang,  Vo Thi Ngoc Tuoi; Alexander V Gorelov, Fawaz Aldabbagh, William M Carroll,  Martin G Meere,  Yury Rochev, A mathematical model for pulsatile release: controlled release of rhodamine B from UVcrosslinked thermoresponsive thin films, Int J Pharm. 2012, 10;427(2):320-7.
6. Myriam G. Tardajos, Maria Nash, Yury Rochev, Helmut Reinecke, Carlos Elvira, Alberto Gallardo, Homologous Copolymerization Route to Functional and Biocompatible Poly-vinylpyrrolidone. Macromolecular Chemistry & Physics, 2012, 213(5), 529-538.
7. Babu R Prasad, Gillian Mullins, Natalia Nikolskaya, David Connolly, Terry J. Smith, Valerie A. Gerard, Stephen J. Byrne, Gemma-Louise Davies, Yurii K. Gun'ko and Yury Rochev,  Effects of Long-term exposure of Gelatinated and Non-gelatinated Cadmium Telluride Quantum Dots on Differentiated PC12 cells. J Nanobiotechnology. 2012 Jan 20;10:4.
8. McMahon S. S, Nikolskaya N, Ní Choileáin S, Hennessy N, O'Brien T, Strappe P, Gorelov A, Rochev Y. Thermosensitive Hydrogel for Prolonged Delivery of Lentiviral Vector Expressing Neurotrophin-3 in vitro. J Gene Med. 2011, 13(11), 591-601.
9. Alexander J. C, Pandit A, Bao G, Connolly D, Rochev Y, Monitoring mRNA in living cells in a 3D in vitro model using TAT-peptide linked molecular beacons, Lab Chip. 2011, 11(22):3908-14.
10. Nash M. E, Carroll W. M, Nikoloskya N, Yang R, O'Connell C, Gorelov A. V, Dockery P, Liptrot C, Lyng F. M, Garcia A, Rochev Y. A,  Straightforward, one-step fabrication of ultrathin thermoresponsive films from commercially available pNIPAm for cell culture and recovery. ACS Appl Mater Interfaces. 2011, 3(6):1980-90.

Books  and  Chapters

Prasad BR, O'Connell E, Smith TJ, Gérard VA, Gun'ko YK, Rochev Y. Evaluating the potential of quantum dots for in vitro biological studies: effects on gene expression using microarray analysis. Methods Mol Biol. 2012;906:171-83.

Gérard VA, Gun'ko YK, Prasad BR, Rochev Y., Synthesis of Biocompatible Gelatinated Thioglycolic Acid-Capped CdTe Quantum Dots ("Jelly Dots"), Methods Mol Biol. 2012; 906:275-81.

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