rESEARCH, Dr. Fawaz ALDABBAGH

Synthesis of Designed Macromolecules and
New Small Molecule Anti-Tumour Agents

The group is headed by Dr. Aldabbagh and has a wide range of multi-disciplinary research interests in Organic and Polymer synthesis, as well as Environmental and Medicinal chemistry. Some current research projects are outlined below;

Organic/Medicinal Chemistry
We are preparing new bioreductive heterocyclic molecules that selectively target tumour cells, in particular associated hypoxic cells.
Organic synthetic methods used include radical cyclizations (in particular using new green photochemical methods) and dipolar cycloadditions. Previous publications have dealt with radical reaction kinetics and mechanisms. Most of our heterocycles are diazole-based molecules, in particular benzimidazolequinones.

Recent examples;


Photochemical Radical Cyclization 

 
New Diazole Heterocyclic Systems via Eschenmoser Hydrazones

Materials/Polymers
Nitroxide-mediated living/controlled radical dispersion polymerizations in supercritical carbon dioxide that produce materials with controlled microstructure and particle morphology are being developed. Supercritical carbon dioxide has unique properties such as acting as a plasticizer allowing the polymer to be isolated as a powder, and circumventing the use of toxic and environmentally damaging volatile organic solvents

Polystyrene prepared in Supercritical Carbon Dioxide

 
Colloidal Stabilization

Poly(acrylamide) and poly(acrylic acid) are thermal and pH-responsive materials respectively. We are making new intricate architectures using the latest living/controlled radical polymerization techniques. Such smart materials are used in drug-delivery, and respond to changes in physiological temperature and the acidic environments associated with tumour cells.
 
Key words: Antibiotics, Bioreductive, Heterocycles, Nitroxides, Polymerizations, Radicals, Sulfur Chemistry

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