Structured PhD (Chemistry)--full-time
College of Science,
School of Chemistry
The School of Chemistry has strengths in synthesis, natural product synthesis, structure determination, theoretical and computational chemistry, analytical chemistry, physical chemistry, inorganic chemistry, organic chemistry, natural products chemistry and marine biodiscovery, medicinal chemistry and materials chemistry. In recent years the Schools output in terms of peer reviewed publications has grown significantly. The School has graduated ~350 PhD students since 1970. More than 60% of these graduates are employed in Irish Industry with the remainder working in the public sector or in education. A number have successful careers outside Ireland. Research activity within the School of Chemistry involves over 70 postgraduate students and postdoctoral researchers in the following research areas:
Analytical Chemistry: There are research themes concerned with the implementation of spectroscopy, electrochemistry, and chemometrics based methods for the development of new analytical methods. Application areas include bio-pharmaceutical and pharmaceutical production processes, environmental sensing, petroleum characterization, and materials for medical devices. The School has top quality MS, NMR (400, 500 and 600 MHz) & X-ray facilities. There is also access to various microscopy techniques. These analytical facilities are used throughout the School.
Synthesis & Mechanism: More than half the School’s research students are engaged in synthesis as part of their research. This includes natural products synthesis, heterocycles, asymmetric synthesis, photochemistry, inorganic materials, carbohydrate synthesis, biomolecular synthesis, pharmaceutical and biopharmaceutical synthesis.
Chemistry Advancing Biology & Medicine: This involves development of biomaterials with potential application in drug delivery. There is also interest in magnetic materials, and new bioactive compounds. The latter have potential as therapeutics for areas such as cancer and infection. There is expertise in carbohydrates, glycoconjugates, proteins, heterocyclic molecules and natural products their development as bioactive agents. Targets include DNA, lectins, and various protein targets, including protein-protein interactions. Design of bioactive compounds is carried out using computational techniques.
Green Chemistry and Energy: Research is concerned with developing the fuels and green chemistry of the future. There are projects in combustion chemistry, biomolecular electronics, energy and environmentally friendly synthesis of small molecules and macromolecules.
Combustion Chemistry Research: The Combustion Chemistry Centre, C3 is engaged in fundamental research on the combustion of fossil and biofuels. Combustion is the ultimate interdisciplinary field: it requires knowledge of chemistry, physics, fluid dynamics, thermodynamics and mathematics. In addition, combustion science has a well defined purpose in society today, facilitating the study and analysis of problems associated with the generation of air pollutants. C3 is concerned with the application of combustion research to the design of energy-efficient engine and gas turbine combustion systems and the impact of their use on toxic and greenhouse gas emissions, thus helping address the problems of urban air pollution and climate change.
Natural Products Chemistry and Marine Biodiscovery: This research covers drug discovery from natural sources, particularly from Irish marine organisms. It involves bioprospecting, extraction, purification and structure elucidation of novel natural drug leads which can be developed pharmaceutically against cancer, infectious diseases and CNS disorders. Another interest is the discovery of bioactive marine food ingredients which may benefit human health by inclusion in the diet.
Structured PhD, full-time
This normally involves working under supervision of one of the academic staff of the School. A list of academic staff and short summary of their research areas is provided below.
Areas of interest
Organic and Polymer Synthesis & Mechanism, Cancer Research, Heterocyclic Chemistry, Radicals (incl. photochemistry), Polymerizations (incl. controlled/living), Supercritical Carbon Dioxide.
Molecular Recognition, Protein-protein & Protein-Small Molecule Interactions, Structural Biology, In-Cell NMR Spectroscopy.
H. J. Curran
Combustion Chemistry, Biofuels, Fuel Efficiency, Emissions Reduction, Global Warming.
Metal-Based Drugs, DNA and peptide hydrolysis, Coordination Chemistry, Crystal Structures and Polymorphism of Pharmaceutical Solids.
Photochemistry, Green Chemistry.
Paramagnetic Host-Guest Materials, Single-Molecule Magnets (SMMs) and Paramagnetic complexes, Magnetic Coolant Materials (magnetic refrigerants), 1, 2 and 3-D Coordination Polymers.
Electrochemistry, Bioelectrochemistry, Analytical Chemistry, Sensors and Diagnostics, Industrial Electrochemistry, Energy, Marine and Environmental Electrochemical Technologies.
P. V. Murphy
Organic synthesis, natural product synthesis. Anti-tumour and anti-infective compounds, carbohydrates & glycoconjugate synthesis. Bioactive molecule design & synthesis especially inhibiting carbohydrate-lectin interactions and protein protein interactions using glycomimetics and peptidomimetics.
Organic synthesis, Asymmetric Catalysis, Ligand Design, Immobilisation, Bioactive Product Synthesis.
Dr Luca Ronconi
Bioinorganic and medicinal chemistry, metal-based anticancer agents, interaction between metal complexes and biologically-relevant macromolecules, inorganic synthesis, coordination compounds, targeted chemotherapy.
Analytical Chemistry, Biopharmaceutical/Pharmaceutical Manufacturing, Environmental Monitoring, Medical Devices.
Natural Product Chemistry, Drug discovery, Marine natural products, Marine Biodiscovery, Marine Functional foods.
Molecular Modeling, Computational Drug Design.
Find out more
Prof. Paul Murphy
T +353 91 492 465