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Uri Frank

Ph.D. 1995 University of Amsterdam, the Netherlands; postdoc at the National Institute of Oceanography, Haifa, Israel ('95-'97); and the University of Jena, Germany (1997-1999); group leader at the University of Heidelberg, Germany (1999-2005); Lecturer at NUIG (2005-2009); Senior Lecturer sine 2009; SFI Principal Investigator since 2007

Contact:
School of Natural Sciences & Regenerative Medicine Institute (REMEDI), NUI Galway
Phone: 353 91 492334
Fax: 353 91 525005
Email: uri.frank

nuigalway.ie

We use an invertebrate model organism, the cnidarian Hydractinia, to address fundamental questions in cell and developmental biology. In particular, we have been working on Wnt-mediated axis patterning and stem cell decision-making.

Our research is funded by Science Foundation Ireland (SFI), the European Regional Development Fund, Enterprise Ireland, and by a Beaufort Marine Biodiscovery grant (Department of Communication, Energy and natural Resources).

Positions available in the lab

If you want to join our lab email me for details. We have a fully funded PhD studentship available, and I am also happy to consider postdoc candidates if they are prepared to apply for funding.

Current group members

Brian Bradshaw (PhD Student)
Hakima Flici (postdoc)
Katerina Rudigerove (research assistant)
Katrin Hensel (PhD student)
James Gahan (PhD student)
John Leech (research assistant)
Liam Doonan (PhD student)
Uri Frank (PI)

Publications

Kanska J, Frank U (2013). Novel roles for Nanos in neural cell fate determination revealed by studies
in a cnidarian. J Cell Sci (in press).

Plickert G, Frank U, Müller WA (2012). Hydractinia, a pioneering model for stem cell biology and reprogramming of somatic cells to pluripotency. Int J Dev Biol 56(6-8): 519-534.

Duffy DJ, Millane RC, Frank U (2012). A heat shock protein and Wnt signaling crosstalk during axial patterning and stem cell proliferation. Dev Biol 362(2): 271-281 .

Millane RC, Kanska J, Duffy DJ, Seoighe C, Cunningham S, Plickert G, Frank U (2011). Induced stem cell neoplasia in a cnidarian by ectopic expression of a POU domain transcription factor. Development 138(12): 2429-2439. PDF

Duffy DJ, Frank U (2011). Modulation of COUP-TF expression in a cnidarian by ectopic Wnt signalling and allorecognition. PLoS One 6(4): e19443.

Mali B, Millane RC, Plickert G, Frohme M, Frank U (2011). A polymorphic, thrombospondin-containing lectin is an oocyte marker in Hydractinia: implications for germ cell specification and sex determination. Int J Dev Biol 55: 103-108.

Künzel T, Heiermann R, Frank U, Müller WA, Tilmann W, Bause M, Nonn A, Helling M, Schwarz RS, Plickert G (2010). Migration and differentiation potential of stem cells in the cnidarian Hydractinia analysed in eGFP-transgenic animals and chimeras. Dev Biol 348: 120-129. PDF

Duffy DJ, Plickert G, Kuenzel T, Tilmann W, Frank U (2010). Wnt signaling promotes oral but suppresses aboral structures in Hydractinia metamorphosis and regeneration. Development 137(18): 3057-3066. PDF

Soza-Ried J, Hotz-Wagenblatt A, Glatting KH, del Val C, Fellenberg K. Bode H, Frank U, Hoheisel J, Frohme, M (2010). The transcriptome of the colonial marine hydroid Hydractinia echinata. FEBS J 277(1): 197-209.

Frank U, Plickert G, Müller WA (2009). Cnidarian interstitial cells: the dawn of stem cell research. In Rinkevich B, Matranga V (eds) Stem cells in marine organisms. Springer, ISBN: 978-90-481-2766-5.

Frank U (2007). The evolution of a malignant dog. Evol & Dev 9(6): 521-522.

Müller WA, Frank U, Teo R, Mokady O, Gütte C, Plickert G (2007). Wnt signaling in hydroid development: Ectopic heads and giant buds induced by GSK-3ß inhibitors. Int J Dev Biol 51: 211-220.

Plickert G, Jacoby V, Frank U, Müller WA, Mokady O (2006). Wnt signaling in hydroid development: Formation of the primary body axis in embryogenesis and its subsequent patterning. Dev Biol 298: 368-378.

Brickner I, Oren U, Frank U, Loya Y (2006). Energy integration between the solitary polyps of the clonal coral Lobophyllia corymbosa. J Exp Biol 209: 1690-1695.

Möhrlen F, Maniura M, Plickert G, Frohme M, Frank U (2006). Evolution of astacin-like metalloproteases in animals and their function in development. Evol & Dev 8(2): 223-231.

Teo R, Möhrlen F, Plickert G, Müller WA, Frank U (2006). An evolutionary conserved role of Wnt-signaling in stem cell fate decision. Dev Biol 289(1): 91-99.

Mali B, Soza Ried J, Frohme M, Frank U (2006). Structural but not functional conservation of an immune molecule: a tachylectin-like gene in Hydractinia. Dev Comp Immunol 30(3): 275-281.

Guduric-Fuchs J, Möhrlen F, Frohme M, Frank U (2004). A fragile X mental retardation-like gene in a cnidarian. Gene 343(2): 231-238.

Müller WA, Teo R, Frank U (2004). Totipotent migratory stem cells in a Hydroid. Dev Biol 275(1): 215-224.

Mali B, Möhrlen F, Frohme M, Frank U (2004). A putative double role of a chitinase in a cnidarian: pattern formation and immunity. Dev Comp Immunol 28(10): 973-981.

Mali B, Frank U (2004). Hydroid TNF-receptor-associated factor (TRAF) and its splice variant: a role in development. Mol Immunol 41(4): 377-384.

Gild S, Frank U, Mokady O (2003). Allogeneic interactions in Hydractinia: is the transitory chimera beneficial? Int J Dev Biol 47: 433-437.

Frank U, Mokady O (2002). Coral biodiversity and evolution recent molecular contributions. Can J Zool 80 (10): 1723-1734.

Fuchs M, Mokady O, Frank U (2002). The ontogeny of allorecognition in a colonial hydroid and the fate of early established chimeras. Int J Dev Biol 46 (5): 699-704.

Frank U, Leitz T, Müller WA (2001). The hydroid, Hydractinia: a versatile, informative cnidarian representative BioEssays 23 (10): 963-971.

Frank U, Rinkevich B (2001). Alloimmune memory is absent in the Red Sea hydrocoral Millepora dichotoma. J Exp Zool 291: 25-29.

Reinhardt B, Frank U, Gellner K, Lohmann JU, Bosch TCG (1999). High-resolution nonradioactive differential display on a DNA sequencer which allows easy band excision. Biotechniques 27: 268-271.

Frank U, Rinkevich B (1999). Scyphozoan jellyfish' mesoglea supports attachment, spreading and migration of anthozoans' cells in vitro. Cell Biol Int 23 (4): 307-311.

Frank U, Oren U, Loya Y, Rinkevich B (1997). Alloimmune maturation in the coral Stylophora pistillata is achieved through three distinctive stages, four months post metamorphosis. Proc Roy Soc Lond B 264: 99-104.

Frank U, Bak RPM, Rinkevich B (1996). Allorecognition responses in the soft coral Parerythropodium fulvum fulvum from the Red Sea. J Exp Mar Biol Ecol 197: 191-201.

Frank U, Brickner I, Rinkevich B, Loya Y, Bak RPM, Achituv Y, Ilan M (1995). Allogeneic and xenogeneic interactions in reef-building corals may induce tissue growth without calcification. Mar Ecol Prog Ser 124: 181-188.

Rinkevich B, Frank U, Gateño D, Rabinowitz C (1994). The establishment of various cell lines from colonial marine invertebrates. In: Müller WEG (ed). Use of aquatic invertebrates as tools for monitoring of environmental hazards. Gustav Fischer Verlag, Stuttgart, pp 253-263.

Frank U, Rabinowitz C, Rinkevich B (1994). In vitro establishment of continuous cell cultures and cell lines from ten colonial cnidarians. Mar Biol 120: 491-499.

Rinkevich B, Frank U, Bak RPM, Müller WEG (1994). Alloimmune responses between Acropora hemprichi conspecifics: nontransitive patterns of overgrowth and delayed cytotoxicity Mar Biol 118: 731-737.

Frank U, Rinkevich B (1994). Nontransitive patterns of historecognition phenomena in the Red Sea hydrocoral Millepora dichotoma. Mar Biol 118: 723-729.

Rinkevich B, Frank U, Bak RPM, Müller WEG (1994). Alloimmune responses between Acropora hemprichi conspecifics: nontransitive patterns of overgrowth and delayed cytotoxicity. Mar Biol 118: 723-729.

Brom TG, Frank U (1992). The diagnostic and phylogenetic significance of widened and pronged hamuli in feathers. Scanning Microscopy 6 (2): 597-602.

Frank U, Brom TG (1992). The diagnostic significance of widened and pronged hamuli in feathers. Proc 21 Meeting of the Bird Strike Committee Europe; working paper 5: 27-34, Jerusalem, Israel.

Frank U, Hove HA ten (1992). In vitro exposure of Spirobranchus giganteus and S. tetraceros (Polychaeta, Serpulidae) to various turbidities; Branchial morphologies an expression of filtering strategy? Oebalia 18: 45-52.

Uri Frank
This page was last updated Sunday, May 05, 2013