HRB Clinical Research Facility Galway Publications LIST 

2011                         

Abraham, J., Prajapati, S., Nishijo, K., Schaffer, B., Taniguchi, E., Kilcoyne, A., McCleish, A., Nelon, L., Giles, F., Efstratiadis, A., Legallo, R., Nowak, B., Rubin, B., Malempati, S., Keller, C. Evasion mechanisms to IGF1r inhibition in rhabdomyosarcoma. Molecular Cancer Therapeutics 2011

Abraham, J., Nelon, L.D., Kubicek, C.B., Kilcoyne, A., Hampton, S.T., Zarzabal, L.A., Giles, F. , Michalek, J.E., Rubin, B.P., Keller, C. Preclinical testing of Erlotinib in a transgenic alveolar rhabdomyosarcoma mouse model. Sarcoma 2011

Barzilay, J.I., Gao, P., O'Donnell, M., Mann, J.F., Anderson, C., Fagard, R., Probstfield, J., Dagenais, G.R., Teo, K., Yusuf, S.; ONTARGET and TRANSCEND Investigators. Albuminuria and decline in cognitive function: The ONTARGET/TRANSCEND studies. Arch Intern Med. 2011 Jan 24;171(2):142-50.

Burke, A.C., Swords, R.T., Kelly, K., Giles, F.J. (2011). Current status of agents active against the T315I chronic myeloid leukemia phenotype.  Expert Opinion on Emerging Drugs 16 (1) 85-103.

Connolly, S.J., Eikelboom, J., Joyner C., Diener, H.-C., Hart, R., Golitsyn, S., Flaker, G., Avezum, A., Hohnloser, S.H., Diaz, R., Talajic, M., Zhu, J., Pais, P., Budaj, A., Parkhomenko, A., Jansky, P., Commerford, P., Tan, R.S., Sim, K.-H., Lewis, B.S., Van Mieghem, W., Lip, G.Y.H., Kim, J.H., Lanas-Zanetti, F., Gonzalez-Hermosillo, A., Dans, A.L., Munawar, M., O'Donnell, M., Lawrence, J., Lewis, G., Afzal, R., Yusuf, S. (2011).  Apixaban in patients with atrial fibrillation. New England Journal of Medicine 364 (9):806-817.

Cortes, J.E., Hochhaus, A., le Coutre, P.D., Rosti, G., Pinilla-Ibarz, J., Jabbour, E., Gillis, K., Woodman, R.C., Blakesley, R., Giles, F.J. , Kantarjian, H.M., Baccarani, M. Minimal cross-intolerance with nilotinib in patients with chronic myeloid leukemia in chronic or accelerated phase who are intolerant to imatinib. Blood 2011.

Feil, S., Newell, J., Minogue, C., Paessler, H.H. (2011). The effectiveness of supplementing a standard rehabilitation program with superimposed neuromuscular electrical stimulation after anterior cruciate ligament reconstruction: a prospective, randomized, single-blind study. Am J Sports Med. 2011 Jun;39(6):1238-47. 

Glynn, L. G., Valderas, J. M., Healy, P., Burke, E.,  Newell, J., Gillespie, P., Murphy, A. W.  The prevalence of multimorbidity in primary care and its effect on health care utilization and cost. Family Practice 2011; doi: 10.1093/fampra/cmr013

Hallahan, B., Newell, J., Soares, J.C., Brambilla, P., Strakowski , S.M., Fleck, D.E., Kiesepp, T., Altshuler, L.L., Fornito, A., Malhi, G.S., McIntosh, A.M., Yurgelun-Todd, D.A., Labar, K.S., Sharma ,V., MacQueen, G.M., Murray, R.M., McDonald, C. (2011). Structural magnetic resonance imaging in bipolar disorder: An international collaborative mega-analysis of individual adult patient data. Biological Psychiatry 69 (4):326-335.

Kelly, K.R., Mahalingam, D., Medina, E., Smith, S., Padmanabhan, S., Bearss, D., O’Dwyer, M., Nawrocki, S.T., Giles, F.J. , Carew, J.S. The novel Pim kinase inhibitor SGI-1776 has potent activity in acute myeloid leukemia independent of FLT3 status and synergistically augments the efficacy of cytarabine. British Journal of Haematology 2011

Lancet, J.E., Ravandi, F., Ricklis, R.M., Cripe, L.D., Kantarjian, H.M., Giles, F.J., List, A.F., Chen, T., Allen, R.S., Fox, J.A., Michelson, G.C., Karp, J.E. A phase 1b study of voreloxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia. Leukemia 2011

Lapusan, S., Vidriales, M.B.,Thomas, X., de Botton, S., Vekhoff, A., Tang, R., Dumontet, C.,    Morariu-Zamfir, R., Lambert, J.M., Ozoux, M.L., Poncelet, P., San Miguel, J.F ., Legrand, O., De Angelo, D., Giles, F.J. , Marie, J.P. Dose-escalation phase I studies of AVE9633, an anti CD33 antibody- maytansinoid conjugate, administered as a single agent by intravenous infusion to adult patients with relapsed or refractory CD33-positive acute myeloid leukemia. Investigational New Drugs 2011

Ma, W., Giles, F., Zhang, X., Wang, X., Zhang, Z., Lee, T.S., Yeh, C.H., Albitar, M. Three novel alternative splicing mutations in BCR-ABL1 detected in CML patients with resistance to kinase inhibitors. International Journal Laboratory Hematology 2011

McElwain, J., Simpkin, A., Newell, J. and Laffey, J. G. (2011), Determination of the utility of the Intubation Difficulty Scale for use with indirect laryngoscopes. Anaesthesia, 66: 1127–1133. doi: 10.1111/j.1365-2044.2011.06891.x

McGrath, E., O'Conghaile, A., Eikelboom, J.W., Dinneen, S.F., Oczkowski, C., O'Donnell, M.J. Validity of Composite Outcomes in Meta-Analyses of Stroke Prevention Trials: The Case of Aspirin. Cerebrovasc Dis 2011 May 11;32(1):22-7.

Murphy, K., Casey, D., Devane, D., Cooney, A., McCarthy, B., Mee, L., Ni Chúlain, M., Murphy, A. W., Newell, J., O' Shea, E. A cluster randomised controlled trial evaluating the effectiveness of a structured pulmonary rehabilitation education programme for improving the health status of people with chronic obstructive pulmonary disease (COPD): The PRINCE Study protocol. BMC Pulmonary Medicine 2011, 11:4. 

O'Donnell, M.J., Fang, J., Mittleman, M.A., Kapral, M.K., Wellenius, G.A. Fine particulate air pollution (PM2.5) and the risk of acute ischemic stroke. Epidemiology 2011 May;22(3):422-31.

Raja Ali, R.A., Dooley, C., Comber, H., Newell, J., Egan, L. Clinical Features, Treatment, and Survival of Patients With Colorectal Cancer With or Without Inflammatory Bowel Disease (2011). Clinical Gastroenterology and Hepatology, Volume 9, Issue 7, 584-589.

Raju, N., Sobieraj-Teague, M., Hirsh, J., O'Donnell, M., Eikelboom, J. Effect of Aspirin on Mortality in the Prevention of Cardiovascular Disease. Am J Med 2011 May 16.

Ryan, J., Curran, C. E., Hennessy, E., Newell, J., Morris, J. C., Kerin, M. J., Dwyer, R.M. (2011). The Sodium Iodide Symporter (NIS) and Potential Regulators in Normal, Benign and Malignant Human Breast Tissue. PLoS ONE (2011) 6(1): e16023

Saposnik, G., Kapral, M.K., Liu, Y., Hall, R., O'Donnell, M., Raptis, S., Tu, J.V., Mamdani, M., Austin, P.C.. IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke. Circulation 2011 February 22;123(7):739-49.

Qu, K.Z., Zhang, K., Ma, W., Li, H., Wang, X., Zhang, X., Giles, F., Lai, M., Afdhal, N.H., Albitar, M. Ubiquitin-Proteasome signature for detection of hepatocellular carcinoma. Journal Gastroenterology and Hepatology 26:751-758, 2011

2010

Anderson, J., Glynn, L.G., Newell. J., Iglesias, A. A., Reddan, D., Murphy, A. W. Chronic kidney disease and anaemia in cardiovascular disease: a high risk combination? Cardiodiabetes. 2010; 3 (2); 8-13.

Bansal, H., Bansal,S., Rao, M., Ying, W., Sang, J., Kelly, K., Swords, R.P., Foley, K.P., Barsoum, J.,Repasky, E., Giles, F.J., Lee, K.P., Padmanabhan, S.. Heat Shock Protein 90 regulates the expression of Wilm’s tumor 1 protein in myeloid leukemias. Blood 116, 4591-4599, 2010

Carew, J.S., Esquivel, J.A., Mahalingam, M., Olaya, C.M., Swords, R., Kelly, K., Giles, F.J.,  Nawrocki, S.T. Lucanthone: A novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. Journal of Biological Chemistry. 2010

Curley. G., Laffey, J.G., Kavanagh, B.P. (2010). Ipsilateral transversus abdominis plane block provides effective analgesia after appendectomy in children: A randomized controlled trial. Anesth Analg. 2010 Oct;111(4):998-1003. Epub 2010 Aug 27

Dowlatshahi, D., O'Donnell, M., Sharma, M. (2010). Possible influence of stroke etiology on hemorrhagic transformation following thrombolysis in warfarin-treated patients. Archives of Neurology. 67 (11).

Eikelboom, J.W., O'Donnell, M., Yusuf, S., Diaz, R., Flaker, G., Hart, R., Hohnloser, S., Joyner, C., Lawrence, J., Pais, P., Pogue, J., Synhorst, D., Connolly, S.J. Rationale and design of AVERROES: apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment. Am Heart J 2010 March;159(3):348-53.

Fisher. T., Stone,R.M., DeAngelo, D., Galinsky, I., Estey, E., Cohen, P., Fox, E., Ehninger, G., Feldman, E.J.,  Schiller, G.J., Klimek, V.M., Nimer, S.D., Gilliland, D.G., Wong, Y.F., Massimini, G., Giles, F.J. A Phase IIB trial of the putative FLT3 and mutlitargeted kinase inhibitor PKC412 (N-benzoylstaurosporine; Midostaurin) in patients with acute myeloid leukemia or high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. Journal of Clinical Oncology 28; 4339-4345, 2010 

Foran, E., Garrity-Park, M. M., Mureau, C., Newell, J., Smyrk, T. C., Limburg, P. J., et al. (2010). Upregulation of DNA methyltransferase - mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6. Molecular Cancer Research, 8(4): 471-481.

Giles, F.J., Rosti, G., Beris, P., Clark, R.E., Le Coutre, P., Mahon, F.-X., Steegmann, J.-L., Valent, P., Saglio, G. Nilotinib is superior to imatinib as first-line therapy of chronic myeloid leukemia: The ENESTnd study.  Expert Review of Hematology 3 (6):665-673, 2010 

Heneghan, H. M., Miller, N., Kelly, R., Newell, J., & Kerin, M. J. (2010). Systemic miRNA-195 differentiates breast cancer from other malignancies and is a potential biomarker for detecting noninvasive and early stage disease. Oncologist, 15(7), 673-682.

Heneghan, H. M., Miller, N., Lowery, A J., Sweeney, KJ ., Newell, J., Kerin, M J.. Circulating microRNAs as novel minimally invasive biomarkers for breast cancer. Ann Surg. 251 (3):499-505 2010.

Kantarjian, H.M., Giles, F.J., Greenberg, P.L., Paquette, R.L.,Wang, E.S., Gabrilove, J.L., Garcia-Manero, G., Hu, K., Franklin, J.L., Berger,D.P. Phase II study of romiplostim in patients with low- or Intermediate-risk myelodysplastic syndrome receiving azacitidine therapy. Blood 116 :3163-3170, 2010

Kantarjian, H.M., Giles, F.J.,Bhalla, K.P., Pinilla, J.,Larson, R.A.,Gattermann, N.,Ottmann, O., Hochhaus, A.,Radich, J.P.,Saglio, G.,Hughes, T.P.,Martinelli, G.,Kim, D.W.,Shou, Y., Gallagher, N.J.,Blakesley, R.,Baccarani, M.,Cortes, J.,le Coutre, P.D.Nilotinib, a potent and selective BCR-ABL inhibitor, is effective in patients with chronic myeloid leukemia in chronic phase following imatinib resistance or intolerance: 24-month follow-up results of a phase 2 study. Blood 2010

Kearon, C., O'Donnell, M. (2010). Should patients with stroke wear compression stockings to prevent venous thromboembolism?  Annals of Internal Medicine. 153 (9): 610-611.

Kelly, K., Swords, R., Mahalingam, D., Giles, F. Optimizing outcomes in patients with chronic myeloid leukemia in chronic phase: comparative safety profiles of newer agents. Leukemia Lymphoma 51; 1399-1413, 2010

Kelly, K., Swords, R., Mahalingam, D., Nawrocki, S., Padmanabhan, S., Giles, F., Carew, S. The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukemia and significantly increases the efficacy of nilotinib. Journal of Cellular and Molecular Medicine 2010

Kheirelseid, E. A. H., Chang, K H., Newell, J., Kerin, M J., Miller, N. Identification of endogenous control genes for normalisation of real-time quantitative PCR data in colorectal cancer. BMC Molecular Biology, 2010, 11:12.

Linkins, L., O'Donnell, M., Julian, J.A., Kearon, C. (2010). Intracranial and fatal bleeding according to indication for long-term oral anticoagulant therapy. Journal of Thrombosis and Haemostasis 8 (10) 2201-2207.

Mita, M., Ricart, A., Mita, A., Romero, O., Tolcher, A., Desai, P., Hook, L., Zang, E., Okereke, C., Kelly, K., Giles, F., Rowinsky, E., Takimoto, C. Phase I study of E7820, an oral inhibitor of integrin α2 expression, with antiangiogenic properties, in patients with advanced malignancies. Clinical Cancer Research 2010

Oczkowski, C., O'Donnell, M. Reliability of proxy respondents for patients with stroke: a systematic review. J Stroke Cerebrovasc Dis 2010 September;19(5):410-6

O'Donnell, M.J., Denis, X., Liu, L., Zhang, H., Chin, S.L., Rao-Melacini, P., Rangarajan, S., Islam, S., Pais, P., McQueen, M.J., Mondo, C., Damasceno, A., Lopez-Jaramillo, P., Hankey, G.J., Dans, A.L., Yusoff, K., Truelsen, T., Diener, H.-C., Sacco, R.L., Ryglewicz, D., Czlonkowska, A., Weimar, C., Wang, X., Yusuf, S.  (2010). Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): A case-control study.  The Lancet 376 (9735):112-123. 

O'Donnell, M., Xavier, D., Diener, C., Sacco, R., Lisheng, L., Zhang, H., Pias, P., Truelsen, T., Chin, S.L., Rangarajan, S., Devilliers, L., Damasceno, A., Mondo, C., Lanas, F., Avezum, A., Diaz, R., Varigos, J., Hankey, G., Teal, P., Kapral, M., Ryglewicz, D., Czlonkowska, A., Skowronska, M., Lopez-Jaramillo, P., Dans, T., Langhorne, P., Yusuf, S. Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke. Neuroepidemiology 2010;35(1):36-44.

Prajapati, S.I., Kilcoyne, A., Samano, A.K., Green, D.P., McCarthy, S.D., Blackman, B.A., Brady, M.M., Zarzabal, L.A., Tatiparthy, A.K., Sledz, T.J., Duong, T., Ohshima-Hosoyama, S., Giles, F.J., Michalek, J.E., Rubin, B.P., Keller, C. MicroCT-based virtual histology evaluation of preclinical medulloblastoma. Molecular Imaging Biology. 2010 

van Rees Vellinga, T.E., Peters, R.J., Yusuf, S., Afzal, R., Chrolavicius, S., O'Donnell, M., Mehta, S.R., Pluta, W., Sacha, J., Eikelboom, J.W. Efficacy and safety of fondaparinux in patients with ST-segment elevation myocardial infarction across the age spectrum. Results from the Organization for the Assessment of Strategies for Ischemic Syndromes 6 (OASIS-6) trial. Am Heart J . 2010 Dec;160(6):1049-55

2009

Anderson, J., Glynn, L G., Newell, J., Iglesias, A A., Reddan, D. and Murphy, AW. The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study. BMC Cardiovascular Disorders 2009, 9:51doi:10.1186/1471-2261-9-51.

Carney J., McDonnell, J G., Ochana, A., Bhinder, R., Laffey, J G. The Transversus Abdominis Plane Block provides effective postoperative analgesia in patients undergoing total abdominal hysterectomy. Anesthesia and Analgesia 2008 Dec;107(6):2056-60.

Dinneen, S F., O' Hara, M C., Byrne, M., Newell, J., Daly, L., O' Shea, D., Smith, D., and Irish DAFNE Study Group. The Irish DAFNE Study Protocol: A cluster randomised trial of group versus individual follow-up after structured education for Type 1 diabetes. Trials 2009, 10:88

Glynn, L G., O'Riordan, C., MacFarlane, A., Newell, J., Iglesias, A A., Whitford, D., Cantillon, P., Murphy, A W.  (2009) Research activity and capacity in primary healthcare: The REACH study: A survey. BMC Family Practice 2009, 10:33

Hogan, M J., Kelly, C A M., Verrier, D., Newell, J., Hasher, L., Robertson, I H. Optimal time-of-day and consolidation of learning in younger and older adults. Experimental Aging Research. 2009;35(1):107-28.

Malik, M A., Subramaniam, R., Maharaj C H., Higgins, B D., Harte, B H., Laffey,  J G. A randomized trial of the Pentax AWS^®, Glidescope^® and Macintosh Laryngoscopes in patients at increased risk for difficult tracheal intubation. Br J Anaesthesia 2009 Nov;103(5):761-8. [PMID: 19783539]

Malik, M A., Subramaniam, R., Churasia, S., Maharaj, C H., Harte, B H., Laffey, J G. Tracheal intubation in patients with cervical spine immobilization: a comparison of the Airwayscope, LMA CTrach, and the Macintosh laryngoscopes. Br J Anaesth. 2009 May;102(5):654-61. Epub 2009 Mar 31

Malik, M A., Hassett, P., Carney, J., Higgins, B D., Harte, B H., Laffey, J G. A comparison of the Glidescope^®,Pentax AWS^®, and Macintosh laryngoscopes when used by novice personnel: A manikin study. Canadian Journal of Anesthesia. 2009;56(11):802-11.

Malik, M A., O'Donoghue, C., Carney, J., Maharaj, C H., Harte, B H., Laffey,  J G. Comparison of the Glidescope®, the Pentax AWS®, and the Truview EVO2® with the Macintosh laryngoscope in experienced anaesthetists: A manikin study. British Journal of Anaesthesia. 2009;102(1):128-34.

Murphy, A W., Cupples, M E., Smith, S M., Byrne, S., Byrne, M C., Newell, J.  Effect of tailored practice and patient care plans on secondary prevention of heart disease in general practice: cluster randomised controlled trial. BMJ 2009;339 b4220.

O’ Riordan, C., Glynn, L G., MacFarlane, A., Newell, J., Iglesias, A A., Whitford, D., Cantillon, P., Murphy, A W. Research activity and capacity in primary care. Forum 2009;26 (9):27-30.

Statistics for Sports and Exercise Science: A Practical Approach
John Newell, Tom Aitchison, Stanley Grant. Pearson Publishers, Oct 2009,
ISBN13: 9780132042543.

2008

Glynn, L G., Buckley, B., Reddan, D., Newell, J., Hinde, J., Dinneen, S F., Murphy, A W.  Multimorbidity and risk among patients with established cardiovascular disease: a cohort study. British Journal of General Practice.  58(552):488-94, 2008 Jul.

Malik, M A., Maharaj, C H., Harte, B H., Laffey, J G.  A Comparison of Macintosh, Truview EV02^â, Glidescope^® and Airwayscope^® Laryngoscopes in Patients with Cervical Spine Immobilization. Br J Anae s 2008; doi: 10.1093/bja/aen231

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