Principal investigator profile

Dr. Faisal Sharif

Doctor Sharif is a senior lecturer in regenerative medicine in National University of Ireland, Galway and a consultant cardiologist for Galway University Hospitals.

Faisal Sharif received his medical degree from the University of Karachi, Pakistan. He completed his general professional training in medicine at Galway University Hospita and completed his Specialist Training in Interventional Cardiology under the Irish Committee on Higher Medical Training from Royal College of Physicans Ireland (2000-2008). He acquired his PhD in vascular biology and Gene Eluting Stents from the Regenerative Medicine Institute (REMEDI) at National University of Ireland Galway (2003-2006). He also holds a Diploma in Health Care Management from Institute of Public Administration in Dublin (2005-2007). He was elected to a two year Fellowship in Interventional Cardiology between Clinique Pasteur, Toulouse France and St James Hospital Dublin (Boston Scientific Travelling Grant). During his tenure in Toulouse, he worked closely with Dr Jean Fajadet and gained expertise Percutaneous Coronary Intervention (PCI) via transradial access. From 2009-2010 he worked at OLV Cardiovascular Centre, Aalst, Belgium and worked with Bernard De Bryune, William Wijns and Jozef Bartunek, among others. During his training abroad he has been actively involved with the EuroPCR. In addition to PCI, he has gained experience in transcatheter aortic valve implantation (TAVI) for aortic stenosis, closure of septal wall defects and percutaneous stem cell injection into the human myocardium.

In October 2010, he returned to Ireland to take up the position of Senior Lecturer in Regenerative Medicine and Interventional Cardiologist at Galway University Hospitals in Ireland. His key area of interest is translational medicine focusing on cardiovascular clinical trials for medical devices and basic science outputs. For basic research, his interest lays in vascular biology and myocardial regeneration.

List of Recent Publications:

Gene Eluting Stents: Delivery of Adenovirus Mediated Endothelial Nitric Oxide Synthase to the Blood Vessel Wall Accelerates Re-endothelialization and Inhibits Restenosis in Rabbit Iliac Arteries
F Sharif, S Hynes, R Cooney, L Howard, J McMahon, K Daly, J Crowley, T O’Brien
Mol Ther. 2008 Oct; 16(10):1674-80

Gene Eluting Stents: A Comparison of Adenoviral and Adeno-Associated Viral Gene-Delivery to the Blood Vessel Wall in vivo
F Sharif, S Hynes, J McMahon, R. Cooney, S. Conroy, P. Dockery, G. Duffy, K.Daly, J. Crowley, J S. Bartlett, T. O’Brien                 
Hum Gene Ther 2006 Jul; 17(7):741-50

Adenoviral-Mediated Gene Transfer of Nitric Oxide Synthase Isoforms and Vascular Cell Proliferation
R Cooney, S Hynes, F Sharif, T O’Brien 
J Vasc Res 2006; 43(5):462-72

Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury.
R. Cooney, S. Hynes, F Sharif, T O’Brien
Gene Ther. 2007 Mar; 14 (5):396-404

X-ray micro-tomography of a coronary stent deployed in a model artery.
Connolly T, Nash D, Buffiere JY, F Sharif, McHugh PE.
Med Eng Phys. 2006 Nov 28

Impact of Atherosclerotic Disease Progression on Mid-Term Clinical Outcome in Diabetic Patients in the Drug-Eluting Stent Era
P Tousek, A Pavei, J Oreglia, G Martin, F Sharif, J Fajadet, B Farah
EuroIntervention. 2009 Mar;4(5):588-92 

Long-term Follow-up of Percutaneous Coronary Intervention of Unprotected Left Main Lesions with Drug Eluting Stents: Predictors of Clinical Outcome
A Pavei, J Oreglia, G Martin, P Tousek, F Sharif, B Farah, A Sauguet, J    Fajadet
EuroIntervention. 2009 Jan; 4(4): 457-63

List of Review Articles:

Practical Tips and Tricks for the Measurement of Fractional Flow Reserve.
F Sharif, Catalina Trana, Olivier Muller, Bernard De Bryune
Catheterization and Cardiovascular Interventions    In Press

Adult stem Cells in the Treatment of Acute Myocardial Infarction.
F Sharif, Jozef Bartunek, Marc Vanderheyden
Catheterization and Cardiovascular Interventions    In Press

Current Status of Vulnerable Plaque Detection.
F  Sharif, R. T Murphy
Catheterization and Cardiovascular Interventions   75:135-144(2010)

Current Status of Catheter and Stent-Based Gene Therapy.
F Sharif, K Daly, J Crowley, T O’Brien
Cardiovascular Research 64(2004)208-216

Book Chapters:

Unprotected Left Main Stenting Using Trans Radial Approach
Faisal Sharif, Bruno Farah, Jean Fajadet (Chapter 16)

Transradial Approach for Cardiovascular Interventions
A Book by Martial Hamon and Eugene McFadden

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