Tuesday, 23 August 2016

As part of the ‘It’s OK to Ask’ campaign, the Health Research Board (HRB) Clinical Research Facility Galway (CRFG) will open its doors and welcome the public on September 1st from 4:00- 7:00 PM. The event will include short, accessible talks about specific clinical trials, a self-guided CRFG tour, and ten thematic exhibitions highlighting areas of research and ongoing clinical studies. Explainers, including consultants and CRFG staff will be on hand to answer questions and describe their work. Concurrently, short expert talks will be delivered by Professor John J Carey, Professor Dr. Andrew Murphy, and Professor Frank Barry in the Clinical Sciences Institute Large Lecture Theatre (227). Launched in May, ‘It’s OK to Ask’ is an on-going public awareness initiative that aims to encourage patients, carers, and the public to ask healthcare professionals if there is a clinical trial study they might be suitable for. Through the ’It’s OK to ask’ campaign, periodic exhibitions in the UHG foyer, themed social media blitzes, and public events are planned. Please register on Eventbrite at: https://www.eventbrite.ie/e/open-house-hrb-clinical-research-facility-galway-tickets-26969365097?utm-medium=discovery&utm-campaign=social&utm-content=attendeeshare&aff=escb&utm-source=cp&utm-term=listing


Thursday, 30 June 2016

A free screening of the documentary film, Stem Cell Revolutions takes place on 4 July at the Clinical Science Institute, NUI Galway, from 7pm. With the tag line ‘You’ve heard so much about stem cells. But what do they really do?’ it has been described as a truly entertaining documentary. According to reviews, it provides a ‘fascinating, unsensationalised and complete guide for anyone who wants an informed appreciation of stem cell science and an understanding of what all the fuss is about’. The screening will be followed by a Q&A session will follow with by Professors Timothy O’ Brien and Matt Griffin, both of University Hospitals Galway and NUI Galway. Professors O’Brien and Griffin are among the many scientists and physicians in Galway who are involved in cutting edge research and clinical trials using bone marrow-derived stem cells in Galway. Through the Health Research Board (HRB) Clinical Research Facility Galway (CRFG), Professors O’Brien and Griffin will be conducting a clinical trial using bone marrow derived stem cells to offset diabetic kidney disease as part of a Horizon 2020 project called NEPHSTROM. Other clinical studies that involve stem cell treatments are also underway at the HRB CRFG. Stem Cell Revolutions Featuring beautiful hand-drawn animations and interviews with leading stem cell scientists, Stem Cell Revolutions charts the history and scientific evolution of stem cell research - from the earliest experiments that first revealed stem cells in the body, to leading current scientific and clinical developments. Stem Cell Revolutions features eminent international scientists in stem cell research, including 2012 Nobel Laureates Shinya Yamanaka and Sir John Gurdon, Nobel Laureate Sir Martin Evans, as well as Sir Ian Wilmut, creator of Dolly the sheep. Acclaimed novelist Margaret Atwood serves as a non-scientific commentator in the film. This screening is part of the ‘It’s OK to ask about clinical research’ public awareness campaign that aims to encourage patients, carers, and the public to ask healthcare professionals if there is a clinical trial study they might be suitable for. The documentary is aimed at adults with a general interest in science and medicine and transition year students upward. Watch the trailer here https://youtu.be/uhfBaZSkiMQ Please reserve seats for the screening through Eventbrite https://www.eventbrite.ie/e/stem-cell-revolutions-documentary-screening-tickets-25954474532?aff=ebrowse or email Danielle.nicholson@nuigalway.ie     For further information contact Danielle Nicholson HRB CRF Galway Clinical Research Engagement & Education Coordinator Danielle.nicholson@nuigalway.ie http://www.nuigalway.ie/hrbcrfg/ Tel – 091 49 4282

Tuesday, 24 May 2016

A large worldwide study involving 49 countries has found that, contrary to popular thought, low-salt diets may not be beneficial and may actually increase the risk of cardiovascular disease (CVD) and death (compared to average salt consumption). The results from the study were published in The Lancet. Prof. Martin O'Donnell, HRB Clinical Research Facility Director, is a co-author on the study. Read the full article here.

17th May 2016
Public Awareness Campaign to Encourage Participation in Clinical Trials

The Health Research Board (HRB) Clinical Research Facility Galway (CRFG) is inviting local researchers, health and social care professionals and patients to highlight the ‘It’s OK To Ask’ campaign to celebrate International Clinical Trials Day, which takes place on Friday, 20 May.
The ‘It’s OK To Ask’ about clinical research message from the public awareness campaign aims to encourage patients, carers, and the public to ask healthcare professionals if there is a clinical trial study they might be suitable for. Read the full article here: http://www.nuigalway.ie/about-us/news-and-events/news-archive/2016/may2016/public-awareness-campaign-to-encourage-participation-in-clinical-trials-1.html

28th September 2015
An Taoiseach Opens New Clinical and Translational Research Facility

An Taoiseach officially opened the New CRF-TRF facility today, saying that "this latest facility represents the point where research and health care meet – where “bench” meets “bedside”. The advances made by researchers and clinicians in this facility will undoubtedly lead to better frontline health outcomes and will ultimately improve patients’ lives". Read the full article here

28th September 2015
Staff of the New Clinical and Translational Research Facility Talk about the New Facility and it's Benefits

Staff of the new CRF-TRF facility, together with principal investigators and Sandra Galvin of HRB-Trials Methodology Research Network, talk about the new facility and it's benefits in the following clips:

17th September 2015
A New Study by Dr. Andrew Smyth, HRB Clinical Research Facility, Published in The Lancet, Shows that Harmful Alcohol Use is Linked with Increased Alcohol-Related Cancers and Injury, with no Reduction in the Risk of Death.

Dr. Andrew Smyth of the HRB Clinical Research Facility, is the lead author of a new study, published today in The Lancet, which investigated associations between alcohol consumption and clinical outcomes in a prospective cohort of countries at different economic levels. The study shows that harmful alcohol use is linked with increased alcohol-related cancers and injury, with no reduction in the risk of death. The threat appears worst in lower-income countries, where harmful alcohol use is more common. Read the full article here.

22nd June. 2015
Staff Move into the New HRB Clinical Research Facility and Translational Research Facility (CRF-TRF)

Staff have moved into the newly completed CRF-TRF building. The building is located on the grounds of University Hospital Galway and is directly adjacent to the University’s Clinical Science Institute, UHG’s Critical Care Facilities, Ward Accommodation Block and the Maternity Wards.

The HRB Clinical Research Facility occupies the ground and first floors. This facility forms part of an Irish Network of Clinical Research Facilities which will allow patients access to state of the art clinical research in stem cells, gene therapy, biomaterials and immunology. The CRF has direct links to the existing hospital at both ground and first floor levels.

8th Jan. 2015
Major European Research Council Funding Success for Prof. Martin O'Donnell, HRB CRFG Director

Prof. Martin O'Donnell is one of two NUI Galway academics to have been approved by the European Research Council (ERC) for starter grants. Prof. O'Donnell's award will support his so-called "blue sky research" project entitled 'Clarifying Optimal Sodium Intake Project' (COSIP) which seeks to clarify how much sodium intake is optimal for health. Read the full article here

9th Oct. 2014
HRB CRFG Plays Key Role in Large-Scale Clinical Trial of Statin Treatment

NUI Galway researchers have been part of a large-scale clinical trial of statin treatment in patients with Acute Respiratory Distress Syndrome (ARDS) which was published this week in the New England Journal of Medicine (NEJM). "The HRB CRFG has enabled Irish researchers to collaborate internationally and contribure to significant clinical findings", according to Graham Love, Chief Executive of the Health Research Board. Read the full article here

14th Aug. 2014
HRB CRFG Acting Director, Prof. Martin O'Donnell Co-author's Study on the Association of Urinary Sodium and Potassium Excretion with Blood Pressure

Prof. Martin O'Donnell is co-author of a publication in The New England Journal of Medicine on the Association of Urinary Sodium and Potassium Excretion with Blood Pressure. The publication suggests that both high and low levels of salt intake may put people with heart disease or diabetes at increased risk of cardiovascular complications. Read the full article here

Interest in the results of the study has led to a number of press releases:








HRB CRFG Supports Research Utilising Smartphones for the Care of Patients with Inflammatory Bowel Disease (IBD)

Smartphones are to be used to deliver care for people with inflammatory bowel disease (IBD). HRB CRFG is supporting research utilising smartphones for the care of patients with the condition. Professor Laurence Egan, a gastroenterologist at University Hospital Galway and Professor of clinical pharmacology and head of the department of pharmacology and therapeutics at NUI Galway is the principle investigator for this research study. Read the Full Article

HRB CRFG/GUH One of Eight sites in National Study: Aspirin Effectiveness in Stable Coronary Artery Disease Patients in Ireland

The final results from an Irish clinical research study have shown that aspirin may be an ineffective treatment in preventing recurrent heart attacks in as many as one in five people. Read the Full Article

Work Begins on NUI Galway Clinical & Translational Research Facility

Work has begun on NUI Galway's Clinical Research Facility and Translational Research Facility (CRF-TRF), which is located on the grounds of University Hospital Galway. The HRB Clinical Research Facility will occupy the ground and first floors of the new building. Read the Full Article.

HRB Clinical Research Facility Features in Article on an Integrated Infrastructure for Irish Health Research

The article by Enda Connolly, Chief Executive of the Health Research Board, looks at the infrastructure being put in place and the research capacity being built that underpins patient-oriented research. Full article.

Associate Director of HRB Clinical Research Facility Speaks to the Irish Medical Times about the Importance of Clinical Prediction Rules in Tackling Stroke

The article examines advances in the management of stroke patients, as well as the importance of stroke networks, treatment protocols and the adoption of standards. Full Irish Medical Times article.

Biostatistics Unit Adjunct Professor George McCabe Receives the 2012 Don Owen Award

The 2012 Don Owen Award, given by the American Statistical Association’s San Antonio Chapter, was presented to George P. McCabe on March 2 at the Conference of Texas Statisticians by chapter vice president, Jonathan Gelfond.
The San Antonio Chapter is proud to honor McCabe for his excellence in research, statistical consultation, and service to the statistical community. The Don Owen Award is presented annually by the San Antonio Chapter and Taylor & Francis.
See http://magazine.amstat.org/blog/2012/05/01/peoplemay2012/ for more information.

Article on the Link-up Between Clinicians and Industry in the Development of Medical Devices Utilising HRB Clinical Research Facility is Published in the Irish Medical Times

Full Irish Medical Times article on page 2

Study on Salt Consumption Led by Associate Director of CRFG is Published in the Journal of the American Medical Association

Please see http://jama.ama-assn.org/content/306/20/2229 for publication

Irish Times article on publication

New Study for Rare but Devastating Cancer Opens 

Director of CRFG Prof. Frank Giles  has opened new clinical study for a rare but devastating type of bone marrow cancer, click here for details

'World First' for HRB Clinical Research Facility Galway

The HRB Clinical Research Facility Galway has enrolled the first patient onto a clinical trial for that for Galway company Marvao Medical devices. The innovative device, a catheter designed to reduce the risk of infection has been placed in a human patient for the first time this month (April 2011). See the Irish Times article for more information.

Director of HRB Clinical Research Facililty Receives Highest Award from Royal Academy of Medicine in Ireland

Professor Francis J. Giles has been awarded the Annual Saint Luke's Silver Award by the Royal Academy of Medicine in Ireland.  This is this highest honour bestowed by the Academy and Professor Giles is the first NUI Galway recipient.  Professor Giles also delivered the 36th Saint Luke's Lecture, entitled 'Optimising Ireland's Contribution to Curing Cancer'.  The Saint Luke's Lecture is sponsored by the Acadmey and Saint Luke's Hospital.  Please see the Royal Academy of Medicine in Ireland website for addtional information.

CRFG Principal Investigator Wins "Best Overall Paper Award" from Royal Academy of Medicine Ireland (RAMI)

HRB funded researcher Dr. Andrew Murphy, Professor of General Practice at NUI Galway and Principal Investigator with the HRB Clinical Research Facility, Galway at NUI Galway, recently won the Royal Academy of Medicine Ireland (RAMI) award for best researcher paper in 2010.  Additional information is available here.

New Preterm Labour Study Opens

A preterm labour research study focusing on developing new predictive tests for women who are prone to delivering early or preterm has opened in the Clinical Research Facility Galway. 

Premature birth occurs when a woman delivers a baby before 37 weeks gestation in her pregnancy.  It occurs in approximately 7% of all pregnancies.  Blood samples from participants will be analysed, and the aim is to identify biomarkers predicting a premature birth. 
Professor John Morrison and research nurse Emma Hawkins outlined details of the study on the Keith Finnegan Show of the Tuesday 25th January on Galway Bay FM. Podcast for the show can be accessed here (Part 2).

Assistant Director of CRFG Highlights Need to Cut Blood Pressure to Reduce Risk of Stroke

At a recent public information night on stroke and dementia in the Ardilaun hotel Professor Martin O'Donnell outlined the 10 most important risk factors to focus on in the fight to prevent stroke. These factors account for over 90% of stroke risk, the most important of which was reducing high blood pressure. See Galway Advertiser for more details.

New Anti-Cancer Drug Trial Opens

See Irish Times and Galway City Tribune for details of the recently opened clinical trial for a novel anti-cancer drug.

New Director of CRFG to Initiate Clinical Trial of New Anti-Cancer Drug

Please see interviews with  Irish Times and Galway City Tribune for details about upcoming clinical trial. 

Stroke Study Led by CRFG Assistant Director Published in Lancet

Prof. Martin O'Donnell led the standardised case-control study which was undertaken in 22 countries between March 1, 2007, and April 23, 2010. Cases were patients with acute first stroke (within 5 days of symptoms onset and 72 h of hospital admission). Controls had no history of stroke, and were matched with cases for age and sex. All participants completed a structured questionnaire and a physical examination, and most provided blood and urine samples.

The findings suggest that ten risk factors are associated with 90% of the risk of stroke. Targeted interventions that reduce blood pressure and smoking, and promote physical activity and a healthy diet, could substantially reduce the burden of stroke.

Please see http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60834-3/fulltext for full text.

Publicity arising from publication -

Irish Times article at http://www.irishtimes.com/newspaper/ireland/2010/0619/1224272868957.html