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Design of scaffolds for nanoscale tissue engineering

 

Introduction

Tissue Engineering endeavours to persuade the body to heal itself through the delivery of supporting structures to the appropriate site independently or in synergy with cells and biomolecules. An understanding of natural micro- and nano-architectures as well as cell behaviour leads to the development of appropriate scaffolds for the next generation of regenerative implants. The focus of this research cluster is the development of bioanalogous biomaterials for regenerative and clinical applications. The development and synthesis of biomaterials is accomplished by creating accurate ex vivo, in vitro and in vivo model systems for specific clinical applications.

People

Prof. Abhay Pandit, Dr. Krishna Burugapalli, Dr. Gopinath Damodaran, Dr. Gildas Rethore, Dr. Hemant Naik, Dr. Jeffrey C. Y. Chan, Dr. William Tiong 

Project

The goal of this project is to synthesize and develop stable extra cellular matrix-based scaffolds that provide a rudiment or a precursor to the body’s regenerative response.

 
Scanning electron micrograph (SEM) showing valvular interstitial cells grown on a cholecyst-derived extra-cellular matrix (ECM) (Courtesy: Dr. Sarah Brody)
 



Orientation of neurite growth on a functionalised PLGA (with a designed laminin peptide) scaffold after 3 days culture (Courtesy Dr. Li Yao)

A precursor bone scaffold (collagen-calcium phosphate) with programmed channels (Courtesy: Michael Keeney)

Sample Publications

Burugapalli K, Thapasimuttu A , Chan JCY, Yao L, Brody S, Kelly JL, Pandit A (2007) Scaffold with a natural mesh-like architecture: Isolation, structural, and in vitro characterization, Biomacromolecules 8 (3):928-936.

Brody S, McMahon J, Yao L, O’Brien M, Dockery P, Pandit A (2007) The Effect of Cholecyst-derived Extracellular Matrix on the Phenotypic Behaviour of Valvular Endothelial and Valvular Interstitial Cells, Biomaterials 28(8):1461-1469.

Breen A, Strappe P, Kumar A, O’Brien T, Pandit A (2006) Optimization of a Fibrin Scaffold for Sustained Release of an Adenoviral Gene Vector, Journal of Biomedical Materials Research: Part A 78(4):702-708.

O’Halloran DM, Collinghan RJ, Griffin M, Pandit AS (2006) Characterization of a Microbial Transglutaminase Cross-linked Type II Collagen Scaffold, Tissue Engineering 12(6):1467-1474.
    

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