Prof. Peter McHugh

Professor of Biomedical Engineering  phone:    353 91 493152  fax:        353 91 563991 e-mail:    peter.mchugh nuigalway.ie Director, Micromechanics Research Unit Biomechanics Cluster Leader, National Centre for Biomedical Engineering Science

Research Interests

Computational micromechanics in the engineering analysis of complex materials and systems; biomechanics of hard and soft tissue; experimental and computational cell mechanics; multi-scale analysis methods for determination of structure-property relationships in biological and implanted materials; computational methods in biomedical engineering applied to linear and non-linear problems, using implicit and explicit solution algorithms; medical implant and device analysis and design.

Journal Publications    

Refereed Journal Publications: Accepted and In Press - 6

Harewood, F., Grogan J. and McHugh, P.E., “ A multiscale approach to failure assessment in deployment for cardiovascular stents”, accepted and in press, Journal of Multiscale Modelling, 2010. 

McDonnell, P., Harrison, N.M. and McHugh, P.E. “ Investigation of the Failure Behaviour of Vertebral Trabecular Architectures under Pure Compression and Wedge Action Loading Conditions”, accepted and in press, Medical Engineering and Physics, 2010.                                                                                                                                                                                   Harrison, N.M. and McHugh, P.E. “ Comparison of trabecular bone behaviour in core and whole bone samples using high resolution modelling of a vertebral body”, accepted and in press, Biomechanics and Modelling in Mechanobiology, 2010 

Hopkins, C, McHugh, P.E. and McGarry, J.P. “ Computational investigation of the delamination of polymer coatings during stent deployment”, accepted and in press, Annals of Biomedical Engineering, 2010.                                                                

Tyndyk, M.A., McGarry, J.P., Barron, V., McHugh, P.E., O’Mahoney, D., Tawackoli, W. and Liebschner, M.A.K., “Effects of intervertebral disc degeneration on the flexibility of the human thoracolumbar spine”, accepted and in press, Journal of Long Term Effects of Medical Implants, 2008.                                                                                              

Riordan, C., Mahajan, A., Brennan, W., Murphy, B.P., Regan, P. and McHugh, P.E., “Biomechanical study of the FDP Demi-Tendon - A new technique for ZoneI/II Flexor tendon grafting”, accepted, Journal of Hand Surgery, 2010.

Refereed Journal Publications : Published - 79

Breen, L., McHugh, P.E. and Murphy, B.P. “ The experimental verification and validation of a custom bioreactor: The experimental application of carotid artery athero-prone and athero-protective wall shear stress and tensile strain to HUVECs”, Annals of Biomedical Engineering, Vol. 38, No. 5, pp. 1880-1892, 2010.

Stops. A.J.F., Harrison, N.M., Haugh, M.G., O’Brien, F.J. and McHugh, P.E., “ Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis”, Journal of the Mechanical Behaviour of Biomedical Materials , Vol. 3, pp. 292-302, 2010.   

O’Cearbhaill, E.D., Murphy, M., Barry, F., McHugh, P.E. and Barron, V. “ Behaviour of Human Mesenchymal Stem Cells in Fibrin-based Vascular Tissue Engineering Constructs”, Annals of Biomedical Engineering, Vol. 38, No. 3, pp. 649-657, 2010. 

  Lohfeld, S., Tyndyk, M.A., Cahill, S., Flaherty, N., Barron, V. and McHugh, P.E., “ A method to fabricate small features on scaffolds for tissue engineering via selective laser sintering”, Journal of Biomedical Science and Engineering, Vol. 3, pp. 138-147, 2010.                                                                                                                                             

Stops. A.J.F., Heraty, K.B., Browne, M., O’Brien, F.J. and McHugh, P.E., “ A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow”, Journal of Biomechanics , Vol. 43, No. 4, pp. 618-626, 2010.                                                                                        

McDonnell, P., Harrison, N.M., Lohfeld, S., Kennedy, O., Zhang, Y. and McHugh, P.E., “Investigation of the mechanical interaction of the trabecular core with an external shell using rapid prototype and finite element models”, Journal of the Mechanical Behaviour of Biomedical Materials, Vol. 3, pp. 63-76, 2010.

Mullins, L.M., Bruzzi, M.S, Sassi, V. and McHugh, P.E. “Differences in the crack resistance of trabecular, osteonal and interstitial bone”, Annals of Biomedical Engineering, DOI: 10.1007/s10439-009-9797-8, Vol. 37, No. 12, pp. 2574-2582, 2009.

McDonnell, P., Harrison, N.M., Liebschner, M.A.K. and McHugh, P.E. “Simulation of vertebral trabecular bone loss using voxel finite element analysis”, Journal of Biomechanics, Vol. 42, pp. 2789-2796, 2009.

Punchard, M.A., O’Cearbhaill, E.D., Mackle, J.N., McHugh, P.E., Smith, T.J., Stenson-Cox, C. and Barron, V. “Evaluation of human endothelial cells post stent deployment in a cardiovascular simulator in-vitro”, Annals of Biomedical Engineering, Vol. 37, No. 7, pp. 1322-1330, 2009.

Cahill, S., Lohfeld, S. and McHugh, P.E. “Finite element predictions compared to experimental results for the effective modulus of bone tissue engineering scaffolds fabricated by Selective Laser Sintering”, Journal of Materials Science: Materials in Medicine, Vol. 20, pp. 1255-1262, 2009.

Breen, L., McHugh, P.E. and Murphy, B.P. “Multi-axial mechanical stimulation of HUVECs demonstrates that combined loading is not equivalent to the superposition of individual wall shear stress and tensile hoop stress components”, ASME Journal of Biomechanical Engineering, Volume 131,  Issue 8, pp. 081001/1-11, 2009.

Mullins, L.P., Bruzzi, M.S. and McHugh, P.E. “Calibration of a Constitutive Model for the Post-Yield Behaviour of Cortical bone”, Journal of the Mechanical Behavior of Biomedical Materials, Vol. 2, No. 5, pp. 460-470, 2009.

McDonnell, P., Liebschner, M.A.K., Tawackoli, W. and McHugh, P.E. “Vibration testing of trabecular bone architectures using rapid prototype models”, Medical Engineering and Physics, Vol. 31, No. 1, pp. 108-115, 2009.

O’Halloran, A., O’Malley, F. and McHugh, P. “A review on dielectric elastomer actuators, technology, applications, and challenges”, Journal of Applied Physics, Vol., 104, No. 7, pp. 071101/1-10, 2008.

Harrison, N.M., McDonnell, P.F., O’Mahoney, D.C., Kennedy, O.D., O’Brien, F.J. and McHugh, P.E. “Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties”, Journal of Biomechanics, Vol. 41, No. 11, pp. 2589-2596, 2008.

Stops. A.J.F., McMahon, L.A., O’Mahoney, D., Prendergast, P. and McHugh, P.E., “A Finite Element Prediction of Strain on Cells in a Highly Porous Collagen-Glycosaminoglycan Scaffold”, ASME Journal of Biomechanical Engineering, Vol. 130, No. 6, pp. 161001/1-11, 2008.

Mullins, L.P., Bruzzi, M.S., and McHugh, P.E., Authors’ response to “ comments on ’Measurement of the microstructural fracture toughness of cortical bone using indentation fracture’”, Journal of Biomechanics, Vol. 41, No. 11, pp. 2602-2603, 2008.  

O’Cearbhaill, E.D., Punchard, M.A., Murphy, M., Barry, F., McHugh, P.E. and Barron, V. “Response of Mesenchymal Stem Cells to the Biomechanical Environment of the Endothelium on a Flexible Tubular Silicone Substrate”, Biomaterials, Vol. 29, pp. 1610-1619, 2008. 

McGarry, J.P. and McHugh, P.E., “Modelling of in-vitro chondrocyte detachment”, Journal of the Mechanics and Physics of Solids, Vol. 56, No. 4, pp. 1554-1565, 2008.

McGarry, J.P., O’Donnell, B., McHugh, P.E., O’Cearbhaill, E. and McMeeking, R.M., “Computational examination of the effect of material inhomogenity on the necking of stent struts in tensile loading”, Journal of Applied Mechanics, Vol. 74, pp. 978-989, 2007.

Tyndyk, M., McHugh, P.E., Barron, V. and O’Mahoney, D., “Generation of a finite element model of the thoracolumbar spine”, Acta of Bioengineering and Biomechanics, Vol. 9, No. 1, pp. 35-46, 2007.

Flaherty, B., McGarry, J.P. and McHugh, P.E., “Mathematical models of cell motility”, Cell Biochemistry and Biophysics, Vol. 49, No. 1, pp. 14-28, 2007.

Punchard, M.A., Stenson-Cox, C., O’Cearbhaill, E., Lyons, E., Gundy, S., Murphy, L., Pandit, A., McHugh, P.E. and Barron V., “Endothelial Cell Response to Biomechanical Forces under Simulated Vascular Loading Conditions”, Journal of Biomechanics, Vol. 40, No. 14, pp. 3146-3154, 2007.

Mullins L.P., Bruzzi, M.S. and McHugh, P.E., “Measurement of the microstructural fracture toughness of cortical bone using indentation fracture”, Journal of Biomechanics, Vol. 40, No. 14, pp. 3285-3288, 2007.

Thakral, R., Kaar, K., McHugh, P.E., Brennan, W. and Lalor, S., “Weber B lateral malleolar fracture and inter fragmentary screw placement”, EJOST - European Journal of Orthopaedic Surgery and Traumatology, Vol. 17, No. 5, pp. 461-464, 2007.

Harewood, F. and McHugh, P.E., “Modelling of size dependent failure in cardiovascular stent struts under tension and bending”, Annals of Biomedical Engineering, Vol. 35, No. 9, pp. 1539-1553, 2007.  

Barron, V., Brougham, C., Coghlan, K., McLucas, E., O’Mahoney, D., Stenson-Cox, C. and McHugh, P.E., “The effect of physiological cyclic stretch on the cell morphology, cell orientation and protein expression of endothelial cells”, Journal of Materials Science: Materials in Medicine, Vol. 8, No. 10, pp. 1973-1981, 2007.   

Connolley, T., Nash, D., Buffiere, J-Y. and McHugh, P.E., “X-ray micro-tomography of a coronary stent deployed in a model artery”, Medical Engineering and Physics, Vol. 29, No. 10, pp. 1132-1141, 2007.

Mullins, L. McGarry, J.P., Bruzzi, M. and McHugh, P.E., “Micromechanical modelling of cortical bone”, Computer Methods in Biomechanics and Biomedical Engineering, Vol. 10, No. 3, pp. 159-169, 2007.

Ilie, D.E., O’Donnell, B.P., McGarry, J.P. and McHugh, P.E., “Computational Modelling of the Extrusion of an Al-SiC Metal Matrix Composite using Macroscale and Microscale Methods”, Journal of Strain Analysis for Engineering Design, Vol. 42, pp. 237-252, 2007.

McDonnell, P., McHugh, P.E. and O’Mahoney, D., “Vertebral Osteoporosis and Trabecular Bone Quality”, Annals of Biomedical Engineering, Vol. 35, No. 2, pp. 170-189, 2007.

Donnelly, E.W., Bruzzi, M., Connolley, T. and McHugh, P.E., “Finite element comparison of performance related characteristics of vascular stents”, Computer Methods in Biomechanics and Biomedical Engineering, Vol. 10, No. 2, pp. 103-110, 2007.   

Harewood, F. and McHugh, P.E., “Comparison of the Implicit and Explicit Finite Element Methods using Crystal Plasticity”, Computational Materials Science, Vol. 39, Issue 2, pp. 481-494, 2007.

Caulfield, B., McHugh, P.E. and Lohfeld, S., “Dependence of mechanical properties of polyamide components on build parameters in the SLS process”, Journal of Materials Processing Technology, Vol. 182, pp. 477-488, 2007.

Lohfeld, S., McHugh, P.E., Serban, D., Boyle, D., O’Donnell, G., Peckitt, N., “Engineering assisted surgery: A route for digital design and manufacturing of customized maxillofacial implants”, Journal of Materials Processing Technology, Vol. 183, pp. 333-338, 2007.

Breen, L., McHugh, P.E., McCormack, B.A., Muir, G., Quinlan, N., Heraty, K. and Murphy, B.P., “Development of a novel bioreactor to apply shear stress and tensile strain simultaneously to cell monolayers”, Review of Scientific Instruments, Vol. 77, 104301, 2006.

You, X., Connolley, T., McHugh, P.E., Cuddy, H. and Motz, C., “A Combined Experimental and Computational Study of Deformation in Grains of Biomedical Grade 316LVM Stainless Steel”, Acta Materialia, Vol. 54, pp. 4825-4840, 2006.

Harewood, F. and McHugh, P.E., “Investigation of Finite Element Mesh Independence in Rate Dependent Materials”, Computational Materials Science, Vol 37, pp. 442-453, 2006.

O’Cearbhaill, E., Barron, V. and McHugh, P.E., “Characterisation of a collagen membrane for its potential use in cardiovascular tissue engineering applications”, Journal of Materials Science: Materials in Medicine, Vol. 17, No. 3, pp. 195-201, 2006.

Murphy, B.P., Cuddy. H., Harewood, F., Connolley, T. and McHugh, P.E., “The influence of grain size on the ductility of micro-scale stainless steel stent struts”, Journal of Materials Science: Materials in Medicine, Vol. 17, No. 1, pp. 1-6, 2006.

Bruzzi, M.S. and McHugh, P.E., “Micromechanical modelling of the static loading of an Al 359-SiC MMC”, Journal of Engineering Materials and Technology, Vol. 127, No. 1, pp. 106-118, 2005.

Weldon, L.M., McHugh, P.E., Carroll W., Costello, E. and O’Bradaigh C.M., “The influence of passivation and electropolishing on the performance of medical grade stainless steels in static and fatigue loading”, Journal of Materials Science: Materials in Medicine, Vol. 16, No. 2, pp. 107-117, 2005.

Farrissey, L.M. and McHugh, P.E., “Determination of elastic and plastic material properties using indentation: Development of method and application to a thin surface coating”, Materials Science and Engineering A, Vol. 399, pp. 254-266, 2005.

McGarry, J.P., Murphy, B.P. and McHugh, P.E., “Computational mechanics modelling of cell-substrate contact during cyclic substrate deformation”, Journal of the Mechanics and Physics of Solids, Vol. 53, No. 12, pp. 2597-2637, 2005.

Lohfeld, S., Barron, V. and McHugh, P.E., “Biomodels of Bone: A Review”, Invited article, Annals of Biomedical Engineering, Vol. 33, No. 10, pp. 1295-1311, 2005.

Connolley, T., McHugh, P.E. and Bruzzi, M.S., “A review of deformation and fatigue of metals at small size scales”, Fatigue and Fracture of Engineering Materials and Structures, Vol. 28, No. 12, pp. 1119-1152, 2005.

Albertini, G., Girardin, E., Giuliani, A., Ilie, D.E., O’Donnell B.P., McGarry, J.P. and McHugh, P.E., “Micromechanical Finite element simulation and experimental determination of residual stresses after extrusion process in metal matrix composites”, Advanced Composites Letters, Vol. 14, Issue 4, 2005.

McGarry, J.P., O’Donnell, B.P., McHugh, P.E. and McGarry, J.G., “Analysis of the mechanical performance of a cardiovascular stent design based on micromechanical modelling”, Computational Materials Science, Vol. 31, pp. 421-438, 2004.

Stenson–Cox, C., Barron, V., Murphy, B.P., McHugh, P.E. and Smith, T., “Profiling the shear stress of atherosclerosis; a genomic view”, Current Genomics, Vol. 5, pp. 287-297, 2004.

Savage, P., O’Donnell, B.P., McHugh, P.E., Murphy, B.P. and Quinn, D., “Coronary stent strut size dependent stress-strain response investigated using micromechanical finite element models”, Annals of Biomedical Engineering, Vol. 32, No.2, pp. 202-211, 2004.

Bruzzi, M.S. and McHugh, P.E., “Predicting the effects of overloads on fatigue crack growth in an Al-SiC MMC using a computational model”, Journal of Engineering Materials and Technology, Vol. 126, No. 2, pp. 172-178, 2004.

Bruzzi, M.S. and McHugh, P.E., “Micromechanical investigation of the fatigue crack growth behaviour of Al-SiC MMCs”, International Journal of Fatigue, Vol. 26, pp. 795-804, 2004.

Barron, V., Lyons, E., Stenson-Cox, C., McHugh, P.E. and Pandit, A., “Bioreactors for cardiovascular cell and tissue growth: A review”, Annals of Biomedical Engineering, Vol. 31, No. 9, pp. 1017-1030, 2003.

Bruzzi, M.S. and McHugh, P.E., “Application of closure based fatigue modelling methodology to Al-SiC MMCs”, International Journal of Fatigue, Vol. 25, pp. 577-584, 2003.

McHugh, P.E. and Connolly, P.J., “Micromechanical modelling of ductile crack growth in the binder phase of WC-Co”, Computational Materials Science, Vol. 27, pp. 423-436, 2003.

Fleming, P., Lenehan, B., O’Rourke, S., McHugh, P.E., Kaar, K. and McCabe, J.P., “Strain on the human sciatic nerve in-vivo during movement of the hip and knee”, The Journal of Bone and Joint Surgery, Vol. 85-B. No. 3., pp. 363-365, April 2003.

Murphy, B.P., Savage, P., McHugh, P.E. and Quinn, D. “The stress-strain behaviour of coronary stent struts is size dependent”, Annals of Biomedical Engineering, Vol. 31, No. 6, pp. 686-691, 2003.

Bruno, G., Girardin, E. Giuliani, A., Manescu, A., Rustichelli, F., O’Donnell, B. and McHugh, P.E. “Residual stress analysis in aerospace MMC materials by neutron diffraction”, Applied Physics A – Materials Science and Processing, Vol. 74, pp. S1701-S1703, 2002 .

Christofides, C., McHugh, P.E., Forn, A. and Picas J.A., “Wear of a thin surface coating: modelling and experimental investigations”, Computational Materials Science, Vol. 25, 1-2, pp. 61-72, 2002.

Bruzzi, M.S. and McHugh, P.E., “Methodology for modelling the small crack fatigue behaviour of aluminium alloys”, International Journal of Fatigue, Vol. 24, 10, pp. 1071-1078, 2002.

Bruzzi, M.S., McHugh P.E., O’Rourke, F. and Linder, T., “Micromechanical Modelling of the Static and Cyclic Loading of an Al 2141 – SiC MMC”, International Journal of Plasticity, Vol. 17, 4, pp. 565-599, 2001.

Farrissey, L., Ludwig, M., McHugh, P.E. and Schmauder, S., “An atomistic study of void growth in single crystalline copper”, Computational Materials Science, Vol. 18, pp. 102-117, 2000.

Schmauder, S., Melander, A., McHugh, P.E., Rohde, J., Honle, S., Mintchev, O., Thuvander, A., Thoors, H., Quinn, D. and Connolly, P., “New Tool Materials with a Structural Gradient for Milling Applications”, J. Phys. IV France, Vol. 9, pp. 147-156, 1999.

Farrissey, L., Schmauder, S., Dong, M., Soppa, E., Poech, M.H. and McHugh, P.E., “Investigation of the Strengthening of Particulate Reinforced Composites using Different Analytical and Finite Element  Models”, Computational Materials Science, Vol. 15, pp. 1-10, 1999.

Connolly, P.J. and McHugh, P.E., “Fracture Modelling of WC-Co Hardmetals using Crystal Plasticity Theory and the Gurson Model”, Fatigue and Fracture of Engineering Materials and Structures, Vol. 22, pp. 77-86, 1999.

McHugh, P.E. and Mohrmann, R., “Modelling of Creep in a Ni base Superalloy using a Single Crystal Plasticity Model”, Computational Materials Science, Vol. 9, pp. 134-140, 1997.

O’Regan, T.L., Quinn, D.F., Howe, M.A. and McHugh, P.E., ’’Void Growth Simulations in Single Crystals’’, Computational Mechanics, Vol. 20, pp.115-121, 1997.

McHugh, P.E. and Riedel, H., ’’A Liquid Phase Sintering Model: Application to Si ₃N ₄ and WC-Co’’, Acta Materialia, Vol. 45, No. 7, pp. 2995-3003, 1997.

Quinn, D.F., Connolly, P.J., Howe, M.A. and McHugh, P.E., ’’Simulation Void Growth in WC-Co Hardmetals using Crystal Plasticity Theory’’, Int. J. Mech. Sci., Vol. 39, No. 2, pp. 173-183, 1997.

O’Grady, M., McCarthy, B., Donnellan, I., McHugh, P.E. and Heslin, P., “Vibration in an Automobile Internal Rear-View Mirror”, Key Engineering Materials, Vols. 118-119, pp. 35-42, 1996.

O’Regan, T.L., Quinn, D.F. and McHugh, P.E., ’’Finite Element Simulations in Metals using Remeshing’’, Key Engineering Materials, Vols. 118-119, pp. 171-178, 1996.

O’Dowd, N.P., Lim, L.H. and McHugh, P.E., ’’Thermomechanical Modelling of Aluminium Matrix Composites’’, Key Engineering Materials, Vols. 118-119, pp. 187-192, 1996.

Lim, L.H., O’Dowd, N.P. and McHugh, P.E., “Computational Modelling of the Cyclic Behaviour of Aluminium and Aluminium Matrix Composites”, Computational Materials Science, Vol. 5, pp. 187-194, 1996.

McHugh, P.E. and Connolly, P., “Modelling the Thermo-Mechanical Behaviour of an Al alloy-SiC Composite - Effects of Particle Shape and Microscale Failure”, Computational Materials Science, Vol. 3, pp. 199-206, 1994.

McHugh P.E., Asaro R.J. and Shih C.F., “Computational Modeling of Metal Matrix Composite Materials-I. Isothermal Deformation Patterns in Ideal Microstructures”, Acta metall. mater., Vol. 41, No. 5, pp. 1461-1476, 1993.

McHugh P.E., Asaro R.J. and Shih C.F., “Computational Modeling of Metal Matrix Composite Materials-II. Isothermal Stress-Strain Behavior”, Acta metall. mater., Vol. 41, No. 5, pp. 1477-1488, 1993.

McHugh, P.E., Asaro, R.J. and Shih, C.F., “Computational Modeling of Metal Matrix Composite Materials-III. Comparisons with Phenomenological Models”, Acta metall. mater., Vol. 41, No. 5, pp. 1489-1499, 1993.

McHugh, P.E., Asaro, R.J. and Shih, C.F., “Computational Modeling of Metal Matrix Composite Materials-IV. Thermal Deformations”, Acta metall. mater., Vol. 41, No. 5, pp. 1501-1510, 1993.

McHugh, P.E., Varias, A.G., Asaro, R.J. and Shih, C.F., “Computational Modeling of Microstructures”, Future Generation Computer Systems, Vol. 5, pp. 295-318, 1989.

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