Dr. Carina Brehony

About

Contact Details:
Email:    carina.brehony@nuigalway.ie
Phone: +353 91-544665
Google Scholar: https://scholar.google.com/citations?user=PJcaoJ8AAAAJ&hl=en
ResearchGate:  https://www.researchgate.net/profile/Carina_Brehony

Location: Room 2008, Clinical Science Institute, Discipline of Bacteriology, University Hospital Galway, Galway, Ireland               

Position: Irish Research Council Post-Doctoral Fellow

Research Area: Water-associated Verocytotoxigenic E. coli in Ireland  

Publications:

Mahon BM, Brehony C, McGrath E, Killeen J, Cormican M, Hickey P, Keane S, Hanahoe B, Dolan A, Morris D. Indistinguishable NDM-producing Escherichia coli isolated from recreational waters, sewage, and a clinical specimen in Ireland, 2016 to 2017. Eurosurveillance. 2017 22(15).

Mulhall RM, Brehony C, O'Connor L, Meyler K, Jolley KA, Bray J, Bennett D, Maiden MC, Cunney R. Resolution of a Protracted Serogroup B Meningococcal Outbreak with Whole-Genome Sequencing Shows Interspecies Genetic Transfer. J Clin Microbiol. 2016 Dec;54(12):2891-2899.

Brehony C, Rodrigues CM, Borrow R, Smith A, Cunney R, Moxon ER, Maiden MC. Distribution of Bexsero® Antigen Sequence Types (BASTs) in invasive meningococcal disease isolates: Implications for immunisation. Vaccine. 2016 Sep 7;34(39):4690-7.

Hill DM, Lucidarme J, Gray SJ, Newbold LS, Ure R, Brehony C, Harrison OB, Bray JE, Jolley KA, Bratcher HB, Parkhill J, Tang CM, Borrow R, Maiden MC. Genomic epidemiology of age-associated meningococcal lineages in national surveillance: an observational cohort study. Lancet Infect Dis. 2015 Dec;15(12):1420-8.

Norheim G, Sanders H, Mellesdal JW, Sundfør I, Chan H, Brehony C, Vipond C, Dold C, Care R, Saleem M, Maiden MC, Derrick JP, Feavers I, Pollard AJ. An OMV Vaccine Derived from a Capsular Group B Meningococcus with Constitutive FetA Expression: Preclinical Evaluation of Immunogenicity and Toxicity. PLoS One. 2015 Sep 21;10(9):e0134353.

Marsay L, Dold C, Green CA, Rollier CS, Norheim G, Sadarangani M, Shanyinde M, Brehony C, Thompson AJ, Sanders H, Chan H, Haworth K, Derrick JP, Feavers IM, Maiden MC, Pollard AJ. A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: A phase I clinical trial. J Infect 2015, Sep;71(3):326-37

Brehony C, Hill DM, Lucidarme J, Borrow R, Maiden MC. Meningococcal vaccine antigen diversity in global databases. Eurosurveillance. 2015;20(49).

Book Chapter: The Genus Neisseria. In: The Prokaryotes – Alphaproteobacteria and Betaproteobacteria. 2014. E. Rosenberg et al. (eds.), Springer-Verlag Berlin Heidelberg (ISBN 978-3-642-30196-4). Julia S. Bennett, Holly B. Bratcher, Carina Brehony, Odile B. Harrison, Martin C. J. Maiden

Bambini S, De Chiara M, Muzzi A, Mora M, Lucidarme J, Brehony C, Borrow R, Masignani V, Comanducci M, Maiden MC, Rappuoli R, Pizza M, Jolley KA. Neisseria adhesin A variation and revised nomenclature scheme. Clin Vaccine Immunol. 2014 Jul;21(7):966-71.

Brehony C, Trotter CL, Ramsay ME, Chandra M, Jolley KA, van der Ende A, Carion F, Berthelsen L, Harðardóttir H, Vazquez J, Murphy K, Toropainen M, Caniça M, Ferreira E, Diggle M, Edwards G, Taha MK, Stefanelli P, Kriz P, Gray S, Fox A, Jacobsson S, Claus H, Vogel U, Tzanakaki G, Heuberger S, Caugant DA, Frosch M, Maiden MCJ. Implications of differential age distribution of disease-associated meningococcal lineages for vaccine development. Clin Vaccine Immunol. 2014 Jun;21(6):847-53.

Brisse S, Brehony C, Conceição T, Cubero M, Glasner C, Le Gouil M, Renvoisé A, Sheppard S, Weinert LA. Microbial molecular markers and epidemiological surveillance in the era of high throughput sequencing: an update from the IMMEM-10 conference. Res Microbiol. 2014 Feb-Mar;165(2):140-53.

Jolley KA, Bliss C, Cody AJ, Bennett JS, Bratcher HB, Brehony C, Colles FM, Wimalarathna H, Harrison OB, Sheppard SK, Maiden MC. Ribosomal Multi-Locus Sequence Typing: universal characterisation of bacteria from domain to strain. Microbiology. 2012 Apr;158(4):1005-15.

Sanders H, Brehony C, Maiden MC, Vipond C, Feavers IM. The effect of iron availability on transcription of the Neisseria meningitidis fHbp gene varies among clonal complexes. Microbiology. 2012. Apr;158(4):869-876.

R Laukkanen-Ninios R, Didelot X, Jolley KA, Morelli G, Sangal V, Kristo P, Brehony C, Imori PFM, Fukushima H, Siitonen A, Tseneva G, Voskressenskaya E, Falcao JP, Korkeala H, Maiden MCJ, Mazzoni C, Carniel E, Skurnik M, Achtman M. Population structure of the Yersinia pseudotuberculosis complex according to Multilocus Sequence Typing. Environ Microbiol. 2011. Dec;13(12):3114-27.

Brehony C, Wilson, DJ & Maiden MC. Variation of the factor H-binding protein of Neisseria meningitidis. Microbiology. 2009. 155, 4155-4169.

Brehony C, Jolley KA, Maiden MC. Multilocus sequence typing for global surveillance of meningococcal disease. FEMS Microbiol Rev. 2007. Jan;31(1):15-26.

Jolley KA, Brehony C, Maiden, MC. Molecular typing of meningococci: recommendations for target choice and nomenclature. FEMS Microbiol Rev. 2007. Jan;31(1):89-96.

Trotter CL, Chandra M, Cano R, Larrauri A, Ramsay ME, Brehony C, Jolley KA, Maiden MC, Heuberger S, Frosch M. A surveillance network for meningococcal disease in Europe. FEMS Microbiol Rev. 2007. Jan;31(1):27-36.

Presentations:

ISEH 2016, ISEG 2016 & Geoinformatics 2016 on Environment, Health, GIS and Agriculture. 2016. NUI, Galway, Ireland. C Brehony, B Mahon, S Kavanagh, M Cormican, RH Madden, C Ludden, C Kelly, L Moran, C Carroll, J Bray, KA Jolley, MC Maiden, and D Morris. Transferable colistin resistance encoding gene mcr-1 not detected in E. coli isolated from humans and retail meats in Ireland.

ISEH 2016, ISEG 2016 & Geoinformatics 2016 on Environment, Health, GIS and Agriculture. 2016. NUI, Galway, Ireland.  C Brehony, B Mahon, M Cormican, RH Madden, C Kelly, L Moran, S Kavanagh, C Carroll, J Bray, KA Jolley, MC Maiden, and D Morris. Diversity among antimicrobial resistant E. coli isolated from Irish retail meats.

Applied Bioinformatics and Public Health Microbiology, 2015. C Brehony, RM Mulhall, D Bennett, R Cunney, MC Maiden. Combining non-culture diagnosis, gene sequencing and whole genome sequence data in resolving a protracted meningococcal disease outbreak by a reference laboratory using web-based tools.

International Pathogenic Neisseria Conference (IPNC), Banff, Canada, 2010. C Brehony, MC Maiden, KA Jolley, and the EUMenNet Consortium. Using population biology to inform vaccine design.

EMGM, Rome, Italy, 2007. C Brehony, MC Maiden, KA Jolley, and the EUMenNet Consortium. Geographic distribution of Neisseria meningitidis antigenic types in European disease isolates over 3 years.

Neisseria Vaccines, Cuba, 2007. C Brehony, MC Maiden, KA Jolley, and the EUMenNet Consortium. Distribution of Neisseria meningitidis PorA types in Europe over 3 years.

IPNC, Cairns, Australia, 2006. C Brehony, MC Maiden, KA Jolley, and the EUMenNet Consortium. Distribution of Hyper-invasive lineages of Neisseria meningitidis in Europe over 3 years.

EMGM, Dublin, Ireland, 2005. C Brehony, MC Maiden, KA Jolley, and the EUMenNet Consortium. EUMenNet: Genetic characterisation of European meningococcal disease isolates.