Dr Aideen Ryan

B.Sc., Ph.D.

Contact Details

Lecturer Above The Bar
School of Medicine
NUI Galway

E: aideen.ryan@nuigalway.ie
 
researcher

Biography

Dr. Aideen Ryan is a Lecturer Above the Bar in the School of Medicine, National University of Ireland, Galway and is a member of the Biomedical Sciences Institute. Dr Ryan has a BSc. in Biochemistry and Microbiology from NUI Galway and a PhD in Medicine from University College Cork. Her PhD research focused on the role of Fas Ligand and immune suppression and cancer, specifically in the area of colon cancer. Dr. Ryan started her post-doctoral career in Prof. Laurence Egan's lab at NUIG, where she studied the role of NF-kappaB in colon cancer metastasis using molecular and cellular technologies, as well as other disease models. Following this, Dr. Ryan moved to the Immunology Group within the Regenerative Medicine Institute (REMEDI). Dr. Ryan’s work has led to a number of significant publications which were the foundation to the acquisition of several recent prestigious independent grants, postdoctoral fellowships and international awards including an SFI Starting Investigator Research Award (2016), Haematology Association of Ireland Best Research Award (2016), a European Association for Cancer Research (EACR) Young Scientist Award (2015), 64th Lindau Nobel Laureate meeting Award (2014), Irish Cancer Society Research Fellowship (2013), and Best Research Presentation (2011), awarded by the Irish Society of Immunology. Dr. Ryan's has multiple industry collaborations in the area of immune-oncology and stromal cell immunology. Over the course of Dr. Ryan’s research career to date, there have been several interesting outcomes, most notably research publications describing novel discoveries in Cancer Research, Oncogene, Molecular Therapy and Cell Cycle, which rank as top journals in the field of Cancer Biology and Stromal cell immunology. Dr. Ryans current research interests include understanding mechanisms of immune modulation of mesenchymal stromal cells, colon tumor cell and stromal cell interactions in the colon cancer microenvironment, as well as understanding mechanisms of immune evasion in colon cancer with particular focus on the influence of tumor cell NF-κB activity and macrophage/stromal cell interactions on the microenvironment.

Peer Reviewed Journals

  Year Publication
(2014) 'Chondrogenic Differentiation Increases Antidonor Immune Response to Allogeneic Mesenchymal Stem Cell Transplantation'
Ryan, AE;Lohan, P;O'Flynn, L;Treacy, O;Chen, X;Coleman, C;Shaw, G;Murphy, M;Barry, F;Griffin, MD;Ritter, T (2014) 'Chondrogenic Differentiation Increases Antidonor Immune Response to Allogeneic Mesenchymal Stem Cell Transplantation'. Molecular Therapy : The Journal Of The American Society Of Gene Therapy, 22 :655-667 [DOI] [Details]
(2016) 'Donor-derived equine mesenchymal stem cells suppress proliferation of mismatched lymphocytes'
Ranera, B;Antczak, D;Miller, D;Doroshenkova, T;Ryan, A;McIlwraith, CW;Barry, F (2016) 'Donor-derived equine mesenchymal stem cells suppress proliferation of mismatched lymphocytes'. Equine Veterinary Journal, 48 :253-260 [DOI] [Details]
(2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'
Lohan, P;Treacy, O;Lynch, K;Barry, F;Murphy, M;Griffin, MD;Ritter, T;Ryan, AE (2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'. Osteoarthritis And Cartilage, 24 :521-533 [DOI] [Details]
(2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'
Lohan, P,Treacy, O,Morcos, M,Donohoe, E,O'donoghue, Y,Ryan, AE,Elliman, SJ,Ritter, T,Griffin, MD (2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'. Stem Cells, 36 :1210-1215 [DOI] [Details]
(2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'
Lohan, P; Treacy, O; Morcos, M; Donohoe, E; O'donoghue, Y; Ryan, AE; Elliman, SJ; Ritter, T; Griffin, MD (2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'. Stem Cells, [DOI] [Details]
(2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'
Ridge, SM;Bhattacharyya, D;Dervan, E;Naicker, SD;Burke, AJ;Murphy, JM;O'leary, K;Greene, J;Ryan, AE;Sullivan, FJ;Glynn, SA (2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'. International Journal Of Cancer, 142 :2056-2067 [DOI] [Details]
(2018) 'Extracellular vesicles as modulators of wound healing'
Cabral, J., Ryan, A.E., Griffin, M.D., Ritter, T. (2018) 'Extracellular vesicles as modulators of wound healing'. Advanced Drug Delivery Reviews, [DOI] [ARAN Link] [Details]
(2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'
Ridge, SM,Bhattacharyya, D,Dervan, E,Naicker, SD,Burke, AJ,Murphy, JM,O'leary, K,Greene, J,Ryan, AE,Sullivan, FJ,Glynn, SA (2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'. International Journal Of Cancer, 142 :2056-2067 [DOI] [Details]
(2017) 'Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment'
Lynch, K,Treacy, O,Gerlach, JQ,Annuk, H,Lohan, P,Cabral, J,Joshi, L,Ryan, AE,Ritter, T (2017) 'Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment'. Frontiers In Immunology, 8 [DOI] [ARAN Link] [Details]
(2017) 'Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways'
Garrido, P,Shalaby, A,Walsh, EM,Keane, N,Webber, M,Keane, MM,Sullivan, FJ,Kerin, MJ,Callagy, G,Ryan, AE,Glynn, SA (2017) 'Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways'. Oncotarget, 8 :80568-80588 [DOI] [Details]
(2017) 'Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?'
Lohan, P;Treacy, O;Griffin, MD;Ritter, T;Ryan, AE (2017) 'Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?'. Frontiers In Immunology, 8 [DOI] [ARAN Link] [Details]
(2017) 'Secreted Factors from Metastatic Prostate Cancer Cells Stimulate Mesenchymal Stem Cell Transition to a Pro-tumourigenic 'Activated' State that Enhances Prostate Cancer Cell Migration'
Ridge SM, Bhattacharyya D, Dervan E, Naicker SD, Burke AJ, Murphy JM, O'Leary K, Greene J, Ryan AE, Sullivan FJ, Glynn SA (2017) 'Secreted Factors from Metastatic Prostate Cancer Cells Stimulate Mesenchymal Stem Cell Transition to a Pro-tumourigenic 'Activated' State that Enhances Prostate Cancer Cell Migration'. International Journal Of Cancer, [DOI] [Details]
(2017) 'Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer'
Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RYS, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, Wink DA. (2017) 'Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer'. Proceedings Of The National Academy Of Sciences Of The United States Of America, [DOI] [Details]
(2016) 'Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?'
O'Malley, G; Heijltjes, M; Houston, AM; Rani, S; Ritter, T; Egan, LJ; Ryan, AE (2016) 'Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?'. Oncotarget, 7 (37):60752-60773 [DOI] [Details]
(2016) 'vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis'
Farrell E;Fahy N;Ryan AE;Flatharta CO;O'Flynn L;Ritter T;Murphy JM; (2016) 'vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis'. Stem Cell Research & Therapy, 7 (1) [DOI] [Details]
(2016) 'vIL-10-overexpressing human MSCs modulate naive and activated T lymphocytes following induction of collagenase-induced osteoarthritis'
Farrell, E,Fahy, N,Ryan, AE,Flatharta, CO,O'Flynn, L,Ritter, T,Murphy, JM (2016) 'vIL-10-overexpressing human MSCs modulate naive and activated T lymphocytes following induction of collagenase-induced osteoarthritis'. Stem Cell Research & Therapy, 7 [DOI] [Details]
(2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'
Lohan P, Coleman CM, Murphy JM, Griffin MD, Ritter T, Ryan AE (2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'. Stem Cell Research & Therapy, 5 (4) [DOI] [Details]
(2014) 'Stem Cells Suppress Proliferation of Mismatched Lymphocytes'
Ranera, B; Antczak, D; Miller, D; Doroshenkova, T; Ryan, AE, McIlwraith, W; Barry, FP (2014) 'Stem Cells Suppress Proliferation of Mismatched Lymphocytes'. Equine Veterinary Journal, [Details]
(2014) 'The involvement of mesenchymal stem cells in the promotion and suppression of tumour metastasis'
SM Ridge, SA. Glynn, AE. Ryan, FJ. Giles, FJ. Sullivan (2014) 'The involvement of mesenchymal stem cells in the promotion and suppression of tumour metastasis'. European Journal Of Cancer, [Details]
(2013) 'Effects of Intratracheal Mesenchymal Stromal Cell Therapy during Recovery and Resolution after Ventilator-induced Lung Injury'
Curley, GF,Ansari, B,Hayes, M,Devaney, J,Masterson, C,Ryan, A,Barry, F,O'Brien, T,O' Toole, D,Laffey, JG (2013) 'Effects of Intratracheal Mesenchymal Stromal Cell Therapy during Recovery and Resolution after Ventilator-induced Lung Injury'. Anesthesiology, 118 :924-933 [DOI] [Details]
(2013) 'Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer'
O'Callaghan, G,Ryan, A,Neary, P,O'Mahony, C,Shanahan, F,Houston, A (2013) 'Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer'. International Journal Of Cancer, 133 :825-834 [DOI] [Details]
(2012) 'Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation'
Treacy, O,Ryan, AE,Heinzl, T,O'Flynn, L,Cregg, M,Wilk, M,Odoardi, F,Lohan, P,O'Brien, T,Nosov, M,Ritter, T (2012) 'Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation'. Plos One, 7 [DOI] [ARAN Link] [Details]
(2012) 'Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat'
Curley, GF,Hayes, M,Ansari, B,Shaw, G,Ryan, A,Barry, F,O'Brien, T,O'Toole, D,Laffey, JG (2012) 'Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat'. Thorax, 67 :496-501 [DOI] [Details]
(2011) 'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity'
Colleran, A,Ryan, A,O'Gorman, A,Mureau, C,Liptrot, C,Dockery, P,Fearnhead, H,Egan, LJ (2011) 'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity'. Journal Of Biological Chemistry, 286 :22886-22893 [DOI] [Details]
(2010) 'Regulation of NF-kappa B responses by epigenetic suppression of I kappa B alpha expression in HCT116 intestinal epithelial cells'
O'Gorman, A,Colleran, A,Ryan, A,Mann, J,Egan, LJ (2010) 'Regulation of NF-kappa B responses by epigenetic suppression of I kappa B alpha expression in HCT116 intestinal epithelial cells'. American Journal Of Physiology-Gastrointestinal And Liver Physiology, 299 :96-105 [DOI] [Details]
(2008) 'The Fas counterattack is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability'
Houston, AM,Michael-Robinson, JM,Walsh, MD,Cummings, MC,Ryan, AE,Lincoln, D,Pandeya, N,Jass, JR,Radford-Smith, GL,O'Connell, J (2008) 'The Fas counterattack is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability'. Human Pathology, 39 :243-250 [DOI] [Details]
(2006) 'Fas ligand promotes tumor immune evasion of colon cancer in vivo'
Ryan, AE,Shanahan, F,O'Connell, J,Houston, AM (2006) 'Fas ligand promotes tumor immune evasion of colon cancer in vivo'. Cell Cycle, 5 :246-249 [Details]
(2006) 'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: Involvement of extracellular signal-regulated kinase 1/2, p38 delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'
Ambrose, M,Ryan, A,O'Sullivan, GC,Dunne, C,Barry, OP (2006) 'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: Involvement of extracellular signal-regulated kinase 1/2, p38 delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'. Molecular Pharmacology, 69 :1879-1890 [DOI] [Details]
(2005) 'Addressing the Fas counterattack controversy: Blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo'
Ryan, AE,Shanahan, F,O'Connell, J,Houston, AM (2005) 'Addressing the Fas counterattack controversy: Blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo'. Cancer Research, 65 :9817-9823 [DOI] [Details]
(2002) 'Rapid development of a quantitative –competitive (qc) RT-PCR assay using a composite primer approach'
O'Connell J, Houston AM, Kelly R, O'Brien D, Ryan AE, Bennett, MW, Nally K (2002) 'Rapid development of a quantitative –competitive (qc) RT-PCR assay using a composite primer approach'. Methods in Molecular Biology, 193 :93-102 [Details]

Book Chapters

  Year Publication
(2014) 'Mechanisms of Nitric Oxide Dependent Regulation of Tumour Invasion and Metastasis'
Ryan AE, Burke AJ, Sullivan FJ, Glynn SA (2014) 'Mechanisms of Nitric Oxide Dependent Regulation of Tumour Invasion and Metastasis' In: ‘NO and Cancer’ – Prognosis, Prevention and Therapy. USA: Springer. [Details]

Conference Publications

  Year Publication
(2012) Attenuation of inflammation by immune modulation for cartilage repair in osteoarthritis
Fahy, N,Farrell, E,Ryan, A,Harte, M,Ritter, T,Murphy, M (2012) JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE Attenuation of inflammation by immune modulation for cartilage repair in osteoarthritis , pp.63-63 [Details]
(2012) RAMI Biomedical Sciences Conference Galway
Fahy, N,Farrell, E,Ryan, A,Harte, M,Ritter, T,Murphy, M (2012) MECHANISM OF ACTION OF ANTI-INFLAMMATORY EFFECTS OF INTERLEUKIN-10 OVEREXPRESSING MESENCHYMAL STEM CELLS RAMI Biomedical Sciences Conference Galway [Details]
(2011) Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation
Treacy, O,Heinzl, T,Cregg, M,Wilk, M,Odoardi, F,O'Brien, T,Ryan, A,Nosov, M,Ritter, T (2011) Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation , pp.72-72 [Details]

Abstract

  Year Publication
(2014) BJU International.
SM Ridge, AE Ryan, S Finn, J O'Leary, FJ Giles, FJ Sullivan, SA Glynn (2014) BJU International. Abstract [Details]
(2014) Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity.
Ridge, M,Ridge, SM,Ryan, AE,Finn, S,O'Leary, J,Giles, FJ,Sullivan, FJ,Glynn, SA (2014) Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity. Abstract [Details]
(2012) Gastroenterology.
GP O'Callaghan, AE Ryan, P Neary, C O'Mahony, F Shanahan, A Houston (2012) Gastroenterology. Abstract [Details]
(2012) Acta Ophthalmologica.
L O'Flynn, O Treacy, AE Ryan, M Morcos, M Nosov, T Ritter (2012) Acta Ophthalmologica. Abstract [Details]
(2012) Section of Biomedical Sciences.
N Fahy, E Farrell, AE Ryan, M Harte, T Ritter, M Murphy (2012) Section of Biomedical Sciences. Abstract [Details]
(2012) Journal of Tissue Engineering and Regenerative Medicine.
N Fahy, E Farrell, AE Ryan, M Harte, T Ritter, M Murphy (2012) Journal of Tissue Engineering and Regenerative Medicine. Abstract [Details]
(2011) Acta Ophthalmologica.
T Ritter, O Treacy, M Wilk, M Morcos, L O'Flynn, AE Ryan, M Nosov (2011) Acta Ophthalmologica. Abstract [Details]
(2010) Gastroenterology.
Ryan AE, Colleran A, O'Gorman A, Mureau C, Egan LJ (2010) Gastroenterology. Abstract [Details]
(2010) Gastroenterology Presentation.
Colleran A, Ryan AE, O’Gorman A, Liptrot CH, Dockery P, Egan LJ (2010) Gastroenterology Presentation. Abstract [Details]
(2010) Gastroenterology.
Raja Affendi Raja Ali, Zulquernain SA, Ryan AE, Colleran A, Hartnett L, O’Gorman A, Lee JM, Egan LJ (2010) Gastroenterology. Abstract [Details]
(2009) Gastroenterology.
Ryan AE, Colleran A, O’Gorman A, Foran E, Egan LJ (2009) Gastroenterology. Abstract [Details]
(2005) Gastroenterology.
Ryan AE, Shanahan F, O’Connell J, Houston AM (2005) Gastroenterology. Abstract [Details]
(2005) Endoscopy.
Ryan AE, Shanahan F, O’Connell J, Houston AM (2005) Endoscopy. Abstract [Details]

Book Review

  Year Publication
(2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries.
Ritter, T,Lal, C,Treacy, O,O'Malley, G,Naughton, M,Naicker, S,Lohan, P,Subhash, HM,Ryan, A,Fahy, G,Leahy, M,Griffin, MD,Rani, S (2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries. Book Review [Details]
(2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries.
Ritter, T,Lal, C,Treacy, O,O'Malley, G,Naughton, M,Naicker, S,Lohan, P,Subhash, HM,Ryan, A,Fahy, G,Leahy, M,Griffin, MD,Rani, S (2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries. Book Review [Details]
(2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries.
Ritter, T,Lal, C,Treacy, O,O'Malley, G,Naughton, M,Naicker, S,Lohan, P,Subhash, HM,Ryan, A,Fahy, G,Leahy, M,Griffin, MD,Rani, S (2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries. Book Review [Details]

Invited Seminars

  Year Publication
(2012) The Immunology Seminar Series, NUI Maynooth.
Ryan, AE (2012) The Immunology Seminar Series, NUI Maynooth. Invited Seminars [Details]
(2012) Biochemistry Seminar Series’, University College Cork.
Ryan, AE (2012) Biochemistry Seminar Series’, University College Cork. Invited Seminars [Details]
(2011) PRTLI Workshop on ‘Inflammation’, Trinity College Dublin.
Ryan, AE (2011) PRTLI Workshop on ‘Inflammation’, Trinity College Dublin. Invited Seminars [Details]
(2009) Irish Epithelial Physiology Group (IEPG), Kilkenny.
Ryan, AE (2009) Irish Epithelial Physiology Group (IEPG), Kilkenny. Invited Seminars [Details]

Presented Papers

  Year Publication
(2013) Irish Association for Cancer research.
Ryan, AE (2013) Irish Association for Cancer research. Presented Papers [Details]
(2012) Keystone Symposium on ‘The role of Inflammation during Carcinogenesis’.
Ryan, AE (2012) Keystone Symposium on ‘The role of Inflammation during Carcinogenesis’. Presented Papers [Details]
(2005) Irish Society Gastroenterology.
Ryan, AE (2005) Irish Society Gastroenterology. Presented Papers [Details]