Dr Aideen Ryan

B.Sc., Ph.D.

Contact Details

Lecturer Above The Bar
School of Medicine
NUI Galway

E: aideen.ryan@nuigalway.ie
 

Biography

Dr. Aideen Ryan is a Lecturer Above the Bar in the School of Medicine, National University of Ireland, Galway and is a member of the Biomedical Sciences Institute. Dr Ryan has a BSc. in Biochemistry and Microbiology from NUI Galway and a PhD in Medicine from University College Cork. Her PhD research focused on the role of Fas Ligand and immune suppression and cancer, specifically in the area of colon cancer. Dr. Ryan started her post-doctoral career in Prof. Laurence Egan's lab at NUIG, where she studied the role of NF-kappaB in colon cancer metastasis using molecular and cellular technologies, as well as other disease models. Following this, Dr. Ryan moved to the Immunology Group within the Regenerative Medicine Institute (REMEDI). Dr. Ryan’s work has led to a number of significant publications which were the foundation to the acquisition of several recent prestigious independent grants, postdoctoral fellowships and international awards including an SFI Starting Investigator Research Award (2016), Haematology Association of Ireland Best Research Award (2016), a European Association for Cancer Research (EACR) Young Scientist Award (2015), 64th Lindau Nobel Laureate meeting Award (2014), Irish Cancer Society Research Fellowship (2013), and Best Research Presentation (2011), awarded by the Irish Society of Immunology. Dr. Ryan's has multiple industry collaborations in the area of immune-oncology and stromal cell immunology. Over the course of Dr. Ryan’s research career to date, there have been several interesting outcomes, most notably research publications describing novel discoveries in Cancer Research, Oncogene, Molecular Therapy and Cell Cycle, which rank as top journals in the field of Cancer Biology and Stromal cell immunology. Dr. Ryans current research interests include understanding mechanisms of immune modulation of mesenchymal stromal cells, colon tumor cell and stromal cell interactions in the colon cancer microenvironment, as well as understanding mechanisms of immune evasion in colon cancer with particular focus on the influence of tumor cell NF-κB activity and macrophage/stromal cell interactions on the microenvironment.

Research Projects

  Project Start Date End Date
RESTRAIN - Investigation of tumour stromal interactions in metastatic colon cancer for the identification of novel immuno-therapeutic targets 01-DEC-16 30-NOV-20
JANSSEN RESEARCH & DEVELOPMENT 20-DEC-15 31-DEC-18
NOS2&COX2 activation of TLR4 & EGFR signalling causes poor outcome in oestrogen receptor-negative breast cancer via pro-survival signals and immune polarisation 01-MAY-14 01-MAY-17
Cellular interactions in tumour microenvironment during inflammation associated 01-OCT-13 01-OCT-17
Molecular Regulation of the tumour Microenvironment in Colon Cancer Metastasis 01-JAN-19 31-JAN-20
Bristol-Myers Squibb Co.- Low dose cyclophosphamide, elotuzumab and nivolumab: a novel immunotherapeutic strategy for multiple myeloma 13-FEB-18 13-FEB-23
Molecular Regulation of the tumour microenvironment in colon cancer metastasis 01-JAN-13 30-APR-16
EI H2020 PROPOSAL PREP SUPPORT - INVESTIGATION OF COLON CANCER INDUCED STROMAL CELL IMMUNOLOGICAL AND METABOLIC PHENOTYPES AND SUBSEQUENT EFFECTS ON THE ANTI-TUMOUR IMMUNE RESPONSE 31-JUL-17 30-APR-19

Contract Researchers

  Researcher Name Project Role Funding Body
Dr Oliver Treacy Investigation of tumour stromal interactions for the identification of novel immunotherapeutic targets Senior Post Doctoral Researcher Science Foundation Ireland (SFI)
Dr Serika Naicker Investigating novel methods for potentiation of monoclonal antibody therapies in cancer Leading researcher on an industry funded project investigating methods to potentiate the effect of monoclonal antibody therapies for cancer Industrial Contracts
Dr. Kevin Lynch Bristol Myers Squibb Post Doctoral Researcher Industrial Contracts

Peer Reviewed Journals

  Year Publication
(2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'
Lohan, P;Treacy, O;Morcos, M;Donohoe, E;O'donoghue, Y;Ryan, AE;Elliman, SJ;Ritter, T;Griffin, MD (2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'. Stem Cells (Dayton, Ohio), 36 :1210-1215 [DOI] [Details]
(2018) 'Stromal Cell PD-L1 Inhibits CD8(+) T-cell Antitumor Immune Responses and Promotes Colon Cancer'
O'Malley, G,Treacy, O,Lynch, K,Naicker, SD,Leonard, NA,Lohan, P,Dunne, PD,Ritter, T,Egan, LJ,Ryan, AE (2018) 'Stromal Cell PD-L1 Inhibits CD8(+) T-cell Antitumor Immune Responses and Promotes Colon Cancer'. Cancer Immunology Research, 6 :1426-1441 [DOI] [Details]
(2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'
Lohan, P; Treacy, O; Lynch, K; Barry, F; Murphy, M; Griffin, MD; Ritter, T; Ryan, AE. (2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'. Osteoarthritis And Cartilage, [Details]
(2016) 'Donor-derived equine mesenchymal stem cells suppress proliferation of mismatched lymphocytes'
Ranera, B,Antczak, D,Miller, D,Doroshenkova, T,Ryan, A,McIlwraith, CW,Barry, F (2016) 'Donor-derived equine mesenchymal stem cells suppress proliferation of mismatched lymphocytes'. Equine Veterinary Journal, 48 :253-260 [DOI] [Details]
(2016) 'Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity'
O'Leary, L,van der Sloot, AM,Reis, CR,Deegan, S,Ryan, AE,Dhami, SPS,Murillo, LS,Cool, RH,de Sampaio, PC,Thompson, K,Murphy, G,Quax, WJ,Serrano, L,Samali, A,Szegezdi, E (2016) 'Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity'. Oncogene, 35 :1261-1270 [DOI] [Details]
(2015) 'Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint'
Fahy, N,Farrell, E,Ritter, T,Ryan, AE,Murphy, JM (2015) 'Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint'. Tissue Engineering Part B-Reviews, 21 :55-66 [DOI] [Details]
(2015) 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'
Bulman, SE,Coleman, CM,Murphy, JM,Medcalf, N,Ryan, AE,Barry, F (2015) 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'. Stem Cell Research & Therapy, 6 [DOI] [Details]
(2015) 'Targeting colon cancer cell NF-kappa B promotes an anti-tumour M1-like macrophage phenotype and inhibits peritoneal metastasis'
Ryan, AE,Colleran, A,O'Gorman, A,O'Flynn, L,Pindjacova, J,Lohan, P,O'Malley, G,Nosov, M,Mureau, C,Egan, LJ (2015) 'Targeting colon cancer cell NF-kappa B promotes an anti-tumour M1-like macrophage phenotype and inhibits peritoneal metastasis'. Oncogene, 34 :1563-1574 [DOI] [Details]
(2015) 'Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications'
Rani, S,Ryan, AE,Griffin, MD,Ritter, T (2015) 'Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications'. Molecular Therapy, 23 (5):812-823 [DOI] [Details]
(2014) 'Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation'
Ryan, AE; Lohan, P; O'Flynn, L; Treacy, O; Chen, X; Coleman, C; Shaw, G; Murphy, M; Barry, F; Griffin, MD; Ritter, T. (2014) 'Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation'. Molecular Therapy, [Details]
(2014) 'Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation'
Treacy O, O'Flynn L, Ryan AE, Morcos M, Lohan P, Schu S, Wilk M, Fahy G, Griffin MD, Nosov M, Ritter T (2014) 'Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation'. American Journal Of Transplantation, 14 (9):2023-2036 [DOI] [Details]
(2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'
Lohan, P,Coleman, CM,Murphy, M,Griffin, MD,Ritter, T,Ryan, AE (2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'. Stem Cell Research & Therapy, 5 [DOI] [Details]
(2013) 'Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?'
Griffin, MD; Ryan, AE; Alagesan, S; Lohan, P; Treacy, O; Ritter, T. (2013) 'Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?'. Immunology And Cell Biology, [Details]
(2013) 'Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu'
O'Flynn, L; Treacy, O; Ryan, AE; Morcos, M; Cregg, M; Gerlach, J; Joshi, L; Nosov, M; Ritter, T. (2013) 'Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu'. Molecular Therapy, [Details]
(2006) 'Fas ligand expression in human and mouse cancer cell lines ; a caveat on over-reliance on mRNA data'
Ryan AE, Lane S, Shanahan F, O'Connell J, Houston AM (2006) 'Fas ligand expression in human and mouse cancer cell lines ; a caveat on over-reliance on mRNA data'. Carcinogenesis, 5 (1) [Details]
(2018) 'Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation'
Lohan, P,Murphy, N,Treacy, O,Lynch, K,Morcos, M,Chen, BL,Ryan, AE,Griffin, MD,Ritter, T (2018) 'Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation'. Frontiers In Immunology, 9 [DOI] [ARAN Link] [Details]
(2014) 'Chondrogenic Differentiation Increases Antidonor Immune Response to Allogeneic Mesenchymal Stem Cell Transplantation'
Ryan, AE;Lohan, P;O'Flynn, L;Treacy, O;Chen, X;Coleman, C;Shaw, G;Murphy, M;Barry, F;Griffin, MD;Ritter, T (2014) 'Chondrogenic Differentiation Increases Antidonor Immune Response to Allogeneic Mesenchymal Stem Cell Transplantation'. Molecular Therapy : The Journal Of The American Society Of Gene Therapy, 22 :655-667 [DOI] [Details]
(2016) 'Donor-derived equine mesenchymal stem cells suppress proliferation of mismatched lymphocytes'
Ranera, B;Antczak, D;Miller, D;Doroshenkova, T;Ryan, A;McIlwraith, CW;Barry, F (2016) 'Donor-derived equine mesenchymal stem cells suppress proliferation of mismatched lymphocytes'. Equine Veterinary Journal, 48 :253-260 [DOI] [Details]
(2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'
Lohan, P;Treacy, O;Lynch, K;Barry, F;Murphy, M;Griffin, MD;Ritter, T;Ryan, AE (2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'. Osteoarthritis And Cartilage, 24 :521-533 [DOI] [Details]
(2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'
Ridge, SM;Bhattacharyya, D;Dervan, E;Naicker, SD;Burke, AJ;Murphy, JM;O'leary, K;Greene, J;Ryan, AE;Sullivan, FJ;Glynn, SA (2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'. International Journal Of Cancer, 142 :2056-2067 [DOI] [Details]
(2018) 'Extracellular vesicles as modulators of wound healing'
Cabral, J., Ryan, A.E., Griffin, M.D., Ritter, T. (2018) 'Extracellular vesicles as modulators of wound healing'. Advanced Drug Delivery Reviews, [DOI] [ARAN Link] [Details]
(2017) 'Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment'
Lynch, K,Treacy, O,Gerlach, JQ,Annuk, H,Lohan, P,Cabral, J,Joshi, L,Ryan, AE,Ritter, T (2017) 'Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment'. Frontiers In Immunology, 8 [DOI] [ARAN Link] [Details]
(2017) 'Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways'
Garrido, P,Shalaby, A,Walsh, EM,Keane, N,Webber, M,Keane, MM,Sullivan, FJ,Kerin, MJ,Callagy, G,Ryan, AE,Glynn, SA (2017) 'Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways'. Oncotarget, 8 :80568-80588 [DOI] [Details]
(2017) 'Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?'
Lohan, P;Treacy, O;Griffin, MD;Ritter, T;Ryan, AE (2017) 'Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?'. Frontiers In Immunology, 8 [DOI] [ARAN Link] [Details]
(2017) 'Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer'
Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RYS, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, Wink DA. (2017) 'Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer'. Proceedings Of The National Academy Of Sciences Of The United States Of America, [DOI] [Details]
(2016) 'Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?'
O'Malley, G; Heijltjes, M; Houston, AM; Rani, S; Ritter, T; Egan, LJ; Ryan, AE (2016) 'Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?'. Oncotarget, 7 (37):60752-60773 [DOI] [Details]
(2016) 'vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis'
Farrell E;Fahy N;Ryan AE;Flatharta CO;O'Flynn L;Ritter T;Murphy JM; (2016) 'vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis'. Stem Cell Research & Therapy, 7 (1) [DOI] [Details]
(2016) 'vIL-10-overexpressing human MSCs modulate naive and activated T lymphocytes following induction of collagenase-induced osteoarthritis'
Farrell, E,Fahy, N,Ryan, AE,Flatharta, CO,O'Flynn, L,Ritter, T,Murphy, JM (2016) 'vIL-10-overexpressing human MSCs modulate naive and activated T lymphocytes following induction of collagenase-induced osteoarthritis'. Stem Cell Research & Therapy, 7 [DOI] [Details]
(2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'
Lohan P, Coleman CM, Murphy JM, Griffin MD, Ritter T, Ryan AE (2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'. Stem Cell Research & Therapy, 5 (4) [DOI] [Details]
(2014) 'Stem Cells Suppress Proliferation of Mismatched Lymphocytes'
Ranera, B; Antczak, D; Miller, D; Doroshenkova, T; Ryan, AE, McIlwraith, W; Barry, FP (2014) 'Stem Cells Suppress Proliferation of Mismatched Lymphocytes'. Equine Veterinary Journal, [Details]
(2014) 'The involvement of mesenchymal stem cells in the promotion and suppression of tumour metastasis'
SM Ridge, SA. Glynn, AE. Ryan, FJ. Giles, FJ. Sullivan (2014) 'The involvement of mesenchymal stem cells in the promotion and suppression of tumour metastasis'. European Journal Of Cancer, [Details]
(2013) 'Effects of Intratracheal Mesenchymal Stromal Cell Therapy during Recovery and Resolution after Ventilator-induced Lung Injury'
Curley, GF,Ansari, B,Hayes, M,Devaney, J,Masterson, C,Ryan, A,Barry, F,O'Brien, T,O' Toole, D,Laffey, JG (2013) 'Effects of Intratracheal Mesenchymal Stromal Cell Therapy during Recovery and Resolution after Ventilator-induced Lung Injury'. Anesthesiology, 118 :924-933 [DOI] [Details]
(2013) 'Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer'
O'Callaghan, G,Ryan, A,Neary, P,O'Mahony, C,Shanahan, F,Houston, A (2013) 'Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer'. International Journal Of Cancer, 133 :825-834 [DOI] [Details]
(2012) 'Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation'
Treacy, O,Ryan, AE,Heinzl, T,O'Flynn, L,Cregg, M,Wilk, M,Odoardi, F,Lohan, P,O'Brien, T,Nosov, M,Ritter, T (2012) 'Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation'. Plos One, 7 [DOI] [ARAN Link] [Details]
(2012) 'Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat'
Curley, GF,Hayes, M,Ansari, B,Shaw, G,Ryan, A,Barry, F,O'Brien, T,O'Toole, D,Laffey, JG (2012) 'Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat'. Thorax, 67 :496-501 [DOI] [Details]
(2011) 'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity'
Colleran, A,Ryan, A,O'Gorman, A,Mureau, C,Liptrot, C,Dockery, P,Fearnhead, H,Egan, LJ (2011) 'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity'. Journal Of Biological Chemistry, 286 :22886-22893 [DOI] [Details]
(2010) 'Regulation of NF-kappa B responses by epigenetic suppression of I kappa B alpha expression in HCT116 intestinal epithelial cells'
O'Gorman, A,Colleran, A,Ryan, A,Mann, J,Egan, LJ (2010) 'Regulation of NF-kappa B responses by epigenetic suppression of I kappa B alpha expression in HCT116 intestinal epithelial cells'. American Journal Of Physiology-Gastrointestinal And Liver Physiology, 299 :96-105 [DOI] [Details]
(2008) 'The Fas counterattack is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability'
Houston, AM,Michael-Robinson, JM,Walsh, MD,Cummings, MC,Ryan, AE,Lincoln, D,Pandeya, N,Jass, JR,Radford-Smith, GL,O'Connell, J (2008) 'The Fas counterattack is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability'. Human Pathology, 39 :243-250 [DOI] [Details]
(2006) 'Fas ligand promotes tumor immune evasion of colon cancer in vivo'
Ryan, AE,Shanahan, F,O'Connell, J,Houston, AM (2006) 'Fas ligand promotes tumor immune evasion of colon cancer in vivo'. Cell Cycle, 5 :246-249 [Details]
(2006) 'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: Involvement of extracellular signal-regulated kinase 1/2, p38 delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'
Ambrose, M,Ryan, A,O'Sullivan, GC,Dunne, C,Barry, OP (2006) 'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: Involvement of extracellular signal-regulated kinase 1/2, p38 delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'. Molecular Pharmacology, 69 :1879-1890 [DOI] [Details]
(2005) 'Addressing the Fas counterattack controversy: Blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo'
Ryan, AE,Shanahan, F,O'Connell, J,Houston, AM (2005) 'Addressing the Fas counterattack controversy: Blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo'. Cancer Research, 65 :9817-9823 [DOI] [Details]
(2002) 'Rapid development of a quantitative –competitive (qc) RT-PCR assay using a composite primer approach'
O'Connell J, Houston AM, Kelly R, O'Brien D, Ryan AE, Bennett, MW, Nally K (2002) 'Rapid development of a quantitative –competitive (qc) RT-PCR assay using a composite primer approach'. Methods in Molecular Biology, 193 :93-102 [Details]

Book Chapters

  Year Publication
(2014) 'Mechanisms of Nitric Oxide Dependent Regulation of Tumour Invasion and Metastasis'
Ryan AE, Burke AJ, Sullivan FJ, Glynn SA (2014) 'Mechanisms of Nitric Oxide Dependent Regulation of Tumour Invasion and Metastasis' In: ‘NO and Cancer’ – Prognosis, Prevention and Therapy. USA: Springer. [Details]

Conference Publications

  Year Publication
(2012) Attenuation of inflammation by immune modulation for cartilage repair in osteoarthritis
Fahy, N,Farrell, E,Ryan, A,Harte, M,Ritter, T,Murphy, M (2012) JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE Attenuation of inflammation by immune modulation for cartilage repair in osteoarthritis , pp.63-63 [Details]
(2012) RAMI Biomedical Sciences Conference Galway
Fahy, N,Farrell, E,Ryan, A,Harte, M,Ritter, T,Murphy, M (2012) MECHANISM OF ACTION OF ANTI-INFLAMMATORY EFFECTS OF INTERLEUKIN-10 OVEREXPRESSING MESENCHYMAL STEM CELLS RAMI Biomedical Sciences Conference Galway [Details]
(2011) Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation
Treacy, O,Heinzl, T,Cregg, M,Wilk, M,Odoardi, F,O'Brien, T,Ryan, A,Nosov, M,Ritter, T (2011) Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation , pp.72-72 [Details]

Abstract

  Year Publication
(2014) BJU International.
SM Ridge, AE Ryan, S Finn, J O'Leary, FJ Giles, FJ Sullivan, SA Glynn (2014) BJU International. Abstract [Details]
(2014) Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity.
Ridge, M,Ridge, SM,Ryan, AE,Finn, S,O'Leary, J,Giles, FJ,Sullivan, FJ,Glynn, SA (2014) Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity. Abstract [Details]
(2012) Gastroenterology.
GP O'Callaghan, AE Ryan, P Neary, C O'Mahony, F Shanahan, A Houston (2012) Gastroenterology. Abstract [Details]
(2012) Acta Ophthalmologica.
L O'Flynn, O Treacy, AE Ryan, M Morcos, M Nosov, T Ritter (2012) Acta Ophthalmologica. Abstract [Details]
(2012) Section of Biomedical Sciences.
N Fahy, E Farrell, AE Ryan, M Harte, T Ritter, M Murphy (2012) Section of Biomedical Sciences. Abstract [Details]
(2012) Journal of Tissue Engineering and Regenerative Medicine.
N Fahy, E Farrell, AE Ryan, M Harte, T Ritter, M Murphy (2012) Journal of Tissue Engineering and Regenerative Medicine. Abstract [Details]
(2011) Acta Ophthalmologica.
T Ritter, O Treacy, M Wilk, M Morcos, L O'Flynn, AE Ryan, M Nosov (2011) Acta Ophthalmologica. Abstract [Details]
(2010) Gastroenterology.
Ryan AE, Colleran A, O'Gorman A, Mureau C, Egan LJ (2010) Gastroenterology. Abstract [Details]
(2010) Gastroenterology Presentation.
Colleran A, Ryan AE, O’Gorman A, Liptrot CH, Dockery P, Egan LJ (2010) Gastroenterology Presentation. Abstract [Details]
(2010) Gastroenterology.
Raja Affendi Raja Ali, Zulquernain SA, Ryan AE, Colleran A, Hartnett L, O’Gorman A, Lee JM, Egan LJ (2010) Gastroenterology. Abstract [Details]
(2009) Gastroenterology.
Ryan AE, Colleran A, O’Gorman A, Foran E, Egan LJ (2009) Gastroenterology. Abstract [Details]
(2005) Gastroenterology.
Ryan AE, Shanahan F, O’Connell J, Houston AM (2005) Gastroenterology. Abstract [Details]
(2005) Endoscopy.
Ryan AE, Shanahan F, O’Connell J, Houston AM (2005) Endoscopy. Abstract [Details]

Book Review

  Year Publication
(2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries.
Ritter, T,Lal, C,Treacy, O,O'Malley, G,Naughton, M,Naicker, S,Lohan, P,Subhash, HM,Ryan, A,Fahy, G,Leahy, M,Griffin, MD,Rani, S (2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries. Book Review [Details]
(2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries.
Ritter, T,Lal, C,Treacy, O,O'Malley, G,Naughton, M,Naicker, S,Lohan, P,Subhash, HM,Ryan, A,Fahy, G,Leahy, M,Griffin, MD,Rani, S (2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries. Book Review [Details]
(2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries.
Ritter, T,Lal, C,Treacy, O,O'Malley, G,Naughton, M,Naicker, S,Lohan, P,Subhash, HM,Ryan, A,Fahy, G,Leahy, M,Griffin, MD,Rani, S (2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries. Book Review [Details]

Invited Seminars

  Year Publication
(2012) The Immunology Seminar Series, NUI Maynooth.
Ryan, AE (2012) The Immunology Seminar Series, NUI Maynooth. Invited Seminars [Details]
(2012) Biochemistry Seminar Series’, University College Cork.
Ryan, AE (2012) Biochemistry Seminar Series’, University College Cork. Invited Seminars [Details]
(2011) PRTLI Workshop on ‘Inflammation’, Trinity College Dublin.
Ryan, AE (2011) PRTLI Workshop on ‘Inflammation’, Trinity College Dublin. Invited Seminars [Details]
(2009) Irish Epithelial Physiology Group (IEPG), Kilkenny.
Ryan, AE (2009) Irish Epithelial Physiology Group (IEPG), Kilkenny. Invited Seminars [Details]

Presented Papers

  Year Publication
(2013) Irish Association for Cancer research.
Ryan, AE (2013) Irish Association for Cancer research. Presented Papers [Details]
(2012) Keystone Symposium on ‘The role of Inflammation during Carcinogenesis’.
Ryan, AE (2012) Keystone Symposium on ‘The role of Inflammation during Carcinogenesis’. Presented Papers [Details]
(2005) Irish Society Gastroenterology.
Ryan, AE (2005) Irish Society Gastroenterology. Presented Papers [Details]

Honours and Awards

  Year Title Awarding Body
2018 Sparkathon 'Future Leader' Award Society for Immunotherapy of Cancer
2018 NCI Cancer Prevention Fellowship Health research Board, National cancer Institute, USA
2018 Presidents Award for Research Excellence Presidents Office, NUI Galway
2017 Recognition as one of the top 3 Cancer Researchers in Ireland for 'Researcher of the year' Irish Cancer Society
2016 Shortlisted for Researcher of the Year Award Irish Cancer Society
2016 Best Clinical Research Presentation Haematology Association of Ireland
2016 Starting Investigator Award Science Foundation Ireland
2016 IRC nomination attendee at the Preseidents address to Women in Science Irish Research Council
2015 Best Reseach Poster Presentation The Irish Association of Cancer Research
2015 European Cancer Research Young Investigator Award European Association for Cancer Research
2015 Highly Rcommended shortlst 'Presidents awards for research excellence' National University of Ireland, Galway
2015 Best Research Poster Irish Association of Cancer Research
2014 Lindau Nobel Laureate Meeting Award Lindau Nobel Laureate Council & The Irish Research Council
2013 Irish Cancer Society Research Fellowship Irish Cancer Society
2012 Best Research Presentation The Irish Society of Immunology
2007 Best Research Presentation Irish Association of Cancer Research
2005 Research Travel Scholarship Irish Cancer Society

Professional Associations

  Association Function From / To
European Association of Cancer Research Member 31-MAY-12 / 31-MAY-16
Irish Association of Cancer Research Member 23-MAY-08 / 29-FEB-16
American Society of Haematology Active Member 01-NOV-16 /
American Association of Cancer Research Active Member 01-NOV-16 /
Matrix Biology Ireland Committee Member 01-OCT-16 /
Haematology Association of Ireland Active Member 01-OCT-16 /
Irish Society of Immunology Member 30-MAY-12 / 12-MAY-16
Irish Flow Cytometry Society Member 01-OCT-12 /
Society for Immunotherapy for Cancer Active Member 01-FEB-17 /

Committees

  Committee Function From / To
School of Medicine Research Committee Committee Member 01-DEC-17 /
School of Medicine Athena Swan Committee Member Committee Member 01-FEB-17 /
Research Advisory Board Irish Cancer Society Advisor to the research portfolio of the charity 15-NOV-16 /
Undergraduate Research Commitee Member of Commitee 01-SEP-14 /
Graduate Research Commitee GRC Commitee member 01-JUL-14 / 30-JUN-17

Employment

  Employer Position From / To
Prof Laurence Egan, NUI Galway Post Doctoral Fellow 01-AUG-06 / 31-MAR-10
NUI Galway Research Fellow 01-JAN-13 / 01-MAY-16
Prof Thomas Ritter, NUI Galway Senior Post Doctoral Fellow 04-NOV-10 / 31-DEC-12
NUI Galway SFI Funded Starting Investigator 01-DEC-16 /

Education

  Year Institution Qualification Subject
2010 Project Management Institute Certificate Project Management
2018 NUI Galway Postgraduate Certificate in Teaching & Learning in Higher Education Teaching and Learning
2001 National University of Ireland, Galway BSc (Hons) Biochenistry, Microbiology
2006 University College Cork PhD Medicine
1997 Scoil Mhuire Ballinasloe Leaving Certificate 7

Languages

  Language
Irish
English

Community Engagement

  Title Type From / To
Outreach Cell Explorers School Visits 01-NOV-17 /
Outreach Research Advocate at the Irish Cancer Society Daffodil Day launch 03-MAR-16 /
Outreach Adjudicator for 'Reellife' Science Competition 04-FEB-14 / 30-NOV-15
Outreach Pint of Science Talk 03-FEB-16 /
Outreach Irish Cancer Society Fundraising Research Showcase 30-JUN-13 / 27-MAY-13
Board Membership Research Advisory Board of the Irish Cancer Society 16-NOV-16 /
Research (e.g. Community based research) Irish Cancer Society Research Day launch 09-JUN-14 / 09-JUN-14

Reviews

  Journal Role
Stem Cell Research And Therapy Reviewer
Journal Of Tissue Engineering And Regenerative Medicine Editoral Board
Immunology And Cell Biology Reviewer
Osteoarthritis And Cartilage Reviewer
Transplantation Reviewer
Cells Tissues Organs Reviewer
Stem Cell Reviews And Reports Reviewer
Transplant immunology Reviewer
Molecular Therapy Reviewer
Stem Cells And Development Reviewer
Plos One Reviewer

Teaching Interests

My teaching interests include:

Cancer cell Signalling
Immuno-pharmacology
Allogeneic Cellular therapy and Host Responses
Immune Microenvironment in Cancer
Immunotherapies for the treatment of Cancer
Gastrointestinal Cancers
Mechanisms of Immune evasion in Cancer
Strategies to modulate the immune microenvironment in cancer



 

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2018 Grace O'Malley PhD Y
2016 Paul Lohan PhD Y

Current Postgraduate Students (Research)

  Student Degree Type Type
Kevin Lynch Doctorate - Structured Ph.D (Medicine) Co-supervisor (1)
Niamh Leonard Doctorate - Structured Ph.D (Medicine) Supervisor

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2012/2013 Clinical Oncology, Haematology 1213-B1461 Gastrointestinal Cancers
2016/2017 Molecular Pharmacology 1617-PM434
2016/2017 Clinical Oncology - Haematology 1617-B1461
2016/2017 Advnaced and Applied Immunology 1617-MD536
2014/2015 Advanced and Applied Immunology 1415-MD536 Cancer Immunology ans Immunotherapies
2016/2017 Pharmacology Research Project 1617-PM431
2014/2015 Course in Basic and Applied Immunology 1415-REM508 Cancer and stromal cell immunology
2013/2014 Clinical Oncology, Haematology 1213-B1461 Gastrointestinal Cancers
2014/2015 Course in Basic and Advanced Immunology 1415-REM508 Stem Cell Immunology
2015-2016 Basic and Advanced Immunology 1516-REM508 Stem Cell transplantation
2016/2017 Stem Cells and Gene Therapy 1617-PM507
2014/2015 Clinical Oncology, Haematology 1415-B1461 Gastrointestinal Cancers
2016/2017 Immunopharmacology 1617-PM435
2016/2017 Basic and Advanced Immunology 1617-REM508
2016/2017 Experimental Neuropharmacology 1617-PM5103
2016/2017 Experimental Toxicology 1617-PM5109

Internal Collaborators

  Name Description of Collaboration
Prof Laurence Egan
Joint supervision of PhD students, Joint research projects and joint research publications
Dr Sharon Glynn
Dr Glynn provides expertise on tumour biology, inflammation and tumour metabolites in the tumour microenvironment
Dr Mary Murphy
Dr Roisin Dwyer
Dr Dwyer provides expertise on iin vivo imaging, extracellualr vesicles, stem cell & tumor biology
Prof Michael O'Dwyer
Joint Research Projects and Joint Publications and Patents

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Dr Christopher Chiu Janssen Pharmaceuticals U.S.A.
Advisor on Industry funded collaboration with Janssen
Prof Karin Vanderkerken VUB BELGIUM
Collaborator role on MMRF Fellowship application
Dr Philip Dunne Queens University Belfast UNITED KINGDOM
Dr Dunne provides expertise on big data analysis, immunohistochemistry and bioinformatics for my research programme
Dr David Wink National Cancer Insititute, Frederick, MD, USA U.S.A.
Dr Wink provides expertise in metabolic and biochemical regulation of immune effector molecules in the tumour microenvironment e.g. Nitric Oxide and Arginnine