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Professor Anthony P. Moran (B.Sc., Ph.D., D.Sc., FRSC, MRIA)

Contact Information

Director, Laboratory of Molecular Biochemistry
School Of Natural Sciences
National University of Ireland, Galway, Ireland
Tel.: 353-91-493163
Fax: 353-91-494598
E-mail: anthony.morannuigalway.ie

Past appointments

• Professor of Microbial Glycobiology and Deputy Director, Institute for Glycomics, Griffith University, Australia (2007-2008)
• Vice-Dean of Research (Science), NUI, Galway (2002-2004)
• Senior Lecturer (1997-2005), College Lecturer (1992-1997), Dept. of Microbiology, NUI, Galway
• Research Scientist, National Public Health Institute, Helsinki, Finland (1990-1991)
• Research Scientist, Leibnitz Centre for Medicine and Bioscience, Borstel, Germany (1988-1990)
• Research Scientist, University of Helsinki, Finland (1985-1988;1990-1991)

Awards and Distinctions

• Scholarship awarded by University College, Dublin (1980).
• Finnish Ministry of Education Fellowship (1985-1986).
• Sigrid Jusélius Foundation Fellowship, Finland (1986-1988; 1990-1992).
• Alexander von Humboldt Foundation Fellowship, Germany (1988-1989; 1989-1990).
• EOLAS Young Investigator Award (1992).
• Society for General Microbiology, Lecture of the Year, Trinity College Dublin (1995).
• Visiting Professor, Faculty of Medicine, University of Bari, Italy (1996).
• Elected Fellow, Royal Academy of Medicine in Ireland (1996).
• Fellowship awarded by Alberta Heritage Foundation for Medical Research (1998).
• Queen Jadwiga Medal, Jagiellonian University, Cracow, Poland (1999).
• Fellowship awarded by Royal Physiographic Society, Sweden (2000).
• Elected Council Member, International Endotoxin Society (2002).
• Alexander von Humboldt Foundation Senior Fellowship, Germany (2003).
• Elected Member, Royal Irish Academy (2003)
• Invited attendee, 53rd Meeting of Nobel Prize Winners, Lindau, Germany (2003).
• Sir Allan Sewell Fellowship, Griffith University, Australia (2006).
• Visiting Professor, Griffith University, Australia (2007-2008).
• Fellow, Royal Society of Chemistry (2008).
• Honorary Member, Golden Key International Honour Society (2008).
• Adjunct Professor, Institute for Glycomics, Griffith University, Australia.

Memberships

• Institute for Food Science and Technology of Ireland (1982-1985);
• Society for General Microbiology (1983-  );
• American Society for Microbiology (1992-  );
• International Endotoxin and Innate Immunity Society (1992- );
• Royal Academy of Medicine in Ireland (1993-  ),
• Irish Society of Gastroenterology (1994-1997);
• New York Academy of Sciences (1999-2000);
• Biochemical Society (2000-  );
• Royal Irish Academy (2003-  );
• Irish Society of Immunology (2004-  );
• European Glycosciences Forum (2007-  );
• Royal Society of Chemistry (2008-..).

Research interests

• Microbial Glycobiology examining glycosylated structures and glycomolecules of microbial origin with relevance to their role in bacterial disease development and the immune response.
• Pathogenic mechanisms of enteric and gastric bacteria, particularly Campylobacter and Helicobacter spp.
• Endotoxin (lipopolysaccharide), polysaccharide and glycolipid research examining the relationship of serospecificity, toxicity, and biological and immunological activities to structure.
• Mechanisms of microbial immunity and exploitation for vaccine development and biotherapeutics
• Infection and immunization-induced autoimmunity, roles in neurological disease (e.g., Guillain-Barré and Multiple Sclerosis) and gastric disease (e.g., gastric atrophy) development.

Editorial boards and editorships

• Member of Editorial Board: Journal of Endotoxin Research (1993-2007); World Journal of Gastroenterology" (2004- ); Innate Immunity (2007- ); Open Immunology Journal (2007-); Open Immunology Reviews (2007- ); Open Immunology Letters (2007- ); International Journal of Carbohydrate Chemistry (2008- ).

• Editorial Contributor: Helicobacter (1996-1998).

• Guest Editor: FEMS Immunology and Medical Microbiology (1996); Irish Journal of Medical Science (1997); Modern Medicine of Ireland" (1997); Carbohydrate Polymers (2001); Reviews in Environmental Science and Biotechnology (2003).

Representative recent publications

From total of over 500 scientific communications including 173 papers in international peer-reviewed journals, 184 peer-reviewed abstracts and reports, 25 book chapters and 16 conference proceedings. In addition, 1 edited CD-ROM and 4 edited books.

• Moran, A.P. (Editor-in-Chief); Holst, O., Brennan, P.J., & von Itzstein, M. (Editors) 2009.                                                       Microbial Glycobiology – Structures, Relevance and Applications. Academic Press, San Diego, USA (1020 pp).
  

• Chaouche-Drider, N., Kaparakis, M., Karrar, A., Fernandez, M.I., Carneiro, L.A., Viala, J., Boneca, I.G., Moran, A.P., Philpott, D.J. & Ferrero, R.L. 2009. A commensal Helicobacter sp. of the rodent intestinal flora activates TLR2 and NOD1 responses in epithelial cells. PLoS ONE. 4: e5396.

• O’Keeffe, J., Gately, C.M., O'Donoghue, Y., Zulquernain, S.A., Stevens, F.M. & Moran, A.P. 2008. Natural killer-cell receptor-positive T-Lymphocytes in normal and Helicobacter pylori-infected human gastric mucosa. Helicobacter 13: 500-505.

• Nilsson, C., Skoglund, A., Moran, A.P., Annuk, A., Engstrand, L. & Normark, S. 2008. Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases. PLoS ONE 3: e3811.

• Moran, A.P. & Trent, M.S. 2008. Helicobacter pylori lipopolysaccharides and Lewis antigens. In: Yamaoka, Y. (ed.): Helicobacter pylori: Molecular Genetics and Cellular Biology, pp. 7-36. Caister Academic Press, Norfolk, U.K.

• Keenan, J.I., Davis, K.A., Beaugie, C.R., McGovern, J.J. & Moran, A.P. 2008. Alterations in Helicobacter pylori outer membrane and outer membrane vesicle-associated lipopolysaccharides under iron- limiting growth conditions. Innate Immunity 14: 279-290.

• O’Keeffe, J., Gately, C.M., Counihan, T., Hennessy, M., Leahy, T., Moran, A.P. & Hogan, E.L. 2008. T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to α-galactosylceramide are impaired. Journal of Neurological Sciences 275: 22-28.

• Gilbert, M., Parker, C. & Moran, A.P. 2008. Campylobacter lipooligosaccharide. In: Nachamkin, I., Szymanski, C.M. & Blaser, M.J. (eds.): Campylobacter, 3rd Edn., pp. 483-504. American Society for Microbiology, Washington, DC.

• Karlyshev, A.V., Wren, B.W. & Moran, A.P. 2008. Campylobacter capsular polysaccharide.  In: Nachamkin, I., Szymanski, C.M. & Blaser, M.J. (eds.):  Campylobacter, 3rd Edn., pp. 505-521. American Society for Microbiology, Washington, DC.

• Nachamkin, I., Shadomy, S.V., Moran, A.P., Cox, N., Fitzgerald, C., Ung, H., Corcoran, A.T., Iskander, J.K., Schonberger, L.B. & Chen, R.T. 2008. Anti-ganglioside antibodies and swine influenza vaccine (A/NJ/1976): a potential contributor to Guillain-Barré syndrome following the swine influenza campaign. Journal of Infectious Diseases 198: 226-233.

• Schmaußer, B., Endrich, S., Beier, D., Moran, A.P., Burek, C., Rosenwald, A., Rieckmann, P., Müller-Hermelink, H.-K. & Eck, M. 2008. Triggering receptor expressed on myeloid cells-1 (TREM-1) expression on gastric epithelium: implication for a role of TREM-1 in Helicobacter pylori infection. Clinical and Experimental Immunology 152: 88-94.

• Moran, A.P. 2008. Relevance of fucosylation and Lewis antigen expression in the bacterial gastroduodenal pathogen Helicobacter pylori. Carbohydrate Research 343:1952-1965.

• O’Keeffe, J. & Moran, A.P. 2008. Conventional, regulatory and unconventional T-cells in the immunological response to Helicobacter pylori. Helicobacter 13: 1-19.

• Snelling, W.J., Moran, A.P., Ryan, K.A., Scully, P., McGourty, K., Cooney, J.C., Annuk, H., O’Toole, P.W. 2007. HorB (HP0127) is a gastric epithelial cell adhesin. Helicobacter 12: 200-209.

• Moran, A.P. 2007. Lipopolysaccharide in bacterial chronic infection: Insights from Helicobacter pylori lipopolysaccharide and lipid A. International Journal of Medical Microbiology 297:307-319.

• Corcoran, A.T. & Moran, A.P. 2007. Influence of growth conditions on diverse polysaccharide production by Camplyobacter jejuni. FEMS Immunology and Medical Microbiology 49: 124-132.

• Kilcoyne, M., Moran, A.P., Shashkov, A.S., Senchenkova, S.N., Ferris, J.A., Corcoran, A.T. & Savage, A.V. 2006. Molecular origin of two polysaccharides of Campylobacter jejuni 81116. FEMS Microbiology Letters 263: 214-222.

• Grebowska, A., Rechcinski, T., Moran, A., Czkwianianc, E., Bak-Romaniszyn, L., Owczarek, A., Dziuba, M., Kowalewicz-Kubat, M., Druszczynska, M., Krzeminska-Pakula, M., Planeta-Malecka, I., Rudnicka, W. & Chmiela, M. 2006. Increased levels of immunoglobuline and non-immunoglobuline markers of host response to H. pylori LPS in the patients with coronary artery disesase (CAD). Current Trends in Immunology 7: 85-96.

• Odenbreit, S., Lindner, S., Gerbert-Vogl, B., Rieder, G., Moran, A.P. & Haas, A.P. 2006. Interleukin-6 induction by Helicobacter pylori in human macrophages is dependent on phagocytosis. Helicobacter 11: 196-207.

• O’Keeffe, J., Gately, C., Counihan, T., Henessey, M., Leahy, T., Ali, E., Moran, A.P. & Hogan, E.L. 2006. Flow cytometric analysis of natural killer receptor+ T cells in multiple sclerosis. In: Tabira, T., Yamamura, T. & Kira, J. (eds.). Proceedings of the 8th International Congress of Neuroimmunology, pp. 55-60. Medimond Srl, Monduzzi Editore, Bologna, Italy.

• Corcoran, A.T., Annuk, H. & Moran, A.P. 2006. The structure of the lipid anchor of Campylobacter jejuni polysaccharide. FEMS Microbiology Letters 257: 228-235.

• Nilsson, C., Skoglund, A., Moran, A.P., Annuk, A., Engstrand, L. & Normark, S. 2006. An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection. Proceedings of the National Academy of Sciences USA 103: 2863-2868.

• Grebowska, A., Rechcinski, T., Bak-Romaniszyn, L., Czkwianianc, E., Moran, A., Druszczynska, M., Kowalewicz-Kulbat, M., Owczarek, A., Dziuba, M., Krzeminska-Pakula, M., Planeta-Malecka, I., Rudnicka, W. & Chmiela, M. 2006. Potential role of LPS in the outcome of Helicobacter pylori related disease. Polish Journal of Microbiology 55: 25-30.

• Durkin, E., Moran, A.P. & Hanson, P.J. 2006. Apoptosis induction in gastric mucous cells in vitro: lesser potency of Helicobacter pylori than Escherichia coli lipopolysaccharide, but positive interaction with ibuprofen. Journal of Endotoxin Research 12: 47-56.

• Moran, A.P., Khamri, W., Walker, M.M. & Thursz, M.R. 2005. Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide. Journal of Endotoxin Research 11: 357-362.

• Khamri, W., Moran, A.P., Worku, M.L., Karim, Q.N., Walker, M.M., Annuk, H., Ferris, J.A., Appelmelk, B.J., Eggleton, P., Reid, K.B. & Thursz, M.R. 2005. Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D. Infection and Immunity 73: 7677-7686.

• Moran, A.P., Annuk, H. & Prendergast, M.M. 2005. Antibodies induced by ganglioside-mimicking Campylobacter jejuni lipooligosaccharides recognise epitopes at the nodes of Ranvier. Journal of Neuroimmunology 165: 179-185.

• De Libero, G., Moran, A.P., Gober, H.J., Rossy, E., Shamshiev, A., Chelnokova, O., Mazorra, Z., Vendetti, S., Sacchi, A., Prendergast, M.M., Sansano, S., Tonevitsky, A., Landmann, R. & Mori, L. 2005. Bacterial infections promote T cell recognition of self-glycolipids. Immunity 22: 763-772.

• Quintana, E., Ernandez, C., Moran, A.P., Esplungues, J.V. & Barrachina, M.D. 2005. Transcriptional up-regulation of nNOS in the dorsal vagal complex during low endotoxemia. Life Sciences 77: 1044-1054.

• Hynes, S.O., Keenan, J.I., Ferris, J.A., Annuk, H. & Moran, A.P. 2005. Lewis epitopes on outer membrane vesicles of relevance to Helicobacter pylori pathogenesis. Helicobacter 10: 146-156.

• Moran, A.P., Broaders, S.A., Rapa, A. & Oderda, G. 2005. In vivo expression of the 25-kDa laminin-binding protein of Helicobacter pylori. FEMS Immunology and Medical Microbiology 43: 331-337.

• Moran, A.P., Shiberu, B., Ferris, J.A., Knirel, Y.A., Senchenkova, S.N., Perepelov, A.V., Jansson, P.-E. & Goldberg, J.B. 2004. Role of Helicobacter pylori rfaJ genes (HP0159 and HP1416) in lipopolysaccharide synthesis. FEMS Microbiology Letters 241: 57-65.

• Viala, J., Chaput, C., Boneca, I.G., Cardona, A., Girardin, S.E., Moran, A.P., Athman, R., Mémet, S., Huerre, M.R., Coyle, A.J., DiStefano, P.S., Sansonetti, P.J., Labigne, A., Bertin, J., Philpott, D.J. & Ferrero, R.L. 2004. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nature Immunology 5: 1166-1174.

• Mandell, L., Moran, A.P., Cocchiarella, A., Houghton, J.M., Taylor, N., Fox, J.G., Wang, T.C. & Kurt-Jones, E.A. 2004. Intact Gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via Toll-like receptor 2 not Toll-like receptor 4. Infection and Immunity 72: 6446-6454.

• Nilsson, H.-O., Ouis, I.-S., Stenram, U., Ljungh, Å, Moran, A.P., Wadström, T. & abu Al-Soud, W. 2004. High prevalence of Helicobacter species detected in laboratory mouse strains by multiplex PCR-denaturing gradient gel electrophoresis and pyrosequencing. Journal of Clinical Microbiology 42: 3781-3788.

• Hynes, S.O., Ferris, J.A., Szponar, B., Wadström, T., Fox, J.G., O’Rourke, J., Larsson, L., Yaquian, E., Ljungh, Å., Clyne, M., Andersen, L.P. & Moran, A.P. 2004. Comparative chemical and biological characterization of the lipopolysaccharides of gastric and enterohepatic helicobacters. Helicobacter 9: 313-323.

• Kanipes, M.I., Holder, L.C., Corcoran, A.T., Moran, A.P. & Guerry, P. 2004. A deep-rough mutant of Campylobacter jejuni 81-176 is non-invasive for intestinal epithelial cells. Infection and Immunity 72: 2452-2455.

• Brzozowski, T., Konturek, P.C., Moran, A.P., Pajdo, R., Kwiecien, S., Konturek, S.J., Sliwowski, Z., Drozdowicz, D., Pawlik, W. & Hahn, E.G. 2004. Involvement of capsaicin-sensitive afferent nerves and cholecystokininin 2/gastrin receptor in gastroprotection and adaptation of gastric mucosa to Helicobacter pylori-lipopolysaccharide. Journal of Pharmacology and Experimental Therapeutics 310: 116-125.

• Tanabe, T., Chamaillard, M., Ogura, Y., Zhu, L., Qiu, S., Masumoto, J., Ghosh, P., Moran, A., Prendergast, M.M., Tromp, G., Williams, C.J., Inohara, N & Nunez, G. 2004. Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO Journal 23:1587-1597.

• Prendergast, M.M., Tribble, D.R., Baqar, S., Scott, D.S., Ferris, J.A., Walker, R.I. & Moran, A.P. 2004. In vivo phase variation and serological response to lipooligosaccharide of Campylobacter jejuni in experimental human infection. Infection and Immunity 72: 916-922.

• Gobert, A.P., Bambou, J.-C., Werts, C., Balloy, V., Chignard, M., Moran, A.P. & Ferrero, R.L. 2004. Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a Toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism. Journal of Biological Chemistry 279: 245-250.

 

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