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DR. THOMAS BARRY – COLLEGE LECTURER

thomas.barrynuigalway.ie

Phone: +353 91 49 3189

Coordinator of 3rd Year Microbiology Undenominated Degree Course

RESEARCH INTERESTS:

Dr. Barry is a research director and a founder member of the Molecular Diagnostics Research Group (MDRG) at NUI,G. This research group consists of 2 senior research postdoctoral scientists, 8 postdoctoral scientists, 4 research assistants and 4 PhD students. Research interests are primarily focused on the research, development and commercialisation of platform nucleic acid based diagnostics technologies for the detection and identification of microbial agents. Dr. Barry is the inventor of the microbial platform nucleic acid based diagnostics, Internal Transcribed Spacer-Probe, RiboSEQ, MycoTECH, MycoSEQ and RiboTECH technologies.
These technologies, over the past 5 years, have generated approximately €10 million in funding and revenue through industry driven commercial product research and development and through intellectual property licensing agreements. While agency research funding of approximately €2.5 million has also been generated over the past five years.

2011 PUBLICATIONS:

Reddington K, O'Grady J, Dorai-Raj S, Niemann S, van Soolingen D, et al. (2011) A Novel Multiplex Real-Time PCR for the Identification of Mycobacteria Associated with Zoonotic Tuberculosis. PLoS ONE 6(8): e23481.doi:10.1371/journal.pone.0023481

Reddington, K., O’Grady, J., Dorai-Raj, S., Maher, M., van Soolingen, D. and Barry, T. A novel multiplex real-time PCR diagnostics assay for the identification and differentiation of Mycobacterium tuberculosis, Mycobacterium canettii and the Mycobacterium tuberculosis complex.  Journal of Clinical Microbiology. (2011), 49 (2): 651-657.

McGuinness, S., Barry, T. & O’Grady, J. Development and preliminary validation of a rapid real-time RT-PCR based method targeting tmRNA for the specific detection of Salmonella. Food Research International (2011 ). - In Press

Scheler, O., Kaplinski, L., Glynn, B., Palta, P., Parkel, S., Toome, K., Maher, M., Barry, T., Remm, M. and Kurg, A. Detection of NASBA amplified bacterial tmRNA molecules on SLICSel designed microarray probes. BMC Biotechnology (2011), 11:17doi:10.1186/1472-6750-11-17

Spain, E., Kojima, R., Kaner, R.B., Wallace, G.G., O’Grady, J., Lacey, K., Barry, T., Keyes, T.E. and  Forster, R.J.,.  High Sensitivity DNA Detection Using Gold Nanoparticle Functionalized Polyaniline Nanofibres, Biosensors and Bioelectronics (2011), doi:10.1016/j.bios.2010.11.017

McCabe, E. M., Burgess, C., D., O'Regan, E., McGuinness, S., Barry, T., Fanning, S. & Duffy, G.  Development and evaluation of DNA and RNA real-time assays for food analysis using the hilA gene of Salmonella enterica subspecies enterica. Food Microbiology (2011), 28(3):447-56.

McCabe, E. M., Burgess, C. M., Walsh, D., O'Regan, E., McGuinness, S., Barry, T., Fanning, S. & Duffy, G. Validation of DNA and RNA real-time assays for food analysis using the hilA gene of Salmonella enterica serovars. Journal of Microbiological Methods (2011), 84, 19-26.

RECENT RESEARCH FUNDING AWARDS:

External Commercial Funding

Development of a suite of assays for bacterial and fungal detection utilizing some of  the listed technologies above (2008-2012, €7.5 million) – Beckman Coulter – Technical Director / Steering Committee

Public Funding

EI Innovation Partnership –  (2010 – 2012, €350K) - PI

BDI SFI CSET: Development of rapid molecular diagnostics assays for pathogenic bacteria using RiboSEQ technology (2010-2015, €1.1m) - PI

INTELLECTUAL PROPERTY:

Dr. Barry is the named inventor of thirteen filed patents in the area of molecular based diagnostics for the detection of pathogens associated with infectious disease. Dr. Barry’s technologies are embedded in commercial products currently available in the marketplace. Companies that have licensed Dr. Barry’s technologies include Roche and Beckman Coulter.

LINKS:

http://ncbes.nuigalway.ie/molecular-diagnostics.aspx

CURRENT RESEARCH TEAM:

Dr. Thomas Barry (Ext. 3189) - Lecturer / Principal Investigator
Professor Terry Smith – Director
Dr. Louise O’Connor – Program Manager (Dangan Ext 2082)
Dr. Barry Glynn – Program Manager (Microbiology Ext 2079)
Dr. Nina Tuite - Post Doc   (Dangan)
Dr. Seamus Coyne - Post Doc (Dangan)
Dr. Marcin Jankiewicz - Post Doc   (Dangan)
Dr. Katrina Lacey – Post Doc (Dangan)
Dr. Martina Wernecke – Post Doc (Dangan)
Sinead Lahiffe – Research Scientist (Dangan)
Ciara Mullen - Research Assistant (Dangan)
Claire Brennan – Research Assistant (Dangan)
Dr. Eoin Clancy – Post Doc - Microbiology
Dr. Noretta Clifford  - Post Doc - Microbiology
Dr. Evelyn Keady – Post Doc - Microbiology
Kate Reddington (3rd yr pg)  - Microbiology
Elizabeth Minogue (2nd yr pg) - Microbiology
Helena Kelly (2nd yr pg) – Microbiology
Helena Coughlan (1st yr pg) - Microbiology





 

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