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Dr Thomas Barry

College Lecturer

thomas.barrynuigalway.ie

Phone: +353 91 49 3189

Coordinator of 3rd Year Microbiology Undenominated Degree Course

RESEARCH INTERESTS

Dr Barry has over 20 years research experience in the discovery of microbial biomarkers and the development of these biomarkers for use in nucleic acid diagnostics technologies. Dr Barry is the research director of the Nucleic Acid Diagnostics Research Laboratory (NADRL), in Microbiology at NUIG. The research group consists of the director, 1 senior research postdoctoral scientist, 2 postdoctoral scientists, 1 research assistant, 3 PhD students and 2 MSc students. Research interests are primarily focused on the biodiscovery, development and commercialisation of platform nucleic acid based diagnostics technologies for the detection and identification of microbial pathogens and contaminants.
Dr Barry is the inventor of the microbial platform nucleic acid based diagnostics, Internal Transcribed Spacer-Probe, RiboSEQ, MycoTECH, MycoSEQ, MtSEQ and RiboTECH technologies. These technologies, over the past 5 years, have generated approximately €7.3 million in funding and revenue through industry driven commercial product research and development and through intellectual property licensing agreements. Associated technologies are embedded in international multinational and SME companies (1 Irish) and with NAD products in the marketplace or products due to be released shortly into the marketplace. Public agency research funding of approximately €1.7 million has also been generated over the past five years.

PUBLICATIONS (2011/2013)

Minogue, E., Reddington, K., Dorai-Raj, S., Tuite, N., Clancy, E., and Barry T. (2013) Diagnostics method for the rapid quantitative detection and identification of low level contamination of high purity water with pathogenic bacteria. Journal of Industrial Microbiology & Biotechnology (In Press).

Kate Reddington, Nina Tuite, Thomas Barry, Justin O’Grady and Alimuddin Zumla. (2013) Advances in multiparametric molecular diagnostics technologies for respiratory tract infections. Current opinion in pulmonary medicine, 19(3):298-304.

J. Gaughran, N. Dimov, E. Clancy T. Barry, T. J. Smith, J.  Ducrée. (2013) Multi-stage, solvent-controlled routing for automated on-disc extraction of total RNA from breast cancer cell homogenate. The 17th Annual IEEE International Conference on Solid-State Sensors, Actuators and Microsystems. (In Press).

Gomez, Diego, McGuinness, Sheila, Reddington, Kate, O'Grady, Justin, Yanguela, Javier and Barry, Thomas (2013) Evaluation of a Novel Listeria Enrichment Broth Combined with a Real-Time PCR Diagnostics Assay for the Specific Detection of Listeria monocytogenes in RTE Pork Products. International Journal Of Food Science And Technology, 48(5):1103-1108.

N. Dimov, J. Gaughran, E. Clancy T. Barry, T. J. Smith, J.  Ducrée. (2013) Automated on-disc total RNA extraction from whole blood towards point-of-care for early-stage diagnostics. The 17th Annual IEEE International Conference on Solid-State Sensors, Actuators and Microsystems (In Press).

McGuinness S, Barry T & O'Grady J (2012) Development and preliminary validation of a real-time RT-PCR based method targeting tmRNA for the rapid and specific detection of Salmonella. Food Research International, 45 :989-992.

Minogue, E, Barry, T, Carroll, C, Smith, P. (2012) Setting epidemiological cut-off values for Aeromonas salmonicida disc diffusion data capable of discriminating between strains on the basis of their possession of sul1 genes. Aquaculture, 364 :329-332.

Kate Reddington, Alimuddin Zumla, Matthew Bates, Dick van Soolingen, Stefan Niemann, Thomas Barry and Justin O’Grady (2012). SeekTB- A two stage multiplex real-time PCR based method for the differentiation of the Mycobacterium tuberculosis complex. Journal Of Clinical Microbiology, 50 (7):2203-2206.

Nam, CHL,Gubala, V,Clancy, E,Barry, T,Smith, TJ,Williams, DE (2012).Ultrathin and smooth poly(methyl methacrylate) (PMMA) films for label-free biomolecule detection with total internal reflection ellipsometry (TIRE). Biosensors & Bioelectronics, 36:250-256.

Clancy, E., Glynn, B., Reddington, K., Smith, T. and Barry, T. Culture confirmation of Listeria monocytogenes using tmRNA as a diagnostics target (2012).  J. Microbiol. Methods, 88 :427-429.

Ott Schelera, Jared T. Kindt, Abraham J. Qavi, Lauris Kaplinski, Barry Glynn, Thomas Barry, Ants Kurg & Ryan C Bailey (2012). Label-free, multiplexed detection of bacterial tmRNA using silicon photonic microring resonators. Biosensors & Bioelectronics, 36 (1):56-61.

Reddington K, O'Grady J, Dorai-Raj S, Niemann S, van Soolingen D. and Barry, T. (2011). A Novel Multiplex Real-Time PCR for the Identification of Mycobacteria Associated with Zoonotic Tuberculosis. PLoS ONE 6(8): e23481.doi:10.1371/journal.pone.0023481

Reddington, K., O’Grady, J., Dorai-Raj, S., Maher, M., van Soolingen, D. and Barry, T. (2011). Novel multiplex real-time PCR diagnostics assay for the identification and differentiation of Mycobacterium tuberculosis, Mycobacterium canettii and the Mycobacterium tuberculosis complex. Journal of Clinical Microbiology. 49 (2): 651-657.

 Scheler, O., Kaplinski, L., Glynn, B., Palta, P., Parkel, S., Toome, K., Maher, M., Barry, T., Remm, M. and Kurg, A. (2011). Detection of NASBA amplified bacterial tmRNA molecules on SLICSel designed microarray probes. BMC Biotechnology. 11:17doi:10.1186/1472-6750-11-17

Spain, E., Kojima, R., Kaner, R.B., Wallace, G.G., O’Grady, J., Lacey, K., Barry, T., Keyes, T.E. and  Forster, R.J. (2011). High Sensitivity DNA Detection Using Gold Nanoparticle Functionalized Polyaniline Nanofibres, Biosensors & Bioelectronics.
doi:10.1016/j.bios.2010.11.017



McCabe, E. M., Burgess, C., D., O'Regan, E., McGuinness, S., Barry, T., Fanning, S. & Duffy, G. (2011).  Development and evaluation of DNA and RNA real-time assays for food analysis using the hilA gene of Salmonella enterica subspecies enterica. Food Microbiology. 28(3):447-56. 



McCabe, E. M., Burgess, C. M., Walsh, D., O'Regan, E., McGuinness, S., Barry, T., Fanning, S. & Duffy, G. (2011). Validation of DNA and RNA real-time assays for food analysis using the hilA gene of Salmonella enterica serovars. Journal of Microbiological Methods. 84, 19-26.

RECENT RESEARCH FUNDING AWARDS:

External Commercial Funding

Development of a suite of assays for bacterial and fungal detection utilizing some of  the listed technologies above (2008-2012, €7.3 million) – Beckman Coulter – Technical Director / Steering Committee

Public Funding

EU FP7 – RiD RTI - Total Grant: €5,997,737.00 - EU contribution to NUIG :  €824,068.00 – 2012-2015.
Theme: FP7-HEALTH-2012-INNOVATION-2 



EI Innovation Partnership – (2010 – 2012, €350K) - PI 


2013 RESEARCH TEAM:

Dr. Thomas Barry (Ext. 3189) - Lecturer / Director of the NADRL

Dr. Nina Tuite –Senior Post Doc and Laboratory manager   
 

Dr. Eoin Clancy – Post Doc 

Dr. Kate Reddington- Post Doc 
 

Dr. Martina Burke – Post Doc 

Claire Brennan – Research Assistant
Elizabeth Minogue - post grad 

Helena Kelly - post grad

Helena Coughlan - post grad
Eoin Higgins - MSc Biotech student
Joanna Turlej - MSc Biomedical Student
6 X 4th year undergraduate students - Microbiology 






 

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