Research Interests

Parasite evolution Drug resistance Pathogen adaptation Human diversity Population structure Selective processes Microbial virulence Host susceptibility Species hybridisation Population genomics Genotype inference

 

     

Peer Reviewed Journals

Downing T, et al. (2013) '¬Genomic confirmation of hybridisation and recent inbreeding in a vector-isolated Leishmania population'. Plos Pathogens, . [Details]

Vanaerschot M, Decuypere S, Downing T, et al. (2012) 'Genetic markers for SSG-resistance in Leishmania donovani and SSG-treatment failure of visceral leishmaniasis patients in the Indian subcontinent'. Journal Of Infectious Diseases, . [Details]

Mannaert A, Downing T, et al. (2012) 'Novel adaptive mechanisms in pathogens: universal aneuploidy in Leishmania'. Trends in parasitology, . [Details]

Downing T, et al. (2012) 'Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex'. Infection Genetics And Evolution, 12 :149-159. [Details]

Downing T (2012) 'The battle of the SNPs'. Nature Reviews Immunology, 10 (1). [Details]

Downing T, et al. (2011) 'Whole genome sequencing of multiple Leishmania donovani cWhole genome sequencing of multiple Leishmania donovani cllinical isolates provides insights into population structure and mechanisms of drug resistance'. Genome Research, 21 (12):2143-2156. [Details]

Downing T, et al. (2010) 'The differential evolutionary dynamics of avian cytokine and toll-like receptor gene classes'. J Immunol, 184 (12):6993-7000. [Details]

Downing T, et al. (2010) 'Variation in chicken populations may affect the enzymatic activity of lysozyme'. Animal Genetics, 41 (2):213-217. [Details]

Downing T, et al. (2009) 'Evidence of the adaptive evolution of immune genes in chicken'. BMC Research Notes, 2 . [Details]

Downing T, et al. (2009) 'Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus'. BMC Evolutionary Biology, 9 (1). [Details]

Downing T, et al. (2009) 'Contrasting evolution of diversity at two disease-associated chicken genes'. Immunogenetics, 61 (4):303-314. [Details]

Cormican P, Lloyd AT, Downing T, et al. (2009) 'The avian toll-like-receptor pathway - subtle differences amidst general conformity'. Developmental And Comparative Immunology, 33 (9):967-973. [Details]

                                                                                                                                     

             

Employment

Employer: Wellcome Trust Sanger Institute Position: Postdoctoral fellow

Education

Year 2004 Institution: Trinity College Dublin Qualification: BACHELOR OF SCIENCE Subject: Human genetics

Year 2005 Institution: Dublin Ciy University Qualification: Msc Subject: Bioinformatics

Year 2009 Institution: Trinity College Dublin Qualification: Phd Subject: Population genetics

         

Teaching Interests

Bioinformatics Genomics Pathogen evolution Population genetics Adaptation

Recent Postgraduates

Helping Olivia Stark (10/10-present; Charite University in Berlin)

 

Modules Taught

2012       Introduction to bioinformatics for biologists: Introduction to programming for biologists

2013       Mathematical population genomics: Mathematical molecular biology II

2013       Introduction to bioinformatics: Introduction to bioinformatics

Internal Collaborators

Prof. Cathal Seoighe

External Collaborators

Dr. Matt Berriman, Wellcome Trust Sanger Institute Dr. James Cotton, Wellcome Trust Sanger Institute Dr. Hideo Imamura, Institute of Tropical Medicine, Antwerp Prof. Jean-Claude Dujardin, Institute of Tropical Medicine, Antwerp Dr. Manu Vanaerschot, Institute of Tropical Medicine, Antwerp Dr. An Mannaert, Institute of Tropical Medicine, Antwerp Dr. Chris Illingworth, Wellcome Trust Sanger Institute Prof. Graham Coombs, Strathclyde University Dr. Katherine Carter, Strathclyde University Dr. Emily Adams, Institute of Tropical Medicine, Amsterdam Dr. Audrey Albertini, FIND diagnostics