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Medicine

Grace Callagy

Professor PhD, MB, MRCPI, FRCPath, FFPath, BS.c

Contact Details

Professor
Discipline of Pathology
NUI Galway
Clinical Science Institute
Costello Road, Galway

T: 87-4488
E: grace.callagy@nuigalway.ie
 
researcher

Biography

Grace Callagy is a Professor of Pathology at NUI Galway and Consultant pathologist at Galway University Hospitals. She obtained her MB from NUI Galway. She did her professional training in general medicine in the Mater Misericordiae hospital, Dublin and then commenced in pathology on the North Dublin Hospitals Rotation and at Addenbrooke’s Hospital in Cambridge, UK.  Professor Callagy received her PhD degree from the University of Cambridge in 2004 where she worked in Professor Carlos Caldas’ laboratory on the molecular profiling of breast cancer. In 2004, she returned to Galway. Practicing as a consultant Histopathologist, her special interest is breast cancer. The research of her group is focused on studying molecular events involved in breast cancer progression and the identification and validation of biomarkers as targets for diagnosis, prognostication and prediction of response to treatment of breast cancer. 

Professor Callagy is a member of the European Working Group of Breast Screening Pathology and a member of the United Kingdom National Co-Ordinating Committee for Breast Pathology and a member of the Molecular Pathology Sub-committee of the Faculty of Pathology, RCPI. She has served on the Scientific Advisory Board of the Breast cancer Campaign (2011 – 2014); on the Pathological Pathological Society of Great Britain and Ireland committee, (January 2008 – 2010); and was a Committee member of the Irish Association for Cancer Research (March 2009 – March 2013).  

Research Interests

My research interest is breast cancer.  Invasive breast cancer is known to be a heterogeneous group of cancers comprising at least six different subtypes. Our work focuses on identifying the molecular events involved in breast cancer progression and the identification and validation of biomarkers as targets for diagnosis, prognostication and prediction of response to treatment for different subgroups of breast cancer.  To this end, we evaluate biomarkers in fixed tissue samples using tissue microarrays that have been made from breast cancers managed at University Hospital Galway. We are currently focusing on the refinement of diagnosis of subsets of triple negative breast cancers.

Accurate diagnosis and classification of breast cancer is essential in order to determine the most appropriate treatment for patients.  In collaboration with members of the European Working Group of Breast Screening Pathology, I have been involved in several international multi-institutional clinical pathology studies concentrating on inter-observer agreement in the quantification of the proliferation markers; the diagnosis of micro-invasive cancer; the assessment of predictors of response to neo-adjuvant chemotherapy and the evaluation of micro-metastatic disease in sentinel lymph nodes.  

Research Projects

  Project Start Date End Date
EXPRESSION OF DICER IN BREAST CANCER AND ITS ASSOCIATION WITH MOLECULAR SUBTYPES, BIOMARKER EXPRESSION AND PATIENT OUTCOMES 01-DEC-11 01-DEC-12
CHARACTERISATION OF EXPRESSION OF MICRORNAS MIR - 125B MIR 148 AND MIR720 IN HER 2 EXPRESSING BREAST CANCER GRACE CALLAGY 13-JAN-11 06-APR-12
BREAST CANCER CAMPAIGN REGULATION OF NCOA3 EXPRESSION DURING UPR AND ITS ROLE IN RESISTANCE TO ENDOCRINE THERAPY OF BREAST CANCER GRACE CALLAGY 01-FEB-12 30-SEP-15

Peer Reviewed Journals

  Year Publication
(2015) 'Updated UK Recommendations for HER2 assessment in breast cancer'
Rakha EA, Pinder SE, Bartlett JM, Ibrahim M, Starczynski J, Carder PJ, Provenzano E, Hanby A, Hales S, Lee AH, Ellis IO; National Coordinating Committee for Breast Pathology (2015) 'Updated UK Recommendations for HER2 assessment in breast cancer'. Journal Of Clinical Pathology, 68(2):93-9 (10.1136) [Details]
(2014) 'Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study'
Balmativola, D,Marchio, C,Maule, M,Chiusa, L,Annaratone, L,Maletta, F,Montemurro, F,Kulka, J,Figueiredo, P,Varga, Z,Liepniece-Karele, I,Cserni, G,Arkoumani, E,Amendoeira, I,Callagy, G,Reiner-Concin, A,Cordoba, A,Bianchi, S,Decker, T,Glaser, D,Focke, C,van Diest, P,Grabau, D,Lips, E,Wesseling, J,Arisio, R,Medico, E,Wells, C,Sapino, A (2014) 'Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study'. Breast Cancer Research And Treatment, 148 :511-523 [DOI] [Details]
(2014) 'Distribution pattern of the Ki67 labelling index in breast cancer and its implications for choosing cut-off values'
Cserni G, Vörös A, Liepniece-Karele I, Bianchi S, Vezzosi V, Grabau D, Sapino A, Castellano I, Regitnig P, Foschini MP, Zolota V, Varga Z, Figueiredo P, Decker T, Focke C, Kulka J, Kaya H, Reiner-Concin A, Amendoeira I, Callagy G, Caffrey E, Wesseling J, Wells C (2014) 'Distribution pattern of the Ki67 labelling index in breast cancer and its implications for choosing cut-off values'. Breast, 23 (2):259-263 [Details]
(2013) 'Prognostic Significance of Deregulated Dicer Expression in Breast Cancer'
Caffrey, E,Ingoldsby, H,Wall, D,Webber, M,Dinneen, K,Murillo, LS,Inderhaug, C,Newell, J,Gupta, S,Callagy, G (2013) 'Prognostic Significance of Deregulated Dicer Expression in Breast Cancer'. Plos One, 8 [DOI] [Details]
(2013) 'Prediction of Oncotype DX and TAILORx risk categories using histopathological and immunohistochemical markers by classification and regression tree (CART) analysis'
Ingoldsby, H,Webber, M,Wall, D,Scarrott, C,Newell, J,Callagy, G (2013) 'Prediction of Oncotype DX and TAILORx risk categories using histopathological and immunohistochemical markers by classification and regression tree (CART) analysis'. Breast, 22 :879-886 [DOI] [Details]
(2012) 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'
Gupta, A,Caffrey, E,Callagy, G,Gupta, S (2012) 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'. Biochemical Society Transactions, 40 :752-758 [DOI] [Details]
(2011) 'TOP2A Amplification in the Absence of That of HER-2/neu: Toward Individualization of Chemotherapeutic Practice in Breast Cancer'
Glynn, RW,Mahon, S,Curran, C,Callagy, G,Miller, N,Kerin, MJ (2011) 'TOP2A Amplification in the Absence of That of HER-2/neu: Toward Individualization of Chemotherapeutic Practice in Breast Cancer'. Oncologist, 16 (7):949-955 [DOI] [Details]
(2010) 'Malignant phyllodes tumour with liposarcomatous differentiation, invasive tubular carcinoma, and ductal and lobular carcinoma in situ: case report and review of the literature'
Abdul Aziz M, Sullivan F, Kerin MJ, Callagy G. (2010) 'Malignant phyllodes tumour with liposarcomatous differentiation, invasive tubular carcinoma, and ductal and lobular carcinoma in situ: case report and review of the literature'. Pathology international, [Details]
(2010) 'Alcohol and unnatural deaths in the West of Ireland: a 5-year review'
van Deurzen CH, Cserni G, Bianchi S, Vezzosi V, Arisio R, Wesseling J, Asslaber M, Foschini MP, Sapino A, Castellano I, Callagy G, Faverly D, Martin-Martinez MD, Quinn C, Amendoeira I, Kulka J, Reiner-Concin A, Cordoba A, Seldenrijk CA, van Diest PJ. (2010) 'Alcohol and unnatural deaths in the West of Ireland: a 5-year review'. J Clin Pathol, 63 (10):900-903 [DOI] [Details]
(2010) 'Nodal-Stage Classification in Invasive Lobular Breast Carcinoma: Influence of Different Interpretations of the pTNM Classification'
van Deurzen, CHM,Cserni, G,Bianchi, S,Vezzosi, V,Arisio, R,Wesseling, J,Asslaber, M,Foschini, MP,Sapino, A,Castellano, I,Callagy, G,Faverly, D,Martin-Martinez, MD,Quinn, C,Amendoeira, I,Kulka, J,Reiner-Concin, A,Cordoba, A,Seldenrijk, CA,van Diest, PJ (2010) 'Nodal-Stage Classification in Invasive Lobular Breast Carcinoma: Influence of Different Interpretations of the pTNM Classification'. Journal Of Clinical Oncology, 28 :999-1004 [DOI] [Details]
(2010) 'BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received'
Dawson, SJ,Makretsov, N,Blows, FM,Driver, KE,Provenzano, E,Le Quesne, J,Baglietto, L,Severi, G,Giles, GG,McLean, C,Callagy, G,Green, AR,Ellis, I,Gelmon, K,Turashvili, G,Leung, S,Aparicio, S,Huntsman, D,Caldas, C,Pharoah, P (2010) 'BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received'. British Journal Of Cancer, 103 :668-675 [DOI] [Details]
(2009) 'Breast carcinoma: molecular markers and subtypes to predict patients at risk of developing metastatic disease'
Inderhaug, C. R.,Murillo, L. S.,Webber, M. J.,Callagy, G. M. (2009) 'Breast carcinoma: molecular markers and subtypes to predict patients at risk of developing metastatic disease'. Breast Cancer Research, 11 [Details]
(2009) 'Evolution of breast cancer management in Ireland: a decade of change'
Heneghan, HM,Prichard, RS,Devaney, A,Sweeney, KJ,Malone, C,McLaughlin, R,Kerin, MJ (2009) 'Evolution of breast cancer management in Ireland: a decade of change'. BMC Surgery, 9 [DOI] [Details]
(2009) 'Intracystic papillary carcinoma of the male breast: a case report and review of the literature'
Sullivan PJ, Sweeney KJ, Hirpara KM, Malone CB, Curtin W, Kerin MJ (2009) 'Intracystic papillary carcinoma of the male breast: a case report and review of the literature'. Ir J Med Sci, [Details]
(2009) 'A rare case of arterial thrombosis in a 37-year-old male with Factor V Leiden mutation'
O'Gorman, S.,Osman, R.,Smith, M.,Callagy, G.,Regan, M.,Kerin, M. (2009) 'A rare case of arterial thrombosis in a 37-year-old male with Factor V Leiden mutation'. Ir J Med Sci, 178 (33):363-366 [Details]
(2008) 'Variations in sentinel node isolated tumour cells/micrometastasis and non-sentinel node involvement rates according to different interpretations of the TNM definitions'
Cserni, G,Bianchi, S,Vezzosi, V,van Diest, P,van Deurzen, C,Sejben, I,Regitnig, P,Asslaber, M,Foschini, MP,Sapino, A,Castellano, I,Callagy, G,Arkoumani, E,Kulka, J,Wells, CA (2008) 'Variations in sentinel node isolated tumour cells/micrometastasis and non-sentinel node involvement rates according to different interpretations of the TNM definitions'. European Journal Of Cancer, 44 :2185-2191 [DOI] [Details]
(2008) 'Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer'
Callagy, GM,Webber, MJ,Pharoah, PDP,Caldas, C (2008) 'Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer'. BMC Cancer, 8 [DOI] [Details]
(2008) 'Multiple source surveillance incidence and aetiology of out-of-hospital sudden cardiac death in a rural population in the West of Ireland'
Byrne, R,Constant, O,Smyth, Y,Callagy, G,Nash, P,Daly, K,Crowley, J (2008) 'Multiple source surveillance incidence and aetiology of out-of-hospital sudden cardiac death in a rural population in the West of Ireland'. European Heart Journal, 29 :1418-1423 [DOI] [Details]
(2006) 'Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index'
Callagy, GM,Pharoah, PD,Pinder, SE,Hsu, FD,Nielsen, TO,Ragaz, J,Ellis, IO,Huntsman, D,Caldas, C (2006) 'Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index'. Clinical Cancer Research, 12 :2468-2475 [DOI] [Details]
(2005) 'Comparative genomic hybridization using DNA from laser capture microdissected tissue'
Callagy G, Jackson L, Caldas C (2005) 'Comparative genomic hybridization using DNA from laser capture microdissected tissue'. Methods Mol Biol, 293:39-55 [Details]
(2005) 'Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays'
Callagy G, Pharoah P, Chin SF, Sangan T, Daigo Y, Jackson L, Caldas C. (2005) 'Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays'. Journal Of Pathology, 205(3):388-96 [Details]
(2004) 'Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer'
Gonzalez MA, Pinder SE, Callagy G, Vowler SL, Morris LS, Bird K, Bell JA, Laskey RA, Coleman N (2004) 'Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer'. J Clin Oncol, 1;21(23):4306-13 [Details]
(2004) 'Geminin predicts adverse clinical outcome in breast cancer by reflecting cell-cycle progression'
23.Gonzalez MA, Tachibana KE, Chin SF, Callagy G, Madine MA, Vowler SL, Pinder SE, Laskey RA, Coleman N (2004) 'Geminin predicts adverse clinical outcome in breast cancer by reflecting cell-cycle progression'. J Pathol, [Details]
(2003) 'A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumour samples'
Chin SF, Daigo Y, Iyer NG, Callagy G, Kranjac T, Gonzalez M, Sangan T, Earl H, Caldas C (2003) 'A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumour samples'. Exp Mol Pathol, 56(5):275-9 [Details]
(2003) 'Molecular profiling of breast cancer using tumour tissue microarrays'
Callagy G, Cattaneo E, Daigo Y, Happerfield L, Bobrow L, Pharoah P, Caldas C. (2003) 'Molecular profiling of breast cancer using tumour tissue microarrays'. Exp Mol Pathol, 12(1):27-34 [Details]
(2000) 'Benign Glandular Peripheral Nerve Sheath Tumour: a case report'
Callagy G, Thornton P, Rawluck D, Farrell MA (2000) 'Benign Glandular Peripheral Nerve Sheath Tumour: a case report'. Clinical Neuropathology, 19(2):104-7 [Details]
(2000) 'Adult neuronal ceroid lipofuscinosis (Kufs’ disease) in two siblings of an Irish family'
Callagy G, O’Neill GM, Staunton H, Farrell MA (2000) 'Adult neuronal ceroid lipofuscinosis (Kufs’ disease) in two siblings of an Irish family'. Clinical Neuropathology, 19(3):109-18 [Details]
(2000) 'Expression of CD44 in uterine cervical squamous neoplasia: a predictor of microinvasion?'
Callagy G, O’Grady A, Butler D, Leader M, Kay E (2000) 'Expression of CD44 in uterine cervical squamous neoplasia: a predictor of microinvasion?'. Gynecologic Oncology, 76(1):73- 9 [Details]
(2000) 'Immunohistochemical measurement of tumor vascular endothelial growth factor in breast cancer: a more reliable predictor of tumor stage than microvessel density or serum vascular endothelial growth factor'
Callagy G, Dimitriadis E, Harmey J, Bouchier-Hayes D, Leader M, Kay E. (2000) 'Immunohistochemical measurement of tumor vascular endothelial growth factor in breast cancer: a more reliable predictor of tumor stage than microvessel density or serum vascular endothelial growth factor'. Applied Immunohistochemistry, 8(2)104-9 [Details]
(1999) 'Clinical course of hepatitis C in a unique cohort of female patient’s 17 years post inoculation'
Kenny-Walsh E. Irish Hepatology Research Group (co-author). (1999) 'Clinical course of hepatitis C in a unique cohort of female patient’s 17 years post inoculation'. N Engl J Med Author Reply 2705, 340(16):1228-33 [Details]
(1999) 'Hepatocellular carcinoma arising in the absence of cirrhosis in genetic haemochromatosis'
Goh J, Callagy G, McEntee G, Bromford J, O’ Keane JC, Crowe J. (1999) 'Hepatocellular carcinoma arising in the absence of cirrhosis in genetic haemochromatosis'. European Journal Of Gastroenterology & Hepatology, 11(8) 915-9 [Details]
(1998) 'Changes in liver histopathology in women infected with hepatitis C through contaminated Anti-D immunoglobulin injections in Ireland'
Albloushi S, Murray F, Callagy G et al (1998) 'Changes in liver histopathology in women infected with hepatitis C through contaminated Anti-D immunoglobulin injections in Ireland'. European Journal Of Gastroenterology & Hepatology, 10(1):69-73 [Details]
(1997) 'Primary hepatic lymphoma in a man with chronic hepatitis C'
Clarke G, MacMathuna P, Fenlon H, Callagy G, O’Keane JC, Carney D, Crowe J. (1997) 'Primary hepatic lymphoma in a man with chronic hepatitis C'. European Journal Of Gastroenterology & Hepatology, 9:87-90 [Details]
(1996) 'weever fish sting – an unusual cause of foot pain'
Mulcahy DM, Devitt A, Shannon F, Reidy D, Callagy G, Walsh M. (1996) 'weever fish sting – an unusual cause of foot pain'. Ir J Med Sci, 165(3):153-4 [Details]

Book Chapters

  Year Publication
(2012) 'European Guidelines for Quality assurance (QA), in breast cancer screening and diagnosis'
Wells CA et. al (2012) 'European Guidelines for Quality assurance (QA), in breast cancer screening and diagnosis' In: Quality Assurance Guidelines for Pathology. Europe: European Commission. [Details]
(2005) 'Comparative Genomic Hybridisation using DNA from Laser Capture Microdissected Tissue'
Callagy G, Jackson L and Caldas C (2005) 'Comparative Genomic Hybridisation using DNA from Laser Capture Microdissected Tissue' In: Methods in Molecular Biology. NJ, USA: Totowa: Humana. [Details]

Conference Publications

  Year Publication
(2009) The microvasculature of invasive ductal breast carcinoma: a sterological approach
Mahon, S.,Miller, N.,Curran, C.,Dockery, P.,Callagy, G.,Kerin, M. J. (2009) Cancer Research The microvasculature of invasive ductal breast carcinoma: a sterological approach [Details]
(2009) Increased Activity of the S Phase Kinase Cdc7 Is Associated with Poor Outcome in Diffuse Large B Cell Lymphoma (DLBCL)
Krawczyk, J,Egan, C,Mulvihill, M,Webber, M,Murillo, L,Ingoldsby, H,Santocanale, C,Callagy, G,O'Dwyer, MC (2009) Increased Activity of the S Phase Kinase Cdc7 Is Associated with Poor Outcome in Diffuse Large B Cell Lymphoma (DLBCL) , pp.760-760 [Details]
(2009) PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL
Natoni, A,Hayat, A,Montagnoli, A,Callagy, G,Samali, A,Santocanale, C,O'Dwyer, MC (2009) BLOOD PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL , pp.934-934 [Details]
(2002) Visualization, Image-Guided Procedures and Display
Varga MJ, Ducksbury P, Callagy G. (2002) Application of content-based image compression to telepathology Visualization, Image-Guided Procedures and Display SPIE Volume 4681, pages 587-95, Medical Imaging, [Details]
(2002) Image Perception, Observer Performance and Technology Assessment
Varga MJ, Ducksbury P, Callagy G. (2002) Performance Visualisation for Image Compression in Telepathology Image Perception, Observer Performance and Technology Assessment SPIE Volume 4380, pages 145-56, Medical Imaging April 2002, [Details]

Conference Contributions

  Year Publication
(1996) Pathology Division of The Royal Academy of Medicine in Ireland,
Kiernan N; Clarke G; Pathnakanthan S; MacMathuna P; Sullivan A; Callagy G; OKeane JC; Crowe J (1996) RIBA-positive, PCRnegative Irish anti-D chronic hepatitis C patients have minimal liver inflammation and fibrosis, not predicted by number of positive RIBA bands. [Oral Presentation], Pathology Division of The Royal Academy of Medicine in Ireland, Ireland , 01-MAR-96 - 01-MAR-96. [Details]
(1999) Pathological Society of Great Britain and Ireland, Cambridge,
Callagy G1, O'Grady A, Butler D, Leader M, Kay E. (1999) The role of CD44 in cervical neoplasia: a predictor of microinvasion?. [Oral Presentation], Pathological Society of Great Britain and Ireland, Cambridge, Cambridge, UK , 06-JAN-99 - 07-JAN-99. [Details]
(1999) International Academy of Pathology, San Francisco,
Callagy G, Dimitriadis E, Harmey J, Bouchier-Hayes D, Leader M, Kay E (1999) Immunohistochemical measurement of VEGF in breast cancer: a more reliable predictor of tumour stage than microvessel density. [Poster Presentation (Refereed)], International Academy of Pathology, San Francisco, San Francisco, CA, USA , 05-MAR-99 - 10-MAR-99. [Details]
(1999) Pathological Society of Great Britain and Ireland, Cambridge,
Callagy G, Dimitriadis E, Harmey J, Bouchier-Hayes D, Leader M, Kay E (1999) Immunohistochemical measurement of VEGF in breast cancer: a more reliable predictor of tumour stage than microvessel density. [Oral Presentation], Pathological Society of Great Britain and Ireland, Cambridge, Cambridge, UK , 06-JAN-99 - 07-JAN-99. [Details]
(1999) Pathology Division of The Royal Academy of Medicine in Ireland,
Callagy, G (1999) Kufs’ disease in two siblings: a clinicopathological study. [Oral Presentation], Pathology Division of The Royal Academy of Medicine in Ireland, Belfast, N. Ireland , 22-JUN-99 - 22-JUN-99. [Details]
(1999) International Academy of Pathology, San Francisco,
Callagy G1, O'Grady A, Butler D, Leader M, Kay E. (1999) The role of CD44 in cervical neoplasia: a predictor of microinvasion?. [Poster Presentation (Refereed)], International Academy of Pathology, San Francisco, San Francisco, CA, USA , 05-MAR-99 - 08-MAR-99. [Details]
(2001) 47th European Association for Study of the Liver,
H.S. Saeed, G. Callagy, L. Happerfield, G. Williams, D. Wright, R. Alexander. (2001) Antibodies to minichromosomal maintenance proteins (mcm-2 and mcm-5) distinguish benign from neoplastic focal liver lesions. [Poster Presentation], 47th European Association for Study of the Liver, Barcelona, Spain , 18-APR-01 - 21-APR-01. [Details]
(2001) Human Genome Organisation Meeting,
Callagy, G (2001) DOP-PCR based array-CGH for extensive amplicon profiling of breast cancers: a new approach for the molecular analysis of paraffin-embedded breast cancers. [Poster Presentation], Human Genome Organisation Meeting, Edinburgh, Scotland, UK , 19-APR-01 - 22-APR-01. [Details]
(2001) British Division of the International Academy of Pathology and Pathological Society of Great Britain and Ireland,
Callagy, G (2001) Molecular profiling of breast cancer using tumour tissue microarrays. [Poster Presentation], British Division of the International Academy of Pathology and Pathological Society of Great Britain and Ireland, Liverpool, UK , 03-JUL-01 - 06-JUL-01. [Details]
(2002) Pathological Society of Great Britain and Ireland, Dublin,
Grace Callagy (2002) Profile of oncogene amplification in breast cancer using array-based comparative genomic hybridisation. [Oral Presentation], Pathological Society of Great Britain and Ireland, Dublin, Dublin, Ireland , 02-JUL-02 - 05-JUL-02. [Details]
(2002) SPIE Medical Imaging Annual Meeting, San Diego,
Grace Callagy (2002) Performance Visualisation for Image Compression in Telepathology. [Oral Presentation], SPIE Medical Imaging Annual Meeting, San Diego, San Diego, California, USA , 07-JAN-02 - 08-JAN-02. [Details]
(2003) University of Aberdeen, Grand Rounds,
Callagy, G (2003) Molecular Profiling of early breast cancer. [Invited Oral Presentation], University of Aberdeen, Grand Rounds, Aberdeen, Scotland, UK , 21-NOV-03 - 21-NOV-03. [Details]
(2004) Mater Misericordiae International Breast Meeting,
Callagy, G (2004) Molecular Profiling in Breast Cancer: where are we now?. [Invited Lecture], Mater Misericordiae International Breast Meeting, Dublin, Ireland , 27-MAY-04 - 28-MAY-04. [Details]
(2005) Faculty of Pathology Annual Meeting,
Callagy, G (2005) The demise of academic pathology. [Chaired Session], Faculty of Pathology Annual Meeting, Dublin, Ireland , 01-FEB-05 - 01-FEB-05. [Details]
(2006) Early Breast Cancer Symposium, Galway,
Callagy, G (2006) Molecular profiling of early breast cancer. [Invited Lecture], Early Breast Cancer Symposium, Galway, Galway, Ireland , 03-JAN-06 - 03-JAN-06. [Details]
(2007) Professor John David Kennedy Memorial Lecture,
Callagy, G (2007) Classification of Breast Cancer in the Molecular Era. [Invited Lecture], Professor John David Kennedy Memorial Lecture, Galway, Ireland , 01-FEB-07 - 01-FEB-07. [Details]
(2008) 31st San Antonio Breast Meeting,
Mahon S, Miller N, Curran C, Dockery P, Callagy G, Kerin MJ (2008) The microvasculature of Invasive Ductal Breast Carcinoma: A Stereological approach. [Poster Presentation (Refereed)], 31st San Antonio Breast Meeting, San Antonio, Texas, USA , 10-DEC-08 - 14-DEC-08. [Details]
(2008) Galway & Nottingham International Breast Cancer Meeting,
Callagy, G (2008) Sentinel Lymph Node Pathology. [Invited Lecture], Galway & Nottingham International Breast Cancer Meeting, Galway, Ireland , 19-JUN-08 - 21-JUN-08. [Details]
(2008) Irish Society of Surgical Pathology, 6th Annual Meeting,
H Ingoldsby*, G Callagy (2008) An Audit of Alcohol and Accidental Deaths in the West of Ireland, Galway University Hospitals 2003-2007. [Poster Presentation (Refereed)], Irish Society of Surgical Pathology, 6th Annual Meeting, Belfast, N.Ireland , 07-NOV-08 - 08-NOV-08. [Details]
(2008) Freyer Memorial Lecture and Surgical Symposium,
S Mahon, N Miller, P Dockery, G Callagy, MJ Kerin (2008) Defining the Microanatomy of Invasive Ductal Breast Carcinoma using Advanced Stereological Parameters. [Poster Presentation (Refereed)], Freyer Memorial Lecture and Surgical Symposium, National University of Galway, Ireland , 05-SEP-08 - 06-SEP-08. [Details]
(2009) Pathological Society of Great Britain and Ireland, Winter Meeting (195th Scientific meeting), London,
Mardiana Abdul Aziz*, Grace Callagy. (2009) Malignant Phyllodes Tumour with Liposarcomatous Differentiation, Invasive Tubular Carcinoma, Ductal and Lobular Carcinoma in Situ. [Poster Presentation (Refereed)], Pathological Society of Great Britain and Ireland, Winter Meeting (195th Scientific meeting), London, London, UK , 08-JAN-09 - 09-MAR-09. [Details]
(2009) Pathological Society of Great Britain and Ireland, Winter Meeting (195th Scientific meeting),
Mardiana Abdul Aziz*, Grace Callagy (2009) Malignant Phyllodes Tumour with Liposarcomatous Differentiation, Invasive Tubular Carcinoma, Ductal and Lobular Carcinoma in Situ. [Poster Presentation (Refereed)], Pathological Society of Great Britain and Ireland, Winter Meeting (195th Scientific meeting), London, UK , 08-JAN-09 - 09-JAN-09. [Details]
(2009) Galway & Nottingham International Breast Cancer Meeting,
Callagy, G (2009) Pathology of Risk. [Invited Lecture], Galway & Nottingham International Breast Cancer Meeting, Galway, Ireland , 18-JUN-09 - 19-JUN-09. [Details]
(2009) Pathological Society of Great Britain and Ireland, Winter Meeting,
H Ingoldsby*, G Callagy (2009) Alcohol and its Association with Accidental Deaths in the West of Ireland. [Poster Presentation (Refereed)], Pathological Society of Great Britain and Ireland, Winter Meeting, London, UK , 08-JAN-09 - 09-JAN-09. [Details]
(2009) 51st Annual Meeting of the American Society of Hematology,
Krawczyk J, Egan C, et al (2009) 8. Increased activity of the S Phase kinase Cdc7 is associated with poor outcome in Diffuse Large B Cell Lymphoma (DLBCL). [Poster Presentation (Refereed)], 51st Annual Meeting of the American Society of Hematology, Ernest N. Morial Convention Centre, New Orleans, LA, USA , 05-DEC-09 - 08-DEC-09. [Details]
(2010) Pathological Society of Great Britain and Ireland, Winter Meeting,
H Ingoldsby*, PJ Gleeson, C Inderhaug, M Sheehan, G Callagy (2010) An Audit of B3 and B4 Categories in Needle Core Biopsies from Screening and Symptomatic Breast Services in the West of Ireland. [Poster Presentation (Refereed)], Pathological Society of Great Britain and Ireland, Winter Meeting, London, UK , 07-JAN-10 - 08-JAN-10. [Details]
(2010) International Gastrointestinal Pathology Symposium/8th Annual Meeting of the Irish Society of Surgical Pathology,
H Ingoldsby, G Callagy (2010) The Prevalence of Drug Use in Unnatural Deaths in the West of Ireland. [Chaired Session], International Gastrointestinal Pathology Symposium/8th Annual Meeting of the Irish Society of Surgical Pathology, Galway, Ireland , 23-SEP-10 - 25-SEP-10. [Details]
(2010) Irish Association for Cancer Research Annual Meeting,
LS Murillo*, CR Inderhaug, MJ Webber, H Ingoldsby, C Santocanale, GM Callagy (2010) MCM2 and its Potential Clinical use in Breast Cancer. [Poster Presentation (Refereed)], Irish Association for Cancer Research Annual Meeting, Galway, Ireland , 03-MAR-10 - 05-MAR-10. [Details]
(2010) The Mater 13th International Breast Cancer Meeting, Dublin,
M Pervaz*, AJ Lowery, H Ingoldsby, R McGrath, MJ Kerin, C Brodie, KJ Sweeney (2010) Prognostic Significance of Type and Density of Tumour Infiltrating Lymphocytes in Breast Cancer. [Poster Presentation (Refereed)], The Mater 13th International Breast Cancer Meeting, Dublin, Dublin, Ireland , 13-MAY-10 - 14-MAY-10. [Details]
(2012) IWSM Proceedings, Prague,
Deirdre Wall, Carl Scarrott, John Newell, Helen Ingoldsby, Grace Callagy, Michael J. Kerin (2012) Identifying Underlying Structure in Classification and Regression Trees using Surrogate Splits. [Poster Presentation (Refereed)], IWSM Proceedings, Prague, Prague, Checz Republic , 08-SEP-12 - 12-SEP-12. [Details]
(2013) Edinburgh Pathology 2013, Joint Meeting with the BDIAP,
H Ingoldsby, E Caffrey, M Webber, D Wall, A Gupta, J Newell, S Gupta, G Callagy (2013) Characterisation of miR-4726 and miR-4728 in breast cancer. [Poster Presentation (Refereed)], Edinburgh Pathology 2013, Joint Meeting with the BDIAP, Edinburgh, UK , 18-JUN-13 - 21-JUN-13. [Details]
(2013) Irish Association for Cancer Research Annual Meeting,
E Caffrey, D Wall, M Webber, K Dinneen, H Ingoldsby, L Murillo, CR Inderhaug, J Newell, S Gupta, G Callagy (2013) Prognostic Significance of Deregulated Dicer Expression in Breast Cancer. [Poster Presentation (Refereed)], Irish Association for Cancer Research Annual Meeting, Dublin, Ireland , 28-FEB-13 - 01-MAR-13. [Details]
(2013) Irish Association for Cancer Research. Dublin, Ireland,
Ananya Gupta, Mark Webber, Grace Callagy, Sanjeev Gupta (2013) Regulation of NCOA3/AIB1 expression by UPR in Breast Cancer: Implications for Endocrine Therapy. [Poster Presentation (Refereed)], Irish Association for Cancer Research. Dublin, Ireland, Dublin, Ireland , 28-FEB-13 - 01-MAR-13. [Details]
(2013) Edinburgh Pathology 2013, Joint Meeting with the BDIAP,
E Caffrey, D Wall, M Webber, K Dinneen, H Ingoldsby, L Murillo, CR Inderhaug, J Newell, S Gupta, G Callagy (2013) Prognostic Significance of Deregulated Dicer Expression in Breast Cancer. [Poster Presentation (Refereed)], Edinburgh Pathology 2013, Joint Meeting with the BDIAP, Edinburgh, UK , 18-JUN-13 - 21-JUN-13. [Details]
(2014) IACR Annual Meeting,
A Gupta, G Callagy, S Gupta. (2014) Regulation of NCOA3/AIB1 expression by the unfolded protein response. [Poster Presentation], IACR Annual Meeting, Galway, Ireland , 27-MAR-14 - 28-MAR-14. [Details]
(2015) IACR Annual Meeting,
A Gupta, MM Hossain, G Callagy, S Gupta (2015) XBP1 regulates the expression of NCOA3/AIB1 during unfolded protein response in breast cancer cells. [Poster Presentation], IACR Annual Meeting, Limerick, Ireland , 26-FEB-15 - 27-FEB-15. [Details]
(2015) IACR Annual Meeting,
C Gao1,2, E Bourke3, M Scobie4, MC Casey6, A McGuire6, A Shalaby3, M Webber3, C Curran6, E Holian7, MA Famme4, T Koolmeister4, G Callagy3, M Kerin6, T Helleday4, LA Eriksson1,2, NF Lowndes5, JA Brown5,6 (2015) Rational Design And Validation Of A TIP60 Histone Acetyltransferase Inhibitor For The Treatment Of Breast Cancer Subtypes. [Poster Presentation], IACR Annual Meeting, Limerick, Ireland , 26-FEB-15 - 27-FEB-15. [Details]
(2015) IACR Annual Meeting,
M C Casey1, A McGuire1, A Shalaby2, M Webber2, C Curran1, GCallagy2, E Bourke2, J Brown1, M Kerin1. (2015) Investigating the role of Ago2 in breast cancer. [Poster Presentation], IACR Annual Meeting, Limerick, Ireland , 26-FEB-15 - 27-FEB-15. [Details]
(2015) AACR Annual Conference,
Walsh E.M. et al. (2015) Identification of triple negative breast cancer (TNBC) subtypes by an immunohistochemistry (IHC) panel with impact on clinical outcomes. [Poster Presentation], AACR Annual Conference, Philadelphia, USA , 18-APR-15 - 22-APR-15. [Details]

Abstract

  Year Publication
(2009) The microvasculature of invasive ductal breast carcinoma: a sterological approach.
Mahon, S,Miller, N,Curran, C,Dockery, P,Callagy, G,Kerin, MJ (2009) The microvasculature of invasive ductal breast carcinoma: a sterological approach. Abstract [Details]

ANET/COS

  Year Publication
(2014) Distribution pattern of the Ki67 labelling index in breast cancer and its implications for choosing cut-off values.
2. Cserni G1, Vörös A2, Liepniece-Karele I3, Bianchi S4, Vezzosi V4, Grabau D5, Sapino A6, Castellano I6, Regitnig P7, Foschini MP8, Zolota V9, Varga Z10, Figueiredo P11, Decker T12, Focke C12, Kulka J13, Kaya H14, Reiner-Concin A15, Amendoeira I16, Callagy G17, Caffrey E17, Wesseling J18, Wells C (2014) Distribution pattern of the Ki67 labelling index in breast cancer and its implications for choosing cut-off values. ANET/COS [Details]

Editorial

  Year Publication
(2010) Arcuate plaques of the face and scalp - Atypical necrobiosis lipoidica (ANL) of the face and scalp.
Lynch, M,Callagy, G,Mahon, S,Murphy, LA (2010) Arcuate plaques of the face and scalp - Atypical necrobiosis lipoidica (ANL) of the face and scalp. Editorial [DOI] [Details]

Meeting

  Year Publication
(2013) Prognostic Significance of Deregulated Dicer Expression in Breast Cancer.
Caffrey, E,Wall, D,Webber, M,Dinneen, K,Ingoldsby, H,Murillo, L,Inderhaug, CR,Newell, J,Gupta, S,Callagy, G (2013) Prognostic Significance of Deregulated Dicer Expression in Breast Cancer. Meeting [Details]
(2013) Characterisation of Expression of MicroRNAs miR-4726 and miR-4728 in HER2-expressing Breast Cancer.
Ingoldsby, H,Caffrey, E,Webber, M,Gupta, S,Callagy, G (2013) Characterisation of Expression of MicroRNAs miR-4726 and miR-4728 in HER2-expressing Breast Cancer. Meeting [Details]
(2009) Atypical necrobiosis lipoidica of the head and neck.
Lynch, M,Callagy, G,Murphy, LA (2009) Atypical necrobiosis lipoidica of the head and neck. Meeting [Details]
(2009) Breast carcinoma: molecular markers and subtypes to predict patients at risk of developing metastatic disease.
Inderhaug, CR,Murillo, LS,Webber, MJ,Callagy, GM (2009) Breast carcinoma: molecular markers and subtypes to predict patients at risk of developing metastatic disease. Meeting [DOI] [Details]
(2008) Sentinel node ITC/micrometastases and non-sentinel node involvement with different interpretations of the TNM definitions.
Cserni, G,Bianchi, S,Vezzosi, V,van Diest, P,van Deurzen, C,Sejben, I,Regitnig, P,Asslaber, M,Foschini, M,Sapino, A,Castellano, I,Callagy, G,Arkoumani, E,Kulka, J,Wells, C (2008) Sentinel node ITC/micrometastases and non-sentinel node involvement with different interpretations of the TNM definitions. Meeting [Details]

Reviews

  Year Publication
(2012) Intracystic papillary carcinoma of the male breast: a case report and review of the literature.
Hussain, A,Sweeney, KJ,Salman, R,Callagy, GM,Sweeney, I,McLaughlin, R (2012) Intracystic papillary carcinoma of the male breast: a case report and review of the literature. Reviews [DOI] [Details]

Professional Associations

  Association Function From / To
Irish Association for Cancer Research Member /
Pathological Society of Great Britain and Ireland Member /
Royal College of Physicians of Ireland Member /
The Royal College of Pathologists, London Member /

Committees

  Committee Function From / To
School Board, College of Medicine, Nursing and Health Sciences Committee member 01-OCT-04 /
European Working Group for Breast Screening Pathology Committee member 01-SEP-07 /
United Kingdom Co-ordinating Committee for Breast Patholog Committee member 01-JUL-06 /

Employment

  Employer Position From / To
Galway University Hospitals Intern 01-JUL-93 / 30-JUN-94
Mater Misericordiae Hospital Medical Rotation, Dublin Senior House Officer in General Medicine 01-JUL-94 / 30-JUN-95
North Dublin Hospital’s Rotation in Pathology, Dublin Registrar in Histopathology 01-JUL-95 / 30-JUN-98
Royal College of Surgeons in Ireland, Dublin. Registrar/Clinical Lecturer in Histopathology 01-JUL-98 / 30-JUN-99
Addenbrooke’s Hospital, Cambridge. Specialist Registrar in Histopathology 01-JUL-99 / 01-JUL-00
Galway University Hospitals & St Columcille’s Hospital Loughlinstown, Dublin Locum Consultant Pathologist 01-JUL-00 / 31-AUG-00
Addenbrooke’s Hospital/Cancer Genomics Programme, University of Cambridge Specialist Registrar in Histopathology/Clinical Training Fellow 01-SEP-00 / 28-FEB-01
Addenbrooke’s Hospital/Cancer Genomics Programme, University of Cambridge Honorary Consultant Histopathologist/Clinical Training Fellow 01-MAR-02 / 30-JAN-04
Addenbrooke's Hospital, Cambridge, UK Locum Consultant Pathologist 01-JAN-04 / 27-FEB-04
Galway University Hospitals Consultant Pathologist and Lead Symptomatic Breast Pathologist 01-APR-04 / 29-OCT-05
NUI Galway & Galway Universtiy Hospitals Professor of Pathology & Consultant Histopathologist 01-OCT-04 /

Reviews

  Journal Role
Breast Reviewer
Histopathology Reviewer
Journal Of Pathology Reviewer

Teaching Interests

As Professor of Pathology and Head of Discipline since 2004, I have been responsible for the undergraduate taught programmes delivered by the Discipline of Pathology at NUIG. I was the module director for Pathology (PA204), Forensic Medicine and Elements of Pathology (PA405) from 2004 until 2010. In 2008, I restructured the undergraduate medical teaching courses and into the integrated modules Health and Disease I (MD201) and II 2008-2010 Forensic Medicine (MD301).

I served as a external examiner for the Final MB Part I exam at Cambridge University from 2013 to 2015 and I am currently the extern examiner for Laboratory Medicine at Trinity College Dublin.

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
Semester I Elements of Pathology PA405
Year 2, Semester 2 Health and Disease I MD201
Year 3, Semester 1 Health and Disease II MD302