Research Interests

Cell stress and neuroprotection. The polyamines are a family of naturally occurring compounds that are widely expressed in animal tissues, including the brain. They have a role in the growth and differentiation of cells, but have also been shown to be neurotoxic and may contribute to neurodegeneration. My research aims to increase understanding of the role of the polyamines in the pathophysiology of CNS disorders. In addition, I am interested in investigating the neuroprotective effect of the neurotrophins, another naturally occurring group of compounds found in the brain.

 

     

Peer Reviewed Journals

Purcell, W.M., Doyle, K.M., Bagga, L. : Derks, M. (1994) 'Histamine release from mast cells by polyamines: an NMDA receptor-mediated event?'. Biochemical Society Transactions, 22 . [Details]

Doyle, K.M.,Shaw, G.G. (1994) 'The mechanism of the neurotoxic effects of spermidine'. Biochemical Society Transactions, 22 . [Details]

Doyle, K.M. : Shaw, G.G. (1996) 'Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo'. British Journal of Pharmacology, 117 :1803-1808. [Details]

Purcell, W.M., Doyle, K.M., Westgate, C. : Atterwill, C.K (1996) 'Characterisation of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex'. Journal of Neuroimmunology, 65 :49-53. [Details]

Purcell, W.M., Doyle, K.M., Westgate, C. & Atterwill, C.K (1998) 'Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour'. Behavioural Pharmacology, 9 :671-681. [Details]

Doyle, K.M.,Shaw, G.G. (1998) 'Investigation of the actions and antagonist activity of some polyamine analogues in vivo'. British Journal of Pharmacology, 124 :386-390. [Details]

Doyle, K.M. & Shaw, G.G. (2004) 'Preliminary characterisation of an in vitro paradigm for the study of the delayed effects of organophosphorus compounds: hen embryo brain spheroids'. Toxicology, 195 (02-Mar):187-202. [DOI] [Details]

Li, J., Henman, M. C., Tatlisumak, T., Shaw, G. G. & Doyle, K. M. (2005) 'The pre-ischaemic neuroprotective effects of N1-dansyl-spermine in a transient focal cerebral ischaemia model in mice'. Brain Research, 1055 :180-185. [DOI] [Details]

Doyle, K.M., Feerick, S., Kirkby, D.L., Eddleston, A. & Higgins, G.A. (2005) 'Effect of L-type calcium channel antagonists on spermine induced CNS excitation in vivo'. Neuroscience Letters, 380 :247-251. [Details]

Li, J., Henman, M. C., Atkinson, J., Fixon-Owoo, S., Tatlisumak, T., Shaw, G. G. & Doyle, K. M. (2006) 'The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice'. Brain Research, 1076 :209-215. [DOI] [Details]

Kavanagh ET, Loughlin JP, Herbert KR, Dockery P, Samali A, Doyle KM, Gorman, AM. (2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'. Biochem Biophys Res Commun, 351 (4):890-895. [DOI] [Details]

Li J, Henman MC, Tatlisumak T, Shaw GG& Doyle, K.M. (2007) 'Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia'. Curr Med Chem, 14 (17):1807-1813. [Details]

Li J, Henman MC, Atkinson, J., Fixon-Owoo, S., Tatlisumak T, Shaw GG & Doyle, K.M. (2009) 'Considerations and recent advances in neuroscience Biochem Soc'. Trans, 37 :299-302. [Details]

Doyle, K.M., Kennedy, D., Gorman, A.M., Healy, S., Gupta, S. : Samali, A. (2011) 'Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders'. J. Cell. Mol. Med. In press, . [Details]

Debnath, M., Doyle, K.M., Langan, C., McDonald, C., Leonard, B. : Cannon, D.M. (2011) 'Inflammation and Psychiatric Disorders: A reappraisal'. Translational Neuroscience In press, . [Details]