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Dr Róisín Dwyer BSc, MSc, PhD
Contact Details
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Biography:
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Róisín Dwyer is a Lecturer in Translational Science in the Discipline of Surgery at NUI Galway. Following graduation from UCD with a degree in Science, Róisín went on to complete an MSc in Biological Sciences at DCU, and then was awarded her PhD in Medicine and Therapeutics from UCD. Róisín's research background in breast cancer led to a 3 year postdoctoral research position at the Mayo Clinic, Rochester, Minnesota. Upon her return to Ireland, she was awarded a National University of Ireland (NUI) Postdoctoral Fellowship in the Sciences, and joined the research team of Professor Michael Kerin in the National Breast Cancer Research Institute (NBCRI) at NUI Galway. She received Health Research Board funding in 2007, and a subsequent Project Grant awarded by the Irish Cancer Society in 2008. Róisín's current research, in collaboration with both national and international research groups, focuses on novel approaches to breast cancer therapy. Her work investigates the potential of adult stem cells as vehicles for targeted delivery of therapeutic agents to breast tumours, with a specific interest in imaging modalities to track their migration in vivo. Other areas of interest include cellular interactions in breast tumours, and circulating biomarkers of disease. |
Peer Reviewed Journals
| Kilbane MT, Ajjan RA, Weetman AP, Dwyer R, McDermott EWM, O'Higgins N J and Smyth PPA (2000) 'Tissue Iodine Content and Serum Mediated 125I Uptake Blocking Activity in Breast Cancer'. Journal of Clinical Endocrinology and Metabolism, 85 :1245-1250. [Details] |
| Smyth PPA (2002) 'The Sodium Iodide Symporter and Thyroid Disease'. Clinical Endocrinology, 56 (4):427-429. [Details] |
| Schatz SM, Bergert ER, Myers RM, Harvey ME, Classic KL, Marler RJ, O'Connor MK and Morris JC (2005) 'A Preclinical Large Animal Model of Adenovirus-Mediated Expression of the Sodium-Iodide Symporter for Radioiodide Imaging and Therapy of Locally Recurrent Prostate Cancer'. Molecular Therapy, 12 (5):835-841. [Details] |
| Bergert ER, Gendler SJ, O'Connor MK and Morris JC (2005) 'In Vivo Radioiodide Imaging and Treatment of Breast Cancer Xenografts Following MUC1-driven Expression of the Sodium Iodide Symporter (NIS)'. Cinical Cancer Research, 11 (4):1483-1489. [Details] |
| Bergert ER, Gendler SJ, O'Connor MK and Morris JC (2006) 'Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors'. Human Gene Therapy, 17 (6):661-668. [Details] |
| Bergert ER, Gendler SJ, O'Connor MK and Morris JC (2006) 'Sodium Iodide Symporter (NIS)-mediated Radioiodide Imaging and Therapy of Ovarian Tumor Xenografts in Mice'. Gene Therapy, 13 (1):60-66. [Details] |
| Khan S, Barry FP, O'Brien T and Kerin MJ (2010) 'Advances in mesenchymal stem cell-mediated gene therapy for cancer'. Stem Cell Research and Therapy, 1 (3). [Details] |
| Kerin MJ (2010) 'Mesenchymal Stem Cells (MSCs) and Cancer: tumour specific delivery vehicles or therapeutic targets?'. Human Gene Therapy, 21 (11):1506-1512. [Details] |
| Ryan J, Curran CC, Hennessy E, Newell J, Morris JC, Kerin MJ (2011) 'The Sodium Iodide Symporter (NIS) and potential regulators in normal, benign and malignant human breast tissue'. PLoS ONE, 6 (1). [ARAN Link] [Details] |
Abstract
| Dwyer, RM,Barry, FP,O'Brien, T,Kerin, MJ (2007) Investigation of the potential of human mesenchymal stem cells (hMSC) as vectors for therapeutic gene delivery to breast tumours. Abstract [Details] |
| Dwyer, RM,Morris, JC,Murphy, M,Barry, FP,O'Brien, T,Kenn, MJ (2008) Investigation of the potential of mesenchymal stem cells (MSCs) for gene delivery to breast tumours. Abstract [Details] |
Conference Paper
| AP Molloy, RM Dwyer and MJ Kerin (2007) The potential role of bone-derived cells in development of breast cancer metastases. Sir Peter Freyer Surgical Symposium. Conference Paper [Details] |
| Shirley M Potter-Beirne, Roisin M Dwyer, Micheal J Kerin (2007) The role of Chemokine production by Primary Breast Cancer Stromal Cells in tumour progression.. Association of Surgeons of Great Britain and Ireland (ASGBI). Conference Paper [Details] |
| RM Dwyer, FP Barry, T O'Brien and MJ Kerin. (2007) Investigation of the Potential of Human Mesenchymal Stem Cells (hMSC) as Vectors for Therapeutic Gene Delivery to Breast Tumours. Irish Society for Gene and Cell Therapy (ISGCT). Conference Paper [Details] |
| RM Dwyer, FP Barry, T O'Brien and MJ Kerin. (2007) Mesenchymal Stem Cells (MSCs) as Potential Vectors for Delivery of Therapeutic Agents to Breast Tumours. NBCRI/NCBES Breast Cancer Research Day. Conference Paper [Details] |
| FT Martin, RM Dwyer, TP Griffin, JM Murphy, FP Barry, T O'Brien and MJ Kerin (2008) The Role of Bone-Derived Mesenchymal Stem Cells (MSCs) in Facilitating Breast Cancer Metastasis. Sylvester O Halloran Surgical Symposium. Conference Paper [Details] |
| FT Martin, RM Dwyer, TP Griffin, JM Murphy, FP Barry, T O'Brien and MJ Kerin (2008) Marrow-Derived Mesenchymal Stem Cells (MSCs) stimulate chemokine secretion and alter gene expression in breast cancer cells. Association of Surgeons of Great Britain and Ireland (ASGBI). Conference Paper [Details] |
| M.C. Hartmann, R.M. Dwyer, S.M. Potter, M.P. Boyle and M.J. Kerin. (2009) Characterisation of primary tumour stromal cells and their role in the breast tumour microenvironment. Sir Peter Freyer Surgical Symposium. Conference Paper [Details] |
| Dwyer R, Ryan J, Havelin R, Morris J, O'Flatharta C, Duffy G, Miller B, Liu ZL, Barrett H, Murphy M, Barry F, O'Brien T, Kerin M (2009) Sodium iodide symporter (NIS) mediated tracking of mesenchymal stem cell (MSC) migration to breast tumours in vivo. European Society for Gene and Cell Therapy (ESGCT). Conference Paper [Details] |
| FT Martin, RM Dwyer, J Kelly, JM Murphy, N Miller, E Hennessy, C Curran, FP Barry, T O'Brien, MJ Kerin (2009) Interactions between Mesenchymal Stem Cells (MSCs) and Breast Cancer Cells support induction of Epithelial - Mesenchymal Transition (EMT). Irish Association for Cancer Research (IACR). Conference Paper [Details] |
| M.C. Hartmann, R.M. Dwyer, M.P. Boyle, S.M. Potter and M.J. Kerin (2009) Potential role of Monocyte Chemotactic Protein-1 (MCP-1) in the Breast Cancer Microenvironment. Sylvester O Halloran Surgical Symposium. Conference Paper [Details] |
| Shirley M Potter, Roisin M Dwyer, Marie P Boyle, Marion C Hartmann, Catherine E Curran, Emer Hennessy and Michael J Kerin. (2009) TUMOUR PROMOTING ROLE OF PRIMARY STROMAL CELLS IN THE BREAST CANCER MICROENVIRONMENT IN VIVO AND IN VITRO. Irish Association for Cancer Research (IACR). Conference Paper [Details] |
| John C Kelly, Roisin M. Dwyer, Fiachra T Martin, Mary Murphy, Frank P Barry, Timothy O'Brien and Michael J. Kerin (2009) Paracrine impact of Mesenchymal Stem Cells (MSCs) on breast cancer cell gene expression. Sylvester O Halloran Surgical Symposium. Conference Paper [Details] |
| John C Kelly, Roisin M. Dwyer, Mary Murphy, Frank P Barry, Timothy O'Brien and Michael J. Kerin (2009) Mesenchymal stem cells and breast cancer: therapeutic delivery vehicles or tumour promoting agents. Sir Peter Freyer Surgical Symposium. Conference Paper [Details] |
| J. Ryan, E. Hennessey, C.C. Curran, J.C. Morris, M.J. Kerin and R.M. Dwyer (2009) Expression of the sodium iodide symporter in breast cancer. Sir Peter Freyer Surgical Symposium. Conference Paper [Details] |
| FT Martin, RM Dwyer, JM Murphy, N Miller, FP Barry, T O'Brien and MJ Kerin (2009) Mesenchymal Stem Cells (MSCs) may promote breast cancer metastatic potential through stimulation of Epithelial-Mesenchymal Transition (EMT). Society of Academic & Research Surgery (SARS). Conference Paper [Details] |
| Hartmann MC, Dwyer RM, Costello M, Kerin MJ (2010) Investigation of potential role of CCL5 in breast cancer progression. Sylvester O Halloran Surgical Symposium. Conference Paper [Details] |
| Hartmann MC, Dwyer RM, Costello M, Kerin MJ (2010) Correlation between circulating and tumour tissue CCL5 and TGFß1 in breast cancer patients. Sir Peter Freyer Surgical Symposium. Conference Paper [Details] |
| Costello M, Hartmann MC, Dwyer RM, Kerin MJ (2010) Potential of circulating chemokines as serum tumour markers in breast cancer. Society of Academic & Research Surgery (SARS). Conference Paper [Details] |
| S Khan, RM Dwyer, SM Potter and MJ Kerin (2010) Breast Tumour Stromal-Epithelial Interactions Stimulate Increased VEGF Secretion And Angiogenesis In Vitro and In Vivo.. Sir Peter Freyer Surgical Symposium. Conference Paper [Details] |
| J. Ryan, C.C. Curran, E. Hennessy, J.C. Morris, M.J. Kerin and R.M. Dwyer (2010) Potential role for thyroid hormones in regulation of mammary Sodium Iodide Symporter expression. Sir Peter Freyer Surgical Symposium. Conference Paper [Details] |
| Sonja Khan, Roisin M Dwyer, Karl J Sweeney and Michael J Kerin (2011) Cellular Interactions in the Primary Tumour Microenvironment. Sir Peter Freyer Surgical Symposium. Conference Paper [Details] |
Conference Poster
| RM Dwyer, FP Barry, T O'Brien and MJ Kerin. (2006) Mesenchymal stem cell-mediated stimulation of breast cancer cell migration. European Association for Cancer Research (EACR). Conference Poster [Details] |
| Shirley Potter Beirne, Roisin M Dwyer, Professor Micheal J Kerin (2007) Secretion and Expression of Monocyte Chemotactic Protein-1 (MCP-1) by Primary Breast Cancer Cell Populations.. Society of Academic & Research Surgery (SARS). Conference Poster [Details] |
| RM Dwyer, FP Barry, T O'Brien and MJ Kerin. (2007) Bone Marrow-Derived Mesenchymal Stem Cells (MSCs) as potential interacting targets for circulating breast cancer cells. Irish Association for Cancer Research. Conference Poster [Details] |
| Shirley M Potter-Beirne, Roisin M Dwyer, Micheal J Kerin (2007) The role of Chemokine production by Primary Breast Cancer Stromal Cells in tumour progression.. Irish Association for Cancer Research. Conference Poster [Details] |
| R.M. Dwyer, F.P. Barry, T. O'Brien, M.J. Kerin. (2007) Investigation of the potential of human Mesenchymal Stem Cells (hMSC) as vectors for therapeutic gene delivery to breast tumours. European Cancer Organisation (ECCO). Conference Poster [Details] |
| AP Molloy, RM Dwyer, MJ Kerin (2007) The potential role of bone derived cells in the development of breast cancer metastases. European Cancer Organisation (ECCO). Conference Poster [Details] |
| Shirley Potter Beirne, Roisin Dwyer, and Michael Kerin. (2007) Distinct Chemokines Mediate Tumourigenicity of Breast Cancer Cells. San Antonio Breast Cancer Symposium. Conference Poster [Details] |
| Molloy AP, Dwyer RM, Kerin MJ. (2007) Osteoblasts and their progenitors stimulate breast cancer cell migration through chemokine secretion. San Antonio Breast Cancer Symposium. Conference Poster [Details] |
| Shirley M Potter-Beirne, Roisin M Dwyer and Michael J Kerin (2007) The Role of Primary Stromal Cell-derived Chemokines in the Breast Tumour Microenvironment. European Cancer Organisation (ECCO). Conference Poster [Details] |
| AP Molloy, RM Dwyer, MJ Kerin (2007) Analysis of the role of osteogenic cells in breast cancer metastasis. Association of Surgeons of Great Britain and Ireland (ASGBI). Conference Poster [Details] |
| AP Molloy, RM Dwyer, MJ Kerin (2007) Role of Osteoblasts in Promoting Breast Cancer Cell Migration and Proliferation. Irish Association for Cancer Research. Conference Poster [Details] |
| RM Dwyer, JC Morris, JM Murphy, FP Barry, T O'Brien and MJ Kerin. (2008) Sodium Iodide Symporter (NIS) mediated Iodide Uptake in Mesenchymal Stem Cells following Adenoviral Transduction. Irish Society for Gene and Cell Therapy (ISGCT). Conference Poster [Details] |
| FT Martin, RM Dwyer, TP Griffin, JM Murphy, FP Barry, T O'Brien and MJ Kerin (2008) Marrow-Derived Mesenchymal Stem Cells (MSCs) stimulate chemokine secretion and gene expression in breast cancer cells. European Association for Cancer Research (EACR). Conference Poster [Details] |
| RM Dwyer, JC Morris, JM Murphy, FP Barry, T O'Brien and MJ Kerin. (2008) Investigation of the potential of Mesenchymal Stem Cells (MSCs) for gene delivery to breast tumours. European Association for Cancer Research (EACR). Conference Poster [Details] |
| Shirley M. Potter, Roisin M. Dwyer, Emer Hennessy, Damian G. Griffin and Michael J. Kerin. (2008) Circulating Stromal Cell Derived Factor-1a (SDF-1a) in Premenopausal Women is Influenced by Phase of Menstrual Cycle. Sir Peter Freyer Surgical Symposium. Conference Poster [Details] |
| Shirley M. Potter, Roisin M. Dwyer, Emer Hennessy, Damien Griffin and Michael J. Kerin. (2008) Circulating Stromal Cell Derived Factor-1a (SDF-1a) in Premenopausal Women is Influenced by Phase of Menstrual Cycle. Association of Surgeons of Great Britain and Ireland (ASGBI). Conference Poster [Details] |
| Udo Greiser, Melissa Hoare, Tyrone Bowes, Roisin Dwyer, Daniel O'Toole, Kaveh Mashayekhi, Mary Murphy, Frank Barry and Timothy O'Brien (2008) Next Generation Mesenchymal Stem Cells for Regenerative Medicine Applications: Antibodies, Peptides and Lipoplexes for isolation, expansion and genetic modification of MSCs from several species. Irish Society for Gene and Cell Therapy (ISGCT). Conference Poster [Details] |
| RM Dwyer, JC Morris, JM Murphy, FP Barry, T O'Brien and MJ Kerin. (2008) Sodium Iodide Symporter (NIS) mediated Iodide Uptake in Mesenchymal Stem Cells following Adenoviral Transduction. American Society of Gene Therapy (ASGT). Conference Poster [Details] |
| Shirley M. Potter, Roisin M. Dwyer, Emer Hennessy, Damien Griffin and Michael J. Kerin. (2008) Hormonal regulation of breast cancer associated chemokines. European Association for Cancer Research (EACR). Conference Poster [Details] |
| FT Martin, RM Dwyer, JM Murphy, FP Barry, T O'Brien and MJ Kerin (2008) Potential promotion of the metastatic potential of circulating Breast Cancer Cells through interactions with Mesenchymal Stem Cells (MSCs). San Antonio Breast Cancer Symposium. Conference Poster [Details] |
| Shirley M Potter, Roisin M Dwyer, Michael J Kerin (2008) Stromal-epithalial cell Cross-talk In The Breast Tumour Microenvironment Elicits Changes In Gene Expression in Breast Cancer Epithelial Cells. San Antonio Breast Cancer Symposium. Conference Poster [Details] |
| Shirley M Potter, Marie P Boyle, Roisin M Dwyer, Nicola Miller and Micheal J Kerin. (2009) DISTINCT PROPERTIES OF BREAST TUMOUR COMPARED TO NORMAL STROMAL CELLS AND THEIR INFLUENCE ON BREAST CANCER EPITHELIAL CELL GENE EXPRESSION. Society of Academic & Research Surgery (SARS). Conference Poster [Details] |
| M.C. Hartmann, R.M. Dwyer, S.M. Potter, P Dockery and M.J. Kerin. (2009) Characterization of primary tumour stromal cells and their potential role in the breast cancer microenvironment. European Cancer Organisation (ECCO)/ESMO. Conference Poster [Details] |
| John C Kelly, Roisin M. Dwyer, Mary Murphy, Frank P Barry, Timothy O'Brien and Michael J. Kerin (2009) Mesenchymal Stem Cell (MSC) secretion of TGFb and VEGF stimulates Epithelial to Mesenchymal Transition (EMT) in breast cancer cell lines. European Cancer Organisation (ECCO)/ESMO. Conference Poster [Details] |
| J. Ryan, E. Hennessy, C.C. Curran, J.C. Morris, M.J. Kerin and R.M. Dwyer (2009) Correlation of Sodium Iodide Symporter (NIS) and Retinoic Acid Receptor Alpha (RARA) expression in breast cancer. European Cancer Organisation (ECCO)/ESMO. Conference Poster [Details] |
| Shirley M Potter, Roisin M Dwyer, Marie P Boyle, Marion C Hartmann, Catherine E Curran, Emer Hennessy and Michael J Kerin. (2009) Role of Stromal-Epithelial interactions in the primary breast tumour microenvironment in vitro and in vivo. American Association for Cancer Research (AACR). Conference Poster [Details] |
| M.C. Hartmann, R.M. Dwyer and M.J. Kerin (2009) Analysis of primary breast tumour stromal cells and their potential role in disease progression. San Antonio Breast Cancer Symposium. Conference Poster [Details] |
| FT Martin, RM Dwyer, JM Murphy, N Miller, FP Barry, T O'Brien and MJ Kerin (2009) Potential Role of Mesenchymal Stem Cells (MSCs) in the Breast Tumour Microenvironment: Stimulation of Epithelial to Mesenchymal Transition (EMT). American Association for Cancer Research (AACR). Conference Poster [Details] |
| Marion C Hartmann, Roisin M Dwyer, Marie P Boyle, Shirley M Potter and Prof Michael J Kerin (2009) Effect of Monocyte Chemotactic Protein-1 (MCP-1) on breast cancer cell proliferation and gene expression. Targeted AntiCancer Therapies (TAT), , 23rd-25th March 2009. Conference Poster [Details] |
| Hartmann MC, Dwyer RM, Costello M, Kerin MJ (2010) CCL5 in Breast Cancer: Circulating systemic levels and gene expression in the primary tumour microenvironment. American Association for Cancer Research (AACR). Conference Poster [Details] |
| Hartmann MC, Dwyer RM, Costello M, Kerin MJ (2010) Circulating and tumour tissue levels of CCL5/RANTES in breast cancer. Irish Association for Cancer Research (IACR). Conference Poster [Details] |
| J. Ryan, C.C. Curran, E. Hennessy, J.C. Morris, M.J. Kerin and R.M. Dwyer (2010) Expression of the Sodium Iodide Symporter and potential regulators in Normal, Benign and Malignant breast tissue. Irish Association for Cancer Research (IACR). Conference Poster [Details] |
| S Khan, RM Dwyer, MC Hartmann and MJ Kerin (2010) Potential Role of Primary Breast Cancer Stromal Cells in the Development of Endocrine Resistance. Irish Association for Cancer Research (IACR). Conference Poster [Details] |
| Roisin M. Dwyer, James Ryan, Ronan Havelin, John C. Morris, Cathal O'Flatharta, Brian Miller, Zhonglin Liu, Mark Foley, Harrison H. Barrett, Mary Murphy, Frank P. Barry, Timothy O'Brien and Michael J. Kerin. (2011) Mesenchymal Stem Cell (MSC) mediated delivery of the Sodium Iodide Symporter (NIS) supports radionuclide imaging and treatment of breast cancer. American Association for Cancer Research (AACR). Conference Poster [Details] |
Reviews
| DWYER, RM et al. (2010) Mesenchymal Stem Cells and Cancer: Tumor-Specific Delivery Vehicles or Therapeutic Targets?. HUMAN GENE THERAPY. Reviews [Details] |
Workshops
| RM Dwyer, FP Barry, T O'Brien and MJ Kerin. (2006) Breast Cancer Cells Migrate in Response to Bone Marrow-Derived Mesenchymal Stem Cells (MSCs). Sir Peter Freyer Surgical Symposium. Workshops [Details] |
| RM Dwyer, FP Barry, T O'Brien and MJ Kerin. (2007) Novel Chemokines Induce Migration of Breast Cancer Cells Towards Bone Marrow-Derived Mesenchymal Stem Cells. Society of Academic & Research Surgery (SARS). Workshops [Details] |
| Dwyer, R. (2007) The Role Of Primarry Stromal Cell-Derived Chemokines In The Breast Tumour Microenvironment. Nottingham International Breast Cancer Conference. Workshops [Details] |
| Shirley Potter, Roisin Dwyer, and Michael Kerin. (2007) Distinct Chemokines Mediate Tumourigenicity Of Breast Cancer Cells. Sir Peter Freyer Surgical Symposium. Workshops [Details] |
| Shirley M Potter, Roisin M Dwyer, Michael J Kerin (2008) Role of Monocyte Chemotactic Protein-1 (MCP-1) in the Primary Breast Tumour Microenvironment. Sir Peter Freyer Surgical Symposium. Workshops [Details] |
| FT Martin, RM Dwyer, JM Murphy, FP Barry, T O'Brien and MJ Kerin (2008) Mesenchymal Stem Cells modify chemokine secretion and gene expression in Breast Cancer Cells. Sir Peter Freyer Surgical Symposium. Workshops [Details] |
| Shirley Potter Beirne, Roisin Dwyer, Kate Harrington and Michael Kerin. (2008) Elevated Plasma SDF-1 alpha Correlates with Tumour Grade. Society of Academic & Research Surgery (SARS). Workshops [Details] |