Research Interests

spinal cord repair, glial scarring, neurotrophic factors, developmental neurobiology, stem cell biology, gene therapy, scaffolds for spinal cord tissue engineering, rnerve regeneration.

 

     

Peer Reviewed Journals

McMahon SS, McDermott KW. (2001) 'Proliferation and migration of glial precursor cells in the developing rat spinal cord'. Journal Of Neurocytology, 30 (9-10):821-828. [Details]

McMahon, S.S. & McDermott, K.W. (2002) 'Morphology and Differentiation of Radial Glia in the Developing Rat Spinal Cord'. JOURNAL OF COMPARATIVE NEUROLOGY, THE, 454 (3):263-271. [Details]

McMahon, S.S., Dockery, P. & McDermott, K.W. (2003) 'Estimation of Nuclear Volume as an Indicator of Maturation of Glial Precursor Cells in the Developing Rat Spinal Cord: A Stereological Approach'. JOURNAL OF ANATOMY, 203 :339-344. [Details]

McDermott K.W., Barry D.S. & McMahon S.S. (2005) 'Role of radial glia in cytogenesis, patterning and boundary formation in the developing rat spinal cord'. JOURNAL OF ANATOMY, 207 :241-250. [Details]

McMahon, SS,McDermott, KW (2006) 'A comparison of cell transplantation and retroviral gene transfection as tools to study lineage and differentiation in the rat spinal cord'. Journal Of Neuroscience Methods, 152 :243-249. [DOI] [Details]

McMahon, SS,McDermott, KW (2007) 'Developmental potential of radial glia investigated by transplantation into the developing rat ventricular system in utero'. Experimental Neurology, 203 :128-136. [DOI] [Details]

Rooney, G.E., Moran, C., McMahon, S.S., Ritter, T., Maenz, M., Flügel, A., Dockery, P., O' Brien, T., Howard, L., Windebank, A.J. , Barry, F.P. (2008) 'Gene-Modified Mesenchymal Stem Cells express functionally active Nerve Growth Factor on an engineered poly lactic glycolic acid (PLGA) substrate'. Tissue Engineering. Part A. Tissue Engineering, 14 (5):681-690. [Details]

Madigan NN, McMahon S, O'Brien T, Yaszemski MJ, Windebank AJ. (2009) 'Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds'. Respiratory Medicine, 169 (2):183-199. [Details]

McMahon SS, Albermann S, Rooney GE, Moran C, Hynes J, Garcia Y, Dockery P, O'Brien T, Windebank AJ, Barry FP. (2009) 'Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury'. Journal Of Anatomy, 215 (3):267-279. [Details]

Rooney GE, McMahon SS, Ritter T, Garcia Y, Moran C, Madigan NN, Flügel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry FP. (2009) 'Neurotrophic factor-expressing mesenchymal stem cells survive transplantation into the contused spinal cord without differentiating into neural cells'. Tissue Engineering Part A, 15 (10):3049-3059. [Details]

Donnelly EM, Strappe PM, McGinley LM, Madigan NN, Geurts E, Rooney GE, Windebank AJ, Fraher J, Dockery P, O'Brien T, McMahon SS. (2010) 'Lentiviral vector-mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar'. Journal Of Gene Medicine, 12 (11):863-872. [Details]

McMahon SS, Albermann S, Rooney GE, Shaw G, Garcia Y, Sweeney E, Hynes J, Dockery P, O'Brien T, Windebank AJ, Allsopp TE, Barry FP.  (2010) 'Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury. '. Cytotherapy, 12 (3):313-325. [Details]

Abu-Rub M, McMahon S, Zeugolis DI, Windebank A, Pandit A.  (2010) 'Spinal cord injury in vitro: modelling axon growth inhibition. '. Drug Discov Today, 15 (11-12):436-443. [Details]

McMahon SS, Nikolskaya N, Choileáin SN, Hennessy N, O'Brien T, Strappe PM, Gorelov A, Rochev Y. (2011) 'Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro'. Journal Of Gene Medicine, 13 (11):591-601. [Details]

Abu-Rub MT, Billiar KL, Van Es MH, Knight A, Rodriguez BJ, Zeugolis DI, McMahon S, Windebank AJ, Pandit A. (2011) 'Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein'. Soft Matter, 7 (6):2770-2781. [DOI] [Details]

     

Abstract

McMahon, S,Brennan, S,Kelly, J,O'Brien, L,Ryan, E,Dockery, P,Rooney, G,Moran, C,Windebank, A,Barry, F (2007) Analysis of cellular environment of the injured rat spinal cord following treatment with cyclosporin A. Abstract [Details]

McMahon, S,Dockery, P,Donnelly, E,Fraher, J,Strappe, P,O'Brien, T (2008) An ultrastructural study of the effect of silencing NG2 inhibitory factor. Abstract [Details]

McMahon, S,Rooney, G,Donnelly, E,O'Brien, T,Fraher, J,Windebank, A,Dockery, P,Hampton, D,Strappe, P (2009) AN ASTROCYTE-DORSAL ROOT GANGLION CO-CULTURE MODEL TO ASSESS NEURITE OUTGROWTH FROM LENTIVIRAL VECTOR EXPRESSED NEUROTROPHIN-3. Abstract [Details]

     

Conference Poster

McMahon S.S., Donnelly E., Fraher J.P., Dockery P., O'Brien T., Strappe P. (2007) Effect of lentiviral vector expressing neurotrophin-3 on neurite outgrowth following spinal cord injury. Irish Society for Gene and Cell Therapy Meeting Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway. Conference Poster [Details]

Siobhan McMahon, Siobhan Brennan, Johanne Kelly, Laura O'Brien, Éanna Ryan, Peter Dockery, Gemma Rooney, Cathal Moran, Anthony Windebank, Frank Barry. (2007) Analysis of the Effect of Cyclosporin A on the Cellular Environment of the Injured Rat Spinal Cord. Irish Society for Gene and Cell Therapy Meeting Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway. Conference Poster [Details]

Eleanor Donnelly, Siobhan McMahon, Peter Dockery, John Fraher, Padraig Strappe, Daniel O'Toole, Lisa McGinley, Timothy O'Brien. (2008) Effect of lentiviral vector expressing Neurotrophin-3 and shRNA for NG2 on cellular environment of injured spinal cord. ESGCT meeting Brugge. Belgium: Conference Poster [Details]

S.McMahon, N Nikolskaya, S. Ní Choileán, N. Hennessy, Y. Rochev. (2008) Thermosensitive Hydrogel For Prolonged Lentivirus Delivery. Neuroscience Ireland Meeting. NUI Galway: Conference Poster [Details]

N. Madigan, G. Rooney, T. Ritter, F. Barry, A. Windebank, T. O'Brien, S. McMahon. (2008) Regeneration Of Injured Spinal Cord Neurons Through Implantable Polymer Bridges Using A Combined Approach Of Neurotrophic Support And Glial Scar Inhibition.. Neuroscience Ireland Meeting NUI. Galway: Conference Poster [Details]

Jacqueline Hynes, Elaine Bourke, Eoin McCarthy Deering, Graham Doherty, Andrea Murray, Peter Dockery, Karen Doyle, Adrienne Gorman, Timothy Allsopp, Frank P. Barry, Siobhan S. McMahon. (2008) Neural stem cells reduce apoptosis following transplantation into injured rat spinal cord.. Neuroscience Ireland Meeting NUI Galway. Conference Poster [Details]

Siobhan S. McMahon, Silke Albermann , Gemma E. Rooney, Timothy O'Brien, Yolanda Garcia, Peter Dockery, Anthony J. Windebank, Timothy E. Allsopp, Frank P. Barry. (2008) Analysis of Neural Stem Cells Following Transplantation into Injured Rat Spinal Cord. Irish Society for Gene and Cell Therapy Meeting University College Cork. Conference Poster [Details]

Eleanor Donnelly, Lisa Mcginley, Peter Dockery, John Fraher, Padraig Strappe, Daniel O'Toole, Nicolas Madigan, Gemma Rooney, Timothy O'Brien, Siobhan McMahon. (2008) Silencing Ng2 Inhibitory Factor And Its Effect On Dorsal Root Ganglia Neurite Outgrowth. Neuroscience Ireland Meeting NUI. Galway: Conference Poster [Details]

Claire O'Leary, Michelle Kilcoyne, Lokesh Joshi, Peter Dockery, Siobhan McMahon. (2008) Analysis Of Neuron Cell Surface Glycosylation Differentials In A Chondroitin Sulphate Proteoglycan Inhibitory Environment. Neuroscience Ireland Meeting NUI Galway. Conference Poster [Details]

Eleanor Donnelly, Siobhan McMahon, Peter Dockery, John Fraher, Padraig Strappe, Daniel O'Toole, Lisa Mcginley, Timothy O'Brien. (2008) Silencing NG2 inhibitory factor and its effect on dorsal root ganglia neurite outgrowth. Irish Society for Gene and Cell Therapy Meeting University College Cork. Conference Poster [Details]

Siobhan S. McMahon, Silke Albermann, Gemma E. Rooney, Timothy O'Brien, Yolanda Garcia, Peter Dockery, Anthony J. Windebank, Timothy E. Allsopp, Frank P. Barry. (2008) Analysis of Neural Stem Cells Following Transplantation into Injured Rat Spinal Cord. Neuroscience Ireland Meeting. NUI Galway: Conference Poster [Details]

Jacqueline Hynes, Elaine Bourke, Eoin McCarthy Deering, Graham Doherty, Andrea Murray, Peter Dockery, Karen Doyle, Adrienne Gorman, Frank P. Barry, Siobhan S. McMahon. Analysis of Cellular Environment of Spinal Cord Lesion Following Transplantation of Neural Stem Cells into Injured Rat Spinal Cord. Meeting of the Anatomical Society of Great Britain and Ireland Nottingham. Conference Poster [Details]

Toal F., Donnelly E., O'Brien T., Kelly J.P., Fraher J.P., Strappe P., Dockery P., McMahon S.S. Efficiency of lentiviral vector transduction in injured rat spinal cord. A stereological analysis. Meeting of the Anatomical Society of Great Britain and Ireland. Durham: Conference Poster [Details]

A. Siobhan McMahon, Siobhan Brennan, Johanne Kelly, Laura O'Brien, Éanna Ryan, Peter Dockery, Gemma Rooney, Cathal Moran, Anthony Windebank, Frank Barry. Analysis of Cellular Environment of the Injured Rat Spinal Cord following Treatment with Cyclosporin. 8th European meeting on glial cell function in health and disease London. Conference Poster [Details]

Donnelly E., McMahon S.S., Strappe P, Rooney G., Fraher J.P., Dockery P., O'Brien T. Effect of Lentiviral Vector Expressing Neurotrophin-3 on Dorsal Root Ganglia Neurite Outgrowth. 8th European meeting on glial cell function in health and disease London. Conference Poster [Details]

Gemma E. Rooney, Siobhan S. McMahon, Thomas Ritter, Yolanda Garcia, Nicolas Madigan, Alexander Flügel, Kim K. Nickander, Peter Dockery, Timothy O'Brien, Linda Howard, Anthony J. Windebank and Frank P. Barry. Glial-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells. SFN Meeting. San Diego: Conference Poster [Details]

     

Invited papers

McMahon, S. (2007) Gene and stem cell therapy approaches to treatment of spinal cord injury. Invited speaker. Irish Network for Neural Stem Cell Investigators Trinity College, Dublin. Invited papers [Details]

               

Workshops

McMahon, S. (2008) Effect of Neural Stem Cells on Spinal Cord Contusion injury. 12th Annual Hilton Head Workshop entitled, Regenerative Medicine: Advancing to Next Generation Therapies Hilton Head, South Carolina, U.S.A. Workshops [Details]