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Dr Thomas Ritter PHD, DIP
Contact Details
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Biography:
| Dr Thomas Ritter leader of research programme, was recruited by REMEDI as a lecturer in Gene Therapy Medicine and assumed his position in March 2005. Dr. Ritter has over 15 year experience in the field of gene therapy in organ transplantation. He obtained his Ph.D. degree in 1994 from the Max-Planck Research group of Immunology/Rheumatology at the University of Erlangen-Nuremberg, Germany where he worked on the molecular characterization of T cell receptors specific for human collagen type II. Having completed his Post-Doctoral Fellowship at Marseille, Center of Immunology in 1995, Dr. Ritter took up a faculty position at the prestigious Charité University Hospital in Berlin, Germany. He worked as a leader of the gene therapy programme in experimental transplantation in the Institute of Medical Immunology under the directorship of Prof. Dr. H.-D. Volk. His research focused on the development of efficient viral gene-transfer systems for application in transplantation medicine. Dr. Ritter was successful in obtaining funding from the German Research Foundation and the Ministry of Health and Research as well as from industry (Schering). His teaching duties in this position included lectures and courses in cellular and molecular immunology for biology and medical students. Dr. Ritter completed his 'Habilitation' (postdoctoral lecture qualification) in Immunology in 2002 followed by a promotion to assistant professor in 2003. Since my appointment in 2005 I was successful in obtaining substantial funding from several funding agencies including Science Foundation of Ireland (SFI), Health Research Board (HRB) and The Irish Research Council for Science, Engineering and Technology (IRCSET). I have published 71 original articles in peer-reviewed journals (27 articles since my appointment at NUI, |
Research Interests
| Transplantation, Gene Therapy, Immunology, Mesenchymal Stem Cells, Immunomoduation, |
Book Chapters
| Griffin, M., Ritter, T. 'Gene Therapy in Organ Transplantation. Book chapter, Wiley, Submitted' In: [Details] |
Peer Reviewed Journals
| Lehmann, M., Risch, K., Nizze, H., Brandenburg, G., Ritter T., Brock, J., Volk, H.-D. (1992) 'Specificity and T-cell -chain receptor usage of a human collagen type II-reactive T-cell clone derived from a healthy patient'. Eur. J. Immunol, 22 :51-56. [Details] |
| Onodera, K., Volk, H.-D., Ritter, T., and Kupiec-Weglinski,, J.W. (1998) 'Thymus requirement and antigen dependency in the infectious“ tolerance pathway in transplant recipients'. J. Immunology, 160 :5765-5772. [Details] |
| Ritter, T., Risch, K., Schröder, G., Kolls, J., Siegling, A., Graser, E., Reinke, P., Brock, J., Lehmann, M., Volk, H.-D. (1999) 'Abolition of anti-CD4-induced allotransplantation tolerance by exogenous IL-2'. Transplantation Proceedings, 31 :1220-1221. [Details] |
| Ritter, T., Seifert, M., Risch, K., Fretz, A., Tanzmann, H., Brock, J., Volk, H.-D., Lehmann, M. (1999) 'Depletion of IL-4 does not prevent tolerance induction in an allogeneic rat kidney transplantation model'. Transplantation Proceedings, 31 :887-888. [Details] |
| Onodera, K., Chandraker A., Volk, H.-D., Ritter, T., Lehmann, M., Sayegh, MH., Kupiec-Weglinski, .W. (1999) 'Distinct tolerance pathways in sensitized allograft recipients after selective blockade of activation signal 1 or signal 2'. Transplantation, 68 :288-293. [Details] |
| Ritter, T, Vogt, K., Rieck, P., Schilling-Schön, A., Kolls, J., Hartmann, C., Volk, H.-D., Pleyer, U. (1999) 'Adenovirus-mediated gene transfer of IL-4 to corneal endothelial cells and rat corneas leads to high IL-4 expression'. Exp Eye Res, 69 :563-568. [Details] |
| Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A.J., Shen, X.-D., Zhao, D., Zaky J., Melenik, J., Lassman, C.R., Kolls. J.K., Alam, J., Ritter, T., Volk, H.-D., Busuttil, R.W., Kupiec-Weglinski, J.W. (1999) 'Upregulation of heme oxygenase-1 protects genetically fat zucker rats from ischemia/reperfusion injury'. J. Clin. Invest, 104 :1631-1639. [Details] |
| Ritter, T., Risch, K., Schröder, G., Kolls, J., Siegling, A., Graser, E., Reinke, P., Brock, J., Lehmann, M., Volk, H.-D (1999) 'Intragraft overexpression of IL-4 is neither sufficient nor essential for tolerance induction in high-responder strain combination'. Transplantation, 68 :1427-1431. [Details] |
| Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A.J., Shen, X.-D., Zhao, D., Zaky J., Melenik, J., Lassman, C.R., Kolls. J.K., Alam, J., Ritter, T., Volk, H.-D., Busuttil, R.W., Kupiec-Weglinski, J.W. (1999) 'Gene transfer of IL-4 prolongs rat renal allograft survival and inhibits p21ras dependent activation pathway'. Surg. Forum, 50 :381-383. [Details] |
| Ke, B., Ritter, T., Kato, H., Zhai, Y., Li, J., Busuttil, R.W., Lehmann M., Volk, H.-D., Kupiec-Weglinski, J.W. (2000) 'Immune response after adenoviral gene transfer in syngeneic heart transplants: effects of anti-CD4 mab therapy'. Transplantation, 70 :191-198. [Details] |
| Ritter, T., Schröder, G., Risch, K., Vergopoulos, A., Shean, M.K., Kolls, J., Brock, J., Lehmann, M., Volk, H.-D. (2000) 'Ischemia/Reperfusion injury mediated downregulation of adenovirus-mediated gene expression in a rat heart transplantation is inhibited by co-application of a TNFRp55-Ig chimeric construct'. Gene Therapy, 7 :1238-1243. [Details] |
| Ke, B., Ritter, T., Kato, H., Zhai, Y., Li, J., Busuttil, R.W., Lehmann M., Volk, H.-D., Kupiec-Weglinski, J.W. (2000) 'Regulatory cells potentiate the efficacy of IL 4 gene transfer in transplant recipients by upregulating Th2-dependent expression of protective molecules in the infectious tolerance pathway'. J. Immunol, 164 :5739-5745. [Details] |
| Hammer, M., Flugel, A., Seifert, M., Lehmann, M., Brandt, C., Volk, H.-D., Ritter, T. (2000) 'Potential of allospecific gene-engineered T-cells in transplantation gene therapy: Specific T-cell activation determines transgene expression in vitro and in vivo'. Human Gene Therapy, 11 :1303-1312. [Details] |
| Ritter, T., Schröder, G., Risch, K., Vergopoulos, A., Shean, M.K., Kolls, J., Brock, J., Lehmann, M., Volk, H.-D. (2000) 'Survival of corneal allografts following adenovirus-mediated gene transfer of interleukin-4'. Graefes Arch Clin Exp Ophthalmol, 238 :531-536. [Details] |
| Kato, H., Ritter, T., Ke, B., Murakami, M., Kusano, M., Busuttil, R.W., Kupiec-Weglinski J.W. (2000) 'Adenovirus-mediated gene transfer of IL-4 prolongs rat renal allograft survival and inhibits the p21(ras)-activation pathway'. Transplant Proc, 32 :245-246. [Details] |
| Flügel, A., Berkowicz T., Ritter, T., Labeur M., Jenne D.E., Li, Z., Ellwart J.W., Willem, M., Lassmann, H., Wekerle, H. (2000) 'Stimulatory and inhibitory action of cytokines on the regulation of hCMV-promoter activity in human cell lines'. Cytokine, 12 :1163-1170. [Details] |
| Hammer, M.H., Zhai, Y., Katori, M., Ritter, T., Volk, H.-D., Coito, A.J., Kupiec-Weglinski, J.W. (2001) 'Homing of in vitro generated antigen-reactive CD4+ T lymphocytes to renal allografts is ?4?1- but not ?L?2-integrin dependent'. J. Immunology, 166 :596-601. [Details] |
| Gelse, K., Q.-J. Yang, Aigner, T., Ritter, T., Wagner, K., Pöschl, E., von der Mark, K., Schneider, H. (2001) 'Fibroblast-mediated delivery of growth factor genes into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer'. Arthritis & Rheum, 44 :1943-1953. [Details] |
| Flügel, A., Berkowicz T., Ritter, T., Labeur M., Jenne D.E., Li, Z., Ellwart J.W., Willem, M., Lassmann, H., Wekerle, H. (2001) 'Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis'. Immunity, 14 :547-560. [Details] |
| Sparmann, G., Behrend, S., Merkord, J., Kleine, H.-D., Graser, E., Ritter, T., Liebe, S., Emmrich, J. (2001) 'Cytokine mRNA levels and lymphocyte infiltration in pancreatic tissue during experimental chronic pancreatitis induced by dibutyltin dichloride'. Digestive Diseases and Sciences, 46 :1647-1656. [Details] |
| Ke, B., Shen, X.D., Melinek, J., Gao, F., Ritter, T., Volk, H.D., Busuttil, R.W., Kupiec-Weglinski, J.W. (2001) 'Heme oxygenase-1 gene therapy: a novel immunomodulatory approach in liver allograft recipients?'. Transplant Proc, 33 :581-582. [Details] |
| Schröder, G., Hammer M.H., Risch, K., Flügel, A., Brock, J., Lehmann, M., Ritter, T., Volk, H.-D. (2001) 'Visualization of alloantigen-specific, EGFP-engineered T lymphocytes in a rat kidney transplantation model'. Transplant Proc, 33 :607-608. [Details] |
| Ke, B., Buelow, R., Shen, X.D., Melinek, J., Amersi, F., Gao, F., Ritter, T., Volk, H.-D-, Busuttil, R.W., Kupiec-Weglinski, J.W. (2002) 'Heme oxygenase 1 gene transfer prevents CD95/Fas Ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway'. Hum Gene Ther, 13 :1189-1199. [Details] |
| Ruan, S., Tate, C., Lee, J.J., Ritter, T., Kolls, J.K., Shellito, J.E. (2002) 'Local delivery of the viral IL-10 gene suppresses tissue inflammation in murine P. carinii infection'. Infect Immun, 70 :6107-6113. [Details] |
| Ke, B., Buelow, R., Shen, X.D., Melinek, J., Amersi, F., Gao, F., Ritter, T., Volk, H.-D-, Busuttil, R.W., Kupiec-Weglinski, J.W. (2002) 'Antigen-dependent transgene expression in transplantation: a novel approach using gene-modified T lymphocytes'. J. Am. Soc. Nephrol, 13 :511-518. [Details] |
| Trousdale, M.D., Stevenson, D., Zhu, Z., Kaslow, H.R., Schechter, J.E., Warren, D.W., Azzarolo, A.M., Ritter, T., Mircheff, A.K. (2002) 'Effect of anti-inflammatory cytokines on the activation of lymphocytes by lacrimal gland acinar cells in an autologous mixed cell reaction'. Adv Exp Med Biol, 506 :789-794. [Details] |
| Mhashilkar, A.M., Doebis, C., Seifert, C., Busch, A., Zani, C., Soo Hoo, J., Nagy, M., Ritter, T., Volk, H.-D., Marasco, W.A. (2002) 'Intrabody-mediated phenotypic knock-out of major histocompatibility complex class I expression in human and monkey cell lines and in primary human keratinocytes'. Gene Therapy, 9 :307-319. [Details] |
| Zhu, Z., Stevenson, D., Ritter, T., Schechter, J.E., Mircheff, A.K., Kaslow, H.R., Trousdale, M.D. (2002) 'Expression of IL-10 and TNF-Inhibitor genes in lacrimal gland epithelial cells suppresses their ability to activate lymphocytes'. Cornea, 21 :210-214. [Details] |
| Doebis,C., Ritter, T., Brandt, C., Schonberger, B., Volk, H.-D., Seifert, M. (2002) 'Efficient in vitro transduction of epithelial cells and keratinocytes with improved adenoviral gene transfer for the application in skin tissue engineering'. Transplant Immunology, 9 :323-329. [Details] |
| Sawitzki, B., Amersi, F., Ritter, T., Fisser, M., Shen, X-D., Busuttil, R., Volk, H.-D., Kupiec-Weglinski, J.W. (2002) 'Upregulation of Bag-1 by ex-vivo gene transfer protects rat livers from ischemia/reperfusion injury'. Human Gene Therapy, 13 :1495-1504. [Details] |
| Holm, P.S., Lage, H., Bergmann, S., Jurchott, K., Glockzin, G., Bernshausen, A., Mantwill, K., Ladhoff, A., Wichert, A., Mymryk, J.S., Ritter, T., Dietel, M., Gansbacher, B., Royer, H.D. (2003) 'Efficiency of cytokine gene transfer in corneal endothelial cells and organ cultured corneas mediated by liposomal vehicles and recombinant adenovirus'. Ophthalmic Research, 35 :117-124. [Details] |
| Sass, G., Soares, M.C., Yamashita, K., Seyfried, S., Zimmermann, W.H., Eschenhagen, T., Kaczmarek, E., Ritter, T., Volk, H.D., Tiegs, G. (2003) 'Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice'. Hepatology, 38 :909-918. [Details] |
| Kawakami, N., Lassmann, S., Li, Z., Odoardi, F., Ritter, T., Ziemssen, T., Klinkert, W.E.F., Ellwart, J.W., Bradl, M., Lassmann, H., Ransohoff, R.M., Volk, H.-D., Wekerle, H., Linington, C., Flügel, A. (2003) 'TNF-inhibitor gene expression suppresses lacrimal gland immunopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis'. Cornea, 22 :343-351. [Details] |
| Yang, J., Reutzel-Selke, A., Steier, C., Jurisch, A., Tullius, S.G., Sawitzki, B., Kolls, J., Volk, H.-D., Ritter, T (2003) 'Targeting of macrophage activity by adenovirus -mediated intragraft over-expression of TNFRp55-Ig, IL-12p40, and vIL-10 ameliorates whereas stimulation of macrophages by over-expression of IFN-? accelerates chronic graft injury in a rat renal allograft model'. J. Am. Soc. Nephrol, 14 :214-225. [Details] |
| Holm, P.S., Lage, H., Bergmann, S., Jurchott, K., Glockzin, G., Bernshausen, A., Mantwill, K., Ladhoff, A., Wichert, A., Mymryk, J.S., Ritter, T., Dietel, M., Gansbacher, B., Royer, H.D. (2004) 'Multidrug-resistant Cancer Cells Facilitate E1-independent Adenoviral Replication: Impact for Cancer Gene Therapy'. Cancer Res, 64 (1):322-328. [Details] |
| Aboul-Enein F, Bauer J, Klein M, Schubart A, Flugel A, Ritter T, Kawakami N, Siedler F, Linington C, Wekerle H, Lassmann H, Bradl M. (2004) 'Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis'. Invest. Ophthal. Vis. Sci, 45 (5):1375-1381. [Details] |
| Aboul-Enein F, Bauer J, Klein M, Schubart A, Flugel A, Ritter T, Kawakami N, Siedler F, Linington C, Wekerle H, Lassmann H, Bradl M. (2004) 'Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammation'. J Neuropathol Exp Neurol, 63 (12):1284-1296. [Details] |
| Beyer F, Doebis C, Busch A, Ritter T, Mhashilkar A, Marasco WM, Laube H, Volk HD, Seifert M (2004) 'Decline of surface MHC I by adenoviral gene transfer of anti-MHC I intrabodies in human endothelial cells - new perspectives for the generation of universal donor cells for tissue transplantation'. J Gene Med, 4 (6):616-623. [Details] |
| Kawakami, N., Lassmann, S., Li, Z., Odoardi, F., Ritter, T., Ziemssen, T., Klinkert, W.E.F., Ellwart, J.W., Bradl, M., Lassmann, H., Ransohoff, R.M., Volk, H.-D., Wekerle, H., Linington, C., Flügel, A. (2004) 'The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of experimental autoimmune encephalomyelitis'. J. Exp. Med, 199 (2):185-197. [Details] |
| Pleyer, U., Yang, J., Knapp, S., Schäcke H., Schmees N., Orlic, N., Otasevic, L., De Ruijter, M., Ritter, T., Keipert, S. (2004) 'FTY720 prevents anti-CD4 induced tolerance but cannot reverse established tolerance in a rat kidney transplantation model'. Am J Transplant, 4 (6):863-871. [Details] |
| Pleyer, U., Yang, J., Knapp, S., Schäcke H., Schmees N., Orlic, N., Otasevic, L., De Ruijter, M., Ritter, T., Keipert, S (2005) 'Effects of a selective steroid receptor agonist (SEGRA) on experimental keratoplasty'. Graefes Arch Clin Exp Ophthalmol, 243 :450-455. [Details] |
| Brandt, C., Yang, J., Hammer, M., Schmitt-Knosalla, I., Siepert, A., Hammer, M.H., Vogt, K., Sawitzki, B., Lehmann, M. Volk, H-D, Ritter, T (2005) 'Allo-specific T-cells encoding for viral IL-10 exert strong immunomodulatory effects in vitro but fail to prevent allogeneic graft rejection'. Am J Transplant, 5 (2):268-281. [Details] |
| Zenclussen, A., C., Gerlof, K., Zenclussen, M.L., Sollwedel, A., Bertoja, A.Z., Ritter, T., Kotsch, K., Leber, J., Volk, H.D (2005) 'Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model'. Am J Pathol, 166 (3):811-822. [Details] |
| Zenclussen, M.L., Anegon, I., Bertoja, A.Z., Chauveau, C., Vogt, K., Gerlof, K., Sollwedel, A., Volk, H.D., Ritter, T., Zenclussen, A.C. (2005) 'Interleukin-4 gene transfer into rat pancreas by recombinant adenovirus'. Scand J Gastroenterology, 40 (9):1109-1117. [Details] |
| Kawakami, N., Odoardi, F., Ziemssen, T., Bradl., M., Ritter, T., Neuhaus, O., Lassmann, H., Wekerle, H., Fluegel, A. (2005) 'Autoimmune CD4+ T cell memory: Life long persistence of encephalitogenic T cell clones in healthy immune repertoires'. J Immunol, 175 (1):69-81. [Details] |
| Trousdale, M.D., Zhu, Z., Stevenson, D., Schechter, J.E., Ritter, T., Mircheff, A. (2005) 'Expression of TNF Inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis'. J. Autoimmune Dis, 2 (1). [Details] |
| Zenclussen, M.L., Anegon, I., Bertoja, A.Z., Chauveau, C., Vogt, K., Gerlof, K., Sollwedel, A., Volk, H.D., Ritter, T., Zenclussen, A.C. (2006) 'Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion'. J Reprod Immunol, 69 (1):35-52. [Details] |
| Brock, P., Sparmann, G., Ritter, T., Jaster, R., Liebe, S., Emmrich, J. (2006) 'Adenovirus-mediated gene transfer of interleukin-4 into pancreatic stellate cells promotes interleukin-10 expression'. J. Cell Mol Med, 10 (4):884-895. [DOI] [Details] |
| Gong, N., Pleyer, U., Yang, J., Vogt, K., Hill, M., Anegon, I., Volk, H.-D., Ritter, T. (2006) 'Influence of local and systemic CTLA4Ig gene transfer on corneal allograft survival'. J. Gene Med, 8 (4):459-467. [DOI] [Details] |
| Murray, T.V.A., McMahon, J.M., Howley, B., Stanely, A., Ritter, T., Mohr, A., Zwacka, R., Fearnhead, H.O. (2007) 'Effects of Interleukin-12p40 gene transfer on rat corneal allograft survival'. Transplant Immunology, 18 :101-107. [Details] |
| Ke, B., Shen, X.-D., Tsuchihashi, S., Gao, F., Araujo, J.A., Busuttil, R.W., Ritter, T., Kupiec-Weglinski, J.W. (2007) 'Viral Interleukin-10 Gene Transfer Prevents Liver Ischemia-Reperfusion Injury: Toll-Like Receptor-4 and Heme Oxygenase-1 Signaling in Innate and Adaptive Immunity'. Hum Gene Ther, 18 (4):355-366. [Details] |
| Listopad, J., Asadullah, K., Sievers, C. Ritter, T., Meisel, C., Sabat, R., Docke, W.-D. (2007) 'Heme oxygenase-1 inhibits T-cell dependent skin inflammation and differentiation and function of antigen presenting cells'. Exp Dermatol, 16 :661-670. [Details] |
| Reeve, J.L.V., Szegezdi, E., Logue, S.E., Ni Chonghaile, T., O'Brien, T., Ritter, T., Samali, A. (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by Doxorubicin and Hypoxia converge on mitochondria and are inhibited by Bcl-xL'. J. Cell Mol Med(IF: 6.8), 11 (3):509-520. [Details] |
| Listopad, J., Asadullah, K., Sievers, C. Ritter, T., Meisel, C., Sabat, R., Docke, W.-D. (2007) 'Local over-expression of nerve growth factor in corneal transplants improves allograft survival'. Invest. Ophthal. Vis. Sci, 48 :1043-1052. [Details] |
| Kuttler, B., Wanka, H., Kloting, N., Gerstmayer, B., Volk, H.D., Sawitzki, B., Ritter, T. (2007) 'Ex-vivo gene transfer of viral interleukin-10 to BB rat islets: No protection after transplantation to diabetic BB rats'. J. Cell Mol Med, 11 (4):868-880. [DOI] [Details] |
| Gong, N., Ecke, I., Mergler, S., Yang, J., Metzner, S., Schu, S., Volk, H.-D., Pleyer, U., Ritter, T. (2007) 'Gene transfer of cyto-protective molecules in corneal endothelial cells and cultured corneas: Analysis of protective effects in vitro and in vivo'. Biochem Biophys Res Commun, 357 (1):302-307. [DOI] [Details] |
| Otasevic, L., Gong, N., Ritter, T., Mergler, S., Pleyer, U. (2007) 'Effects of Spirolactone on corneal allograft survival in the rat'. Ophthalmic Res, 39 :325-329. [Details] |
| Fabian, D., Gong, N., Vogt, K., Volk, H.-D., Pleyer, U., Ritter, T. (2007) 'Influence of Inducible Co-stimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival'. Graefes Arch Clin Exp Ophthalmol, 245 (10):1515-1521. [Details] |
| Ke, B., Shen, X.-D., Tsuchihashi, S., Gao, F., Araujo, J.A., Busuttil, R.W., Ritter, T., Kupiec-Weglinski, J.W. (2007) 'Effects of local and systemic viral Interleukin-10 gene transfer on corneal allograft survival'. Gene Ther, 14 (6):484-490. [DOI] [Details] |
| Murray, T.V.A., McMahon, J.M., Howley, B., Stanely, A., Ritter, T., Mohr, A., Zwacka, R., Fearnhead, H.O. (2008) 'A non-apoptotic role for Caspase-9 in muscle differentiation'. J Cell Sci, 121 ((Pt 22)):3786-3793. [Details] |
| Rooney GE, Moran C, McMahon SS, Ritter T, Maenz M, Flügel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry FP. (2008) 'Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate'. Tissue Eng Part A, 14 (5):681-690. [Details] |
| Holohan, C., Szegezdi, E., Ritter, T., O'Brien, T., Samali, A. (2008) 'Cytokine-induced beta-cell apoptosis is NO dependent, mitochondria-mediated and inhibited by bcl-xl'. J. Cell Mol Med, 12 (2):591-606. [DOI] [Details] |
| Kealy, B, Liew, A, McMahon, JM, Ritter, T, O'Doherty, A, Hoare, M, Greiser, U, Maenz, M, O'Shea, C, Barry FP, O'Brien T (2009) 'Comparison of viral and non-viral vectors for gene transfer to human endothelial progenitor cells'. Tissue Eng Part C Methods, 15 (2):223-231. [Details] |
| Rooney, G.E., McMahon, S.S., Ritter, T., Garcia, Y., Moran, C., Madigan, N.N., Fluegel, A., Dockery, P., O'Brien, T., Howard, L., Windebank, T., Barry, F.P. (2009) 'Neurotrophic factor-expressing mesenchymal stem cells survive transplantation into the contused spinal cord without differentiating into neural cells'. Tissue Eng Part A, 15 (10):3049-3059. [Details] |
| Gong, N., Pleyer, U., Ritter, T., Knop, E., Chen, X. (2009) 'Corneal allograft endothelial cell replacement represents a reparative response to transplant injury'. Mol Vis, 15 :654-661. [Details] |
| Hoare M, Greiser U, Schu S, Mashayekhi K, Aydogan E, Murphy M, Barry F, Ritter T, O'Brien T (2010) 'Enhanced lipoplex-mediated gene expression in mesenchymal stem cells using reiterated nuclear localization sequence peptides'. J Gene Med, 12 (2). [Details] |
| Stanjolivic, S., Schlickeiser, S., Appelt, C., Vogt, K., Schmitt-Knosalla, I., Haase, S., Ritter, T., Sawitzki, B. and U. Pleyer. (2010) 'Influence of combined treatment with rapamycin and cyclosporine A on corneal allograft survival in mice'. Graefes Arch Clin Exp Ophthalmol, 248 (10):1447-1456. [Details] |
| Maenz, M., Morcos,M., & Ritter, T. (2011) 'A comprehensive flow-cytometric analysis of graft infiltrating lymphocytes, draining lymph nodes and serum during the rejection phase in a fully allogeneic rat cornea transplant model'. Mol Vis, 17 :420-429. [ARAN Link] [Details] |
| Schu, S., Nosov, M., O’Flynn, L., Shaw, G., Treacy, O., Barry, F., Murphy, M., O’Brien, T., Ritter, T (2011) 'Immunogenicity of allogeneic mesenchymal stem cells'. J Cell Mol Med, . [Details] |
| Schlickeiser, S., Stanjolivic, S., Appelt, C., Vogt, K., Vogel, S., Haase, S., Ritter, T., Volk, H.-D., Pleyer, U., Sawitzki, B. (2011) 'Control of tumor necrosis factor-induced dendritic cell maturation and subsequent priming of T cells by hybrid-type N-glycans'. J. Immunology, 186 (9):5201-5211. [DOI] [Details] |
| Nosov, M., Wilk, M., Morcos, M., Cregg, M., O’Flynn, L., Treacy, O., Ritter, T (2012) 'Role of lentivirus-mediated overexpression of Programmed Death Ligand-1 on corneal allograft survival'. Am J Transplant, . [Details] |
Editorial
| Ritter, T,Gong, N,Pleyer, U (2005) Is ex vivo adenovirus mediated gene transfer a therapeutic option for the treatment of corneal diseases?. Editorial [DOI] [Details] |
Reviews
| Pleyer, U., Rieck, P., Ritter, T., Hartmann C. (1998) Immunreaktion nach perforierender Keratoplastik. II. Prävention und Therapie. Ophthalmologe. Reviews [Details] |
| Pleyer, U., Ritter, T., Volk, H.-D. (2000) Immune tolerance and gene therapy in transplantation. Immunology Today. Reviews [Details] |
| Pleyer, U., Dannowski, H., Volk, H.-D., Ritter, T. (2001) Invited review: Corneal allograft rejection: Current understanding. Ophthalmologica. Reviews [Details] |
| Sawitzki, B., Lehmann, M., Ritter, T., Graser, E., Kupiec-Weglinski, J.W., Volk, H.D. (2001) Regulatory tolerance-mediating T cells in transplantation tolerance. Transplant Proc. Reviews [Details] |
| Pleyer, U., Dannowski, H., Reszka, R., Volk, H.-D., Hartmann, C., Ritter, T. (2001) Gentherapie in der Ophthalmologie. Übersicht über Perspektiven und Möglichkeiten für Erkrankungen der Kornea. Klin. Monatsblätter für Augenheilkunde. Reviews [Details] |
| Ritter, T., Lehmann, M., Volk, H.-D. (2002) Invited review: Improvements in gene therapy: Averting the immune response to adenoviral vectors. Biodrugs. Reviews [Details] |
| Pleyer, U., Ritter, T. (2003) Invited Review: Gene therapy in immune mediated diseases of the eye. Progress in Retinal and Eye Research. Reviews [Details] |
| Ritter, T., Volk, H.-D (2003) Gentherapie in der Transplantation: Experimentelle Ansätze zum Transfer anti-inflammatorischer und zytoprotektiver Gene zur Transplantaterhaltung. Dtsch Med Wochenschr. Reviews [Details] |
| Ritter T., Volk, H.-D. (2004) Role of IL-10 in transplantation. Invited Review. Landes Bioscience, Ed. FM Marincola, 2004. Reviews [Details] |
| Ritter T., Kupiec-Weglinski JW. (2005) Gene therapy for the prevention of ischemia/reperfusion injury in transplantation. Invited review. Curr Gene Ther. Reviews [Details] |
| Zenclussen AC, Zenclussen ML, Ritter, T., Volk, H.-D. (2005) The use of gene therapy tools in reproductive immunology research. Curr Gene Ther. Reviews [Details] |
| RITTER, T et al. (2009) Gene therapy in transplantation: Toward clinical trials. CURRENT OPINION IN MOLECULAR THERAPEUTICS. Reviews [ARAN Link] [Details] |
| RITTER, T et al. (2009) Novel gene therapeutic strategies for the induction of tolerance in cornea transplantation. EXPERT REVIEW OF CLINICAL IMMUNOLOGY. Reviews [Details] |
| Ritter, T., and Pleyer, U. (2009) Novel gene therapeutic approaches for the induction of tolerance in cornea transplantation. Exp. Rev. Clin. Immunol. Reviews [Details] |
| Griffin M, Greiser U, Barry FP, O'Brien T, Ritter T (2010) Genetically Modified Mesenchymal Stem Cells and Their Clinical Potential in Acute Cardiovascular Disease. Discovery Medicine. Reviews [Details] |
| Griffin, M., Ritter, T., Mahon, B. (2010) Immunological aspects of allogeneic mesenchymal stem cell therapies. Invited Review. Human Gene Therapy. Reviews [Details] |
| Duffy, M. M., Ritter, T., Ceredig, R. and Griffin, M.D. (2011) Mesenchymal Stem Cell Effects on T-cell Effector Pathways. Stem Cell Research & Therapy. Reviews [Details] |
