Research Interests

To restore nitric oxide bioavailability in the atherosclerotic blood vessel via gene transfer. The overall aim is to study gene therapy approaches to atherosclerosis in animal models and ultimately to translate the results of this research to clinical trials. 1.The use of adenoviral and AAV vectors encoding nitric oxide synthase and superoxide dismutase to study potential gene therapy approaches to cholesterol-induced vascular dysfunction. 2.The study of gene therapy approaches to diabetic vascular dysfunction using adenoviral mediated gene transfer to the blood vessels of the alloxan induced diabetic rabbit. 3.Adenoviral-mediated gene transfer to the islets of Langerhans and gene therapy approaches to IDDM. 4.Gene therapy of lipid disorders, cardiovascular disease and diabetes mellitus.

 

 

Book Chapters

Katusic ZS, Tsutsui M, Chen AFY, O'Brien T, Crotty TB (1998) 'Adventitial fibroblasts as target cells for expression of recombinant endothelial nitric oxide synthase gene' In: The Biology of Nitric Oxide. [Details]

Caplice N, O'Brien T, Simari RD (1999) 'Adenoviral vectors for cardiovascular gene transfer' In: Adenoviral Vectors for Cardiovascular Diseases. [Details]

Chen AFY, O'Brien T, Katusic ZS (1999) 'Therapeutic implications of recombinant endothelial nitric oxide synthase gene expression in cerebral and peripheral arteries' In: Pathophysiology and Clinical Applications of Nitric Oxide, Therapeutic Applications 5. [Details]

Chen AFY, O'Brien T, Katusic ZS (2000) 'Functional influence of gene transfer of recombinant nitric oxide synthase to cardiovascular system' In: NITRIC OXIDE Biology and Pathobiology, Section III, Principles of Pathobiology. [Details]

Katusic ZS, Chen AFY, O'Brien T (2000) 'Cerebrovascular effects of recombinant endothelial nitric oxide synthase gene expression and activation' In: Mechanisms of Cerebrovascular Function and Regulation. [Details]

Bell, M, Flaherty, G, O'Brien, T, Mulkerrin, EC (2003) 'Endocrine and metabolic problems' In: Mulkerrin Medicine for Older Patients - Cases and Practice, Eireann Publications. [Details]

Michela Zanetti, Livius V d'Uscio, Timothy E Peterson, Zvonimir S Katusic and Timothy O'Brien (2004) 'Analysis of Superoxide Anion Production in Tissue' In: Edited by JP Fennell and AH Baker. [Details]

Sen S, Strappe, PM, O'Brien T (2004) 'Gene transfer in Endothelial Dysfunction and Hypertension' In: Humana Press Inc Totowa, NJ. [Details]

O'Brien, T (2006) 'Disorders of high-density lipoprotein cholesterol' In: The American Association of Clinical Endocronologists. [Details]

Murphy, MS, O'Brien, T (2008) 'Therapy of Dyslipidemias' In: Pharmacology and Therapeutics. [Details]

Duffy AM, O'Brien T, McMahon JM (2010) 'Generation of Anti-Oxidant Adenovirus Gene Transfer Vectors Encoding CuZnSOD, MnSOD and Catalase' In: Methods Mol Biol. [Details]

Smith D, Dubé M, Jellinger P, Mehta A, Montague T, Murphy B, O'Brien T, Patel A, Rodbard H (2010) 'Disorders of HDL metabolism' In: American College of Endocrinology CME Publication. [Details]

O'Reilly M, O Brien T (2010) 'Controversies in the management of diabetes mellitus' In: Are statins the best way to treat diabetic dyslipidemia. [Details]

Eglon M, McGrath B, O'Brien, T (2010) 'HPLC Purification of Adenoviral Vectors' In: Methods Mol Biol. [Details]

Hynes SO, McCabe C, O'Brien T (2011) 'ß Cell Protection by Inhibition of iNOS through Lentiviral Vector-Based Strategies' In: Methods Mol Biol. [Details]

O'Loughlin A, O'Brien T, (2011) 'Topical stem and progenitor cell therapy for Diabetic foot ulcers' In: Type 1 Diabetes/Book 3. Croatia: In Tech Publishers. [Details]

Vincenz L, Szegezdi E, Jaegar R, Holohan C, O'Brien T, Samali A. (2011) 'Cytokine-Induced B-cell stress and death in Type 1 Diabetes' In: Type 1 Diabetes Complications. Croatia: Intech Publisher. [Details]

 

Peer Reviewed Journals

O'Brien T, Barrett B, Murray DM, Dinneen S, O'Sullivan DJ (1990) 'Usefulness of Biochemical Screening of Diabetic Patients for Hemochromatosis'. Diabetes Care, 13 (5):532-534. [Details]

Murray DM, O'Brien T, Mulrooney R, O'Sullivan DJ (1990) 'Autonomic Dysfunction and Silent Myocardial Ischemia on Exercise Testing in Diabetes Mellitus'. Diabetic Medicine, 7 :580-584. [Details]

O'Brien T, Bolster M, Sullivan P. (1990) 'Fabry's Disease: A Family Study'. IRISH JOURNAL OF MEDICAL SCIENCE, 159 :580-584. [Details]

Kinsella P, O'Brien T, Brosnan E, O'Sullivan DJ. (1991) 'A case of pregnancy associated osteoporosis and empty sella syndrome'. IRISH MEDICAL JOURNAL, 84 :25-26. [Details]

Klein L, Miller TD, Radam TE, O'Brien T, Nguyen TT, Kottke BA (1992) 'Acute physical exercise alters apolipoprotein E and CIII concentrations of apo E rich very low density lipoprotein fraction'. Atherosclerosis, 97 :37-51. [Details]

O'Brien T, Gharib H, Suman VJ, van Heerden JA (1992) 'Treatment of toxic solitary thyroid nodules: Surgery vs radioactive iodine'. Surgery, 112 :1166-1170. [Details]

Dinneen SF, O'Mahony MS, O'Brien T, Cronin C, Murray DM, O'Sullivan DJ (1992) 'Serum ferritin in newly diagnosed and poorly controlled diabetes mellitus'. Irish J Med Sci, 161 :636-638. [Details]

Dinneen SF, O'Mahony MS, O'Brien T, Cronin C, Murray DM, O'Sullivan DJ. (1992) 'Serum ferritin in newly diagnosed and poorly controlled diabetes mellitus'. IRISH JOURNAL OF MEDICAL SCIENCE, 161 :636-638. [Details]

O'Brien T, Buithieu J, Nguyen TT, Klein L, Bren N, Wentworth M, Hallaway BJ, Kottke BA (1993) 'Separation of high-density lipoproteins into apolipoprotein E-poor and apoliprotein E-rich subfractions by fast protein liquid chromatography using a heparin affinity column'. J Chromatogr (Biomedical Applications), 613 :239-246. [Details]

O'Brien T, O'Brien PC, Service FJ (1993) 'Insulin surrogates in insulinoma'. J Clin Endocrinol Metab, 77 :448-451. [Details]

O'Brien T, Nguyen TT, Buithieu J, Kottke BA (1993) 'Lipoprotein compositional changes in the fasting and postprandial state on a high-carbohydrate low-fat and a high-fat diet in subjects with noninsulin-dependent diabetes mellitus'. J Clin Endocrinol Metab, 77 :1345-1351. [Details]

O'Brien T, Dinneen SF, O'Brien PC, Palumbo PJ (1993) 'Hyperlipidemia in patients with primary and secondary hypothyroidism'. Mayo Clinic Proceedings, 68 :860-866. [Details]

O'Brien T, Young WF Jr, Palumbo PJ, O'Brien PC, Service FJ (1993) 'Hypertension and dyslipidemia in patients with insulinoma'. Mayo Clinic Proceedings, 68 :141-146. [Details]

O'Riordan DS, O'Brien T, Grant CS, Gharib H, Weaver A, Gharib H, van Heerden JA (1993) 'Surgical management of hyperparathyroidism in multiple endocrine neoplasia syndrome'. Surgery, 114 :1031-1039. [Details]

Wentworth M, O'Brien T, Rastogi A, Kottke BA (1993) 'Apolipoprotein A-II levels and coronary artery disease in subjects with and without diabetes: A study with use of a specific radioimmunoassay for apolipoprotein A-II'. Mayo Clinic Proceedings, 68 :556-560. [Details]

O'Riordain DS, O'Brien T, Weaver, Gharib H, Hay ID, Grant CS, van Heerden JA (1994) 'Medullary thyroid carcinoma in multiple endocrine neoplasia types 2a and 2b'. Surgery, 116 :1017-1023. [Details]

O'Riordain DS, O'Brien T, van Heerden JA, Service FJ, Grant CS (1994) 'Surgical management of insulinoma associated with multiple endocrine neoplasia type 1'. World J of Surgery, 18 :488-494. [Details]

O'Brien T, Nguyen TT, Harrison J, Bailey K, Dyck PJ, Kottke BA (1994) 'Lipids and Lp(a) lipoprotein levels and coronary artery disease in subjects with non-insulin-dependent diabetes mellitus'. Mayo Clinic Proceedings, 69 :430-435. [Details]

O'Brien T, Nguyen TT, Bren ND, Kottke BA (1995) 'Diet and Lp(a) in NIDDM'. Nutr Metab Cardiovasc Dis, 5 :17-22. [Details]

O'Brien T, Nguyen TT, Hallaway BJ, Hodge D, Bailey K, Holmes D, Kottke BA (1995) 'The role of lipoprotein A-I and lipoprotein A-I / A-II in predicting the presence of coronary artery disease'. Arteriosclerosis, Thrombosis and Vascular Biology, 15 :228-231. [Details]

O'Riordain DS, O'Brien T, Crotty TB, Gharib H, Grant C, van Heerden JH (1995) 'Multiple endocrine neoplasia type 2B: More than an endocrine disorder'. Surgery, 118 :936-942. [Details]

O'Brien T, O'Riordain D, Gharib H, Scheithauer BW, Ebersold M, van Heerden JA (1996) 'Results of treatment of pituitary disease in multiple endocrine neoplasia type I'. Neurosurgery, 39 :273-279. [Details]

O'Brien T, Nguyen TT, Hallaway BJ, Hodge D, Bailey K, Kottke BA (1996) 'HDL subparticles and coronary artery disease in NIDDM'. Atherosclerosis, 121 :285-291. [Details]

Yap J, O'Brien T, Tazelaar HD, McGregor CGA (1997) 'Immunosupression prolongs adenoviral mediated transgene expression in cardiac allograft transplantation'. Cardiovascular Research, 35 :529-535. [Details]

O'Brien T, Katz K, Hodge D, Nguyen TT, Hay I, Kottke BA (1997) 'The effect of the treatment of hypothyroidism and hyperthyroidism on plasma lipids and apolipoproteins AI, AII and E'. Clinical Endocrinology, 46 :17-20. [Details]

Kullo IJ, Mozes G, Schwartz RS, Gloviczki P, Tsutsui M, Katusic ZS, O'Brien T (1997) 'Enhanced endothelium-dependent relaxations after gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries'. Hypertension, 30 :314-320. [Details]

Kullo IJ, Mozes G, Schwartz R, Gloviczki P, Crotty TB, Barber DA, Katusic ZS, O'Brien T (1997) 'Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity'. Circulation, 96 :2254-2261. [Details]

Cable DG, O'Brien T, Kullo IJ, Schwartz RS, Schaff HV, Pompili VJ (1997) 'Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries'. Cardiovascular Research, 35 :553-559. [Details]

Cable DG, O'Brien T, Schaff HV, Pompili VJ (1997) 'Recombinant endothelial nitric oxide synthase-transduced human saphenous veins: Gene therapy to augment nitric oxide production in bypass conduits'. Circulation, 96(Suppl):II-173-8, 1997 :173-178. [Details]

Chen AFY, Jiang SW, Crotty TB, Tsutsui M, Smith LA, O'Brien T, Katusic ZS (1997) 'Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries'. Proc Natl Acad Sci USA, 94 :12568-12573. [Details]

Kullo IJ, Schwartz RS, Pompili V, Tsutsui M, Milstien S, Fitzpatrick LA, Katusic ZS, O'Brien T (1997) 'Expression and function of recombinant endothelial NO synthase in coronary artery smooth muscle cells'. Arteriosclerosis, Thrombosis and Vascular Biology, 17 :2405-2412. [Details]

Chen AF, O'Brien T, Tsutsui M, Kinoshita H, Pompili VJ, Crotty TB, Spector DJ, Katusic ZS (1997) 'Expression and function of recombinant endothelial nitric oxide synthase gene in the canine basilar artery'. Circulation Research, 80 :327-335. [Details]

O'Sullivan DJ, Cronin C, Buckley D, Mitchell TM, Jenkins DJ, Greally J, O'Brien T. (1997) 'Unusual manifestations of type 1 autoimmune polyendocrinopathy'. IRISH MEDICAL JOURNAL, 90 :100-103. [Details]

Kullo IJ, Mozes G, Schwartz R, Gloviczki P, Crotty TB, Barber DA, Katusic ZS, O'Brien T. (1997) 'Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity'. CIRCULATION, 96 :2254-2261. [Details]

Onoue H, Tsutsui M, Smith L, Stelter A, O'Brien T, Katusic Z (1998) 'Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery after experimental subarachnoid hemorrhage'. Stroke, 28 (9):1959-1965. [Details]

Levine JA, Jensen MD, Eberhardt NL, O'Brien T (1998) 'Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth'. J Clin Invest, 101 :1557-1564. [Details]

Jeppsson A, Pellegrini C, O'Brien T, Miller VM, Tazelaar HD, McGregor C (1998) 'Transbronchial gene transfer of endothelial nitric oxide synthase to transplanted lungs'. Annals of Thoracic Surgery, 66 (2):318-324. [Details]

Cable DG, Caccitolo JA, Pearson PJ, O'Brien T, Mullany CJ, Daly RC, Orszulak TA, Schaff HV. (1998) 'New approaches to prevention and treatment of vasospasm of radial artery bypass grafts'. CIRCULATION, 98 :15-22. [Details]

Mozes G, Mohasci T, Gloviczki P, Menawat S, Kullo IJ, Spector D, Taylor J, Crotty T, O'Brien T (1998) 'Adenovirus-mediated gene transfer of macrophage colony stimulating factor to the arterial wall in vivo'. Arterioscler Thromb Vasc Biol, 18 :1157-1163. [Details]

Mozes G, Kullo IJ, Mohasci TG, Cable D, Crotty T, Gloviczki P, Katusic ZS, O'Brien T (1998) 'Ex vivo gene transfer of endothelial nitric oxide synthase to atherosclerotic rabbit aortic rings improves relaxations to acetylcholine'. Atherosclerosis, 141 (2):265-271. [Details]

Jeppsson A, Lee RJ, Pelligrini C, O'Brien T, Tazelaar HD, McGregor CGA (1998) 'Gene therapy in lung transplantation: effective gene transfer via the airways'. Journal of Thoracic and Cardiovascular Surgery, 115 (3):638-643. [Details]

Tsutsui M, Chen AFY, O'Brien T, Crotty TB, Katusic Z (1998) 'Adventitial expression of recombinant eNOS gene restores NO production in arteries without endothelium'. Arterioscler Throm Vasc Biol, 18 :1231-1241. [Details]

Pellegrini C, O'Brien T, Yap J, Jeppsson A, Tazelaar HD, McGregor CGA (1998) 'Systemic evaluation of distribution of transgene expression after adenovirus-mediated gene transfer to the transplanted heart'. Transplant International, 11 (5):373-377. [Details]

Cable DG, Caccitolo JA, Pearson PJ, O'Brien T, Mullany CJ, Daly RC, Orszulak TA, Schaff HV (1998) 'New approaches to prevention and treatment of vasospasm of radial artery bypass grafts'. Circulation, 98:II-15-II-22, 1998 . [Details]

O'Brien T, Nguyen TT, Hodge D, Kottke BA (1998) 'The effect of a high carbohydrate diet on Apo-E poor and Apo-E rich HDL subparticles in NIDDM'. Nutrition, Metabolism and Cardiovascular Diseases, 8 :85-91. [Details]

Pellegrini C, O'Brien T, Jeppsson A, McGregor CGA (1998) 'Influence of temperature on adenovirus-mediated gene transfer'. European Journal of Cardio-thoracic Surgery, 13 :599-603. [Details]

Tsutsui M, Chen AF, O'Brien T, Crotty TB, Katusic ZS (1998) 'Adventitial expression of recombinant eNOS gene restores NO production in arteries without endothelium'. Arterioscler Thromb Vasc Biol, 18 :1231-1241. [Details]

Levine JA, Eberhardt NL, Jensen MD, O'Brien T (1998) 'Adenoviral-mediated gene transfer to human adipocytes in vitro, and human adipose tissue ex vivo and rabbit femoral adipose tissue in vivo'. Journal of Nutritional Science & Vitaminology, 44 (4):569-572. [Details]

Cable DG, Caccitolo JA, Caplice N, O'Brien T, Simari RD, Daly RC, Dearani JA, Mullany CJ, Orszulak TA, Schaff HV (1999) 'The role of gene therapy for intimal hyperplasia of bypass grafts'. Circulation, 100: II-392-II-396, 1999 . [Details]

Peus D, Meves A, Vasa RA, Beyerle A, O'Brien T, Pittelkow MR. (1999) 'H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation'. FREE RADICAL BIOLOGY AND MEDICINE, 27 :1197-1202. [Details]

Yap J, O'Brien T, Pellegrini C, Barber DA, Tazelaar HD, Severson SR, Miller VM, McGregor CGA (1999) 'Distribution and function of recombinant endothelial nitric oxide synthase in transplanted hearts'. Cardiovascular Research, 42 (3):720-727. [Details]

Castro MR, Nguyen TT, O'Brien T (1999) 'Clomiphene-induced severe hypertriglyceridemia and pancreatitis: a case report and review of the literature'. Mayo Clinic Proceedings, 74 :1125-1128. [Details]

Peus D, Meves A, Vasa RA, Beyerle A, O'Brien T, Pittelkow MR (1999) 'H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation'. Free Radical Biology and Medicine, 27 :1197-1202. [Details]

Mohasci T, Mozes G, Sato J, Gloviczki P, Katusic Z, O'Brien T (1999) 'L-arginine availability is not limiting for nitric oxide generation from recombinant endothelial nitric oxide synthase'. J Vasc Res, 36 (6):437-444. [Details]

O'Brien T, Karlsen AE, Andersen HU, Mandrup-Poulsen T, Nerup J (1999) 'Absence of toxicity associated with adenoviral-mediated transfer of b-galactosidase reporter gene to neonatal rat islets in vitro'. Diabetes Res Clin Pract, 44 :157-163. [Details]

Tsutsui M, Onoue H, Iida Y, Smith L, O'Brien T, Katusic ZS (1999) 'Adventitia-dependent relaxations of canine basilar arteries transduced with recombinant endothelial nitric oxide synthase gene'. Am J Physiol (Heart Circ Physiol 45), 276 :h1846-h1852. [Details]

Cable D, Caccitolo J, Pfiefer EA, Daly RC, Dearani JA, Mullany CJ, O'Brien T, Orzsulak TA, Schaff HV (1999) 'Endothelial regulation of vascular contractions in radial and internal mammary arteries'. Annals of Thoracic Surgery, 67 :1083-1090. [Details]

Onoue H, Tsutsui M, Smith L, O'Brien T, Katusic ZS (1999) 'Adventitial expression of recombinant endothelial nitiric oxide synthase gene reverses vasoconstrictor effect of endothelin-1'. J Cer Blood Flow Met, 19 :1029-1037. [Details]

Alexander MY, Brosnan MJ, Hamilton CA, Downie P, Devlin AM, Dowell F, Martina W, Prentice HM, O'Brien T, Dominiczak AF (1999) 'Gene transfer of endothelial nitric oxide synthase improves nitric-oxide dependent endothelial function in a hypertensive rat model'. Cardiovascular Research, 43 :798-807. [Details]

Cable DG, Pompili VJ, O'Brien T, Schaff HV (1999) 'Recombinant gene transfer of eNOS augments coronary artery relaxations during hypoxia'. Circulation, 100: II-335-II-339, 1999 . [Details]

Tsutsui M, Onoue H, Iida Y, Smith L, O'Brien T, Katusic ZS. (1999) 'Adventitia-dependent relaxations of canine basilar arteries transduced with recombinant endothelial nitric oxide synthase gene'. AMERICAN JOURNAL OF PHYSIOLOGY Heart Circ. Physiol, 45 (276):H1846-H1852. [Details]

Tsutsui M, Onoue H, Iida Y, Smith L, O'Brien T, Katusic Z (2000) 'Effects of recombinant endothelial nitric oxide synthase gene expression on reactivity of small cerebral arteries'. Heart Circ Physiol, 278 :h420-h427. [Details]

Zanetti M, Sato J, Katusic Z, O'Brien T (2000) 'Gene transfer of endothelial nitric oxide synthase improves endothelium-dependent relaxations in aorta from diabetic rabbits'. Diabetologia, 43 :340-347. [Details]

Jeppsson AZ, Pellegrini C, Lee R, O'Brien T, Miller VM, Tazelaar HD, McGregor CGA (2000) 'Improved efficiency of gene transfer to the transplanted lung by retrograde vascular gene delivery'. Transpl Int, 13 :241-246. [Details]

Khurana VG, Smith LA, Weiler DA, Springett MJ, Meyer FB, Marsh WR, O'Brien T, Katusic ZS (2000) 'Adenovirus-mediated gene transfer to human cerebral arteries'. J Cereb Blood Flow Metab, 20 :1360-1371. [Details]

Sato J, Mohacsi T, Noel A, Jost C, Gloviczki P, Mozes G, Katusic ZS, O'Brien T (2000) 'In vivo gene transfer of endothelial nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits enhances endothelium-dependent relaxations'. Stroke, 31 :968-975. [Details]

Balsiger BM, Kennedy FP, Abu-Lebdah H, Collazo-Clavell M, Jensen MD, O'Brien T, Hensrud DD, Dinneen SF, Thompson GB, Que F, Williams DE, Clark MM, Grant JE, Frick MS, Bueller RA, Mai J, Sarr MG (2000) 'Prospective evaluation of Roux-En-Y gastric bypass as primary operation for medically complicated obesity'. Mayo Clinic Proceed, 75 (7). [Details]

Hanke CJ, O'Brien T, Pritchard KA Jr, Campbell WB (2000) 'Inhibition of adrenal cell aldosterone synthesis by endogenous nitric oxide production'. Hypertension, 35 ((1 Part 2 Suppl S)):324-328. [Details]

Nguyen TT, Kruckeberg KE, O'Brien JF, Ji ZS, Karnes PS, Crotty TB, Hay ID, Mahley RW, O'Brien T (2000) 'Familial splenomegaly: Macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation'. J Clin Endocrinol Metab, 85 (11):4354-4358. [Details]

Jeppsson A, Pellegrini C, O'Brien T, Miller VM, Tazelaar HD, Taner CB, McGregor CG (2000) 'Gene transfer of endothelial nitric oxide synthase to pulmonary allografts: impact on acute rejection'. Transplant International, 13 (1):s591-s596. [Details]

Sato J, Nair KS, Hiddinga J, Eberhardt NE, Fitzpatrick LA, Katusic ZS, O'Brien T (2000) 'eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis'. Cardiovasc Res, 47 (4):697-706. [Details]

Tsutsui M, Onoue H, Iida Y, Smith L, O'Brien T, Katusic Z. (2000) 'B1 and B2 bradykinin receptors on adventitial fibroblasts of cerebral arteries are coupled to recombinant endothelial nitric oxide synthase'. AMERICAN JOURNAL OF PHYSIOLOGY Heart Circ. Physiol, 278 :H367-372. [Details]

Zanetti M, Katusic ZS, O'Brien T (2000) 'Expression and function of recombinant endothelial nitric oxide synthase in endothelial cells'. J Vasc Res, 37 (6):449-456. [Details]

Cable DG, Dearani JA, O'Brien T, Orszulak TA, Puga FJ, Schaff HV (2000) 'Surgical treatment of valvular heart disease in patients with acromegaly'. J Heart Valve Disease, 9 (6):828-831. [Details]

Pellegrini C, Jeppsson A, Taner CB, O'Brien T, Miller VM, Tazelaar HD, McGregor CGA (2000) 'Highly efficient, ex vivo gene transfer to the transplanted heart by hypothermic perfusion with a low dose of adenoviral vector'. J Thor Cardiovasc Surg, 119 :493-500. [Details]

Tsutsui M, Onoue H, Iida Y, Smith L, O'Brien T, Katusic Z (2000) 'B1 and B2 bradykinin receptors on adventitial fibroblasts of cerebral arteries are coupled to recombinant endothelial nitric oxide synthase'. Am J Physiol Heart Circ, 278 :h367-h372. [Details]

Sawka A, Singh RJ, Hiddinga HJ, McConnell JP, Eberhardt NL, Caplice NM, O'Brien T. (2001) 'Remnant lipoproteins from patients with Type III hyperlipoproteinemia increase endothelial secretion of plasminogen activator inhibitor-1'. BIOCHEMICAL AND BIOMEDICAL RESEARCH COMMUNICATIONS, 285 :15-19. [Details]

Zanetti M, Sato J, Katusic ZS, O'Brien T (2001) 'Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta'. Am J Physiol Heart Circ Physiol, 280 :h2516-h2523. [Details]

Zanetti M, Zwacka RM, Engelhardt JF, Katusic ZS, O'Brien T (2001) 'Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia'. Arteriosclerosis, Thrombosis and Vascular Biology, 21 :195-200. [Details]

Sawka A, Singh RJ, Hiddinga HJ, McConnell JP, Eberhardt NL, Caplice NM, O'Brien T (2001) 'Remnant lipoproteins from patients with Type III hyperlipoproteinemia increase endothelial secretion of plasminogen activator inhibitor-1'. Biochem Biophys Res Comm, 285 :15-19. [Details]

Yap J, Pellegrini C, O'Brien T, Tazelaar HD, McGregor CGA (2001) 'Conditions of vector delivery improve efficiency of adenoviral-mediated gene transfer to the transplanted heart'. Eur J Cardiothor Surgery, 19 :702-707. [Details]

Zanetti M, Sato J, Jost CJ, Gloviczki P, Katusic ZS, O'Brien T (2001) 'Gene transfer of manganese superoxide dismutase reverses vascular dysfunction in the absence but not in the presence of atherosclerotic plaque'. Human Gene Therapy, 12 :1407-1416. [Details]

Sato J, O'Brien T, Katusic ZS, Fu A, Nygren JA, Singh R, Nair KS (2001) 'Dietary antioxidants preserve endothelium dependent vasorelaxation in rats fed a high fat diet'. Atherosclerosis, 161 :327-333. [Details]

Hofbauer LC, Riggs BL, Dunstan CR, Spelsberg TC, O'Brien T, Khosla S (2001) 'Effects of immunosuppressants on osteoprotegerin and osteoprotegerin-ligand production by human osteoblastic and coronary artery smooth muscle cells: Potential implications for post-transplant osteoporosis and vascular disease'. Biochem Biophys Res Comm, 280 (1):334-339. [Details]

Ugurlu MM, Griffin MD, O'Brien T, Tazelaar HD, Miller VM, McGregor CGA (2001) 'The effects of CTLA-4Ig on acute lung allograft rejection - a comparison of intrabronchial gene therapy with systemic administration of protein'. Transplantation, 71 :1867-1871. [Details]

Abunasra HJ, Smolenski RT, Morrison K, Yap J, Sheppard M, O'Brien T, K Suzuki, Jayakumar J, Yacoub MH (2001) 'Efficacy of adenoviral gene transfer of Superoxide Dismutase and Nitric Oxide Synthase in reducing ischemia reperfusion injury'. Eur J Cardiothorac Surg, 20 :153-158. [Details]

Zanetti M, Sato J, Katusic ZS, O'Brien T. (2001) 'Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta'. AMERICAN JOURNAL OF PHYSIOLOGY Heart Circ. Physiol, 280 :H2516-H2523. [Details]

Hofbauer LC, Riggs BL, Dunstan CR, Spelsberg TC, O'Brien T, Khosla S. (2001) 'Effects of immunosuppressants on osteoprotegerin and osteoprotegerin-ligand production by human osteoblastic and coronary artery smooth muscle cells: Potential implications for post-transplant osteoporosis and vascular disease'. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 280 (1):334-339. [Details]

Zanetti M, Katusic ZS, O'Brien T. (2002) 'Adenoviral-mediated overexpression of catalase inhibits endothelial cell proliferation'. AMERICAN JOURNAL OF PHYSIOLOGY, 283 (6):H2620-H2626. [Details]

Eguchi D, D'Uscio LV, Wambi C, Weiler D, Kovesdi I, O'Brien T, Katusic ZS (2002) 'Inhibitory effect of recombinant iNOS expression on vasomotor function of canine basilar artery'. Am J Physiol, 283 (6):h2560-h2566. [Details]

Chui, C, O'Brien, T, Schaff, HV (2002) 'Gene Transfer to Cornary Artery Bypass Conduits'. Ann Thorac Surg discussion 1166, 74 (4):1161-1166. [Details]

Kudva YC, O'Brien T, Crotty TB (2002) 'Diabetic mastopathy or sclerosing lymphocytic lobulitis is a breast disorder specific for type 1 diabetes mellitus'. Diabetes Care, 25 :121-126. [Details]

Akiyama M, Eguchi D, Weiler D, O'Brien T, Kovesdi I, Scotland RS, Sessa WC, Katusic ZS (2002) 'Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries'. Stroke, 33 :1071-1076. [Details]

Zanetti M, Katusic ZS, O'Brien T (2002) 'Adenoviral-mediated overexpression of catalase inhibits endothelial cell proliferation'. Am J Physiol, 283 (6):h2620-h2626. [Details]

Eguchi D, D'Uscio LV, Wambi C, Weiler D, Kovesdi I, O'Brien T, Katusic ZS (2002) 'Inhibitory effect of recombinant iNO expression on vasomotor function of canine basilar artery'. AMERICAN JOURNAL OF PHYSIOLOGY, 283 (6):H2560-H2566. [Details]

Khurana VG, Smith LA, Baker TA, Eguchi D, O'Brien T, Katusic ZS (2002) 'Protective vasomotor effects of in vivo recombinant endothelial nitric oxide synthase gene expression in a canine model of cerebral vasospasm'. Stroke, 33 :782-789. [Details]

Abunasra HJ, Smokenski RT, Yap J, Sheppard M, O'Brien T, Yacoub MH (2003) 'Multigene adenoviral therapy for the attenuation of ischemia-reperfusion injury after preservation for cardiac transplantation'. J Thorac Cardiovasc Surg, 125 (5):998-1006. [Details]

Zanetti M, Katusic ZS, O'Brien T (2003) 'In vivo gene transfer of inducible nitric oxide synthase to carotid arteries form hypercholesterolemic rabbits'. Stroke, 34 :1293-1298. [Details]

Khurana V, O'Brien T, Katusic ZS (2003) 'A direct mechanical method for accurate and efficient adenoviral vector delivery to tissues'. Gene Therapy, 10 :443-452. [Details]

Sean O. Hynes, Leslie A. Smith, Darcy M. Richardson, Imre Kovesdi, O'Brien T, Zvonimir S. Katusic. (2004) 'In vivo expression and function of recombinant GTP cyclohydrolase I in the rabbit carotid artery'. AMERICAN JOURNAL OF PHYSIOLOGY, 286 (2):570-574. [Details]

Hynes SO, LA, Smith, DM, Richardson, IK, O'Brien, T, Zvonimir, SK (2004) 'In Vivo Expression and Function of Recombinant GTP Cyclohydrolase I in the Rabbit Carotid Artery'. Am J Physiol Heart Circ Physiol, 286 (2):h570-h574. [DOI] [Details]

Flaherty, G, Bell, M, Dunne, F, O'Brien, T. (2005) '(2005). Mesenchymal stem cell transplantation for tissue repair'. Sem Plast Surg 19:229-239, 19 :229-239. [Details]

Duffy AM, O'Doherty AM, O'Brien T, Strappe P (2005) 'Purification of adenovirus and adeno-associated virus: comparison of novel membrane-based technology to conventional techniques'. Gene Ther, 12 (1):s62-s72. [Details]

Liew A, Barry F, O'Brien T (2005) 'The malady of ascent - an overview of high altitude illness'. Modern Medicine 35 No.2 Feb 2005: 37- 41, 35 (2):37-41. [Details]

McCabe C, Samali A, O'Brien T. (2005) 'Don't Lose Heart - Therapeutic Value of Apoptosis Prevention in the Treatment of Cardiovascular Disease'. Journal of Cellular and Molecular Medicine 2005 Jul-Sep; 9(3):609-22, 9 (3):609-622. [Details]

Szvegezdi E, Duffy A, O'Mahoney ME, Logue SE, Mylotte LA, O'Brien T, Samali A (2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'. Biochem Biophy Res Commun, 349 (4):1406-1411. [DOI] [Details]

O'Brien, T. (2006) 'Endothelial progenitor cells: diagnostic and therapeutic considerations'. Bioessays. 2006 Mar;28(3):261-70, 28 (3):261-270. [Details]

Cooney, R, Hynes, SO, Sharif, F, Howard, O'Brien, T (2006) 'Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury'. Gene Therapy, 14 :396-404. [Details]

Sharif F, Hynes SO, McMahon J, Cooney R, Conroy S, Dockery P, Duffy G, Daly K, Crowley J, Bartlett JS, O'Brien T (2006) 'Gene-Eluting Stents: Comparison of Adenoviral and Adeno-Associated Viral Gene Delivery to the Blood Vessel Wall In Vivo'. Hum Gene Ther, 17 (7):741-750. [Details]

Breen A, Strappe P, Kumar A, O'Brien T, Pandit A (2006) 'Optimization of a fibrin scaffold for sustained release of an adenoviral gene vector'. J Bio Mater Res A, 78 (4):702-708. [Details]

McCabe C, Samali A, O'Brien T (2006) 'Beta cell cytoprotective strategies: establishing the relative roles for iNOS and ROS'. Biochem Biophys Res Commun, 342 (4):1240-1248. [DOI] [Details]

Delappe E, McGreevy C, Ni Chadhain N, Grimes H, O'Brien T, Mulkerrins E (2006) 'Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation'. Eur J Clin Nutr, 60 (8):1009-1015. [Details]

Duffy A, Liew A, O'Sullivan J, Avalos G, Samali A, O'Brien T (2006) 'Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins'. Endothelium, 13 (1):9-16. [DOI] [Details]

Cooney R, Hynes SO, Duffy AM, Sharif F, O'Brien T (2006) 'Adenoviral-mediated gene transfer of nitric oxide synthase isoforms and vascular cell proliferation'. J Vasc Res, 43 (5):462-472. [DOI] [Details]

McMahon JM, Conroy S, Lyons M, Greiser U, O'Shea C, Strappe P, Howard L, Murphy MM, Barry F, O'Brien T (2006) 'Gene transfer into rat mesenchymal stem cells: a comparative study of viral and nonviral vectors'. Stem Cells Dev, 15 (1):87-96. [Details]

Cooney, R, Hynes, S, Duffy, A, Sharif, F, O'Brien, T (2006) 'Adenoviral-mediated gene transfer of nitric oxide synthase isoforms and vascular cell proliferation'. Journal of Vas Res, 43 (5):462-472. [DOI] [Details]

Stender S, Murphy M, O'Brien T, Stengaard C, Ulrich-Vinther M, Soballe K, Barry F (2007) 'Adeno-associated viral vector transduction of human mesenchymal stem cells'. European Cells And Materials, 31 :93-99. [Details]

Reeve, J, Stenson-Cox, C, O'Doherty, A, Porn-Ares, I, Ares, M, O'Brien, T, Samali, A (2007) 'OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/-mice aortas'. Biochemical and Biophysical Research Communications, 356 (3):681-686. [DOI] [Details]

Rao, VP, Branzoli SE, Miyagi N, O'Brien, T, Tazelaar HD, Russell SJ, McGregor CG (2007) 'Recombinant adenoviral gene transfer does not affect cardiac allograft vasculopathy'. J Heart Lung Transplant, 26 (12):1281-1285. [Details]

Dwyer RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Hennessy E, Murphy JM, Barry FP, O'Brien T, Kerin MJ (2007) 'Monocyte Chemotactic Protein-1 (MCP-1) secreted by primary breast tumors stimulates migration of Mesenchymal Stem Cells (MSCs)'. Clinical Cancer Research, 13 (17):5020-5027. [Details]

McCabe C, O'Brien T (2007) 'Beta cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery'. Biochem Biophys Res Commun, 357 (1):75-80. [DOI] [Details]

Reeve JL, Szegezdi E, Logue SE, Chonaighle TN, O'Brien T, Ritter T, Samali A (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL'. J Cell Mol Med, 11 (3):509-520. [DOI] [Details]

Rooney, GE, Moran, C, McMahon, SS, Ritter, T, Maenz, M, Flügel, A, Dockery, P, O' Brien, T, Howard, L, Windebank, AJ , Barry, FP (2008) 'Gene-Modified Mesenchymal Stem Cells express functionally active Nerve Growth Factor on an engineered poly lactic glycolic acid (PLGA) substrate'. Tissue Eng Part A, 14 (5):681-690. [Details]

Mohr A, Lyons M, Deedigan L, Harte T, Shaw G, Howard L, Barry F, O'Brien T, Zwacka R (2008) 'Mesenchymal Stem Cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model'. J Cell Mol Med, 12 (6b):2628-2643. [Details]

Mylotte LA, Duffy AM, Murphy M, O'Brien T, Samali A, Barry F, Szegezdi E (2008) 'Metabolic flexibility permits MSC survival in an ischemic environment'. Stem Cells, 26 (5):1325-1336. [DOI] [Details]

Rooney, GE, Howard, L, O' Brien, T, Windebank, AJ, Barry, FP (2008) 'Elevation of cAMP Induces Transient Upregulation of Neural Markers in Mesenchymal Stem Cells Cultured in a Defined Element Serum-Free Environment'. Stem Cells Dev, . [Details]

Breen, A, Dockery, P, O'Brien, T, and Pandit, A (2008) 'Fibrin Scaffold Promotes Adenoviral Gene Transfer and Controlled Vector Delivery'. J Biomed Mater Res A, . [Details]

Breen, A, Dockery A, O' Brien T, and Pandit A (2008) 'The use of Therapeutic Gene eNOS delivered via a Fibrin Scaffold Enhances Wound Healing in a Compromised Wound Model'. Biomaterials, 29 (21):3143-3151. [DOI] [Details]

Sharif F, Hynes SO, Cooney R, Howard L, McMahon J, Daly K, Crowley J, Barry F, O'Brien, T (2008) 'Gene Eluting Stents: Adenoviral-Mediated Delivery of eNOS to the Blood Vessel Wall Accelerates Re-Endothelialization and Inhibits Restenosis'. Mol Ther, 16 (10):1674-1680. [DOI] [Details]

Gilbert, J, Purcell, J, Strappe, P, McCabe, M, O'Brien, T, O'Dea, S (2008) 'Comparative evaluation of viral, non-viral and physical methods of gene delivery to normal and transformed lung epithelial cells'. Anticancer Drugs, 19 (8):783-788. [Details]

Stender S, Murphy M, O'Brien T, Stengaard C, Ulrich-Vinther M, Søballe K, Barry F. (2008) 'Gene delivery to the vasculature mediated by low-titre adeno-associated virus serotypes 1 and 5'. J Gene Med, 10 (2):143-151. [Details]

Holohan, C, Szegezdi, E, Ritter, T, O'Brien, T, Samali, A (2008) 'Cytokine-induced Beta- Cell Apoptosis is no-dependent, mitochondria-mediated and inhibited by BCL-XL'. J Cell Mol Med, 12 (2):591-606. [DOI] [Details]

O'Brien, T (2008) 'Genetic engineering of the blood vessel wall to improve nitric oxide bioavailability'. Bio-Medical Materials And Engineering, 18 :301-302. [DOI] [Details]

Breen A, Mc Redmond G, Dockery P, O'Brien T, Pandit A (2008) 'Assessment of Wound Healing in the Alloxan Induced Diabetic Rabbit Ear Model'. J Invest Surg, 21 (5):261-269. [Details]

McMahon SS, Albermann S, Rooney GE, Moran C, O'Brien T, Hynes J, Garcia Y, Dockery P, Windebank AJ, Barry FB (2009) 'Effect of Cyclosporin A on functional recovery in the spinal cord following contusion injury'. J Anat, 215 (3):267-279. [Details]

Madsen D, Cantwell ER, O'Brien T, Johnson PA, Mahon BP (2009) 'AAV-2 induces cell mediated immune responses directed against multiple epitopes of the capsid protein VP1'. J Gen Virol, 90 (pt11):2622-2633. [Details]

Rooney, GE, McMahon SS, Ritter T, Garcia Y, Moran C, Madigan NN, Fluegel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry F (2009) 'Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells'. Tissue Eng, 15 (10):3049-3059. [Details]

Kubiak C, De Andres-Trelles F, Kuchinke W, Huemer KH, Thirstrup S, Whitfield K, Libersa C, Barraud B, Grahlert X, Dreier G, Grychtol R, Temesvari Z, Blasko G, Kardos G, O'Brien T, Cooney M, Gaynor S, Schieppati A, Sanz N, Hernandez R, Asker-Hagelberg C, Johansson H, Bourne S, Byrne J, Asghar A, Husson JM, Gluud C, Demotes-Mainard J (2009) 'Common definition for categories of clinical reseach: a prerequisite for a survey on regulatory requirements by the European Clinical Research Infrastructures Network (ECRIN)'. Trials, 10 . [Details]

Rooney GE, Howard L, O'Brien T, Windebank AJ, Barry FP (2009) 'Elevation of cAMP n mesenchymal stem cellls transiently upregulates neural markers rather than inducing neural differentiation'. Stem Cells Dev, 18 (3):387-398. [Details]

O'Toole D, Hassett P, Contreras M, Higgins DB, McKeown STW, McAuley DF, O'Brien T, Laffey JG (2009) 'Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-?B dependent mechanism'. Thorax, 64 (11):976-982. [Details]

Halloday C, Keeney M, Greiser U, Murphy M, O'Brien T, Pandit A (2009) 'A matrix reservoir for improved control of non-viral gene delivery'. Journal of Controlled Release, 136 (3):220-225. [Details]

Molloy AP, Dwyer RM, Martin FT, Griffin TP, Murphy JM, Barry FP, O'Brien T, Kerin MJ (2009) 'Mesenchymal Stem Cell (MSC) secretion of chemokines during differentiation into Osteoblasts, and their potential role in mediating interactions with breast cancer cells'. International Journal of Cancer, 124 (20):326-332. [Details]

Eglon M, Duffy AM, O'Brien T, Strappe PM (2009) 'Purification of adenoviral vectors by combined anion exchange and get filtration chromatography'. JGene Med, 11 (11):978-989. [Details]

Kulkarni M, Breen A, Greiser U, O'Brien T, Pandit A (2009) 'Fibrin-Lipoplex System for Controlled Topical Delivery of Multiple Genes'. Biomacromolecules, 10 (6):1650-1654. [Details]

Duffy GP, Ahsan T, O'Brien T, Barry FP, Nerem M (2008) (2009) 'Bone Marrow Derived Mesenchymal Stem Cells Promote Angiogenic Processes in a Time and Dose Dependent Manner In vitro'. Tissue Engineering, 15 (9):2459-2470. [Details]

MacLoughlin, RJ, Higgins, BD, Laffey JG, O'Brien, T (2009) 'Optimized Aerosol Delivery to a Mechanically Ventilated Rodent'. Journal of Aerosol Medicine and Pulmonary drug delivery, 22 (3). [Details]

Kealy, B, Liew, A, McMahon, JM, Ritter, T, O'Doherty, A, Hoare, M, Greiser, U, Maenz, M, O'Shea, C, Barry FP, O'Brien T (2009) 'Comparison of viral and non-viral vectors for gene transfer to human endothelial progenitor cells'. Tissue Eng Part C Methods, 15 (2):223-231. [Details]

O'Shea CA, Hynes SO, Shaw G, Coen BA, Hynes AC, McMahon J, Murphy M, Barry F, O'Brien T (2010) 'Bolus delivery of mesenchymal stem cells to injured vasculature in the rabbit arotid artery produces a dysfunctional endothelium'. Tissue Eng Part A, 16 (5):1657-1665. [DOI] [Details]

McMahon SS, Albermann S, Rooney GE, Shaw G, Garcia Y, Sweeney E, Hynes J,Dockery P, O'Brien T, Windebank AJ, Allsopp TE, Barry FP. (2010) 'Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury'. Cytotherapy, 12 (3):313-325. [DOI] [Details]

Griffin, M., Greiser, U., Barry, F., O'Brien, T., & Ritter, T. (2010) 'Genetically Modified Mesenchymal Stem'. Discovery Medicine, 9 (46):219-223. [ARAN Link] [Details]

Hoare M, Greiser U, Schu S, Mashayekhi K, Aydogan E, Murphy M, Barry FB, Ritter T, O'Brien T (2010) 'Enhanced lipoplex-mediatd gene expression in mesenchymal stem cells using reiterated nuclear localization sequence peptides'. J Gene Med, 12 (2):207-218. [DOI] [Details]

Duffy GP, D'Arcy S, Ahsan T, Nerem RM, O'Brien T, Barry F (2010) 'Mesenchymal stem cells overexpressing ephrin b2 rapidly adopt an early endothelial phenotype with simultaneous reduction of osteogenic potential'. Tissue Eng Part A, 16 (9):2755-2768. [DOI] [Details]

Peng Hor C, O'Donnell JM, Murphy AW, O'Brien T, Krompans TJB (2010) 'General Pratitioners’ Attitudes and Preparedness toward Clinical Decision Support in e-Prescribing (CDS-dP) Adoption in the West of Ireland: a cross sectional study'. BMC Medical Informatics and Decision Making, 10 (1). [Details]

Donnelly EM, Strappe PM, McGinley LM, Madigan NN, Geurts E, Rooney GE,Windebank AJ, Fraher J, Dockery P, O'Brien T, McMahon SS. (2010) 'Lentiviralvector-mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glialscar'. J Gene Med, 12 (11):863-872. [DOI] [Details]

Martin FT, Dwyer RM, Kelly J, Khan S, Murphy JM, Curran C, Miller N, Hennessy E, Dockery P, Barry FP, O'Brien T, Kerin MJ (2010) 'Potential Role of Mesenchymal Stem Cells (MSCs) in the Breast Tumor Microenvironment: Stimulation of Epithelial to Mesenchymal Transition (EMT)'. Breast Cancer Res Treat, 124 :317-326. [Details]

O'Brien T, Barry F. (2010) 'Introduction to Series on Mesenchymal Stromal (Stem) Cells-MSCs'. Hum Gene Ther Impact Factor 4.2, 21 (9):1037-1038. [DOI] [Details]

McGinley L, McMahon J, Strappe P, Barry F, Murphy M, O'Toole D, O'Brien T (2011) 'Lentiviral Vector Mediated modification of Mesenchymal Stem Cells & enhanced survival in an in vitro mode of Ischaemia'. Stem Cell Research & Therapy, 2 . [Details]

Bowes T, Hanley SA, Liew A, Eglon M, Mashayekhi K, O'Kennedy R, Barry F, Taylor WR, O'Brien T, Griffin MD, Finlay WJ, Greiser U. (2011) 'Developing cell-specific antibodies to endothelial progenitor cells using avian immune phage display technology'. Journal Of Biomolecular Screening, . [Details]

Heneghan HM, Miller M, McAnena OJ, O'Brien T, Kerin MJ (2011) 'Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers'. J Clin Endocrinol Metab, . [Details]

Hassett P, Curley GF, Contreras M, Masterson C, Higgins BD, O'Brien T, Devaney J, O'Toole D, Laffey JG. (2011) 'Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury'. Intensive Care Medicine, . [Details]

Holladay CA, Duffy AM, Chen X, Sefton MV, O'Brien TD, Pandit AS. (2011) 'Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold'. Biomaterials, . [Details]

Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O'Brien T, O'Toole D, Laffey JG (2011) 'Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat'. Thorax, . [Details]

Sharif F, Hynes S, McCullagh KJA, Ganley S, Geiser U, McHugh P, Crowley J, Barry F, O'Brien T. (2011) 'Gene-Eluting Stents: liposome-based eNOS enhances re-endothelialisation but does not prevent restenosis in a hypercholesterolemic model'. Gene Therapy. Impact Factor 4.8, . [Details]

Kulkarni MM, Greiser U, O'Brien T, Pandit A (2011) 'A Temporal Gene Delivery System Based on Fibrin Microspheres. '. Mol PharmImpact Factor 4.5, 8 (2):439-446. [Details]

McMahon SS, Nikolskaya N, Choileáin SN, Hennessy N, O'Brien T, Strappe PM, Gorelov A, Rochev Y. (2011) 'Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro'. Journal Of Gene Medicine, . [Details]

Hynes SO, McCabe C, O'Brien T. (2011) 'ß cell protection by inhibition of iNOS through lentiviral vector-based strategies'. Methods Mol Biol, 704 :153-168. [Details]

Holladay C, Power K, Sefton M, O'Brien T, Gallagher WM, Pandit A. (2011) 'Functionalized scaffold mediated interleukin-10 gene delivery significantly improves survival rates of stem cells in vivo'. Molecular Therapy, 19 (5):969-978. [Details]

Dwyer RM, Ryan J, Havelin RJ, Morris JC, Miller BW, Liu Z, Flavin R, O'Flatharta C, Foley MJ, Barrett HH, Murphy M, Barry FP, O'Brien T, Kerin MJ. (2011) 'Mesenchymal Stem Cell (MSC) mediated delivery of the Sodium Iodide Symporter (NIS) supports radionuclide imaging and treatment of breast cancer'. Stem Cells. Impact Factor 7.7, . [Details]

Flynn A, O'Brien T. (2011) 'Stem cell therapy for cardiac disease'. Expert Opin Biol Ther Impact Factor 3.2, 11 (2):177-187. [Details]

Schu S, Nosov M, O'Flynn L, Shaw G, Treacy O, Barry F, Murphy M, O'Brien T, Ritter T. (2011) 'Immunogenicity of allogeneic mesenchymal stem cells'. J Cell Mol Med, . [Details]

Mulcahy P, O'Doherty A, Paucard A, O'Brien T, Kirik D, Dowd E. (2011) 'Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone'. Journal Of Neuroscience, . [Details]

Vaughan EE, Liew A, Mashayekhi K, Dockery P, McDermott J, Kealy B, Flynn A, Duffy A, Coleman C, O'Regan A, Barry FP, O'Brien T. (2012) 'Pre-treatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease'. Cell Transplantation. Impact Factor 5.1, . [Details]

 

Conference Publications

McCullagh K, Hughes O, Cooney R, O'Connell E, Mashayekhi K, Eglon M, O' Brien T (2010) Gene Profile Analysis of NOS transduced human arterial Smooth Muscle Cells TERMIS-EU Meeting, Galway , 13-JUN-10 - 17-JUN-10 [Details]

 

Abstract

Murray DP, O'Brien T, Mulrooney R, O'Sullivan DJ (1988) Autonomic dysfunction and silent myocardial ischemia in patients with diabetes mellitus. European Cardiology Society Eur Heart J. Abstract [Details]

O'Brien T, Murray DM, Mulrooney R, Fennell WF, O'Sullivan DJ (1988) The Incidence and Mechanism of Silent Myocardial Ischemia in Patients with Diabetes Mellitus. British Diabetic Association Diabetic Med. Abstract [Details]

O'Brien T (1988) The incidence and mechanism of silent myocardial ischemia on exercise testing in diabetes mellitus. Irish Cardiac Society Irish J Med Sci. Abstract [Details]

O'Brien T, Murray DM, Mulrooney R, O'Sullivan DJ (1988) Silent Myocardial Ischemia in Diabetes Mellitus. American College of Cardiology, J Am Coll Card. Abstract [Details]

O'Brien T, Barrett B, Murray DM, Dinneen S, O'Sullivan DJ (1989) Is biochemical screening of diabetics for hemochromatosis worthwhile. American Diabetes Association Diabetes. Abstract [Details]

O'Mahony MS, Cronin C, Dinneen SF, Murray DM, O'Brien T, O'Sullivan DJ (1990) Serum ferritin in newly diagnosed diabetes mellitus and poorly controlled diabetes mellitus. British Diabetic Association Diabetic Med. Abstract [Details]

O'Brien T, Young WF, Palumbo PJ, O'Brien PC, Service FJ (1991) Is the hyperinsulinemia of insulinoma associated with hypertension and hypertriglyceridemia. European Association for the Study of Diabetes, Diabetalogia. Abstract [Details]

O'Brien T, Young WF, Davila DG, Scheitauer BW, VanHeerden JA, Kovacs K, Horvath E, Vale W (1991) Cushings syndrome associated with production of CRH, ACTH, and ADH by a pheochromocytoma. American College of Physicians, Minnesota Affiliate: Minneapolis. Abstract [Details]

O'Brien T, Nguyen TT, Kottke BA (1992) A preliminary report on the distribution of Lp(a) among VLDL, LDL, and HDL particles separated by HPLC in subjects with NIDDM. Second International Lp(a) Conference. New Orleans, La, USA: Abstract [Details]

O'Brien T, Buithieu J, Klein L, Nguyen T, Kottke BA (1992) The use of HPLC with a heparin affinity column to separate apo E poor and apo E rich HDL subparticles. 25th Annual Lofland Conference on Arterial Wall Metabolism. Boston: Abstract [Details]

O'Brien T, Mc Mahon M, Mishark K, Lennon VA, Camilleri M (1992) How best to feed a patient with an immune paraneoplastic gut dysmotility syndrome. American Society of Parenteral and Enteral Nutrition. Orlando: Abstract [Details]

Buithieu J, O'Brien T, Klein L, Nguyen T, Kottke BA (1992) Rapid separation of human plasma lipoprotein fractions with high performance liquid chromatography. 25th Annual Lofland Conference on Arterial Wall Metabolism. Boston: Abstract [Details]

O'Brien T, Gharib H, Suman V, van Heerden JA (1992) Treatment of solitary toxic thyroid nodules: Surgery vs Radioiodine. American Association of Endocrine Surgeons. Miami: Abstract [Details]

O'Brien T, Nguyen T, Harrison J, Bailey K, Dyck P, Kottke BA (1992) Lp(a) in NIDDM. European Atherosclerosis Society. Nice: Abstract [Details]

Klein L, Buithieu J, O'Brien T, Nguyen TT, Kottke BA (1992) The application of Sudan - B Black for detection of lipoprotein fractions separated from plasma by high performance liquid chromatography. Sixteenth International Symposium on Column Liquid Chromatography. Baltimore, Md: Abstract [Details]

O'Riordan DS, O'Brien T, van Heerden JA, Service FJ, Weaver A, Grant CS (1993) Subtotal pancreatectomy for insulinoma in multiple endocrine neoplasia type 1. International Surgery Week Hong Kong. Abstract [Details]

O'Riordan DS, O'Brien T, Grant CS, Gharib H, Weaver A, van Heerden JA (1993) Surgical management of hyperparathyroidism in multiple endocrine neoplasia. American Association of Endocrine Surgeons. Abstract [Details]

O'Brien T, Nguyen TT, Kottke BA (1993) A high-carbohydrate diet and lipoprotein composition in NIDDM. Irish Endocrine Society, Dublin, Ireland Irish J Med Sci. Abstract [Details]

O'Brien T, Nguyen TT, Kottke BA (1993) A high carbohydrate diet and high density lipoprotein subparticles in non-insulin dependent diabetes mellitus. American Diabetes Association. Abstract [Details]

O'Brien T, Nguyen TT, Hallaway BJ, Kottke BA (1993) HDL subparticles and coronary artery disease. American Heart Association Circulation. Abstract [Details]

O'Brien T, O'Brien P, Service FJ (1993) Insulin Surrogates in Insulinoma. Endocrine Society, Las Vegas. Abstract [Details]

O'Brien T, Quan R, Sanan D, Spector D, Taylor J (1993) Adenoviral mediated gene transfer of apo E to the rabbit carotid artery in vivo. European Atherosclerosis Society. Abstract [Details]

O'Brien T, Nguyen TT, Kottke BA (1993) The effect of a high carbohydrate diet on postprandial transfer of apolipoproteins between triglyceride rich and high density lipoproteins. European Atherosclerosis Society Jerusalem, Isreal. Abstract [Details]

Kullo IJ, O'Brien T, Katusic ZS, Pompili VJ (1995) Adenoviral-mediated delivery and expression of the endothelial nitric oxide synthase gene in isolated porcine coronary arteries and cultured smooth muscle cells. Gene Therapy for Acquired Diseases, Nashville, TN. Abstract [Details]

O'Riordain DS, O'Brien T, Gharib H, Grant CS, van Heerden JA (1995) Endocrine and extraendocrine features of multiple endocrine neoplasia type 2B. British Journal of Surgery. Abstract [Details]

O'Brien T, Kullo I, Chen A, Katusic Z (1996) Adenoviral mediated gene transfer of nitric oxide synthase (NOS) to the vascular wall yields functional enzymatic activity. European Atherosclerosis Society Florence. Abstract [Details]

Pompili VJ, O'Brien T, Kullo I, Spector D, Schwartz RS, Holmes DR, Katusic ZS (1996) Adenoviral transduction of endothelial cell nitric oxide synthase gene yielding functional enzymatic activity in porcine coronary arteries. American College of Cardiology JACC. Abstract [Details]

Cable DG, O'Brien T, Schaff HV, Katusic ZS, Pompili VJ (1996) Adenoviral transfection of human saphenous veins with e NOS: Gene therapy applied to coronary bypass conduits. American Heart Association, New Orleans Circulation. Abstract [Details]

Kullo IJ, Pompili VJ, Tsutsui M, Fitzpatrick LA, Katusic ZS, O'Brien T (1996) Transfer of endothelial nitric oxide synthase gene to coronary smooth muscle cells inhibits cell proliferation. American Heart Association, New Orleans Circulation. Abstract [Details]

Chen AFY, Tsutsui M, Kinoshita H, O'Brien T, Crotty TB, Pompili VJ, Katusic ZS (1996) Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery. International Angiology. Abstract [Details]

Kullo I, Schwartz RS, Tsutsui M, Katusic ZS, Pompili VJ, O'Brien T (1996) Endothelial nitric oxide synthase gene transfer to porcine coronary smooth muscle cells inhibits cell proliferation. Restenosis Summit VIII. Cleveland, OH: Abstract [Details]

Chen AFY, Kinoshita H, Tsutsui M, O'Brien T, Pompili VJ, Crotty T, Katusic ZS (1996) Effect of recombinant endothelial nitric oxide synthase gene expression on reactivity of isolated canine basilar artery. FASEB. Abstract [Details]

O'Brien T, Kullo I, Chen A, Katusic Z (1996) Adenoviral-mediated gene transfer of nitric oxide synthase (NOS) to the vascular wall yields functional enzymatic activity. Diabetes, Lipoproteins and Atherosclerosis: EASD Lipoprotein Study Group. Dublin: Abstract [Details]

Kullo IJ, Serry R, Menawat S, Mozes G, Gloviczki P, Taylor J, O'Brien T (1996) Adenoviral-mediated gene transfer of monocyte chemotactic protein-1 (MCP-1) to the arterial wall. IX International Vascular Biology Meeting, Seattle, Washington J Vasc Res. Abstract [Details]

Yap JYM, O'Brien T, Tazelaar HD, McGregor CGA (1996) Optimization of gene transfer to the transplanted heart. American Heart Association, New Orleans Circulation. Abstract [Details]

Kullo IJ, Mozes G, Tsutsui M, Gloviczki P, Schwartz RS, Katusic ZS, O'Brien T (1996) Effects of overexpression of type III nitric oxide synthase gene in rabbit carotid arteries in vivo. American Heart Association, New Orleans Circulation. Abstract [Details]

Cable DG, O'Brien T, Schaff HV, Pompili VJ (1996) Recombinant eNOS transduced saphenous veins: Gene therapy in bypass conduits. IX International Vascular Biology Meeting. Seattle, Washington: Abstract [Details]

Chen AF, O'Brien T, Crotty TB, Katusic ZS (1996) Normal vasomotor function after ex vivo recombinant adenoviral vector-mediated gene transfer and expression in canine basilar artery. 21st International Joint Conference on Stroke and Cerebral Circulation. Abstract [Details]

Chen AFY, Tsutsui M, Kinoshita H, O'Brien T, Pompili VJ, Katusic ZS (1996) Adenoviral-mediated transfer of recombinant endothelial nitric oxide synthase gene in canine basilar artery. Joint Conference on Arteriosclerosis, Thrombosis and Vascular Biology, Salt Lake City, UT. Abstract [Details]

Katusic ZS, Tsutsui M, Chen AFY, O'Brien T, Crotty TB (1996) Effect of recombinant endothelial nitric oxide synthase gene expression on endothelium dependent relaxations in canine arteries. IX International Vascular Biology Meeting, Seattle, Washington. Abstract [Details]

Kullo, Mozes G, Cable D, Crotty T, Gloviczki P, Katusic Z, O'Brien T (1997) Nitric oxide synthase gene transfer improves cholesterol-induced vasomotor dysfunction in the rabbit aorta. Biomedicine J Investigative Medicine 1997. Abstract [Details]

Kullo I, Mozes G, Schwartz RS, Gloviczki P, Crotty TB, Katusic ZS, O'Brien T (1997) Vascular adenoviral mediated gene transfer of endothelial nitric oxide synthase to the chow and cholesterol fed rabbit alters vascular reactivity. European Atherosclerosis Society, Brugges 1997 Atherosclerosis. Abstract [Details]

Kudva YC, O'Brien T, Crotty TB (1997) Diabetic mastopathy: a clinicopathologic study. American Diabetes Association Boston Diabetes. Abstract [Details]

Chen AFY, Smith LA, Crotty TB, O'Brien T, Katusic ZS (1997) In vivo adenoviral mediated expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries. Brain, Journal of Cerebral Blood Flow and Metabolism. Abstract [Details]

Chen AFY, Smith LA, Crotty TB, O'Brien T, Katusic ZS (1997) Effect of in vivo recombinant adenoviral-mediated gene transfer on vascular reactivity of canine cerebral arteries. Stroke. Abstract [Details]

Lee RJ, O'Brien T, Tazelaar HD, McGregor CGA (1997) Adenoviral transduction in the transplanted rat lung. International Society for Heart and Lung Transplantation, London, UK. Abstract [Details]

Cable D, O'Brien T, Schaff HV (1997) Vasospasm of radial artery bypass grafts: Studies of endothelial regulation of vascular smooth muscle function and manipulation by gene therapy. Western Surgical Society. Abstract [Details]

Tsutsui M, Chen AF, O'Brien T, Crotty TB, Katusic ZS (1997) Adventitial expression of recombinant endothelial nitric oxide synthase gene restores nitric oxide production in arteries without endothelium. American Heart Association, Orlando, Florida Circulation. Abstract [Details]

Tsutsui M, Chen AF, O'Brien T, Crotty TB, Katusic ZS (1997) Adventitial expression of recombinant endothelial nitric oxide synthase gene restores nitric oxide production in cerebral arteries without endothelium. Journal of Cerebral Blood Flow and Metabolism. Abstract [Details]

Katusic ZS, Chen AFY, O'Brien T, Crotty TB (1997) Adventital fibroblasts as target cells for expression of recombinant endothelial nitric oxide synthase gene. Jap J Pharmacol. Abstract [Details]

O'Brien T, Karlsen AE, Anderson HU, Mandrup-Poulsen T, Nerup J (1997) Absence of toxicity with adenoviral mediated gene transfer to the islets of Langerhans. International Diabetes Federation, Helsinki Finland Late Breaking Research Session. Abstract [Details]

Tsutsui M, Chen AFY, O'Brien T, Crotty TB, Katusic ZS (1997) Heterogeneity of adenovirus-mediated transfer of endothelial nitric oxide synthase gene in isolated canine arteries. FASEB J. Abstract [Details]

Chen AFY, Smith LA, Crotty TB, O'Brien T, Katusic ZS (1997) In vivo eNOS gene transfer in cerebral arteries via cerebrospinal fluid. FASEB J. Abstract [Details]

O'Brien T, Mozes G, Kullo IK, Cable D, Crotty T, Gloviczki P, Katusic Z (1997) Nitric oxide synthase gene transfer improves cholesterol-induced vasomotor dysfunction in the rabbit aorta. International Atherosclerosis Symposium, Paris, France Atherosclerosis. Abstract [Details]

Kullo IJ, Schwartz RS, Tsutsui M, Milstein S, Katusic ZS, O'Brien T (1997) Tetrahydrobiopterin increases activity of recombinant endothelial nitric oxide synthase. FASEB J. Abstract [Details]

O'Brien T, Yap J, Tazelaar HD, McGregor CGA (1997) Immunosuppression prolongs adenoviral mediated transgene expression in cardiac allograft transplantation. Molecular and Cellular Biology of Gene Therapy. utah: Abstract [Details]

Mozes G, Kullo I, Mohasci T, Gloviczki P, O'Brien T (1997) Adenoviral mediated gene transfer of macrophage colony stimulating factor to the vessel wall results in an intimal infiltrate. European Atherosclerosis Society, Brugges 1997 Atherosclerosis. Abstract [Details]

Chen AFY, Smith LA, Tsutsui M, Crotty TB, O'Brien T, Katusic ZS (1997) In vivo expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries. 7th Symposium on Mechanisms of Vasodilatation, Maastricht, The netherlands J Vasc Res 3. Abstract [Details]

Yap J, O'Brien T, Tazelaar HD, McGregor CGA (1997) Immunosuppression prolongs adenoviral mediated transgene expression in cardiac allograft transplantation. International Society for Heart and Lung Transplantation, London UK J Heart and Lung Transplantation. Abstract [Details]

Kullo IJ, Mozes G, Schwartz RS, Gloviczki P, Crotty TB, Katusic ZS, O'Brien T (1997) Enhanced endothelium-dependent relaxations after gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries. American College of Physicians, Philadelphia. Abstract [Details]

Cable DG, Caccitolo JA, pearson PJ, O'Brien T, Mullany CJ, daly RC, Orszulak TA, Schaff HV (1997) New approaches to prevention and treatment of vasospasm of radial artery bypass grafts. American Heart Association, Orlando, Florida Circulation. Abstract [Details]

Kullo IJ, Mozes G, Schwartz RS, Gloviczki P, Crotty TB, Katusic ZS, O'Brien T (1997) Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity. JACC. Abstract [Details]

Yap J, O'Brien T, Tazelaar HD, McGregor CGA (1997) Adenoviral mediated ex vivo gene transfer to the transplanted heart. Society of Cardiothoracic Surgeons of Great Britain and Ireland, Dublin. Abstract [Details]

Kullo, Mozes G, Cable D, Crotty T, Gloviczki P, Katusic Z, O'Brien T (1997) Nitric oxide synthase gene transfer improves cholesterol-induced vasomotor dysfunction in the rabbit aorta. Molecular and Cellular Biology of Gene Therapy. utah: Abstract [Details]

Cable DG, O'Brien T, Pompili VJ, Schaff HV (1997) Adenoviral mediated gene transfer of eNOS to canine coronary arteries augments hypoxic induced relaxations. Molecular and Cellular Biology of Gene Therapy. utah: Abstract [Details]

Sato J, Fitzpatrick LA, Katusic ZS, O'Brien T (1998) Transfer of the endothelial nitric oxide synthase gene to coronary smooth muscle cells blocks cell cycle progression in G1. CirculationAmerican Heart Association. Dallas, Texas: Abstract [Details]

O'Brien T, Mozes G, Kullo I, Gloviczki P, Katusic Z (1998) Nitric oxide synthase gene transfer improves cholesterol-induced vasomotor dysfunction in the rabbit aorta. Vascular and Myocardial Aspects of Ischemic Heart Disease. Lake Tahoe: Abstract [Details]

Onoue H, Tsutsui M, Smith L, O'Brien T, Katusic ZS (1998) Adventitial expression of recombinant endothelial nitric oxide synthase gene reverses vasoconstrictor effect of endothelin-1. FASEB Journal. Abstract [Details]

Cable DG, Caccitolo JA, O'Brien T, Schaff HV (1998) Adenoviral-mediated gene transfer of eNOS to canine gastroepiploic arteries: a technique to limit vasospasm. FASEB Journal. Abstract [Details]

Jeppsson A, Pellegrini C, O'Brien T, Miller VM, Tazelaar HD, Taner CB, McGregor C (1998) Gene transfer in lung transplantation: Vascular gene delivery. Scandanavian Association of Thoracic Surgery. Abstract [Details]

Pellegrini C, Jeppsson A, O'Brien T, Miller VM, Tazelaar HD, McGregor (1998) CGA:Transgene expression in cardiac allografts is not prolonged by high circulating levels of cyclosporine. European Association for Cardio-Thoracic Surgery. Abstract [Details]

O'Brien T, Karlsen AE, Andersen HU, Mandrup-Poulsen T, Nerup J (1998) Absence of toxicity associated with adenoviral-mediated gene transfer to the islets of Langerhans. American Society of Gene Therapy, 1st Annual Meeting. Seattle, WA: Abstract [Details]

Pittelkow MR, Vasa R, Meves A, Beyerle A, O'Brien T, Peus D (1998) UVB-induced H, 20, 2 activates ERK1/2 but not p38 pathway via EGFR phosphorylation: Effects on keratinocyte growth and survival. J Derm Science. Abstract [Details]

Cable DG, Pompili VJ, O'Brien T, Schaff HV (1998) The role of eNOS gene therapy to augment coronary relaxations during hypoxia. Circulation American Heart Association. Dallas, Texas: Abstract [Details]

Chen FY, Mertens LL, Parisi JE, O'Brien T, Katusic ZS (1998) Adenoviral receptor-mediated gene transfer to human cerebral artery. XIIth International Congress of Pharmacology, Munchen, Germany. Abstract [Details]

Jeppsson A, Pellegrini C, O'Brien T, Miller VM, Tazelaar HD, Taner CB, McGregor CGA (1998) Gene transfer of endothelial nitric oxide synthase to acute rejecting pulmonary allografts. Third International Congress on Lung Transplantation. Paris: Abstract [Details]

Cable DG, Caccitolo JA, Caplice N, O'Brien T, Simari RD, Daly RC, Dearani JA, Mullany CJ, Orszulak TA, Schaff HV (1998) The role of gene therapy for intimal hyperplasia of bypass grafts. CirculationAmerican Heart Association. Dallas, Texas: Abstract [Details]

Tsutsui M, Iida Y, Onoue H, Smith L, O'Brien T, Katusic ZS (1998) Expression of recombinant endothelial nitric oxide synthase gene reverses contractile effect of serum into relaxations. CirculationAmerican Heart Association. Dallas, Texas: Abstract [Details]

Tsutsui M, Iida Y, Onoue H, Smith L, O'Brien T, Katusic ZS (1998) Angiotensin II causes relaxations of canine cerebral arteries transduced with recombinant endothelial nitric oxide synthase gene. CirculationAmerican Heart Association. Dallas, Texas: Abstract [Details]

Pittelkow MR, Vasa R, Meves A, Beyerle A, O'Brien T, Peus, D (1998) UVB-induced H-20-2 activitates ERK1/2 but no P38 pathway via EGFR phosphorylation: Effects on keratinocyte growth and survival. Journal of Investigative Dermatology. Abstract [Details]

Onoue H, Tsutsui M, Smith L, O'Brien T, Katusic ZS (1998) Recombinant eNOS gene expression and cerebral arterial reactivity to endothelin-1 - implications for gene therapy of chronic cerebral vasospasm. American Society of Gene Therapy, 1st Annual Meeting. Seattle, WA: Abstract [Details]

Pellegrini C, O'Brien T, Taner CB, Miller VM, Tazelaar HD, McGregor CGA (1998) Is adenoviral-mediated gene transfer to transplanted hearts enhanced by University of Wisconsin solution?. American Society of Gene Therapy, 1st Annual Meeting. Seattle, WA: Abstract [Details]

Severson SR, Jeppsson A, O'Brien T, Pellegrini C, Miller VM, Tazelaar HD, McGregor CGA (1998) In vivo assessment of endothelial nitric oxide synthase transduced to transplanted lungs. FASEB Journal. Abstract [Details]

Jeppsson A, Pellegrini C, O'Brien T, Miller VM, Tazelaar HD, McGregor C (1998) Gene transfer in lung transplantation: Retrograde gene delivery via the pulmonary vein improves transduction efficiency. The International Society for Heart and Lung Transplantation, Chicago Illinois The Journal of Heart and Lung Transplantation. Abstract [Details]

Chen AFY, Mertens LL, Jiang S, Parisi JE, O'Brien T, Katusic ZS (1998) Gene transfer to human cerebral artery. FASEB Journal. Abstract [Details]

Pellegrini C, O'Brien T, Yap J, Taner CB, Jeppsson A, Miller VM, Tazelaar HD, McGregor CGA (1998) Adenovirus-mediated gene transfer to the transplanted heart results predominantly in cardiomyocyte transgene expression. American Society of Gene Therapy, 1st Annual Meeting. Seattle, WA: Abstract [Details]

Taner CB, Jeppsson A, Pellegrini C, Miller VM, O'Brien T, Tazelaar HD, McGregor CGA (1998) Gene transfer in lung transplantation. The FASEB Journal. Abstract [Details]

Levine J, Eberhardt N, Jensen M, O'Brien T (1998) Adenoviral-mediated gene transfer to adipose tissue. American Society of Gene Therapy, 1st Annual Meeting. Seattle, WA: Abstract [Details]

Kudva YC, O'Brien T, Crotty TB (1998) Sclerosing lymphocytic lobulitis: A breast disorder specific for type 1 diabetes mellitus. Endocrine Society, 80th Annual Meeting, June 24-27, 1998, New Orleans Abstracts:. Abstract [Details]

Chen AFY, Mertens LL, Parisi JE, O'Brien T, Katusic ZS (1998) Adenoviral-receptor mediated gene transfer to human cerebral arrtery. Vascular and Myocardial Aspects of Ischemic Heart Disease, Lake Tahoe. Abstract [Details]

Jeppsson A, Pellegrini C, O'Brien T, Miller VM, Tazelaar HD, McGregor C (1998) Adenoviral mediated transbronchial gene transfer of endothelial nitric oxide synthase to transplanted lungs. Society of Thoracic surgery. New Orleans: Abstract [Details]

Zanetti M, O'Brien T (1999) Copper zinc superoxide dismutase gene transfer to endothelial cells reduces glucose-mediated cytotoxicity. Diabetes. Abstract [Details]

Hofbauer LC, Riggs BL, Dunstan CR, O'Brien T, Khosla S (1999) Cyclosporin A and glucocorticoids inhibit osteoprotegerin production in human osteoblastic and coronary artery smooth muscle cells: potential mechanism of post-transplant osteoporosis and vascular disease. ASBMR, J Bone Miner. Abstract [Details]

Zanetti M, Sato J, Katusic ZS, O'Brien T (1999) Effects of eNOS gene transfer on vascular reactivity of alloxan-induced diabetic rabbit aorta. Diabetes. Abstract [Details]

Jeppsson A, Pellegrini C, O'Brien T, Miller VM, Tazelaar HD, Taner CB, McGregor CGA (1999) Gene transfer of endothelial nitric oxide synthase to transplanted lungs. Acta Physiol Scan. Abstract [Details]

O'Brien T, Sato J, Kullo I, Mozes G, Gloviczki P, Katusic Z (1999) Endothelial nitric oxide synthase gene transfer to the vasculature. Gene Therapy. Abstract [Details]

Zanetti M, Katusic ZS, O'Brien T (1999) Transfer of the endothelial nitric oxide synthase gene to human umbilical vein endothelial cells inhibits cell proliferation. American Society of Gene Therapy 2nd Annual Meeting. Abstract [Details]

Sato J, Nair K, Hiddinga J, Eberhardt NL, Fitzpatrick LA, Katusic ZS, O'Brien T (1999) Transfer of the endothelial nitric oxide synthase gene to coronary smooth muscle cells inhibits cell proliferation via up-regulation of p27 and p21 and not apoptosis. Circulation. Abstract [Details]

Cable DG, Dearani JA, O'Brien T, Orszulak TA, Puga FJ, Schaff HV (1999) Surgical treatment of valvular heart disease in patients with acromegaly. World Congress on Heart Valve Disease, London UK. Abstract [Details]

Sato J, Mohasci T, Noel AA, Gloviczki P, Mozes GI, Katusic ZS, O'Brien T (1999) Effects of in vivo gene transfer of endothelial nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits. American Society of Gene Therapy 2nd Annual Meeting. Abstract [Details]

O'Brien T, Sato J, Fu A, Nygren J, Katusic Z, Nair KS (1999) Obesity-associated vascular dysfunction is prevented by antioxidant treatment. Circulation. Abstract [Details]

Hanke CJ, Pritchard KA Jr, O'Brien T, Campbell WB (1999) Infection of adrenal zona glomerulosa cells with endothelial-nitric oxide synthase adenovirus: inhibition of aldosterone synthesis by endogenous nitric oxide. Council for High Blood Pressure Research. Abstract [Details]

Zanetti M, Sato J, Katusic ZS, O'Brien T (1999) Gene transfer of endothelial nitric oxide synthase and manganese superoxide dismutase improves vascular reactivity of aortas from diabetic rabbits. Circulation. Abstract [Details]

Cable DG, Dearani JA, O'Brien T, Orszulak TA, Puga FJ, Schaff HV (1999) Surgical Treatment of Valvular Heart Disease in Patients with Acromegaly and Cardiomyopathy. J Am Coll Cardio. Abstract [Details]

O'Brien T, Sato J, Kullo I, Mozes G, Gloviczki P, Katusic Z (1999) Endothelial nitric oxide synthase gene transfer to the vasculature. Cytoreductive Gene Therapy, Rochester MN. Abstract [Details]

Sato J, Chiu CK, Zanetti M, O'Brien T (1999) Manganese superoxide dismutase gene transfer and glucose-mediated inhibition of endothelial cell migration. Diabetes. Abstract [Details]

Zanetti M, Sato J, Katusic ZS, O'Brien T (1999) Transfer of the endothelial nitric oxide synthase gene to human umbilical vein endothelial cells inhibits cell proliferation. FASEB Experimental Biology, Washington DC, April 1999. Abstract [Details]

Pellegrini C, Taner CB, Jeppsson A, O'Brien T, Miller VM, Tazelaar HD, McGregor CGA (1999) Highly efficient gene transfer to the transplanted heart by circulation of a low dose of adenoviral vector. American Society of Gene Therapy 2nd Annual Meeting. Abstract [Details]

Zanetti M, O'Brien T (1999) Adenoviral-mediated catalase gene transfer to endothelial cells reduces cell proliferation. Circulation. Abstract [Details]

O'Brien T, Zanetti M, Katusic ZS (2000) Gene transfer approaches to limiting vascular dysfunction in experimental diabetes mellitus: endothelial Nitric Oxide Synthase vs superoxide dismutase. Juvenile Diabetes Foundation. Abstract [Details]

Zanetti M, Sato J, Katusic ZS, O'Brien T (2000) Gene transfer of manganese and copper/zinc superoxide dismutase improves vascular dysfunction in diabetic aorta. Diabetes. Abstract [Details]

Sawka AM, Singh RJ, McConnell JP, Katusic ZS, O'Brien T (2000) Triglyceride-rich remnant lipoproteins enhance plasminogen activator inhibitor-1 production by human aortic endothelial cells. FASEB Journal. Abstract [Details]

Chiu C, O'Brien T, Katusic ZS, Cable DG, Schaff HV (2000) Gene transfer to saphenous vein coronary bypass conduits. FASEB J. Abstract [Details]

O'Brien T, Jeppsson A, Pellegrini C, Lee R, Miller V, Tazelaar H, McGregor C (2000) Improved efficiency of gene transfer to the transplanted lung by retrograde vascular gene delivery. Mol Therapy. Abstract [Details]

Sato J, Mohácsi T, Noel A, Jost C, Gloviczki P, Mozes G, Katusic Z, O'Brien T (2000) In vivo gene transfer of endothelial nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits enhances endothelium-dependent relaxations. Atherosclerosis. Abstract [Details]

Chiu C, O'Brien T, Katusic ZS, Schaff HV (2000) Gene transfer to saphenous vein coronary bypass conduits. Mol Therapy. Abstract [Details]

Sato J, Singh RJ, O'Brien T, Katusic ZS, Fu A, Nygren JA, Nair KS (2000) Dietary antioxidants preserve endothelium dependent vasorelaxation in obese rats. Clin Chem june 2000. Abstract [Details]

Zanetti M, O'Brien T (2000) Adenoviral-Mediated Gene Transfer of Catalase to Endothelial Cells Reduces Cell Proliferation via Increased Apoptosis. NAVBO. Abstract [Details]

Chiu C, O'Brien T, Katusic ZS, Schaff HV (2000) Adenoviral mediated gene transfer to coronary artery bypass grafts in vivo. ASGT. Abstract [Details]

Sawka A, Singh RJ, Hiddinga HJ, McConnell JP, Eberhardt NL, Caplice NM, O'Brien T (2000) Low concentrations of remnant lipoproteins increase plasminogen activator inhibitor-1 secretion by human aortic endothelial cells. Diabetes. Abstract [Details]

Sato J, Katusic ZS, O'Brien T (2000) Endothelial nitric oxide synthase and not superoxide dismutase gene transfer to the atherosclerotic rabbit aorta improves endothelial function. Mol Therapy. Abstract [Details]

Khurana VG, Simari RD, O'Brien T (2001) Paintbrush-assisted gene delivery. Mol Therapy. Abstract [Details]

Khurana GV, Smith LA, Weiler DA, Baker TA, O'Brien T, Katusic ZS (2001) Recombinant endothelial nitric oxide synthase gene expression in vivo attenuates post-subarachnoid hemorrhage cerebral vasospasm. FASEB J. Abstract [Details]

Ugurlu M, Griffin M, O'Brien T, Tazelaar H, Miller V, McGregor C (2001) The effects of CTLA4-Ig on acute lung allograft rejection - a comparison of intrabronchial gene therapy with systemic administration of protein. Mol Therapy. Abstract [Details]

Branzoli S, O'Brien T, Tazelaar H, McGregor C (2001) Successful gene targeting to the coronary arteries or myocardium. Mol Therapy. Abstract [Details]

Zanetti M, Sato J, Jost C, Gloviczki P, Katusic Z, O'Brien T (2001) Gene transfer of manganese superoxide dismutase reverses vascular dysfunction in arteries without but not with atherosclerotic plaque. Mol Therapy. Abstract [Details]

Harrington, SWS, O'Brien, T, Fitzpatrick, LA (2001) Over Expression of Bone Sialoprotein Enhances Nodule Formation and Calcification in Vascular Smooth Muscle Cells. Journal of Bone and Mineral Research, Suppl. Abstract [Details]

O'Brien T (2003) Nitric oxide synthase : Prospects for gene therapy of vascular disease. Finnish Gene Therapy Society Annual Meeting FGTS2003, University of Turku, Finland. Abstract [Details]

Sen, S, Bartlett, J, O'Brien, T (2003) Effect of Serotype on Adeno-Assoociated Virus, (AAV) Mediated Gene Transfer to Human Vascular Cells. Registrar’s Prize Award (Royal Academy of Medicine) at RCPI, Dublin. Abstract [Details]

O'Brien, T (2003) An Update on Gene Therapy for Clinicians. Western Anasesthetic Symposium, Galway. Abstract [Details]

O'Brien, T (2003) Gene Transfer to Restore NO Bioavailability in the Blood Vessel Wall. Molecular Medicine Seminar. Abstract [Details]

Bell, M, Murphy J, Corcoran M, O'Brien T (2003) An unusual cause of Cushing’s syndrome : a case report. Irish Endocrine Society 28th Annual Meeting. Abstract [Details]

Sen S, Bartlett J, Aktar Y, Courtney D, Sultan S, O'Brien T (2003) Adeno-Associated Virus (AAV) mediated gene delivery to vascular cells in the rabbit carotid artery module, A controlled randomised clinical trial. Sir Peter Freyer Memorial lecture and Surgical Symposium in associated with the Irish Society of Surgical Oncology. Abstract [Details]

Hynes, SO, Leslie, A, Smith, T, Darcy, R, O'Brien, T, Zvonimir, K (2003) In Viro Expression and Function of GTP Cyclohydrase I in the Rabbit Carotid Artery. FASEB. Abstract [Details]

Sen S, Bartlett J, Akhtar Y, Adegbola T, Sultan S, O'Brien T (2003) Serotypes of Adeno-Associated Virus mediated gene transfer in vasculature. European Society of Gene Therapy, 11th Annual Congress, Edinburgh. Abstract [Details]

Sen S, Bartlett J, Akhtar Y, Sultan S, O'Brien T (2003) Effect of adenovirus associated virus (AAV) serotype on vascular gene delivery in vivo. American Heart Association, Orlando, Florida. Abstract [Details]

Cooney R, O'Brien T (2003) Adenoviral mediated gene transfer of NOS isoforms and cell proliferaton. Irish Angiology Society, 4th Annual Meeting. Abstract [Details]

Cooney, R, O'Brien, T (2004) Adenoviral Mediated Gene Transfer of NOS is of Vascular Cell Proliferation. 7th Annual Meeting of the American Society of Gene Therapy. Abstract [Details]

Breen, A, Anilkumar, T, Starppe, P, O'Brien, T, Pandit, A (2004) Optimisation of a Fibrin Scaffold for Adenoviral Mediated Gene Delivery. Presentation at the European Society for Gene Therapy, Tampere, Finland. Abstract [Details]

McCabe, C, O'Brien, T (2004) Adenoviral-mediated combinatorial antioxidant gene transfer: a therapeutic approach toward augmenting pancreatic insulin-producing cell defence status against cytokine-induced oxidative damage. 12th Annual Congress of the ESGT, Tampere, Finland. Abstract [Details]

Cooney, R, O'Brien, T (2004) Adenoviral Mediated Gene Transfer of Nitric Oxide Synthase Isoforms and Vascular Cell Proliferation. 12th Annual Congress of the ESGT, Tampere, Finland. Abstract [Details]

Martin Z, Costello C, Duffy A, McLoughlin P, Martin F, Fitzpatrick JM, O'Malley MK, O'Brien T (2004) (2004) Using recombinant adenoviruses to facilitate superoxide dismutase (SOD) overexpression in human vascular smooth muscle cells. Irish Medical Journal Science Limerick. Abstract [Details]

Breen, A, Anilkumar, T, Strappe, P, O'Brien, T, Pandit, A (2004) Optimisation of a Fibrin Scaffold for Adenoviral Mediated Gene Delivery. Tissue Engineering Society International and the European Tissue Engineering Society, Lausanne, Switzerland. Abstract [Details]

McCabe, C, O'Brien, T (2004) Adenoviral Antioxidant Gene Transfer Therapy Approach towards diminishing pancreatic ß-Susceptibility to Cytokine-Induced Oxidative Damage. 7th Annual Meeting of the American Society of Gene Therapy. Abstract [Details]

Sen, S, Bartlett, Jeff S, Cahill, P, O'Brien, T (2004) Cyclical Mechanical Stretch and AAV2 Mediated to Cultured Human Vascular Cells. 7th Annual Meeting of the American Society of Gene Therapy. Abstract [Details]

Duffy, A, O'Doherty, A, O'Brien, T, Strappe, P (2004) Purification of Adenoviral and Adeno-Associated Viral Vectors using the Membrane-Based Methods of the Adenopure TM Kit and ViraKit. 12th Annual Congress of the ESGT, Tampere, Finland. Abstract [Details]

O'Shea, C, Nelson, R, O'Brien, T, Strappe, P (2004) Lentiviral-mediated gene transfer to cells of the Vasculature. 12th Annual Congress of the ESGT, Tampere, Finland. Abstract [Details]

Martin Z, Costello C, Duffy A, McLoughlin P, Martin F, Fitzpatrick JM, O'Malley MK, O'Brien T (2004) Modifying superoxide dismutase [SOD] activity in an experimental model for atherosclerosis. Irish Medical Journal Science Galway. Abstract [Details]

Cooney R, O'Brien T (2004) Adenoviral mediated gene transfer of nos is of vascular cell proliferation. 7th Annual Meeting of the American Society of Gene Therapy. Abstract [Details]

Cooney R, O'Brien, T (2004) Adenoviral mediated gene transfer of nitric oxide synthase isoforms and vascular cell proliferation. 12th Annual Congress of the ESGT, Tampere, Finland, November. Abstract [Details]

O'Shea C, Nelson R, McMahon J, Strappe P and O'Brien T (2005) Pseudotyping of lentiviral vectors with VSV-G and Baculoviral gp64 envelope demonstrated efficient gene delivery to vascular cells. American Society for Gene Therapy, St Louis, USA. Abstract [Details]

Duffy AM, O'Doherty AM, O'Brien T, Strappe PM (2005) (2005) Purification of adenovirus and adeno-associated virus: comparison of novel membrane-based technology to conventional techniques. Gene Therapy. Abstract [Details]

Conroy S, O Brien T (2005) Differential transduction of vascular endothelial cells by AAV pseudotypes. 13th Annual Congress of the European Society for Gene Therapy, Prague, Czech Republic. Abstract [Details]

Bell M, Conroy S, Ritter T, Houlihan C, Samali A, O' Brien T (2005) Cytoprotection of RIN cells from Cytokine-Mediated toxicity by gene transfer of anti-apoptotic proteins. Irish Endocrine Society. Limerick: Abstract [Details]

Sharif, F, McMahon, J, Hynes, SO, Hynes, N, Liew, A, Crowley, J, O'Brien, T (2005) Temporo-profile of Stent Based Adenovirus Mediated Gene Therapy. Irish Journal of Medical Science. Abstract [Details]

Duffy A, Liew A, Samali A, O' Brien T (2005) Adenoviral-mediated antioxidant overexpression: possible protective role against hyperglycemic conditions in HAEC. American Society for Gene Therapy. Abstract [Details]

McMahon JM, Shariff F, O'Brien, T (2005) Development of Gene Therapy Approaches to Occlusive Atherosclerotic Vascular Disease using Stent-Based Gene Delivery. British Society for Gene Therapy Annual Meeting, Manchester, UK. Abstract [Details]

Reeve J, Stenson-Cox C, Porn-Ares I, Ares M, O'Brien T, Samali A (2005) Transcriptosome profiling of human Coronary Artery Smooth Muscle Cells in response to oxidized Low Density Lipoprotein. Royal Academy of Medicine Ireland, Section of Biomedical Sciences Summer Meeting. Abstract [Details]

Bell M, Conroy S, O' Brien T (2005) Absence of cytoprotection of RINm5F cells against cytokine-mediated toxicity by gene transfer of heat shock protein 70. American Diabetes Association (ADA), San Diego, California. Abstract [Details]

Martin Z, Costello C, Duffy A, McLoughlin P, Fitzpatrick JM, Martin F, O'Malley MK, O'Brien T (2005) Overexpression of copper-zinc superoxide dismutase (CuZnSOD) has an anti-atherogenic effect in a model for atherosclerosis. Journal of American College Surgeons. San Francisco, USA: Abstract [Details]

Martin Z, Costello C, Duffy A, McLoughlin P, Fitzpatrick JM, Martin F, O'Malley MK, O'Brien T (2005) Gene expression responses to endogenous anti-oxidant activity in human vascular smooth muscle cells. British Journal of Surgery, Newcastle,UK. Abstract [Details]

O'Brien, T (2005) Prospects of Gene and Cell Therapy for Vascular disease. Irish Angiology Society, 5th Annual Meeting. Abstract [Details]

Breen A, Anilkumar T, Strappe P, O'Brien T, Pandit A (2005) Viral Vector Mediated Gene Delivery via an Optimised Fibrin Scaffold. 19th European Conference on Biomaterials, Sorrento. Abstract [Details]

Curtin C, Conroy S, Murphy M, O'Brien T, Barry F (2005) Transduction of rabbit mesenchymal stem cells with the different adeno-associated virus pseudotypes. 13th Annual Congress of the European Society for Gene Therapy, Prague, Czech Republic. Abstract [Details]

Duffy A, Liew A, O' Sullivan J, Samali A, Avalos G, O' Brien T (2005) Distinct Effects of High Glucose Conditions on endothelial cells of macrovascular and microvascular origin. Irish Angiology Society, Fifth Annual Meeting, March 2005 and Irish Endocrinology Society. Abstract [Details]

Breen A, Barker TH, Hubbell JA, O' Brien T, Pandit, A (2005) Ability of a Fibrin Scaffold to Bind an Adenoviral Vector for Sustained Gene Delivery. 8th Annual Meeting of the Tissue Engineering Society International, Shanghai, 2005 and 13th Annual Congress of the European Society for Gene Therapy, Prague. Abstract [Details]

Breen A, Strappe P, Anilkumar T, O'Brien T, Pandit A (2005) Optimisation of a Fibrin Scaffold for Viral Vector Mediated Gene Delivery. 5th Annual Meeting of Irish Angiology Society, Galway. Abstract [Details]

Eglon M, Duffy A, Harte M, O Brien T, Strappe P (2005) Development and validation of an adenoviral vector purification system for cGMP production. 13th Annual Congress of the European Society for Gene Therapy. Prague, Czech Republic: Abstract [Details]

Liew A, McDermott J, Kealy B, Gaffney M, Sharif F, DeLappe E, O'Brien T (2005) EPC number and functions in patients with poorly controlled, uncomplicated Type 1 Diabetes Mellitus. Irish Endocrine Society 30th Annual Meeting. Abstract [Details]

McMahon J, Conroy S, O'Shea C, Lyons M, Greiser U, Strappe P, Howard PL, Murphy M, Barry F, O'Brien T (2005) Gene transfer into mesenchymal stem cells: a comparative study of viral and non-viral vectors. 13th Annual Congress of the European Society for Gene Therapy. Prague, Czech Republic: Abstract [Details]

Breen A, Strappe P, Barker T, Hubbell J, O'Brien T, Pandit, A (2006) Characterisation of the Release Rate and Binding Ability of an Adenoviral Vector to a Fibrin Scaffold for Sustained Gene Delivery. Society for Biomaterials, Pittsburgh, USA. Abstract [Details]

O'Shea, C, O'Brien, T (2006) Engrafment of MScs into injured vasculture - A potential therapeutic approach. European Society of Gene Therapy, Athens. Abstract [Details]

Breen A, Barker T, Hubbell J, O'Brien T, Pandit A (2006) In vivo Adenoviral Vector Gene Delivery Via a Fibrin Scaffold. Bioengineering in Ireland, Galway. Abstract [Details]

Breen A, O'Brien T, Pandit A (2006) In Vivo Sustained Expression of a Gene is seen from an Adenoviral Vector Gene Delivery System via a Fibrin Scaffold. Tissue Engineering and Regenerative Medicine World Congress, Pittsburg, USA. Abstract [Details]

Kealy, B, O'Brien, T (2006) Endothelial Progenitor cells for diabetic ulcer healing. European Society of Gene Therapy, Athens. Abstract [Details]

Caroline Curtin, William Curtin, Mary Murphy, Timothy O'Brien, Frank Barry (2006) Stem cell delivery to osteoarthritic tissue. ECM VII Meeting on Cartilage and Joint Repair. Davos, Switzerland: Abstract [Details]

McGrath, BM, O'Shea, C, Howard, L, Murphy, M, Barry, F, O'Brien, T, Strappe, P (2006) Lentiviral vector transduction efficiency and biosafety profile of aldult mesenchymal stem cells. American Societ of Gene Therapy 2006 Meeting, Baltimore, Maryland, USA. Abstract [Details]

Ronan Cooney, Sean Hynes, Sharif Faisal, Timothy O'Brien (2006) NOS Isoforms, Intimal Hyperplasia and Endothelial Regeneration after Balloon Injury. American Society for Gene Therapy, Baltimore, USA. Abstract [Details]

Lisa McGinley, Gillian Cosgrave, Aoife Duffy, Padraig Strappe, Tim O'Brien (2006) Antioxidant Gene Delivery to Retinal Epithelial Cells: A Gene Therapy Approach to Macular Degeneration. ASGT conference. Baltimore: Abstract [Details]

McDermott JH, Liew A, Avalos G, O'Brien T (2006) Endothelial progenitor cells in Type 1 Diabetes: Declining in tandem with increasing cardiovascular risk?. Irish Endocrine Society 31st Annual Meeting. Abstract [Details]

Liew A, McDermott J, Sharif F, Dockery P, Gaffney M, O'Brien T (2006) Induction of therapeutic angiogenesis by endothelial progenitor cells. Irish Endocrine Society 31st Annual Meeting. Abstract [Details]

Ganly S, Hopkins C, McMahon J, Barron V, McHugh PE, O'Brien T (2007) Investigation of non-viral gene delivery to the vasculature using a polymer-stent platform to combat ISR: A Bioengineering Approach. Irish Society For Gene and Cell Therapy, Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway, Ireland. Abstract [Details]

Donnelly E, McMahon SS, Strappe P,  Rooney G, Fraher JP, Dockery P, O'Brien T (2007) Effect of Lentiviral Vector Expressing Neurotrophin-3 on Dorsal Root Ganglia Neurite Outgrowth. 8th European meeting on glial cell function in health and disease, London, UK. Abstract [Details]

Duffy, G, Kavanagh, C, Sloane, P, Mooney, E, Bowes, T, O'Brien, T, Barry, F (2007) Retrieval of Engrafted Mesenchymal Stem Cells form the Injured Myocardium. 13th Annual Meeting of the International Society for Cellular Therapy, Sydney, Australia. Abstract [Details]

Duffy G, Ahsan T, O'Brien T, Barry F, Nerem R (2007) Angiogenic Interactions between Mesenchymal Stem Cells and Vascular Cells. Tissue Engineering and Development, Keystone, Colorado, USA. Abstract [Details]

McGinley L, O'Toole D, Strappe P, O'Brien T (2007) Viral vector mediated protection from oxidative stress using antioxidant enzymes. Irish Society for Gene and Cell Therapy, Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway, Ireland. Abstract [Details]

Viñas Castells R, Breen A, Damodaran G, Ritter T, O'Brien T, Pandit A (2007) EDC Cross-Linked Collagen Scaffold as a Vehicle for Gene Delivery. 21st European Conference on Biomaterials, Brighton, UK. Abstract [Details]

Bowes T, Greiser U, Barry F, O'Brien T (2007) Detailed Flow Cytometric Analysis of early endothelial progenitor cells demonstrates their heterogenous composition. 13th Annual Meeting of the International Society for Cellular Therapy. Sydney, Australia: Abstract [Details]

Curtin C, Murphy M, O'Flatharta C, Curtin W, Dockery P, O'Brien T, Barry F (2007) Stem Cell Delivery to a Functional Osteoarthritic Explant Model. 2nd Mesenchymal Stem Cell Meeting. York, UK: Abstract [Details]

Curtin C, Murphy, M, O'Flatharta, C, Curtin, W, Dockery, P, O'Brien T, Barry F (2007) Evaluation of adult Stem Cell Targeting Strategies in goat and human osteoarthritic models. Proceedings of the 5th International Society for Stem Cell Research, Cairns, Australia. Abstract [Details]

Curtin CM, Scarpa T, Paoletti S, Curtin W, Dockery P, O'Brien T, Barry F, Murphy M (2007) Chitlac: A Novel Biomaterial to Promote Adhesion of Mesenchymal Stem Cells to Osteoarthritic Cartilage. 13th Annual Meeting of the International Society for Cellular Therapy, Sydney, Australia. Abstract [Details]

Hoare M, Greiser U, Barry F, O'Brien T (2007) Liposomes and Mesenchymal Stem Cells. Proceedings of the Inaugaral Irish society for Gene and Cell therapy, Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway, Ireland. Abstract [Details]

Kavanagh C, Sloane P, Dwyer R, Coleman CM, O'Brien T, Barry F (2007) Myocardial Infarct-Produced Chemokine Stimulus Promotes Stem Cell Migration. Irish Society for Gene and Cell Therapy, Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway, Ireland. Abstract [Details]

Kavanagh C, Sloane P, Dwyer R, Coleman CM, O'Brien T, Barry F (2007) Myocardial Infarct-Produced Chemokine Stimulus Promotes Stem Cell Migration. Proceedings of the 5th International Society For Stem Cell Research. Cairns, Australia: Abstract [Details]

McMahon SS, Donnelly E, Fraher JP, Dockery P, O'Brien T, Strappe P (2007) Effect of lentiviral vector expressing neurotrophin-3 on neurite outgrowth following spinal cord injury. Irish Society for Gene and Cell Therapy Meeting, Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway, Ireland. Abstract [Details]

O'Doherty A, Rosenblat M, Aviram M, O'Brien T (2007) AAV-medaited delivery of paraoxonase 1 (PON1) to the apoE-/- mouse as gene therapy for atherosclerosis. 25th Annual Meeting American Society of Gene Therapy, Seattle, USA. Abstract [Details]

Purcell JC, MacLoughlin R, Duffy C, Power J, O'Brien T, O'Dea S (2007) A study on the effects of aerosolization of plasmid DNA, Liposomally encased plasmid DNA, and siRNA degradation using the Aeroneb lab Pro Nebuliser. International Society for Aerosols in Medicine (ISAM), 16th Congress, Vinci Congress Center, Tours, France. Abstract [Details]

Purcell JC, Power J, O'Brien T, O'Dea S (2007) Effects of aerosolisation on integrity of plasmid DNA, liposomally encased plasmid DNA, protein and siRNA using Aeroneb Pro Nebuliser. Irish Society for Gene and Cell Therapy, Regenerative Medicine Institute (REMEDI), National University of Ireland, Galway, Ireland. Abstract [Details]

Rooney, GE, Moran, C, McMahon, SS, Ritter, T, Maenz, M, Fluegel, A, Dockery, P, O' Brien, T, Howard, L, Windebank, AJ, Barry, FP (2007) A Tissue engineering strategies for spinal cord Injury using mesenchymal stem cells. Keystone Tissue Engineering and Developmental Biology conference Utah USA. Abstract [Details]

Uzbeck, M, A Liew, J McDermott, D Gallagher, I Saleem, G Avalos, JJ Gilmartin, T O'Brien (2007) Endothelial progenitor cell number: A novel concept in pathogenesis of increased cardiovascular risks in obstructive sleep apnoea syndrome. Poster presentation in British Thoracic Society UK. Abstract [Details]

Curtin C, Murphy M, O'Flatharta C, Curtin W, Dockery P, O'Brien T, Barry F (2007) Evaluation of Stem Cell Targeting Strategies to Osteoarthritic Cartilage using an Explant Culture System. Irish Society of Gene & Cell Therapy Conference, Galway. Abstract [Details]

MacLoughlin R, Higgins B, Laffey J, O' Brien T (2007) Optimization of aerosol delivery to the lungs of Sprague-Dawley rat, an in vitro study of aerosol performance. International Society for Aerosols in Medicine (ISAM), 16th Congress, Vinci Congress Center. Tours, France: Abstract [Details]

MacLoughlin R, Higgins B, Laffey J, O'Brien T (2007) A systematic approach to maximising aerosol delivery of adeno-associated viral (AAV) vector to the lungs. British Association for Lung Research (BALR), 'Gene and Stem Cell Therapies for Lung Diseases', National University of Ireland, Maynooth, Ireland. Abstract [Details]

Schu S, O'Flynn L, Shaw G, Busch A, Volk HD, Murphy M, O'Brien T, Ritter T (2007) Down-regulation of MHC class I on mesenchymal stem cells protects them from T-cell mediated cytotoxicity in an inflammatory surrounding. 1st meeting of the ISGCT, Galway, Ireland. Abstract [Details]

Toal F, Donnelly E, O'Brien T, Kelly JP, Fraher JP, Strappe P, Dockery P, McMahon SS (2007) Efficiency of lentiviral vector transduction in injured rat spinal cord, A stereological analysis.  Meeting of the Anatomical Society of Great Britain and Ireland, Durham, UK. Abstract [Details]

Hoare M, Greiser U, Barry F, O'Brien T (2007) Non-viral genetic modification of stem cells. 10th American Society of Gene Therapy, Seattle, Washington, USA. Abstract [Details]

McDermott JH, Liew A, MacCarthy F, Sheahan J, Logie JJ, Hadoke PW, Walker BR, O'Brien T (2007) Deleterious effect of hydrocortisone on endothelial progenitor cell number and function. Oral Presentation in Irish Endocrine Society 32nd Annual Meeting, Dublin, Ireland. Abstract [Details]

Schu S, O'Flynn L, Shaw G, Busch A, Volk H (2007) D, Murphy M, O'Brien T, Ritter T. Down-regulation of MHC class I protects mesenchymal stem cells against T-cell mediated cytotoxicity in an inflammatory surrounding, 3rd World Congress on Regenerative Medicine, Leipzig, Germany. Abstract [Details]

Viñas Castells R, Breen A, Damodaran G, Ritter T, O'Brien T, Pandit A (2007) A Cross- Linked Collagen Scaffold as a Vehicle for Gene Delivery. Tissue Engineering International and Regenerative Medicine Society, London, UK. Abstract [Details]

Curtin C, Scarpa T, Paoletti S, Curtin W, Dockery P, O'Brien T, Barry F, Murphy M (2007) Evaluation of a Novel Biomaterial to Enhance Adhesion of Mesenchymal Stem Cells to Osteoarthritic Cartilage. Irish Society of Gene & Cell Therapy Conference Galway. Abstract [Details]

Purcell JC, Power J, O'Brien T, O'Dea S (2007) Effects of aerosolisation on integrity of plasmid DNA, liposomally encased plasmid DNA, protein and siRNA using Aeroneb Pro Nebuliser. British Assosiation for Lung Research, Maynooth, Ireland. Abstract [Details]

Rooney, Gemma E, McMahon, S, Ritter, T, Garcia, Y, Madigan, N, Flugel, A, Nickander, Kim, Dockery, P, O'Brien, T, Howard, L, Windebank, AJ, Barry, F (2008) Glial-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells. Society for Neuroscience, Washington, USA. Abstract [Details]

M Eglon, A Duffy, P Strappe, T O' Brien (2008) Purification of Adenoviral Vectors For Gene Therapy. ISGCT Annual Conference, UCC. Abstract [Details]

Eleanor Donnelly, Siobhan McMahon, Peter Dockery, John Fraher, Padraig Strappe, Daniel O'Toole, Lisa McGinley, Timothy O'Brien (2008) Analysis Silencing NG2 inhibitory factor and its effect on dorsal root ganglia neurite outgrowth. ISGCT Annual Conference. UCC: Abstract [Details]

McMahon S, Albermann S, Rooney GE, O'Brien, T, Garcia Y, Dockery P, Windebank AJ, Allsopp TE, Barry FP (2008) Analysis of Neural Stem cells following transplantation into injured rat spinal cord. Neuroscience Ireland Meeting. NUI Galway: Abstract [Details]

Frank Barry, Mary Murphy, Cindy Coleman, Tim O'Brien, Margaret Rae, Karen Duffy (2008) Mesenchymal Stem Cells: Characterization, Therapeutic Evaluation and Manufacturing. TCES Conference, University of Nottingham. Abstract [Details]

M Eglon, A Duffy, P Strappe, T O'Brien (2008) Purification of Adenoviral Vectors For Gene Therapy. 16th ESGCT Annual Congress Brugge, Belgium. Abstract [Details]

FT Martin, RM Dwyer, JM Murphy, FP Barry, T O'Brien, MJ Kerin (2008) The metastatic potential of circulating Breast Cancer Cells is promoted through interactions with Mesenchymal Stem Cells. San Antonio Breast Cancer Symposium, San Antonio, Texas, USA. Abstract [Details]

FT Martin, RM Dwyer,TP Griffin, JM Murphy, FP Barry, T O'Brien, MJ Kerin (2008) The Role of Bone-Derived Mesenchymal Stem Cells (MSCs) in Facilitating Breast Cancer Metastasis. Sylvester O Halloran Surgical Symposium, Limerick. Abstract [Details]

Curtin, C, Murphy, M, O'Flatharta, C, Curtin, W, Dockery, P, O'Brien, T, Barry, F (2008) Evaluation of Cartilage Repair Strategies using an Osteoarthritic Explant Model. 12th Annual Hilton Head Workshop, Regenerative Medicine: Advancing to Next Generation Therapies, Hilton Head Island, South Carolina, USA. Abstract [Details]

Kavanagh C, Sloane P, Dwyer R, Coleman CM, O'Brien T, Barry F (2008) Myocardial Infarct-Produced Chemokine Stimulus Promotes Stem Cell Migration. 12th Annual Hilton Head Workshop, Regenerative Medicine: Advancing to Next Generation Therapies, Hilton Head Island, South Carolina USA. Abstract [Details]

RM Dwyer, JC Morris, JM Murphy, FP Barry, T O'Brien, MJ Kerin (2008) Sodium Iodide Symporter (NIS) mediated Iodide Uptake in Mesenchymal Stem Cells following Adenoviral Transduction. American Society of Gene Therapy (ASGT), Boston, Massacheusetts, USA. Abstract [Details]

LA Mylotte, E Szegezdi, T O'Brien, M Murphy, C Coleman, F Barry (2008) Investigation of chondrogenic differentiation of MSCs in a hypoxic environment. ISCT Miami. Abstract [Details]

Nicolas Madigan, Siobhan McMahon, Thomas Ritter, Gemma Rooney, Frank Barry, Anthony Windebank, Timothy O'Brien (2008) Regeneration of injured spinal cord neurons through implantable polymer bridges using a combined approach of neurotrophic support and glial scar inhibition. ISGCT Annual Conference, UCC. Abstract [Details]

Curtin, Caroline, Murphy, Mary, Curtin, William, Docker, Peter, O'Flatharta, Cathal, O'Brien, Timothy, Barry, Frank (2008) Targeting Stem Cells for Cartilage Repair. ISGCT Annual Conference, University College Cork. Abstract [Details]

RM Dwyer, JC Morris, JM Murphy, FP Barry, T O'Brien and MJ Kerin (2008) Sodium Iodide Symporter (NIS) mediated Iodide Uptake in Mesenchymal Stem Cells following Adenoviral Transduction. ISGCT Annual Conference. UCC: Abstract [Details]

Schu S, O'Flynn L, Shaw G, Busch A, Volk HD, Barry F, Murphy M, O'Brien T, Ritter T (2008) MHC class I dependent lysis of allogenic MSCs by cytotoxic T cells is reduced in Ad-Ox18sc 'intrabody' expressing MSCs. ISGCT Annual Conference. UCC: Abstract [Details]

N Madigan, G Rooney, T Ritter, F Barry, A Windebank, T O'Brien, S McMahon (2008) Regeneration of Injured Spinal Cord Neurons through Implantable Polymer Bridges Using A Combined Approach Of Neurotrophic Support And Glial Scar Inhibition. Neuroscience Ireland Meeting. NUI Galway: Abstract [Details]

Eleanor Donnelly, Siobhan McMahon, Peter Dockery, John Fraher, Padraig Strappe, Daniel O'Toole, Lisa McGinley, Timothy O'Brien (2008) Analysis Silencing NG2 inhibitory factor and its effect on dorsal root ganglia neurite outgrowth. Neuroscience Ireland Meeting. NUI Galway: Abstract [Details]

RM Dwyer, JC Morris, JM Murphy, FP Barry, T O'Brien and MJ Kerin (2008) Investigation of the potential of Mesenchymal Stem Cells (MSCs) for gene delivery to breast tumors. European Association for Cancer Research (EACR) Lyon, France. Abstract [Details]

Holladay, C, Murphy, M, Greiser, U, O'Brien, T, Pandit, A (2008) Complexing DNA with Dendrimers to Enhance Gene Delivery from Collagen Scaffolds to Mesenchymal Stem Cells. Podium presentation at the Tissue Engineering and Regenerative Medicine International Society, Porto, Portugal. Abstract [Details]

Kulkarni, M, Breen A, Greiser, U, O'Brien T, Pandit, A (2008) Bio-molecular Interaction between Fibrin and Lipoplexes Results in Extended Release of Plasmid DNA. Tissue Engineering and Regenerative Medicine International Society, Porto, Portugal. Abstract [Details]

Joseph N Mackle, David Blond, Frank Barry, Timothy O' Brien, Mary Murphy, Valerie Barron (2008) Development of a carbon nanotube based Electroactive scaffold for production of a tissue engineered cardio patch. American Heart Association's Scientific Sessions. Abstract [Details]

LA Mylotte, E Szegezdi, T O'Brien, M Murphy, C Coleman, F Barry (2008) Investigation of chondrogenic differentiation of MSCs in a hypoxic environment. Gordon Research Conference, Musculoskeletal Biology & Bioengineering, Proctor Academy, Andovery, NH. Abstract [Details]

Curtin C, Murphy M, Curtin W, Dockery P, O'Flatharta C, O'Brien T, Barry F (2008) Development of mesenchymal stem cell targeting strategies for cartilage repair C. World Congress of Osteoarthritis, Italy. Abstract [Details]

Mylotte LM, O'Brien T (2008) Importance of Metabolically Flexibile Mscs for Cardiac Repair. 4th Conference on Cardiovascular Cell and Gene Therapy, Mt Sinai School of Medicine. Abstract [Details]

Vaughan, Erin and O'Brien, T (2008) The Role of Osteopontin in Angiogenesis 4th Conference on Cardiovascular Cell and Gene Therapy, Mt. Sinai School of Medicine, Cardiovascular Institute and Center for Cardiovascular Health, NY. Abstract [Details]

Udo Greiser, Melissa Hoare, Tyrone Bowes, Roisin Dwyer, Daniel O'Toole, Kaveh Mashayekhi, Mary Murphy, Frank Barry and Timothy O'Brien (2008) Next Generation Mesenchymal Stem Cells for Regenerative Medicine Applications: Antibodies, Peptides and Lipoplexes for isolation, expansion and genetic modification of MSCs from several species. ISGCT Annual Conference, UCC. Abstract [Details]

Liew A, Bowes T, Coleman C, Greiser U, O'Brien T (2008) Critical Role for Osteopontin in Endothelial Progenitor Cell (EPC) Function. International Society for Cell Therapy in Miami, FL. Abstract [Details]

LA Mylotte, E Szegezdi, T O'Brien, M Murphy, C Coleman, F Barry (2008) Investigation of chondrogenic differentiation of MSCs in a hypoxic environment. Musculoskeletal Biology & Bioengineering: Integrating Musculoskeletal Science, Proctor Academy, Andover, NH. Abstract [Details]

Breen, A, Dockery, P, O' Brien, T and Pandit, A (2008) Fibrin Delivery of Adenoviral Vector Encoding eNOS Promotes Wound Healing in a Dermal Wound Model. Poster presentation at the 8th World Biomaterials Congress, Amsterdam, Holland. Abstract [Details]

Lisa McGinley, Daniel O'Toole, Jill McMahon, Padraig Strappe, Timothy O'Brien (2008) Viral vector mediated delivery of antioxidant and anti-apoptotic proteins. ISGCT Annual Conference, UCC. Abstract [Details]

Siobhan S McMahon, Silke Albermann, Gemma E Rooney, Timothy O'Brien, Yolanda Garcia, Peter Dockery, Anthony J Windebank, Timothy E Allsopp, Frank P Barry (2008) Neural stem cells differentiate into neurons and glia following transplantation into injured rat spinal cord. Neuroscience Ireland Meeting, NUI Galway. Abstract [Details]

Joseph N Mackle, David Blond, Werner Blau, Frank Barry, Timothy O' Brien, Mary Murphy, Valerie Barron (2008) Development of a Carbon Nanotube Based Electroactive Scaffold for Production of a Tissue Engineered Cardiac Patch. AHA Scientific Sessions 2008, New Orleans. Abstract [Details]

Curtin, Caroline, Murphy, Mary, Curtin, William, Dockery, Peter, O'Flatharta, Cathal, O'Brien, T, Barry, Frank (2008) Development of a Functional Human Osteoarthritic Explant Model for Evaluation of Cartilage Repair Strategies. 12th Annual Hilton Head Workshop, Regenerative Medicine: Advancing to Next Generation Therapies. Abstract [Details]

Aydodan, E, Cregg, M, Schu, S, Ryan, C, Murphy, M, O'Brien, T, Barry, F, Ritter, T (2008) Influence of genetic modification of mesenchymal stem cells on their differentiation capacity and immunogenicity. ISGCT Annual Conference. UCC: Abstract [Details]

MacLoughlin R, Higgins B, Laffey J, O'Brien T (2008) Aerosol delivery of rAAV pseudotypes 2, 2/5 and 2/6. ISGCT Annual Conference. UCC: Abstract [Details]

Siobhan McMahon, Peter Dockery, Eleanor Donnelly, John Fraher, Padraig Strappe, Timothy O'Brien (2008) An ultrastructural study of the effect of silencing NG” inhibitory factor. 16th ESGCT Annual Congress Brugge, Belgium. Abstract [Details]

Udo Greiser, Melissa Hoare, Tyrone Bowes, Roisin Dwyer, Daniel O'Toole, Kaveh Mashayekhi, Mary Murphy, Timothy O'Brien, Frank Barry (2008) Next Generation Mesenchymal Stem Cells for Regenerative Medicine Applications: Antibodies, Peptides and Lipoplexes for isolation, expansion and genetic modification of MSCs. 16th ESGCT Annual Congress Brugge, Belgium. Abstract [Details]

Garry Duffy, Sinead Darcy, Tabassum Ahsan, Robert M Neerem, Timothy O'Brien, Frank Barry (2008) Mesenchymal stem cells over-expressing ephrin-B2: A potential pro-angiogenic stem cell source. 16th ESGCT Annual Congress Brugge, Belgium. Abstract [Details]

Barry McGrath, Timothy O'Brien (2008) Efficient transduction of adult human and rat mesenchymal stem cells with a third genertaion HIV-1 derived lentivirus. 16th ESGCT Annual Congress Brugge, Belgium. Abstract [Details]

E Mooney, JN Mackle, F Barry, T O'Brien, M Murphy, V Barron (2008) Electrical Stimulation of Mesenchymal Stem Cells in the Presence of Carbon Nanotubes. AHA Scientific Sessions 2008, New Orleans. Abstract [Details]

Liew A, Bowes T, Coleman CM, Greiser U, O'Brien T (2008) Endothelial Progenitor Cell Dysfunction in Diabetes Mellitus: A Role for Osteopontin. 12th Annual Hilton Head Workshop, Regenerative Medicine: Advancing to Next Generation Therapies, Hilton Head Island, South Carolina USA. Abstract [Details]

Claire Kavanagh, Peter A Sloane, Roisin Dwyer, Cynthia Coleman, Timothy O'Brien Frank Barry (2008) Mesenchymal stem cell migration in response to a myocardial infarct-produced chemokine stimulus. ISGCT Annual Conference. UCC: Abstract [Details]

Siobhan S McMahon, Silke Albermann , Gemma E Rooney, Timothy O'Brien, Yolanda Garcia, Peter Dockery, Anthony J Windebank, Timothy E Allsopp, Frank P Barry (2008) Analysis of Neural Stem Cells Following Transplantation into Injured Rat Spinal Cord. ISGCT Annual Conference. UCC: Abstract [Details]

Vaughan, Erin, Liew, A, Coleman C, O'Brien, T (2008) The Role of Osteopontin in Angiogenesis. ISGCT Annual Conference. Abstract [Details]

Caroline Curtin, Mary Murphy, Cynthia Coleman, William Curtin, Peter Dockery, Cathal O'Flatharta, Timothy O'Brien, Frank Barry (2008) Allogenic mesenchymal stem cells for regenerative medicine. Oral presentation European Society of Sports Traumatology Knee Surgery and Arthroscopy (ESSKA), Porto, Portugal. Abstract [Details]

Castells, R, Yao, Li, Tiong, W, Wallace, M, Ritter, T, Kelly, J, O'Brien, T, Pandit, A (2008) EDC/NHS and PAMAM Dendrimer Cross-linked Collagen Scafold for Sustained Gene Delivery. 8th World Biomaterials Conference, The Netherlands. Abstract [Details]

FT Martin, RM Dwyer, JM Murphy, FP Barry, T O'Brien, MJ Kerin (2008) Marrow-Derived Mesenchymal Stem Cells (MSCs) stimulate chemokine secretion and gene expression in breast cancer cells. European Association for Cancer Research (EACR), Lyon, France. Abstract [Details]

Ronan Mac Loughlin, Brendan Higgins, John Laffey and Timothy O'Brien (2008) Aerosol delivery of AAV5-gfp to the rodent lung. 16th ESGCT Annual Congress Brugge, Belgium. Abstract [Details]

Duffy G, Kavanagh C, Mooney E, Coleman C, Bowes T, O'Brien T, Barry F (2008) Novel techniques for the retrieval of engrafted mesenchymal stem cells from the injured myocardium. ISCT Miami. Abstract [Details]

Curtin, C, Murphy, M, O'Flatharta, C, Curtin, W, Dockery, P, O'Brien, T, Barry, F (2008) Assessment of Stem Cell Targeting Strategies in a Functional Human Osteoarthritic Explant Model. 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, California, USA. Abstract [Details]

McMahon S, Albermann S, Hynes J, Rooney G, Moran C, Shaw G, O'Brien T, Garcia Y, Dockery P, Windebank AJ, Allsopp TE, Barry F (2008) Effect of Neural Stem Cells and Cyclosporin-A on Cellular Environment of Contused Rat Spinal Cord. 12th Annual Hilton Head Workshop, Regenerative Medicine: Advancing to Next Generation Therapies, Hilton Head Island, South Carolina USA. Abstract [Details]

Griallais, R, Breen, A, Kulkarni, M, Dockery, P, O'Brien, T, Pandit, A (2008) Stereological Methods in the Assessment of Functionalised Scaffolds in Vivo. Tissue Engineering and Regenerative Medicine International Society, Porto, Portugal. Abstract [Details]

T Ritter, E Aydogan, M Cregg, S Schu, C Ryan, M Murphy, T O'Brien, F Barry (2008) Influence of genetic modification of mesenchymal stem cells on their differentiation capacity and immunogenicity. 16th ESGCT Annual Congress, Brugge, Belgium. Abstract [Details]

Eleanor Donnelly, Siobhan McMahon, Peter Dockery, John Fraher, Padraig Strappe, Daniel O'Toole, Lisa McGinley, Timothy O'Brien (2008) Effect of lentiviral vector expressing Neurotrophin-3 and shRNA for NG2 on cellular environment of injured spinal cord. 16th ESGCT Annual Congress Brugge, Belgium. Abstract [Details]

Lisa McGinley, Daniel O'Toole, Jill McMahon, Padraig Strappe, Timothy O'Brien (2008) Viral vector mediated delivery of antioxidant and anti-apoptotic proteins to mesenchymal stem cells. 16th ESGCT Annual Congress Brugge, Belgium. Abstract [Details]

O'Brien, T (2008) Development of regenerative therapies using genetically modified cell transplantation. Abstract [Details]

O'Loughlin A, Woldron-Lynch F, Cronin K, Dineen S, Griffin D, Lee J, Jaffrey S, O'Brien T, Dunne F (2008) Non-Islet Cell Tumour Hypoglycaemia due to Renal Sarcoma. Irish Endocrine Society. Abstract [Details]

Javid S, O'Sullivan EP, Dineen S, O'Brien T, Dunne F (2009) Glycaemic, blood pressure and lipid control in type 1 diabetes. 69th Scientific Sessions, American Diabetes Association, New Orleans. Abstract [Details]

M Kulkarni, A Breen, U Greiser, T O'Brien, A Pandit (2009) Fibrin-lipoplex system for controlled delivery of multiple genes. Oral Presentation at the 36th Annual Meeting and Exposition of the Controlled Release Society, Copenhagen, Denmark. Abstract [Details]

O'Loughlin A, Kulkumari M, Ward J, Pandit A, O'Brien T (2009) Type 1 bovine collagen is an effective biomaterial for topical delivery of peripheral blood mononuclear cells and circulating angiogenic cells. Irish Society for Cell and Gene Therapy conference, Cork. Abstract [Details]

Vaughan E, Duffy A, O'Brien T (2009) Osteopontin Stimulates Secretion of Angiogenic Proteins in Endothelial Cells. Oral Presentation, Irish Society for Cell and Gene Therapy conference, Cork. Abstract [Details]

Vaughan E, Duffy A, O'Brien T (2009) Osteopontin Stimulates Secretion of Angiogenic Proteins in Endothelial Cells. Oral Presentation, American Heart Association Scientific Sessions. Abstract [Details]

Duffy K, Madden K, O'Brien T, Barry FB (2009) European Regulatory Compliance in the Manufacture of Human Cellular Therapeutic Products. International Society for Cell and Gene Therapy, Cork. Abstract [Details]

Kavanagh C, Duffy G, Mashayekhi K, O' Brien T, Barry FB (2009) Secreted Frizzled Protein 2, a Cardioprotective Gene is Upregulated in Mesenchymal Stem Cells Following Engraftment in the Injured Myocardium. American Heart Association, National Scientific Session. Abstract [Details]

FT Martin, RM Dwyer, JM Murphy, N Miller, FP Barry, T O'Brien, MJ Kerin (2009) Mesenchymal Stem Cells (MSCs) meay promote breast cancer metastatic potential through stimulation of Epithelial-Mesenchymal Transition (EMT). Oral presentation at the Society of Academic and Research Surgeons (SARS), Cambridge, UK. Abstract [Details]

FT Martin, RM Dwyer, J Kelly, JM Murphy, N Miller, E Hennessy, C Curran, FP Barry, T O'Brien, MJ Kerin (2009) Interactions between Mesenchymal Stem Cells (MSCs) and Breast Cancer cells support induction of Epithelial - Mesenchymal Transition (EMT). Irish Association for Cancer Research, Athlone. Abstract [Details]

Javid S, O'Sullivan EP, Dinneen S, O'Brien T, Dunne F (2009) The impact of obesity on attainment of ADA targets in patients with type 2 diabetes. 69th Scientific Sessions, American Diabetes Association, New Orleans. Abstract [Details]

M Kulkarni, A Breen, U Greiser, T O'Brien, A Pandit (2009) Towards development of safe and efficient fibrin based topical gene delivery systems for angiogenesis in compromised wound healing. 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen. Abstract [Details]

FT Martin, RM Dwyer, JM Murphy, N Miller, C Curran, E Hennessy, FP Barry, T O'Brien, MJ Kerin (2009) Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: Stimulation of epithelial to mesenchymal transition (EMT). American Association for Cancer Research, Denver, Colarado, USA. Abstract [Details]

JC Kelly, RM Dwyer, M Murphy, FP Barry, T O'Brien and MJ Kerin (2009) Mesenchymal stem cells and breast cancer: therapeutic delivery vehicles or tumour promoting agents. Oral presentation at Sir Peter Freyer Surgical Symposium, Galway. Abstract [Details]

JC Kelly, RM Dwyer, M Murphy, FP Barry, T O'Brien and MJ Kerin (2009) Mesenchymal Stem Cell (MSC) secretion of TGFß and VEGF stimulates Epithelial to Mesenchymal Transition (EMT) in breast cancer cell lines. European Cancer Conference (ECCO), Berlin. Abstract [Details]

Bowes T, Greiser U, Murphy M, O'Brien T, Barry F (2009) Single Chain Antibodies from Chicken Immune Phage Display Libraries: Reagents for Regenerative Medicine Applications and Targeting Devices for Anti - Metastasis Therapeutics. 17th Annual Conference of the European Society of Gene and Cellular Therapy, Hannover, Germany. Abstract [Details]

M Kulkarni, A Breen, U Greiser, T O'Brien, A Pandit (2009) Towards development of safe and efficient fibrin based topical gene delivery stytems for angiogenesis in compromised wound healing. Oral presentation at the 5th Joint Meeting of The European Tisue Repair Society and The Wound Healing Society (ETRS-WHS), Limoges, France. Abstract [Details]

Bowes T, Greiser U, Finlay J, O'Brien T and Barry F (2009) Antibodies Generated Using Chicken Immune Phage Display, their Role in Regenerative Medicine and as Potential Therapeutics in Metastasis. 3rd Annual Conference of the Irish Society of Gene and Cellular Therapy 2009, Cork, Ireland. Abstract [Details]

O'Loughlin A, Kulkumari M, Ward J, Pandit A, O'Brien T (2009) Collagen is an effective biomaterial for cell delivery to a diabetic wound. Irish Endocrine Society Meeting, Cork. Abstract [Details]

RM Dwyer, J Ryan, R Havelin, JC Morris, C O'Flatharta, G Duffy, B Miller, Z Liu, HH Barrett, M Murphy, FP Barry, T O'Brien and MJ Kerin (2009) Sodium Iodide Symporter (NIS) mediated tracking of Mesenchymal Stem Cell (MSC) migration to breast tumours in vivo. Oral presentation at European Society for Gene and Cell Therapy, Hannover Germany. Abstract [Details]

O'Loughlin A, McIntosh C, Dinneen SF, O'Brien T (2010) Preparing the wound to heal. Lower Extremity Wound Conference. Galway: Abstract [Details]

O'Louhglin A, Kulkarni M, Dockery P, Pandit A, O'Brien T (2010) EPCs - Are they good for the Sole? Irish Endocrine Society. Irish Journal of Medical Science. Abstract [Details]

Vaughan E, Duffy A, O'Brien T (2010) The role of osteopontin in endothelial progenitor cell function. EASD. Stockholm: Abstract [Details]

Holladay C, Sefton M, Dockery P, Murphy M, O'Brien T (2010) Interleukin-10 Transfection Improves Stem Cell Retention within a scaffold after Implantation. ESB. Tampere: Abstract [Details]

Carolyn Holladay, Aoife Duffy, Xizhe Chen, Timothy O'Brien, Michael Sefton, Abhay Pandit (2010) Enhancing Stem Cell Retention within a Functionalised Scaffold after Implantation in an Infarcted Heart. Oral presentation at TERMIS-NA, Orlando. Abstract [Details]

Hynes SO, Sharif F, McCullagh K, Ganly S, Crowley J, Greiser U, McHugh P, O'Brien T (2010) Gene Eluting Stents: Enhanced Vessel Healing from Viral and Non-Viral Vectors. Arteriosclerosis, Thrombosis and Vascular Biology 2010 Scientific Sessions, Hosted by the American Heart Association, San Francisco. Abstract [Details]

Ganly S, Hynes S, Sharif F, Barron V, McCullagh K, McHugh P, Crowley J, O'Brien T, Greiser U (2010) A Comparison of Gene Delivery both in vitro and in vivo, from Phosphorylcholine-Coated Stents, using Commercial and Novel Lipoplex Formulations. TERMIS-EU Meeting, Galway. Abstract [Details]

Stocca A, O'Toole D, Duffy A, O'Brien T (2010) The role of MRP8 in in stent restonosis in the diabetic rat. EASD. Stockholm: Abstract [Details]

O'Loughlin A, Ward J, Kulkurani M, Pandit A, Dinneen S, O'Brien T (2010) Cell therapy for diabetic ulceration: Collagen is an effective biomaterial for cell delivery to a diabetic wound. Communications for the Spring Meeting of the Medical Research Society, held in conjunction with the Academy of Medical Sciences and the Royal College of Physicians, London. Abstract [Details]

Vaughan E, Duffy A, O'Brien T (2010) Osteopontin Enhances the Angiogenic Potential of Endothelial Progenitor Cells. ASGCT 2010 13th Annual Meeting, Washington DC. Abstract [Details]

McGinley L, O'Toole D, Duffy A, Chen X, Stocca A, McMahon J, O'Brien T (2010) Strategies for Promoting Survival of Transplanted Mesenchymal Stem Cells in a Myocardial Infarction Model. ASGCT 2010 13th Annual Meeting, Washington DC. Abstract [Details]

Donnelly E, McMahon S, Dockery P, Fraher J, Strappe P, Madigan N, McGinley L, Windebank T, O'Brien T (2010) Modification of the inhibitory enviroment of spinal cord injury by lentiviral vector containing NT-3 and shRNA for NG2. American Society of Gene and Cell Therapy, Washington DC. Abstract [Details]

McGinley, L, O'Toole D, Duffy A, Chen X, Stocca A, McMahon J, O'Brien T (2010) Strategies for Promoting Survival and Engraftment of Transplanted Mesenchymal Stem Cells. TERMIS EU2010, Galway. Abstract [Details]

O'Loughlin A, Kulkarni M, Ward J, Dockery P, Pandit A, O'Brien T (2010) Mediating Cell Delivery to a Diabetic Wound with the Use of a Collagen Scaffold. TERMIS-EU Meeting, Galway. Abstract [Details]

Madigan NN, Rooney GE, Knight AM, Chen B, Gross LA, Dadsetan M, Yaszemski MJ, McMahon SS, O'Brien T, Windebank AJ (2010) Axonal Regeneration Supported by Schwann Cells and Mesenchymal Stem Cells through Hydrogel Scaffolds in the Transected Rat Spinal Cord.. TERMIS-EU Meeting, Galway. Abstract [Details]

Kulkarni M, Greiser U, O'Brien T, Pandit A (2010) ID 3558 Fibrin Microspheres Extend the Gene Delivery Capacity in a Fibrin Scaffold. ESB. Tampere: Abstract [Details]

Vaughan E, Duffy A, O'Brien T (2010) The role of osteopontin in endothelial progenitor cell function. European Association for the Study of Diabetes, 46th Annual Meeting, Stockholm. Abstract [Details]

O'Loughlin A, McIntosh C, Dinneen SF, O'Brien T (2010) Clinical Audit of Diabetes-related Lower Extremity Amputation in a Tertiary Referral Hospital. Irish Endocrine Society. Abstract [Details]

O'Loughlin A, McIntosh C, Dinneen SF, O'Brien T (2010) Clinical Audit of Diabetes-related Lower Extremity Amputation in a Tertiary Referral Hospital. Irish Journal of Medical Science. Abstract [Details]

Curtin C, Murphy M, Ritter T, Curtin W, O'Brien T, Barry F (2010) Mesenchymal Stem Cells Overexpressing Bcl-xl Enhance Tissue Repair in an Osteoarthritic Cartilage Explant Model. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, USA. Abstract [Details]

Stocca A, O'Toole D, Duffy A, O'Brien T (2010) The role of MRP8 in in stent restenosis in the diabetic rat. TERMIS EU2010, Galway. Abstract [Details]

Donnelly E, Madigan N, Rooney G, Strappe P, Windebank A, O'Brien T, McMahon T (2010) Lentiviral vector treatment of the inhibitory spinal cord injury environment in vitro and in vivo. TERMIS-EU Meeting. Galway: Abstract [Details]

Ganly S, Hynes SO, Sharif F, McCullagh K, Barron V, Crowley J, McHugh P, O'Brien T, Greiser U (2010) A comparision of three liposomal formulations for gene delivery from coronary artery stents. ASGCT 2010 Clinical Trials Training Course and 13th Annual Meeting Washington DC. Abstract [Details]

Carolyn Holladay, Karen Power, William Gallagher, Michael Sefton, Timothy O'Brien, Abhay Pandit (2010) Interleukin-10 Functionalised Scaffold Improves Stem Cell Retention In Vivo. TERMIS-NA, Orlando. Abstract [Details]

Vaughan EE, O'Loughlin A, Liew A, Duffy A, O'Brien T (2010) OPN exposure increases the angiogenic potential of endothelial progenitor cells. Irish Endocrine Society. Abstract [Details]

Vaughan EE, O'Loughlin A, Liew A, Duffy A, O'Brien T (2010) OPN exposure increases the angiogenic potential of endothelial progenitor cells. Irish Journal of Medical Science Poster 27. Abstract [Details]

Dwyer RM, Ryan J, Havelin RJ, Morris JC, O'Flatharta C, Miller BW, Liu Z, Foley MJ, Barrett HH, Murphy M, Barry FP, O'Brien T and Kerin MJ (2011) Mesenchymal Stem Cell (MSC) mediated delivery of the Sodium Iodide Symporter (NIS) supports radionuclide imaging and treatment of breast cancer. American Association for Cancer Research, Orlando, Florida. Abstract [Details]

Aonghus O'Loughlin, Mangesh Kulkarni, Peter Dockery, Georgina Shaw, Mary Murphy, Abhay Pandit, Timothy O'Brien (2011) Topical Mesenchymal Stem Cells as Skin Replacement Therapy for Diabetic Foot Ulceration. Irish Association of Plastic Surgeons Summer Meeting 2011 Ashford Castle, Co Mayo. Abstract [Details]

   

Conference Paper

Sen S, Bartlett J, Akhtar Y, Courtney, D, Sultan S. O'Brien T. (2003) Adeno-Associated Virus (AAV) Mediated Gene Delivery to Vascular Cells in the Rabbit Carotid Artery Module. A Controlled Randomised Clinical Trial.. Sir Peter Freyer Memorial Lecture and Surgical Symposium in association with the Irish Society of Surgical Oncology * NUI,Galway. Conference Paper [Details]

Breen, A, Strappe, P, Anilkumar, TV, O'Brien, T, Pandit, A. (2005) Optimisation of a Fibrin Scaffold for Sustained Release of an Adenoviral Gene Vector . Conference Paper [Details]

   

Editorial

O'Brien, T,Barry, FP (2009) Stem Cell Therapy and Regenerative Medicine. Editorial [Details]

O'Brien, T,Barry, F (2010) Introduction to Series on Mesenchymal Stromal (Stem) Cells-MSCs. Editorial [DOI] [Details]

           

Reviews

O'Brien T, Bolster M, Sullivan P (1990) Fabry's Disease: A Family Study. Irish J Med Sci. Reviews [Details]

Kinsella P, O'Brien T, Brosnan E, O'Sullivan DJ (1991) A case of pregnancy associated osteoporosis and empty sella syndrome. Irish Medical Journal. Reviews [Details]

O'Brien T, Silverberg J, Nguyen T (1992) Nicotinic acid-induced toxicity associated with cytopenia and decreased levels of thyroxine-binding globulin. Mayo Clin Proc. Reviews [Details]

O'Brien T, Young WF, Davilla DG, Scheitauer BW, Kovacs K, Horvath E, Vale W, van Heerden JA (1992) Cushing's syndrome associated with ectopic production of corticotrophin-releasing hormone, corticotrophin and vasopressin by a pheochromocytoma. Clin Endocrinol. Reviews [Details]

O'Brien T, Palumbo PJ (1993) Hyperlipidemia and diabetes mellitus. G Ital Diabetol. Reviews [Details]

O'Brien T (1996) The influence of hormones on lipids in women. PrimePractice. Reviews [Details]

O'Sullivan DJ, Cronin C, Buckley D, Mitchell TM, Jenkins DJ, Greally J, O'Brien T (1997) Unusual manifestations of type 1 autoimmune polyendocrinopathy. Ir Med J. Reviews [Details]

O'Brien T, Nguyen TT (1997) Lipids and lipoproteins in women. Mayo Clin Proc. Reviews [Details]

O'Brien T (1997) Lp(a) and diabetes mellitus. Endocrine Practice. Reviews [Details]

O'Brien T, Nguyen TT, Zimmerman B (1998) Hyperlipidemia and diabetes mellitus. Mayo Clinic Proceedings. Reviews [Details]

O'Brien T (1998) Gene transfer and vascular disease. Journal of the Irish College of Physicians and Surgeons. Reviews [Details]

O'Brien T, Nguyen TT (1998) Pathogenic role of triglycerides in the cardiovascular disease of type 2 diabetes mellitus. Current Opinion in Endocrinology and Diabetes. Reviews [Details]

Chen AFY, O'Brien T, Katusic ZS (1998) Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system. Trends in Pharmacological Sciences. Reviews [Details]

Bashoff EC, Johnson LM, Jovanovic L, LaRosa JC, O'Brien T (1998) Women and diabetes: Special health concerns. Patient Care. Reviews [Details]

O'Brien T (1999) The effects of hormonal therapy on plasma lipids and the risk of coronary artery disease in women. Medical Updates on Therapy, Diagnosis and Prevention, J American International Health Council. Reviews [Details]

Ganda O, Hill Golden S, O'Brien T (1999) Early and aggressive intervention to prevent heart disease in diabetes mellitus. Patient Care. Reviews [Details]

Zanetti M, O'Brien T, Palumbo PJ (1999) Gene therapy for type I diabetes. J It Diabetology. Reviews [Details]

Leung N, O'Brien T, McMahon MM (1999) Parenteral feeding in a patient with hypertriglyceridemia and increased liver enzyme levels. Endocrine Practice. Reviews [Details]

O'Brien T (2000) Adenoviral vectors and gene transfer to the blood vessel wall. Editorial Arterioscler Throm Vasc Biol. Reviews [Details]

O'Brien T, Simari RD (2000) Gene therapy for cardiovascular disease: A time for optimism and caution. Mayo Clinic Proceedings. Reviews [Details]

Simari RD, O'Brien T (2001) Clinical Applications of Vascular Gene Transfer. Current Cardiology Reports. Reviews [Details]

Vella A, Pineda A, O'Brien T (2001) Low-density-lipoprotein apheresis: Therapy for refractory hyperlipidemia. Mayo Clinic Proceedings. Reviews [Details]

Simari, RD, O'Brien, T (2002) Clinical Trials in Vascular Gene Therapy: The Missing Piece of the Puzzle. Archives of Pathology and Laboratory Medicine. Reviews [Details]

Sen S, O'Brien T (2003) Improving endothelial dysfunction in diabetes mellitus. Irish Medical News. Reviews [Details]

Kudva Y, Reynolds CA, O'Brien T, Crotty TB (2003) Mastopathy and Diabetes. Current Diabetes Reports. Reviews [Details]

Bell, M, O'Brien, T, Lappin, D (2004) (2004) The role of dual blockade of the renin-angiotensin system in diabetic nephropathy. Diabeteswise. Reviews [Details]

Flaherty G, Bell M, O'Keeffe D, Crowley J, T O'Brien (2004) When head rules heart. Lancet. Reviews [Details]

Sharif, F, Daly, K, Crowley, J, O'Brien, T, (2004) (2004) Current status of catheter and stent-based gene therapy. Cardiovascular Research. Reviews [Details]

Sen S, Strappe PM, O'Brien T (2005) Gene transfer in endothelial dysfunction and hypertension. Methods Mol Med. Reviews [Details]

O'Brien, T Samali, A, Duffy, AM, Reeve, JL (2005) Don’t Lose Heart - Therapeutic Value of Apoptosis Prevention in the Treatment of Cardiovascular Disease. Journal of Cellular and Molecular Medicine. Reviews [Details]

Zanetti M, d'Uscio LV, Peterson TE, Katusic ZS, O'Brien T (2005) Analysis of superoxide anion production in tissue. Methods Mol Med. Reviews [Details]

O'Brien, T, Flaherty, G (2005) The malady of ascent - an overview of high altitude illness. Modern Medicine. Reviews [Details]

Barry FP, Murphy JM, O'Brien T, Mahon BP (2005) (2005) Mesenchymal stem cell transplantation for tissue repair. Sem Plast Surg. Reviews [Details]

O'Brien, T (2006) Disorders of high-density lipoprotein cholesterol. Accepted by the American Association of Clinical Endocrinologists. Reviews [Details]

Flaherty, G, Bell, M, Dunne, F, O'Brien, T (2006) Preparing patients with diabetes for international travel. Modern Medicine. Reviews [Details]

Flaherty, G, Umeed, M, O'Brien, T, Fry, G (2006) Public Awareness of the Health Risks Associated with Trekking to High Altitude. British Travel Health Association Journal. Reviews [Details]

O'Brien T (2006) Review of High Density Lipoproteins. Endocrine Self-Assessment Committee of the American Medical Accreditation Program (AMAP) Research Committee. Reviews [Details]

Flaherty G, Sharif F, Bell M, Daly K, O'Brien T (2006) Reversible dilated cardiomyopathy: an unusual presentation of thyrotoxicosis. Ir Med J. Reviews [Details]

McCabe C, Samali A, O'Brien T (2006) Cytoprotection of beta cells: rational gene transfer strategies. Diabetes Metab Res Rev. Reviews [Details]

Liew A, Barry F, O'Brien T (2006) Endothelial progenitor cells: diagnostic and therapeutic considerations. Bioessays. Reviews [Details]

Flynn A, Barry F, O'Brien T (2007) UC-blood derived mesenchymal stromal cells: an overview. Cytotherapy. Reviews [Details]

Gaffney, MM, Hynes, SO, Barry, F, O'Brien, T (2007) Cardiovascular gene therapy: current status and therapeutic potential. British journal of Pharmacology. Reviews [Details]

Flynn, A, O'Brien, T (2007) Alferminogene Tadenovac, an angiogenic FGF4 gene therapy for coronary artery disease. IDrugs. Reviews [Details]

McCabe C, O'Brien T (2007) The rational design of beta cell cytoprotective gene transfer strategies: targeting deleterious iNOS expression. Mol Biotechnol. Reviews [Details]

Liew, A, McDermott, JH, Barry, F, O'Brien, T (2008) Endothelial progenitor cells for the treatment of diabetic vasculopathy: panacea or pandora’s box?. Diabetes Obes Metab. Reviews [DOI] [Details]

O'Brien, T (2008) Genetic engineering of the blood vessel wall to improve nitric oxide bioavailability. Bio-Medical Materials and Engineering. Reviews [Details]

Madigan NN, O'Brien T, Yaszemski MJ, Windebank AJ (2009) Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds. Respir Physiol Neurobiol. Reviews [Details]

O'Brien T, Barry, FP (2009) Mayo Clinic Proceedings. Stem Cell Therapy and Regenerative Medicine. Reviews [Details]

O'Connor DM, O'Brien T (2009) Nitric Oxide synthase gene therapy: progress and prospects. Expert Opinion on Biological Therapy. Reviews [Details]

O'Loughlin A, Waldron-Lynch F, Cronin KC, Dineen S, Lee J, Griffin D, Casey M, Nusrat N, Jaffrey S, O'Brien T, Dunne F (2009) When a nephrectomy cures hypoglycaemia. BMJ Case reports. Reviews [Details]

Breen A, O'Brien T, Pandit A (2009) Fibrin as a Delivery System for Therapeutic Drugs and Biomolecules. Tissue Eng Part B Rev. Reviews [Details]

O'Brien T, Barry F (2010) Introduction to Series on Mesenchymal Stromal (Stem) Cells-MSCs. Human Gene Therapy. Reviews [Details]

O'Loughlin A, McIntosh C, Dineen SF, O'Brien T (2010) Review paper: basic concepts to novel therapies: a review of the diabetic foot. Int J Low Extrem Wounds. Reviews [Details]

Dwyer RM, Khan S, Barry FP, O'Brien T, Kerin MJ (2010) Advances in mesenchymal stem cell-mediated gene therapy for cancer. Stem Cell Res Ther. Reviews [Details]

Odile Cohen-Haguenauer, Nicolas Creff, Pedro Cruz, Celia Tunc, Alessandro Aïuti, Christopher Baum, Fatima Bosch, Pontus Blomberg, Klaus Cichutek, Mary Collins, Olivier Danos, Frédéric Dehaut, Marc Federspiel, Eithan Galun, Henk Garritsen, Hansjörg Hauser, Martin Hildebrandt David Klatzmann, Otto Merten, Eugenio Montini, Tim O'Brien, Amos Panet, Linda Rasooly, Daniel Scherman, Manfred Schmidt, Matthias Schweitzer, Pierre Tiberghien, Thierry Vandendriessche, Holger Ziehr, Seppo Ylä-Herttuala, Christof von Kalle, Gösta Gahrton and Manuel Carrondo (2010) Relevance of an Academic GMP Pan-European Vector Infra-structure (PEVI). Curr Gene Ther. Reviews [Details]

Moran CJ, Shannon FJ, Barry FP, O'Byrne JM, O'Brien T, Curtin W (2010) Translation of science to surgery: linking emerging concepts in biological cartilage repair to surgical intervention. J Bone Joint Surg Br. Reviews [Details]

Griffin M, Greiser U, Barry FP, O'Brien T, Ritter T (2010) Genetically Modified Mesenchymal Stem Cells and Their Clinical Potential in Acute Cardiovascular Disease. Discovery Medicine. Reviews [Details]

Kulkarni M, Greiser U, O'Brien T, Pandit A (2010) Liposomal Gene Delivery Mediated by Tissue-Engineered Scaffolds. Trends Biotechnology. Reviews [Details]

Mieske K, Flaherty G, O'Brien T (2010) Journeys to High Altitude- Risks and Recommendations for Travelers with Preexisting Medical Conditions. Journal of Travel Medicine. Reviews [Details]

Kate Whitfiel, Karl-Heinz Huemer, Diana Winter, Steffen Thirstrup, Christian Libersa, Beatrice Barraud, Christine Kubiak, Lea Stankovski, Xina Grahlert, Gabriele Dreier, Sebastian Geismann, Wolfgang Kuchinke, Anke Strenge-Hesse, Zsuza Temesvari, Gyorgy Blasko, Gabriella Kardos, Timothy O'Brien, Margaret Cooney, Siobhan Gaynor, Arrigo Schieppati, Mariantonia Serrano, Fernando de Andres, Nuria Sanz, Raquel Hernandez, German Kreis, Charlotte Asker-Hagelberg, Hanna Johansson, Adeeba Asghar, Jean-Marc Husson, Jacques Demotes and Christian Gluud (2010) Compassionate use of interventions: results of a European Clinical Research Infrastructures Network (ECRIN) survey of ten European countries. Trials. Reviews [Details]

Donnelly A, Johar S, O'Brien T, Tuan RS (2010) Welcome to Stem Cell Research & Therapy. Stem Cell Res Ther. Reviews [Details]

Holladay C, O'Brien T, Pandit A (2010) Non-viral gene therapy for myocardial engineering. Wiley Interdiscip Rev Nanomed Nanobiotechnol. Reviews [Details]

Locke P, O'Brien T, Tuar RS (2011) Stem Cell Research & Therapy marks its first anniversary. Editorial Stem Cell Research & Therapy. Reviews [Details]

Flynn A, O'Brien T (2011) Stem Cell Therapy for Cardiac Disease. Expert Opinion on Biol Therapy. Reviews [Details]