- Our People
- Natural Sciences
Dr. Adrienne Gorman BA (MOD) Biochemistry, PhD Biochemistry
Contact Details
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Biography:
Book Chapters
| Gorman A, McCarthy J, Finucane D, Reville W, Cotter T. (1996) 'Morphological assessment of apoptosis' In: Cotter, T.G.; Martin, S.J (eds). Techniques in Apoptosis: A User's Guide. [Details] |
| Reed Herbert K, Samali A, Gorman AM. (2006) 'The role of heat shock proteins in neuronal differentiation and development' In: Richter-Landsberg, C (eds). Heat Shock Proteins in Neural Cells. [Details] |
| Fitzgerald, U, Gorman AM, Samali A. (2006) 'Heat shock proteins and the regulation of apoptosis' In: Richter-Landsberg, C (eds). Heat Shock Proteins in Neural Cells. [Details] |
Peer Reviewed Journals
| Gorman A, O'Beirne G, Regan C, Williams DC. (1989) 'Antiproliferative actions of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor'. J. Neurochem, 53 :849-855. [Details] |
| Regan CM, Gorman A, Larsson OM, Maguire C, Martin ML, Schousboe A, Williams DC. (1990) 'In vitro screening for anticonvulsant-induced teratogenesis in neural primary cultures and cell lines. Preliminary observations'. Int. J. Devl. Neuroscience, 8 :143-150. [Details] |
| Zisterer DM, Gorman A, Williams DC, Murphy MP. (1992) 'The effects of the peripheral-type benzodiazepine acceptor ligands, Ro-5-4864 and PK-11195, on mitochondrial respiration'. Methods and Findings in Experimental and Clinical Pharmacology, 14 :85-90. [Details] |
| Griffiths R, Dunlop J, Gorman A, Senior J, Grieve A. (1994) 'L-Trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters'. Biochem. Pharmacol, 47 :267-272. [Details] |
| Gorman A, Griffiths R. (1994) 'Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors'. Neuroscience, 59 :299-308. [Details] |
| Gorman A, Grieve A, Griffiths R. (1995) 'Modulation by ionotropic excitatory amino acids and K+ of trans-ACPD stimulated phosphoinositide hydrolysis in mouse cerebellar granule cells'. J. Neurochem, 65 :2473-2483. [Details] |
| Gorman A, Scott MP, Rumbsby PC, Meredith C, Griffiths R. (1995) 'Excitatory amino acid-induced cytotoxicity in primary cultures of mouse cerebellar granule cells correlates with elevated, sustained c-fos protooncogene expression'. Neurosci. Lett, 191 :116-120. [Details] |
| Gorman A, McGowan A, Cotter TG. (1996) 'Oxidative stress and apoptosis in neurodegeneration'. J. Neurol. Sci, 139 :45-52. [Details] |
| Samali A, Gorman A, Cotter TG. (1996) 'Apoptosis: The story so far'. Experientia, 52 :933-941. [Details] |
| Fernandes RS, Gorman AM, McGahon A, Lawlor M, McCann S, Cotter TG. (1996) 'The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia'. Leukaemia, 10 :S17-S21. [Details] |
| McGowan A, Ruiz-Ruiz MC, Gorman A, Lopez-Rivas A, Cotter TG. (1996) 'The role of proteases, PARP and free radicals during apoptosis of several leukemic cell lines'. FEBS Lett, 392 :299-303. [Details] |
| Samali A, Gorman A, Cotter TG (1997) 'Role of Bcr-abl in resistance to apoptosis'. Adv. Pharmacol, 41 :533-552. [Details] |
| Gorman AM, Samali A, McGowan AJ, Cotter TG. (1997) 'The use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'. Cytometry, 29 :97-105. [Details] |
| Gorman A, McGowan A, Cotter TG. (1997) 'Role of peroxide and superoxide anion during tumour cell apoptosis'. FEBS Lett, 404 :27-33. [Details] |
| Gorman A, Orrenius S, Ceccatelli S. (1998) 'Apoptosis in neuronal cells: Role of caspases'. NeuroReport, 9 :R49-R55. [Details] |
| Gorman A.M., Heavey G., Creagh E.M., Cotter T.G., Samali A. (1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'. FEBS Lett, 445 :98-102. [Details] |
| Gorman A, Bonfoco E, Zhivotovsky B, Orrenius S, Ceccatelli S. (1999) 'Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells'. Eur. J. Neurosci, 11 :1067-1073. [Details] |
| Gorman AM, Hirt UA, Orrenius S, Ceccatelli S. (1999) 'Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo'. J. Immunol. Methods, 226 :43-48. [Details] |
| Gorman AM, Hirt UA, Orrenius S, Ceccatelli S. (2000) 'Dexamethasone pre-treatment interferes with apoptotic death in glioma cells'. Neurosci, 96 :417-425. [Details] |
| Gorman AM, Ceccatelli S, Orrenius S. (2000) 'Role of mitochondria in neuronal apoptosis Dev'. Neurosci, 22 :348-358. [Details] |
| Daré E, Gorman AM, Ahlbom E, Götz M, Momoi T, Ceccatelli S (2001) 'Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons'. Neurotoxicity Research, 3 :501-514. [Details] |
| Wu J, Gorman A, Xinghua Z, Ceccatelli S, Chen E. (2002) 'Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure'. Investigative Ophthalmology And Visual Science, 43 :3349-3354. [Details] |
| Bree RT, Stenson C, Grealy M, Byrnes L, Gorman AM, Samali A. (2002) 'Cellular longevity: role of apoptosis and replicative senescence'. BioGerontology, 3 :195-206. [Details] |
| Quigney, DJ,Gorman, AM,Samali, A (2003) 'Heat shock protects PC12 cells against MPP+ toxicity'. Brain Research, 993 :133-139. [DOI] [Details] |
| Concannon CG, Gorman AM, Samali A (2003) 'On the role of Hsp27 in regulating apoptosis'. Apoptosis, 8 :61-70. [Details] |
| Gorman AM, Segezdi E, Quigney DJ, Samali A. (2005) 'Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells'. BIOCHEM. BIOPHYS. RES. COMMUN, 327 :801-810. [DOI] [Details] |
| O'Driscoll, CM,Gorman, AM (2005) 'Hypoxia induces neurite outgrowth in PC12 cells that is mediated through adenosine A2A receptors'. Neuroscience, 131 :321-329. [Details] |
| Ní Chongaile T., Concannon C., Szegezdi E., Gorman A.M., Samali A. (2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL'. Apoptosis, 11 (7):1247-1255. [Details] |
| Szegezdi E, Logue SE, Gorman AM and Samali A (2006) 'Mediators of ER stress-induced apoptosis'. EMBO Reports, 7 :880-885. [Details] |
| Kavanagh ET, Loughlin JP, Herbert KR, Dockery P, Samali A, Doyle KM, Gorman, AM. (2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'. Biochem Biophys Res Commun, 351 (4):890-895. [DOI] [Details] |
| Szegezdi E, Reed Herbert K, Kavanagh ET, Samali A and Gorman AM (2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'. J. Cell Mol Med (EPub ahead of print PMID: 18266951), 12 (6A):2482-2496. [DOI] [Details] |
| Gorman AM (2008) 'Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling'. J Cell Mol Med [Epub ahead of print] PMID: 18624755, 12 :2263-2280. [Details] |
| Read DE, Reed Herbert K, Gorman AM (2008) 'Heat shock enhances NGF-induced neurite elongation which is not mediated by Hsp25 in PC12 cells'. Brain Res, 1221 :14-23. [DOI] [Details] |
| Read DE, Gorman AM (2009) 'Involvement of Akt in neurite outgrowth'. Cell Mol Life Sci, 66 :2975-2984. [Details] |
| Read DE, Gorman AM (2009) 'Heat shock protein 27 in neuronal survival and neurite outgrowth'. Biochem Biophys Res Commun, 382 :6-8. [Details] |
| Yao L, Wang S, Cui W, Sherlock R, O'Connell C, Damodaran G, Gorman A, Windebank A, Pandit A. (2009) 'Effect of functionalized micropatterned PLGA on guided neurite growth'. Acta Biomater, 5 (2):580-588. [Details] |
| Healy SJM, Gorman AM, Mousavi-Shafaei P, Gupta S, Samali A (2009) 'Targeting the endoplasmic reticulum-stress response as an anti-cancer strategy'. Eur J Pharmacol; Special Issue: New vistas in anti-cancer therapy, 625 :234-246. [Details] |
| Walsh S, Gorman AM, Finn DP, Dowd E. (2010) 'The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats'. Brain Res, 1363 (40):40-48. [DOI] [Details] |
| Mnich K, Dowd E, Finn D, Gorman AM (2010) 'Inhibition by anandamide of 6-hydroxydopamine-induced cell death'. International Journal Of Cell Biology, . [Details] |
| Fulda S, Gorman AM, Osamu H, Samali A (2010) 'Cellular Stress Responses: cell survival and cell death'. Int J Cell Biol, . [Details] |
| Walsh S, Mnich K, Gorman AM, Finn D, Mackie K, Dowd E (2010) 'Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson’s disease'. Brain Res Bull, 81 :543-548. [Details] |
| Yao L, Damodaran G, Nikolskaya N, Gorman AM, Windebank A, Pandit A (2010) 'The effect of laminin gradient of enzymatically cross-linked collagen scaffold on neurite growth'. J Biomedical Materials Res, 92 :484-492. [Details] |
| Doyle KM, Kennedy D, Gorman AM, Gupta S, Samali A (2011) 'Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders'. J Cell Mol Med, 15 :2025-2039. [Details] |
| Molloy NH, Read DE, Gorman AM (2011) 'Nerve growth factor in cancer cell death and survival'. Cancers, 3 :510-530. [ARAN Link] [Details] |
| Gorman AM, Healy SJM, Jäger R, Samali A (2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'. Pharmacology And Therapeutics, . [Details] |
| Jäger R, Bertrand MJM, Gorman AM, Vandenabeele P, Samali A (2012) 'The unfolded protein response at the crossroads of cellular life and death during ER stress'. Biology of the Cell, . [DOI] [Details] |
Other Journals
| Gorman AM, Zhivotovsky B. (1999) 'Challenging the dogmas' Cell Death Diff 6 :207-211. [Details] |
| Gorman AM (2006) 'Helping keep our neurons alive with neurotrophins' The Irish Scientist Yearbook 14 . [Details] |
| Doyle KM, Gorman AM (2008) 'Considerations and recent advances in neuroscience' Biochem Soc Trans 37 :299-302. [Details] |
| Doyle KM, Gorman AM (2009) 'Considerations and recent advances in neuroscience. Meeting report of 2nd Neuroscience Ireland Conference' Biochem Soc Trans 37 :299-302. [Details] |
Editorial
| Afshin Samali, Simone Fulda, Adrienne M. Gorman, Osamu Hori, and Srinivasa M. Srinivasula (2010) Cell Stress and Cell Death. International Journal of Cell Biology. Editorial [DOI] [Details] |
