Research Interests

Cellular signalling and biochemistry of stress response and apoptosis

Research Projects

Project: CS/2011/375 FP7 PROPOSAL PREPARATION CO-ORDINATOR SUPPORT ENTERPRISE IRELAND PROF AFSHIN SAMALI ( REI1057) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-FEB-11 / 30-SEP-11

Project: EU TNF LIGAND RECEPTOR QLK3 2001 00498 SAMALI ( RE5502) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-02 / 26-NOV-07

Project: PC20080340 Prof Afshin Samali Evaluation Targets o ( REI1003) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-FEB-09 / 31-MAR-10

Project: SFI OVERHEADS EQUIPMENT AFSHIN SAMALI ( RSF1052) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-08 / 31-DEC-08

Project: IRCSET EMBARK 2007, MARIANNE VAN DIJK ( RCS705) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-07 / 28-FEB-11

Project: SFI 09 SIRG B1575 AFSHIN SAMALI NOVEL RATIOMETRIC APPROACH TO IDENTIFY DECISIVE MOLECULAR ( RSF0920) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-09 / 30-SEP-13

Project: REGULATION IRE1 SIGNAL SFI 09/RFP/BIC2371 - A SAMALI ( RSF0908) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-09 / 30-SEP-13

Project: PRTLI3 BMES 2 2 ( RH3230) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUL-02 / 28-JAN-08

Project: 989 MF 33 00 M EFFECTS OF HSP ( RM0533) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUL-00 / 29-NOV-04

Project: HAEMATOLOGY RESEARCH FUND A SAMALI ( RIB253) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 15-MAY-06 / 14-MAY-13

Project: SFI RFP 05 RFP BIC002 A SAMALI ( RSF513) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-MAY-06 / 30-APR-09

Project: MF2003 MF 75 03 CARDIAC DISEASE A SAMALI ( RM3075) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JAN-04 / 29-NOV-04

Project: APOPTOSIS A SAMALI NCBES T SMITH ( RNR246) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 15-JAN-04 / 15-JAN-07

Project: MF2004 MF65 04 DR. AFSHIN SAMALI ( RM4065) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-04 / 30-JUL-06

Project: IHF GENE EXPRESSION SAMALI ( RHF500) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-SEP-01 / 31-DEC-04

Project: TRIDENT EC STREP COORDINATION ( RE6070) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-06 / 30-SEP-09

Project: 10 YEAR CELEBRATION APOPTOSIS AFSHIN SAMALI ( RNR1033) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUN-10 / 31-MAY-11

Project: IRISH CANCER SOCIETY CRF09SZE AFSHIN SAMALI ( RCR601) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-DEC-09 / 30-NOV-12

Project: MF2002 MF86 02 M MICHAEL O DWYER ( RM2086) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-DEC-02 / 29-NOV-04

Project: EI CFTD 06 112 TRITAN A SAMALI ( REI496) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUL-06 / 28-FEB-10

Project: CANCER CARE WEST A SAMALI M O DWYER ( ROG942) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUL-06 / 30-SEP-09

Project: TARGETING THE HSP72-IRE1 INTERACTION TO MODULATE THE UNFOLDED PROTEIN RESPONSE IN BREAST CANCER 2010NOVPR13 ( RIN273) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-MAR-11 / 28-FEB-14

Project: HAEMATOLOGY RESEARCH FUND A. SAMALI ORTHO BIOTECH ( RIB252) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 15-MAY-06 / 14-MAY-11

Project: SFI ER STRESS-INDUCED APOPTOSIS AFSHIN SAMALI ( RSF610) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 31-MAR-06 / 31-MAR-10

Project: CRI SECLECTIVE REGULATORS TRAIL A SAMALI ( RCR502) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-05 / 18-NOV-10

Project: MILL FND MAJOR A SAMALI OX LDL INDUCED APOPTOSIS ( RMM500) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-NOV-01 / 15-OCT-09

Project: ROLE IN DBP 1 IN BREAST CANCER DEVELOPMENT AND RESISTANCE TO THERAPY IRISH CANCER SOCIETY CRS11CLE AFSHIN SAMALI ( RCR602) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-11 / 30-SEP-14

Project: IRISH CANCER SOC CRS10VIN A SAMALI ( RCR508) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-10 / 30-SEP-13

Project: ENTERPRISE IRELAND FP7 PROPOSAL PREPARATION CO-ORDINATOR SUPPORT CS/2011/427 AFSHIN SAMALI ( REI1078) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 22-SEP-11 / 21-MAY-12

Project: HRB HRA 2009 59 AFSHIN SAMALI ( RHR896) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-09 / 30-SEP-12

Project: MF 81 2005 M A SAMALI M KEANE ( RM5081) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-05 / 30-APR-07

Project: MF2003 MF99 03 M M O DWYER A SAMALI ( RM3099) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-APR-04 / 25-DEC-04

Project: TRIDENT EC STREP INNOVATION PROJ AFSHIN SAMALI ( RE6567) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-OCT-06 / 30-SEP-09

Project: APOPTOSIS SAMALI IND OVERHEADS N VAT ( RNR787) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-FEB-06 / 31-DEC-12

Project: EI FEASIBILITY EVE IP 2006 413Y SAMALI ( REI460) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-MAR-07 / 30-SEP-07

Project: PRTLI3 BMES 2 3 ( RH3235) Role: ROLE_DESC Description: DESCRIPTION Start/End Dates: 01-JUL-02 / 12-MAY-08

 

Book Chapters

Verfaillie, T; Jäger, R; Samali, A; Agostinis, P (2012) 'ER stress signaling pathways in cell survival and death' In: ER stress in health and disease. New York: Springer. [Details]

Healy, SJM; Verfaillie, T; Jäger, R; Agostinis, P; Samali, A (2012) 'Biology of the endoplasmic reticulum' In: ER stress in health and disease. New York: Springer. [Details]

Herbert-Reed K., Samali A., Gorman A.M. (2005) 'The role of heat shock proteins in neuronal differentiation and development' In: Richter-Landsberg, C (eds). Heat Shock Proteins in Neural Cells. Landes Bioscience, TX, USA. [Details]

FitzGerald U., Gorman A.M., Samali A. (2005) 'Heat shock proteins in regulation of neural apoptosis' In: Richter-Landsberg, C (eds). Heat Shock Proteins in Neural Cells. Landes Bioscience, TX, USA. [Details]

Gill C., Meyer M., Samali A. (2005) 'Molecular basis of inhibition of apoptosis by Heat shock proteins' In: Sreedhar, A.S (eds). Stress response: a molecular Biology approach. Research Signpost, India. [Details]

Reeve J., Duffy A., O'Brien T., Samali A. (2005) 'Don’t loose Heart: Therapeutic value of anti-apoptotic strategies in the treatment of cardiovascular disease' In: J. Cell. Mol. Med. [Details]

Vincenz, L; Szegezdi, E; Jäger, R; Holohan, C; O’Brien, T; Samali, A (2011) 'Cytokine-induced b-cell stress and death in type 1 diabetes mellitus' In: Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments. Croatia: Intech. [Details]

 

Peer Reviewed Journals

Samali A., Cotter T.G. (1996) 'Heat shock proteins increase resistance to apoptosis'. Exp. Cell Res, 223 :163-170. [Details]

Samali A., Gilje B., Døskeland S.O., Cotter T.G., Houge G. (1997) 'The ability to cleave 28S rRNA during apoptosis is a cell type dependent trait unrelated to DNA fragmentation'. Cell Death & Differ, 4 :289-293. [Details]

Samali A., Zhivotovsky B., Jones D.P., Orrenius S. (1998) 'Detection of pro-caspase-3 in cytosol and mitochondria of various tissues'. FEBS Lett, 431 :167-169. [Details]

Pörn-Ares M.I., Samali A., Orrenius S. (1998) 'Cleavage of calpain inhibitor, calpastatin, during apoptosis'. Cell Death & Differ, 5 :1028-1033. [Details]

Zhivotovsky B., Samali A., Gahm A., Orrenius S. (1999) 'Caspases: their intracellular localisation and translocation during apoptosis'. Cell Death & Differ, 6 :644-651. [Details]

Samali A., Cai J., Zhivotovsky B., Jones D.P., Orrenius S. (1999) 'Presence of pre-apoptotic complex of pro-caspase-3 with Hsp60 and Hsp10 in mitochondrial fraction of Jurkat cells'. EMBO J, 18 :2040-2048. [Details]

Samali A., Holmberg C.I., Sistonen L., Orrenius S. (1999) 'Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins'. FEBS Letts, 461 :306-310. [Details]

Fadeel B., Gleiss B., Wiedmer T., Sims P.J., Henter J.H., Orrenius S., Samali A. (1999) 'Phosphatidylserine exposure during apoptosis is a cell type specific event. Biochem'. Biophys. Res. Commun, 266 :504-511. [Details]

Gorman A.M., Heavey G., Creagh E.M., Cotter T.G., Samali A. (1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'. FEBS Lett, 445 :98-102. [Details]

Samali A., Nordgren H., Zhivotovsky B., Peterson E., Orrenius S. (1999) 'A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced inhibition of caspases leads to necrosis'. Biochem. Biophys. Res. Commun, 255 :6-11. [Details]

Neopikhanov V., Samali A., Wreiber K., Engstrand L., Uribe A. (2000) 'Soluble proteins of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis'. Digestion, 61 :22-29. [Details]

Samali A., Robertson J.D., Peterson E., Manero F., van Zeijl L., Paul C., Cotgreave I.A., Arrigo A-P., Orrenius S. (2001) 'Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli'. Cell Stress & Chaperones, 6 :49-58. [Details]

Zachrisson C., Neopikhanov V., Samali A., Uribe A. (2001) 'Interleukin-1, interleukin-8, tumor necrosis factor alpha and inteferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines'. Eur. J. Gastro. Hepatol, 13 :551-559. [Details]

Concannon C., Orrenius S., Samali A. (2001) 'Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c'. Gene Expression, 9 :195-201. [Details]

O'Mahoney M., Logue S., Szegezdi E., FitzGerald U., Stenson-Cox C., Samali A. (2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'. Ann. NY Acad. Sci, 1010 :728-732. [Details]

Quigney D., Gorman A.M., Samali A. (2003) 'Heat shock inhibits MPP+-induced cell death in PC-12 cells'. Brain Res, 993 :133-139. [Details]

Halvey P.J., Watson W.H., Hansen J.M., Go Y-M., Samali A., Jones D.P. (2005) 'Compartmental oxidation of thiol/disulfide redox couples during EGF signaling'. Biochem. J, 386 :215-219. [DOI] [Details]

Concannon C., FitzGerald U., Holmberg C., Szegezdi E., Sistonen L., Samali A. (2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization'. Cell Stress & Chaperones, 10 :59-65. [Details]

Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochem. Biophys. Res. Commun, 327 :801-810. [Details]

Szegezdi E., Duffy A., O'Mahoney M.E., Logue S.E., Mylotte L.A., O'Brien T., Samali A. (2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'. Biochem Biophys Res Commun, 349 :1406-1411. [Details]

van der Sloot A.M., Tur V., Szegezdi E., Mullally M.M., Samali A., Serrano L., Quax W. (2006) 'Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor'. Proc Natl Acad Sci USA, 103 :8634-8639. [DOI] [Details]

McCabe, C., Samali A., O'Brien T (2006) 'beta cell cytoprotective strategies: establishing the relative roles for iNOS and ROS'. Biochem Biophys Res Commun, 342 :1240-1248. [Details]

Szegezdi E., Cahill S., Meyer M., O'Dwyer M. and Samali A. (2006) 'TRAIL Sensitization by Arsenic Trioxide is Caspase-8 Dependent and Involves Modulation of Death Receptor Components and Akt'. Br. J. Cancer, 94 :398-406. [DOI] [Details]

Ní Chongaile T., Concannon C., Szegezdi E., Gorman A.M., Samali A. (2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL'. Apoptosis, 11 (7):1247-1255. [Details]

Duffy A, Liew A, O'Sullivan J, Avalos G, Samali A, O'Brien T (2006) 'Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins'. Endothelium, 13 (1):9-16. [DOI] [Details]

Kavanagh ET, Loughlin JP, Herbert KR, Dockery P, Samali A, Doyle KM, Gorman, AM. (2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'. Biochem Biophys Res Commun, 351 (4):890-895. [DOI] [Details]

Halvey P.J., Hansen J.M., Johnson J.M., Go Y.M., Samali A, Jones D.P.. (2007) 'Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase'. Antioxid Redox Signal, 9 :807-816. [DOI] [Details]

Reeve JL, Szegezdi E, Logue SE, Chonaighle TN, O'Brien T, Ritter T, Samali A (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL'. J Cell Mol Med, 11 (3):509-520. [DOI] [Details]

Samali A., O'Mahoney M., Reeve J., Logue S., Szegezdi E., McMahon J., Fearnhead H.O. (2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'. Apoptosis, 12 :465-474. [Details]

Reeve J.L., Stenson-Cox C., O'Doherty A., Pörn-Ares I., Ares M., O'Brien T., Samali A (2007) 'OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas'. Biochem Biophys Res Commun, 356 :681-686. [Details]

Mylotte LA, Duffy AM, Murphy M, O'Brien T, Samali A, Barry F and Szegezdi E (2008) 'Metabolic Flexibility Permits MSC Survival in an Ischemic Environment'. Stem Cells, 26 :1325-1336. [Details]

Mhaille AN, McQuaid S, Windebank A, Cunnea P, McMahon J, Samali A, FitzGerald U. (2008) 'Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions'. J Neuropathol Exp Neurol, 67 :200-211. [Details]

Tur V, van der Sloot AM, Reis CR, Szegezdi E, Cool RH, Samali A, Serrano L, Quax WJ. (2008) 'DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design'. J Biol Chem, 283 (29):20560-20568. [DOI] [Details]

Szegezdi E, Herbert KR, Kavanagh ET, Samali A, Gorman AM. (2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'. J Cell Mol Med, 12 (6A):2482-2496. [Details]

Holohan C., Szegezdi E., Ritter T., O'Brien T., Samali A. (2008) 'Cytokine-induced beta-cell apoptosis is no-dependent, mitochondria-mediated and inhibited by BCL-X(L)'. J Cell Mol Med, 12 :591-606. [Details]

Reis CR, van der Sloot AM, Szegezdi E, Cool RH, Samali A, Serrano L, Quax WJ (2009) 'Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase toward Its Death Receptors (dagger)'. Biochemistry, 48 (10):2180-2191. [DOI] [Details]

Mahalingam D, Keane M, Pirianov G, Mehmet H, Samali A, Szegezdi E. (2009) 'Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines'. Br J Cancer, 100 (9):1415-1424. [DOI] [Details]

Duiker EW, de Vries EGE, Mahalingam M, Meersma GJ, Boersma-van Ek W, Hollema H, Lub-de Hooge MN, van Dam GM, Cool RH, Quax WJ, Samali A, van der Zee AGJ, de Jong S (2009) 'Enhanced anti-tumor efficacy of a DR5-specific TRAIL variant over rhTRAIL in a bioluminescent ovarian cancer xenograft model'. Clin. Can. Res, 15 (6):2048-2057. [DOI] [Details]

Szegezdi E, O'Reilly A, Davy Y, Vawda R, Taylor DL, Murphy M, Samali A, Mehmet H. (2009) 'Stem cells are resistant to TRAIL receptor-mediated apoptosis'. J Cell Mol Med, 13 (13):4409-4414. [DOI] [Details]

Mahalingam D, Szegezdi E, Keane M, Jong S, Samali A (2009) 'TRAIL receptor signalling and modulation: Are we on the right TRAIL?'. Cancer Treat Rev, 35 (3):280-288. [Details]

Szegezdi E, Macdonald DC, Ní Chongaile T, Gupta S, Samali A (2009) 'Bcl-2 family on guard at the ER'. Am J Physiol Cell Physiol, 296 (5):C941-C953. [Details]

Reis CR, van der Sloot AM, Natoni A, Szegezdi E, Setroikromo R, Meijer M, Sjollema K, Stricher F, Cool RH, Samali A, Serrano L, Quax WJ. (2010) 'Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants'. Cell Death Dis, . [ARAN Link] [Details]

Samali A, Fitzgerald U, Deegan S, Gupta S. (2010) 'Methods for monitoring endoplasmic reticulum stress and the unfolded protein response'. Int J Cell Biol, . [ARAN Link] [Details]

Szegezdi E, Reis CR, Van Der Sloot A, Natoni A, O'Reilly A, Reeve J, Cool RH, O'Dwyer M, Knapper S, Serrano L, Quax WJ, Samali A. (2010) 'Targeting AML through DR4 with a novel variant of rhTRAIL'. J Cell Mol Med, . [Details]

Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A. 2010 Jul 6 PubMed PMID: 20625543, PubMed Central PMCID: PMC2897763. (2010) 'HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction'. PLoS Biol, 8 (7). [ARAN Link] [Details]

Vrielink J, Heins MS, Setroikromo R, Szegezdi E, Mullally MM, Samali A, Quax WJ. (2010) 'Synthetic constrained peptide selectively binds and antagonizes death receptor 5'. FEBS J, 277 :1653-1665. [DOI] [Details]

Gupta S, Cuffe L, Szegezdi E, Logue SE, Neary C, Healy S, Samali A. (2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization.010; PubMed Central PMCID: PMC2821636'. Int J Cell Biol, . [ARAN Link] [Details]

Fulda S, Gorman AM, Hori O, Samali A. (2010) 'Cellular stress responses: cell survival and cell death'. Int J Cell Biol, 2010 :214074-23 pp. [Details]

Samali A, Fulda S, Gorman AM, Hori O, Srinivasula SM. (2010) 'Cell stress and cell death'. Int J Cell Biol, 2010 :245803-2pp. [Details]

Mahalingam D, Natoni A, Keane M, Samali A, Szegezdi E. (2010) 'Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells'. Br J Cancer, 102 :754-764. [DOI] [Details]

Natoni, A; Murillo, LS; Kliszak, AE; Catherwood, MA; Montagnoli, A; Samali, A; O'Dwyer, M; Santocanale, C (2011) 'Mechanisms of action of a dual Cdc7/Cdc9 kinase inhibitor against quiescent and proliferating CLL cells'. Molecular Cancer Therapeutics, 10 :1624-1634. [Details]

Cawley K, Deegan S, Samali A, Gupta S. (2011) 'Assays for detecting the unfolded protein response'. Methods Enzymol, 490 :31-51. [Details]

Szegezdi, E; van der Sloot, AM; Mahalingam, D; O'Leary, L; Cool, RH; Munoz, IG; Montoya, G; Quax, WJ; de Jong, S; Samali A; Serrano, L (2012) 'Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: Apoptosis induction by TRAIL'. Molecular & Cellular Proteomics, . [Details]

                           

Other Item

Samali, A. (2007) A tribute to Professor Richard A. Lockshin on his 70th birthday. J Cell Mol Med. Other Item [Details]

Samali, A. (2007) Apoptosis: a mapped path to cell death. J Cell Mol Med. Other Item [Details]

 

Reviews

Healy, SZ, Gorman, AM, Mousavi-Shafaei, P, Gupta, S, Samali, A. (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. Reviews [Details]

Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A. (2011) Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders. Reviews [Details]

Gorman, AM; Healy, SJM; Jäger, R; Samali, A (2012) Stress management at the ER: regulators of ER stress-induced apoptosi. Reviews [Details]

Jäger, R; Bertrand, MJ; Gorman, AM; Vandenabeele, P; Samali, A (2012) The unfolded protein response at the crossroads of cellular life and death during ER stress. Reviews [Details]

Stenson-Cox C., FitzGerald U., Samali A. (2003) In the cut and thrust of apoptosis, serine proteases come of age. Biochem. Pharmacol. Reviews [Details]

Concannon C.G., Gorman A.M., Samali A. (2003) On the role of Hsp27 in regulating apoptosis. Apoptosis. Reviews [Details]

Szegezdi E., FitzGerald U., Samali A. (2003) Caspase-12 and ER-stress-mediated apoptosis: The story so far. Ann. NY Acad. Sci. Reviews [Details]

Bree R.T., Neary C., Samali A., Lowndes N.F. (2004) The switch from DNA repair to apoptosis after chromosomal breaks. DNA Repair. Reviews [Details]

Logue S.E., Gustafsson Å.B., Samali A., Gottlieb R.A. (2005) Ischemia/Reperfusion injury at the intersection with cell death. Mol. Cell. Cardiol. Reviews [Details]

McCabe C., Samali A., O'Brien T. (2006) Cytoprotection of beta cells: rational gene transfer strategies. Diabetes Metab Res Rev. Reviews [Details]

Szegezdi E., Logue S.E., Gorman A.M., Samali A. (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. Reviews [Details]

Plantivaux A, Szegezdi E, Samali A, Egan L. (2009) Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?. Ann N Y Acad Sci. Reviews [Details]

         

             

Employment

Employer: National University of Ireland, Galway Position: Senior Lecturer

Employer: National University of Ireland, Galway Position: Lecturer

           

   

Current Postgraduate Students

Svetlana Saveljeva, Doctorate - Ph.D.(Science)   -   Supervisor

Laura Carleton, Doctorate - Ph.D.(Science)   -   Supervisor

Ruth Morrell, Doctorate - Ph.D.   -   Co-supervisor (1)

Donna Kennedy, Doctorate - Ph.D.(Science)   -   Co-supervisor (1)

Paul O Reilly, Doctorate - Ph.D.(Science)   -   Supervisor

Niamh Molloy, Doctorate - Ph.D.(Science)   -   Supervisor

Neysan Donnelly, Doctorate - Ph.D.(Science)   -   Supervisor

Anna Halpin Mccormick, Doctorate - Ph.D.(Science)   -   Supervisor

Lisa Vincenz, Doctorate - Ph.D.(Science)   -   Supervisor

Karen Cawley, Doctorate - Ph.D.(Science)   -   Supervisor

Lynda O Leary, Doctorate - Ph.D.(Science)   -   Supervisor

Tadhg Mc Namara, Doctorate - Ph.D.(Science)   -   Supervisor

Marianne Van Dijk, Doctorate - Ph.D.(Science)   -   Supervisor

Shane Deegan, Doctorate - Ph.D.(Science)   -   Supervisor