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Dr Andrew Flaus BSc, PhD.
Contact Details
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Biography:
| 2006 to present: Lecturer, Department of Biochemistry, NUI Galway, Ireland 1999-2006: Postdoc with Dr Tom Owen-Hughes, Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Scotland 1996-1998: Postdoc with Prof Tim Richmond, Institut Fuer Molekularbiologie u. Biophysik, ETH (Swiss Federal Inst of technology), Zurich, Switzerland 1990-1995: PhD student with Prof Tim Richmond, Institut f. Molekularbiologie u. Biophysik, ETH (Swiss Federal Inst of technology), Zurich, Switzerland 1986-1990: BSc (Hons) in Biochemistry and Molecular Genetics, Department of Chemistry and Biochemistry and Department of Genetics, Massey University, Palmerston North, New Zealand (honours research with Drs Gill Norris and Chris Moore) 1979-1985: Secondary schooling at Lindisfarne College, Hastings, New Zealand |
Peer Reviewed Journals
| Flaus A, Owen-Hughes T. (2003) 'Mechanisms for nucleosome mobilization'. Biopolymers, 68 (4):563-578. [Details] |
| Flaus A, Owen-Hughes T. (2003) 'Dynamic properties of nucleosomes during thermal and ATP-driven mobilization'. Mol Cell Biol, 23 (21):7767-7779. [Details] |
| Bruno M, Flaus A, Stockdale C, Rencurel C, Ferreira H, Owen-Hughes T. (2003) 'Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities'. Mol Cell, 12 (6):1599-1606. [Details] |
| Whitehouse I, Stockdale C, Flaus A, Szczelkun MD, Owen-Hughes T. (2003) 'Evidence for DNA translocation by the ISWI chromatin-remodeling enzyme'. Mol Cell Biol, 23 (6):1935-1945. [Details] |
| Flaus A, Owen-Hughes T. (2004) 'Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?'. Curr Opin Genet Dev, 14 (2):165-173. [Details] |
| Bruno M, Flaus A, Owen-Hughes T. (2004) 'Site-specific attachment of reporter compounds to recombinant histones'. Methods Enzymol, 375 :211-228. [Details] |
| Flaus A, Rencurel C, Ferreira H, Wiechens N, Owen-Hughes T. ( (2004) 'Sin mutations alter inherent nucleosome mobility'. EMBO J, 23 (2):343-353. [Details] |
| Stockdale C, Bruno M, Ferreira H, Garcia-Wilson E, Wiechens N, Engeholm M, Flaus A, Owen-Hughes T. (2006) 'Nucleosome dynamics'. Biochem Soc Symp, 73 :109-119. [Details] |
| Costelloe T, Fitzgerald J, Murphy NJ, Flaus, A & Lowndes, NF (2006) 'Chromatin modulation and the DNA damage response'. Exp Cell Res, 312 :2677-2686. [Details] |
| Flaus A, Martin DM, Barton GJ, Owen-Hughes T. (2006) 'Identification of multiple distinct Snf2 subfamilies with conserved structural motifs'. Nucleic Acids Res, 34 (10):2887-2905. [Details] |
| Stockdale C, Flaus A, Ferreira H, Owen-Hughes T. (2006) 'Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes'. J Biol Chem, 281 (24):16279-16288. [Details] |
| Duerr, H, Flaus A, Owen-Hughes T, Hopfner KP. (2006) 'Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures'. Nucleic Acids Res, 34 (15):4160-4167. [Details] |
| Ferreira H, Somers J, Webster R, Flaus A, Owen-Hughes T. (2007) 'Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability'. Mol Cell Biol, 11 :4037-4048. [Details] |
| Ferreira H, Flaus A, Owen-Hughes T. (2007) 'Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms'. J Mol Biol, 374 (3):563-579. [Details] |
| Engeholm M, de Jager M, Flaus A, Brenk R, van Noort J, Owen-Hughes T. (2009) 'Nucleosomes can invade DNA territories occupied by their neighbours'. Nature Structural & Molecular Biology, 16 (2):151-158. [Details] |
| Pinto, DM, Flaus, A. (2010) 'Structure and function of histone H2AX'. Subcellular Biochemistry, 50 :55-78. [Details] |
Flaus, A., Owen-Hughes, T. (2011) 'Mechanisms for ATP-dependent chromatin remodelling: The means to the end'. FEBS Journal, 278 (19):3579-3595.  [Details] |