Peer Reviewed Journals

Debacker, K,Frizzell, A,Gleeson, O,Kirkham-McCarthy, L,Mertz, T,Lahue, RS (2012) 'Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions'. Plos Biology, 10 . [DOI] [Details]

Anne-Marie M. Gannon, Aisling Frizzell, Evan Healy, and Robert S. Lahue (2012) 'MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells'. Nucleic Acids Research, . [Details]

Gellon, L,Razidlo, DF,Gleeson, O,Verra, L,Schulz, D,Lahue, RS,Freudenreich, CH (2011) 'New Functions of Ctf18-RFC in Preserving Genome Stability outside Its Role in Sister Chromatid Cohesion'. Plos Genetics, 7 . [DOI] [Details]

Sommer, D,Stith, CM,Burgers, PMJ,Lahue, RS (2008) 'Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae'. Nucleic Acids Research, 36 :4699-4707. [DOI] [Details]

Razidlo, DF,Lahue, RS (2008) 'Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms'. Dna Repair, 7 :633-640. [DOI] [Details]

Dhar, A,Lahue, RS (2008) 'Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae'. Nucleic Acids Research, 36 :3366-3373. [DOI] [Details]

Erlich, R. L., Fry, R. C., Begley, T. J., Daee, D. L., Lahue, R. S., Samson, L. D. (2008) 'Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiae'. PLoS ONE, 3 (e3717). [Details]

Claassen, DA,Lahue, RS (2007) 'Expansions of CAG.CTG repeats in immortalized human astrocytes'. Human Molecular Genetics, 16 :3088-3096. [DOI] [Details]

Daee, D.L., Mertz, T. and Lahue, R. S. (2007) 'Post-replication repair inhibits CAGoCTG repeat expansions in Saccharomyces cerevisiae'. Molecular and Cellular Biology, 27 :102-110. [Details]

Collins, N.S, Bhattacharyya, S. and Lahue, R. S. (2007) 'Rev1 enhances CAGoCTG repeat stability in Saccharomyces cerevisiae'. DNA Repair, 6 :38-44. [Details]

Farrell, B.T. and Lahue, R.S. (2006) 'CAGoCTG repeat instability in cultured human astrocytes'. Nucleic Acids Res, 34 :4495-4505. [Details]

Pelletier, R., Farrell, B. T., Miret, J. J., and Lahue, R. S. (2005) 'Mechanistic features of CAGoCTG repeat contractions in cultured cells revealed by a novel genetic assay'. Nucleic Acids Res, 33 :5667-5676. [Details]

Bhattacharyya, S. and Lahue, R. S. (2005) 'Srs2 helicase of Saccharomyces cerevisiae selectively unwinds triplet repeat DNA'. J. Biol. Chem, 280 :33311-33317. [Details]

Corrette-Bennett, S. E., Borgeson, C., Sommer, D., Burgers, P. M. J., and Lahue, R. S. (2004) 'DNA Polymerase ?, RFC, and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae'. Nucleic Acids Res, 32 :6268-6275. [Details]

Dixon, M. J. and Lahue, R. S. (2004) 'DNA elements important for CAGoCTG repeat thresholds in Saccharomyces cerevisiae'. Nucleic Acids Res, 32 :1289-1297. [Details]

Bhattacharyya, S. and Lahue, R. S. (2004) 'Yeast Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats'. Mol. Cell. Biol, 24 :7324-7330. [Details]

Pelletier, R., Krasilnikova, M. M., Samadashwily, G. M., Lahue, R., and Mirkin, S. M. (2003) 'Replication and expansion of trinucleotide repeats in yeast'. Mol. Cell. Biol, 23 :1349-1357. [Details]

Dixon, M. J. and Lahue, R. S. (2002) 'Examining the potential role of DNA polymerases eta and zeta in triplet repeat instability in yeast'. DNA Repair, 1 :765-773. [Details]

Bhattacharyya, S., Rolfsmeier, M. L., Dixon, M. J., Wagoner, K. and Lahue, R. S. (2002) 'Identification of RTG2 as a modifier gene for CTGoCAG repeat instability in Saccharomyces cerevisiae'. Genetics, 162 :579-589. [Details]

Corrette-Bennett, S. E., Mohlman, N. L., Rosado, Z., Miret, J. J., Hess, P. M., Parker, B. O., and Lahue, R. S. (2001) 'Efficient repair of large DNA loops in Saccharomyces cerevisiae'. Nucleic Acids Research, 29 :4143-4143. [Details]

Rolfsmeier, M. L., Dixon, M. J., Pessoa-Brandao, L., Pelletier, R., Miret, J. J. and Lahue, R. S. (2001) 'Cis-elements regulating trinucleotide repeat instability in Saccharomyces cerevisiae'. Genetics, 157 :1569-1579. [Details]

Rolfsmeier, M. L., and Lahue, R. S. (2000) 'Stabilizing effects of interruptions on trinucleotide repeat expansions in Saccharomyces cerevisiae'. Mol. Cell. Biol, 20 :173-180. [Details]

Rolfsmeier, M. L., Dixon, M. J., and Lahue, R. S. (2000) 'Mismatch repair blocks expansions of interrupted trinucleotide repeats in yeast'. Molec. Cell, 6 :1501-1507. [Details]

Spiro, C., Pelletier, R., Rolfsmeier, M. L., Dixon, M. J., Lahue, R. S., Gupta, G., Park, M. S., Chen, X., Mariappan, S. V. S., and McMurray, C. T. (1999) 'Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats'. Molec. Cell, 4 :1079-1085. [Details]

Corrette-Bennett, S. E., Parker, B. O., Mohlman, N. L., and Lahue, R. S. (1999) 'Correction of large mispaired DNA loops by extracts of Saccharomyces cerevisiae'. J. Biol. Chem, 274 :17605-17611. [Details]

Miret, J. J., Pessoa-Brandao, L., and Lahue, R. S. (1998) 'Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae'. Proc. Natl. Acad. Sci, 95 :12438-12443. [Details]

Miret, J. J., Pessoa-Brandao, L., and Lahue, R. S. (1997) 'Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae'. Molecular And Cellular Biology, 17 :3382-3387. [Details]

Alani, E., Sokolsky, T., Studamire, B., Miret, J. J. and Lahue, R S. (1997) 'Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition'. Mol. Cell. Biol, :2436-2447. [Details]

Miret, J. J., Parker, B. O. and Lahue, R. S. (1996) 'Recognition of DNA insertion/deletion mismatches by an activity in S. Cerevisiae'. Nucleic Acids Research, 24 :721-729. [Details]

Selva, E. M., New, L., Crouse, G. F., and Lahue, R. S. (1995) 'Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae'. Genetics, 139 :1175-1188. [Details]

Miret, J. J., Milla, M., and Lahue, R. S. (1993) 'Characterization of a DNA mismatch binding activity from yeast'. J. Biol. Chem, 268 :3507-3513. [Details]

Cooper, D. L., Lahue, R. S., and Modrich, P. (1993) 'Methyl-directed mismatch repair is bidirectional'. J. Biol. Chem, 268 :11823-11829. [Details]

Lahue, R. S., Au, K. G., and Modrich, P. (1989) 'DNA mismatch correction in a defined system'. Science, 245 :160-164. [Details]

Su, S-S., Lahue, R. S., Au, K. G., and Modrich, P. (1988) 'Mispair specificity of methyl-directed mismatch correction in vitro'. J. Biol. Chem, 263 :6829-6835. [Details]

Lahue, R. S., Su, S-s., and Modrich, P. (1987) 'Requirement for d GATC sequences in Escherichia coli mutHLS mismatch correction'. Proc. Natl. Acad. Sci, 84 :1482-1486. [Details]

Lahue, R. S., Su, S-s., Welsh, K. W., and Modrich, P. (1987) 'Analysis of methyl-directed mismatch repair in vitro'. UCLA Symp. Mol. Cell. Biol, :125-134. [Details]

Lahue, R. S., and Schachman, H. K. (1986) 'Communication between polypeptide chains in aspartate transcarbamoylase: conformational changes at the active sites of unliganded chains resulting from ligand binding to other chains'. J. Biol. Chem, 261 :3079-3084. [Details]

Lahue, R. S., and Schachman, H. K. (1984) 'The influence of quaternary structure on the active site of an oligomeric enzyme, catalytic subunit of aspartate transcarbamoylase'. J. Biol. Chem, 259 :13906-13913. [Details]

DeJersey, J. D., Lahue, R. S., and Martin, R. B. (1980) 'Terbium luminescence as a probe of the calcium binding site of trypsin and ?-chymostrypsin'. Arch. Biochem. Biophys, 205 :536-542. [Details]

                                                                                     

Other Item

Bhattacharyya, S, Dixon, MD, and Lahue, RS (2004) Genetic asays for triplet repeat instability in yeast. Methods Mol. Biol. Other Item [Details]

                     

Reviews

Lahue, RS (2004) DNA mismatch repair and trinucleotide repeat instability: the expansion connection. ChemTracts-Biochemistry and Molecular Biology. Reviews [Details]

Lahue, RS and Slater, DL (2003) DNA repair and trinucleotide repeat instability. Frontiers in Bioscience. Reviews [Details]