Research Interests

Responses of bacteria to their environments; gene regulation; responses of bacteria to toxic compounds; proteomics; gene microarrays; development of novel biosensors; survival stratgeies of food-borne pathogens; bacterial pathogens.

 

     

Peer Reviewed Journals

O'Byrne CP, Ni Bhriain N, Dorman CJ. (1992) 'The DNA supercoiling-sensitive expression of the Salmonella typhimurium his operon requires the his attenuator and is modulated by anaerobiosis and by osmolarity'. Mol Microbiol, 6 (17):2467-2476. [Details]

O'Byrne CP, Dorman CJ. (1994) 'The spv virulence operon of Salmonella typhimurium LT2 is regulated negatively by the cyclic AMP cAMP -cAMP receptor protein system'. J Bacteriol, . [Details]

O'Byrne CP, Dorman CJ. (1994) 'Transcription of the Salmonella typhimurium spv virulence locus is regulated negatively by the nucleoid-associated protein H-NS'. FEMS Microbiol Lett, . [Details]

Davis MJ, Coote PJ, O'Byrne CP. (1996) 'Acid tolerance in Listeria monocytogenes: the adaptive acid tolerance response ATR and growth-phase-dependent acid resistance'. Microbiology, 140 (10):2975-2982. [Details]

Roe AJ, McLaggan D, Davidson I, O'Byrne C, Booth IR. (1998) 'Perturbation of anion balance during inhibition of growth of Escherichia coli by weak acids'. J Bacteriol, 180 (4):767-772. [Details]

Humphrey TJ, Williams A, McAlpine K, Jorgensen F, O'Byrne C. (1998) 'Pathogenicity in isolates of Salmonella enterica serotype Enteritidis PT4 which differ in RpoS expression: effects of growth phase and low temperature'. Epidemiol Infect, 121 (2):295-301. [Details]

Jordan KN, Oxford L, O'Byrne CP. (1999) 'Survival of low-pH stress by Escherichia coli O157:H7: correlation between alterations in the cell envelope and increased acid tolerance'. Appl Environ Microbiol, 65 (7):3048-3055. [Details]

Fraser KR, Harvie D, Coote PJ, O'Byrne CP. (2000) 'Identification and characterization of an ATP binding cassette L-carnitine transporter in Listeria monocytogenes'. Appl Environ Microbiol, 66 (11):4696-4704. [Details]

Roe AJ, McLaggan D, O'Byrne CP, Booth IR. (2000) 'Rapid inactivation of the Escherichia coli Kdp K+ uptake system by high potassium concentrations'. Mol Microbiol, 35 (5):1235-1243. [Details]

O'Byrne CP, and Fraser KR. (2000) 'Molecular strategies for osmoregulation in the human food-borne pathogen Listeria monocytogenes'. Recent Research Developments in Microbiology, 4 :617-629. [Details]

Ferreira A, O'Byrne CP, Boor KJ. (2001) 'Role of sigma B in heat, ethanol, acid, and oxidative stress resistance and during carbon starvation in Listeria monocytogenes'. Appl Environ Microbiol, 67 (10):4454-4457. [Details]

Roe AJ, O'Byrne C, McLaggan D, Booth IR. (2002) 'Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity'. Microbiology, 148 (7):2215-2222. [Details]

Booth IR, Cash P, O'Byrne C. (2002) 'Sensing and adapting to acid stress'. Antonie Van Leeuwenhoek, 81 (01-Apr):33-42. [Details]

Fraser KR, O'Byrne CP. (2002) 'Osmoprotection by carnitine in a Listeria monocytogenes mutant lacking the OpuC transporter: evidence for a low affinity carnitine uptake system'. FEMS Microbiol Lett, 211 (2):189-194. [Details]

O'Byrne CP, Booth IR. (2002) 'Osmoregulation and its importance to food-borne microorganisms'. Int J Food Microbiol, 74 (3):203-216. [Details]

Kinghorn SM, O'Byrne CP, Booth IR, Stansfield I. (2002) 'Physiological analysis of the role of truB in Escherichia coli: a role for tRNA modification in extreme temperature resistance'. Microbiology, 148 (11):3511-3520. [Details]

Fraser KR, Sue D, Wiedmann M, Boor K, and O'Byrne CP. (2003) 'The role of sigma B B in regulating the compatible solute uptake systems of Listeria monocytogenes: Osmotic induction of opuC is B-dependent'. Appl Environ Microbiol, 69 (4):2015-2022. [Details]

Ferreira A, Sue D, O'Byrne CP, Boor KJ. (2003) 'sB contributions to survival of lethal acidic conditions and to the acquired acid tolerance response are influenced by growth phase in Listeria monocytogenes'. Appl Environ Microbiol, 69 (5):2692-2698. [Details]

Hirshfield IN, Terzulli S, O'Byrne C. (2003) 'Weak organic acids: a panoply of effects on bacteria'. Sci Prog, 86 (4):245-269. [Details]

Birch RM, O'Byrne C, Booth IR, Cash P. (2003) 'Enrichment of E. coli proteins by column chromatography on reactive dye columns'. Proteomics, 3 (5):764-776. [Details]

Tuite, NL, Fraser, KR, and O'Byrne, CP. (2005) 'Homocysteine toxicity in Escherichia coli is caused by a perturbation of branched-chain amino acid biosynthesis'. J. Bacteriol, 187 (13):4362-4371. [DOI] [Details]

Fraser KR, Tuite NL, Bhagwat A, O'Byrne C.P. (2006) 'Global effects of homocysteine on transcription in Escherichia coli: induction of the gene for the major cold-shock protein'. CspA. Microbiology, 152 (8):2221-2231. [Details]

Abram F, Su WL, Wiedmann M, Boor KJ, Coote P, Botting C, Karatzas KA, O'Byrne CP. (2008) 'Proteomic analyses of a Listeria monocytogenes mutant lacking sigma B identify new components of the sigmaB regulon and highlight a role for sigma B in the utilization of glycerol'. Appl. Environ. Micro, 74 :594-604. [Details]

O'Byrne CP, Karatzas KA. (2008) 'The role of sigma B sigma B in the stress adaptations of Listeria monocytogenes: overlaps between stress adaptation and virulence'. 65 :115-140. [Details]

Abram F, Starr E, Karatzas KA, Matlawska-Wasowska K, Boyd A, Wiedmann M, Boor KJ, Connally D, O'Byrne CP. (2008) 'Identification of components of the sigma B regulon in Listeria monocytogenes that contribute to acid and salt tolerance'. Appl Environ Microbiol, 74 (22):6848-6858. [DOI] [Details]

Cunningham, E., O'Byrne, CP., and J.D. Oliver (2009) 'Effect of weak acids on Listeria monocytogenes survival: Evidence for a viable but nonculturable state in response to low pH'. Food Control, 20 :1141-1144. [Details]

Heavin, S.B., Brennan,O.M., Morrissey, J.P., and O'Byrne, CP. (2009) 'Inhibition of Listeria monocytogenes by acetate, benzoate and sorbate: weak acid tolerance is not influenced by the glutamate decarboxylase system'. Letters in Applied Microbiology, 49 :179-185. [Details]

Cunningham, E,O'Byrne, C,Oliver, JD (2009) 'Effect of weak acids on Listeria monocytogenes survival: Evidence for a viable but nonculturable state in response to low pH'. Food Control, 20 :1141-1144. [DOI] [Details]

Matlawska-Wasowska K, Finn R, Mustel A, O'Byrne CP, Baird AW, Coffey ET, Boyd A. (2010) 'The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis'. BMC Microbiology, 10 (1). [ARAN Link] [Details]

Karatzas KA, Brennan O, Heavin S, Morrissey J, O'Byrne CP. (2010) 'Intracellular accumulation of high levels of gamma-aminobutyrate by Listeria monocytogenes 10403S in response to low pH: uncoupling of gamma-aminobutyrate synthesis from efflux in a chemically defined medium'. Appl Environ Microbiol, 76 (11):3529-3537. [DOI] [ARAN Link] [Details]

Louis P, and O'Byrne CP. (2010) 'Life in the gut: Microbial responses to stress in the gastrointestinal tract'. Science Progress, 93 :7-36. [Details]

O'Byrne CP, Feehily C, Ham R, Karatzas KA. (2010) 'A modified rapid enzymatic microtiter plate assay for the quantification of intracellular gamma-aminobutyric acid and succinate semialdehyde in bacterial cells'. J Microbiol Methods, . [Details]

O'Byrne CP and M. Utratna (2010) 'Listeria monocytogenes: at the coalface of host-pathogen research'. Bioengineered Bugs, 1 (6):1-7. [Details]

Matlawska-Wasowska, K., Finn, R., Mustel, A., O'Byrne, C., Baird, A., Coffey, E., et al. (2011) 'The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis'. BMC Microbiology, 10 (1). [ARAN Link] [Details]

Utratna, M., Shaw, I., Starr, E., O'Byrne, C.P. (2011) 'Rapid, transient, and proportional activation of σB in response to osmotic stress in Listeria monocytogenes'. Applied and Environmental Microbiology, 77 (21):7841-7845. [Details]

Lane, M.M., Burke, N., Karreman, R., Wolfe, K.H., O'Byrne, C.P., Morrissey, J.P. (2011) 'Physiological and metabolic diversity in the yeast Kluyveromyces marxianus'. Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology, 100 (4):507-519. [Details]

                               

Reviews

OBYRNE, CP et al. (2008) The Role of Sigma B (sigma(B)) in the Stress Adaptations of Listeria monocytogenes: Overlaps Between Stress Adaptation and Virulence. ADVANCES IN APPLIED MICROBIOLOGY, VOL 65. Reviews [Details]

     

Workshops

O'Byrne, C. (2002) From heart disease in humans to weak acid stress in E. Coli. NUI Galway, Department of Microbiology. Workshops [Details]

O'Byrne, C. (2002) Exploring links between weak acid stress in Escherichia coli and heart disease in humans. Moyne Institute for Preventative Medicine, Trinity College Dublin. Trinity College Dublin: Workshops [Details]

O'Byrne, C. (2002) Acetate stress in Escherichia coli: A problem with methionine biosynthesis and homocysteine toxicity. Microbial Stress Response Conference. Salve Regina University, Newport, RI, USA: Workshops [Details]

O'Byrne, C. (2004) Understanding the basis for homocysteine toxicity in Escherichia coli. University College Cork, Department of Microbiology. University College Cork: Workshops [Details]

O'Byrne, C. (2005) Escherichia coli as a model system for understanding heart disease in humans?. University of Edinburgh, Institute of Cell and Molecular Biology. University of Edinburgh: Workshops [Details]

O'Byrne, C. (2007) Coping with stress: the role of sigma B in modulating gene expression in the human pathogen Listeria monocytogenes. University College Dublin, School of Biomolecular and Biomedical Science. University College Dublin: Workshops [Details]