Dr. Emer Bourke PhD, BSc
|Dr. Emer Bourke was awarded her B.Sc. and Ph.D. by the Department of Pharmacology, University College Dublin. Her first postdoctoral position was funded as a Marie Curie Association European Individual Postdoctoral Fellow in the Istituto Mario Negri in Milan, Italy. Following this she returned to Ireland, this time as a Marie Curie European Reintegration Postdoctoral Fellow, working in the Centre for Chromosome Biology at NUI Galway. During her time she advanced becoming a HRB funded Senior postdoctoral fellow. As a self-funded postdoctoral fellow, she published in prestigious journals such as Blood, EMBO journal, Oncogene and Cell Stem Cell.
In 2010, she was appointed as a Lecturer in Biomolecular Science in the Institute of Technology Sligo, before returning to NUI Galway to take up the position as a Lecturer and group leader within the Discipline of Pathology. Her research group focuses on investigating mechanisms of genomic instability in breast cancer and is funded by a Millennium Research Fund Award.
| The centrosome is a cellular organelle which duplicates once per cell cycle to direct the formation of the bipolar spindle during cell division. Excessive centrosome number (>2 centrosomes per cell; termed centrosome amplification) is a characteristic of most human tumours. The phenomenon is triggered by DNA damage and in turn, perpetuates genomic instability by inducing errors during cell division. Recent studies have shown that the induction of extra centrosomes drives an oncogene-like transformation of breast cells into a malignant invasive phenotype capable of metastasis to other sites in the body. Current work in my lab characterizes this tumourigenic transformation in breast cell lines and patient tissue samples. We hypothesise that centrosome amplification is one of the key pathways linking genomic instability to structural and intracellular changes which promote tumour progression.
|Chiara Saladino, Emer Bourke, Ciaran Morrison (2012) 'Centrosomes, DNA Damage and Aneuploidy' In: H. Schatten (eds). The Centrosome. Springer. [Details]|
Peer Reviewed Journals
|Gao C*, Bourke E*, Scobie M, Famme MA, Koolmeister T, Helleday T, Eriksson LA, Lowndes NF, Brown JA. (2014) 'Rational design and validation of a Tip60 histone acetyltransferase inhibitor'. Scientific Reports, . [Details]|
|Mohrin M, Bourke E, Alexander D, Warr M, Barry-Holson K,, LeBeau M, Morrison CG and Passegué E. (2010) 'Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis'. Cell Stem Cell Impact Factor 24, 7 (2):174-185. [Details]|
|Brown, J.A., Bourke, E., Liptrot, C., Dockery, P. and Morrison, C.G. (2010) 'MCPH1/BRIT1 limits ionising radiation-induced centrosome amplification'. Oncogene, 29 :5537-5544. [Details]|
|Bourke, E., Brown J.A., Takeda, S., Hochegger, H. and Morrison C.G. (2010) 'DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2'. Oncogene, 29 :616-624. [Details]|
|Saladino, C,Bourke, E,Conroy, PC,Morrison, CG (2009) 'Centriole Separation in DNA Damage-Induced Centrosome Amplification'. Environmental And Molecular Mutagenesis, 50 :725-732. [DOI] [Details]|
|Faure, V,Wenner, T,Cooley, C,Bourke, E,Farr, CJ,Takeda, S,Morrison, CG (2008) 'Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line'. Dna Repair, 7 :713-724. [DOI] [Details]|
|Bourke, E,Dodson, H,Merdes, A,Cuffe, L,Zachos, G,Walker, M,Gillespie, D,Morrison, CG (2007) 'DNA damage induces Chk1-dependent centrosome amplification'. Embo Reports, 8 :603-609. [DOI] [Details]|
|Dodson, H,Bourke, E,Jeffers, LJ,Vagnarelli, P,Sonoda, E,Takeda, S,Earnshaw, WC,Merdes, A,Morrison, C (2004) 'Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM'. Embo Journal, 23 :3864-3873. [DOI] [Details]|
|Bourke E, Bosisio, D, Golay, J, Polentarutti, N & Mantovani, A (2003) 'The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells'. Blood, 102 (3):956-963. [Details]|
|Bourke E, Cassetti A, Villa A, Fadlon E, Colotta F, Mantovani A (2003) 'IL-1 beta scavenging by the type II IL-1 decoy receptor in human neutrophils'. Journal Of Immunology, 170 (12):5999-6005. [Details]|
|Bourke E, Kennedy, EJ & Moynagh, PN (2000) 'Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells'. Journal Of Biological Chemistry, 275 (51):39996-40002. [Details]|
|Bourke E. & Moynagh PN (1999) 'Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-kappa B'. Journal Of Immunology, 163 (4):2113-2119. [Details]|