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Dr. Lucy Byrnes
Contact Details
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Biography:
| 2010 - Vice-Dean for Graduate Studies, College of Science 2007 - Senior lecturer; Biochemistry Department, National University of Ireland, Galway 1996 - 2007; Lecturer; Biochemistry Department, National University of Ireland, Galway 1994 - 1996 Lecturer; Zoology Department, University College Dublin 1992 - 1994 Post-doctoral Scientist; National Diagnostics Centre, BioResearch Ireland, National University of Ireland, Galway. 1987 - 1991 Ph.D. student; Microbiology Department, National University of Ireland, Galway. 1986 - 1987 Research Technician; Cell Biology Department, Baylor College of Medicine, Houston, Texas, U.S.A. 1982 - 1986 B.Sc.; Biochemistry, National University of Ireland, Galway. |
Research Interests
| Developmental biology, gene expression in the early zebrafish embryo, role of IGF signalling in zebrafish, molecular and cellular basis of cardiovascular disease in zebrafish. |
Peer Reviewed Journals
| Byrnes L, Luo CC, Li WH, Yang CY and Chan L (1987) 'Chicken apolipoprotein A-I; cDNA sequence, tissue expression and evolution'. Biochem Biophys Res Comm, 148 :485-492. [Details] |
| BYRNES, L et al. (1990) 'ATLANTIC SALMON (SALMO-SALAR) SERUM-ALBUMIN - CDNA SEQUENCE, EVOLUTION, AND TISSUE EXPRESSION'. DNA AND CELL BIOLOGY, 9 :647-655. [Details] |
| Powell, R, Byrnes L, Barry T and Gannon, F (1990) 'A rapid procedure to isolate major abundance mRNA transcripts and study the transcription profile of a tissue'. Technique, 2 :213-215. [Details] |
| Powell R Byrnes L Gannon F (1990) 'Transgenic fish'. The Genetic Engineer And Biotechnologist, 10 :7-9. [Details] |
| Powell R, Byrnes L and Gannon, F (1991) 'Sequence of a cDNA clone encoding an Atlantic salmon ribodomal protein'. Gene, 101 :303-304. [Details] |
| Powell R, Higgins DG, Wolff J, Byrnes L, Stack M, Sharp PM and Gannon, F (1991) 'The salmon gene encoding apolipoprotein A-I: cDNA sequence, tissue expression and evolution'. Gene, 104 :155-161. [Details] |
| Byrnes L Gannon F (1992) 'Sequence analysis of a second cDNA for salmon serum albumin'. Gene, 120 :319-320. [Details] |
| Hardiman G, Byrnes L and Gannon F (1994) 'An analysis of highly expressed salmon liver genes during smoltification in the Atlantic salmon (Salmo salar L)'. Molecular Marine Biol Biotech, 3 :51-56. [Details] |
| Hardiman G, Byrnes L, Peden J, Wolff J and Gannon F (1994) 'Cloning and sequencing of an Atlantic salmon (Salmo salar) cytochrome c oxidase subunit III gene (coxIII) and analysis of coxIII gene expression during parr-smolt transformation'. Molecular Marine Biol Biotech, 3 :210-216. [Details] |
| Dercykere F, Byrnes L, Wagner A, McMorrow T and Gannon, F (1995) 'Salmon HNF1:cDNA sequene, evolution, tissue specificity and binding to the salmon serum albumin promoter'. J Mol Biol, 2247 :1-10. [Details] |
| Fluoriot G, ducouret B, Byrnes L and Valotaire Y (1998) 'Transcriptional regulation of expression of the rainbow trout albumin gene by estrogen'. J Mol Endocrinol, 20 :355-362. [Details] |
| Stenson, C. McNair, A., Byrnes, L., Murphy, M., Smith, T. and F. Gannon (2000) 'Atlantic salmon HNF-3/fork head; cDNA sequence, evolution, expression and functional analysis'. DNA AND CELL BIOLOGY, 19 :59-68. [Details] |
| Ayaso, E., Nolan, C.M. and L. Byrnes (2002) 'Zebrafish insulin-like growth factor-1 receptor: molecular cloning and developmental expression'. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 191 :137-148. [DOI] [Details] |
| Carton, M.W., Schmitz, M., Cutts, C.J., Kelly, A.K., Hill, J.A., Brabazon, E.D., Adams, C.E. and L. Byrnes (2002) 'Expressed sequence tags in larval Arctic charr (Salvelinus alpinus)'. FISH PHYSIOL. BIOCHEM, 26 :231-238. [Details] |
| Brabazon, E.D., Bree, R.T., Carton, M.W., Grealy, M. and L. Byrnes (2002) 'Cyclin dependent kinase 8 is expressed both maternally and zygotically during zebrafish embryo development'. BIOCHEM. BIOPHYS. ACTA, 1576 :203-208. [Details] |
| Bree RT Stenson C Grealy M Byrnes L Gorman AM Samali A (2002) 'Cellular longevity: role of apoptosis and replicative senescence'. Biogerontology, 3 :195-206. [Details] |
| Eivers, E., McCarthy, K., Glynn, C., Nolan, C.M. and L. Byrnes (2004) 'Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo'. THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 48 :1131-1140. [DOI] [Details] |
| Grassick, A., Murray, P.G., Thompson, R., Collins, C.M., Byrnes, L., Birrane, G., Higgins, T.M. and M.G. Tuohy (2004) 'Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii'. EUROPEAN JOURNAL OF BIOCHEMISTRY, 271 :4495-4506. [DOI] [Details] |
| Bree, R.T., McLoughlin, S., Jin, S.W., McMeel, O.M., Stainier, D.Y.R., Grealy, M., and L. Byrnes (2005) 'nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafish'. BIOCHEM. BIOPHYS. RES. COMMUN, 333 :722-728. [Details] |
| Nolan, C.M., McCarthy, K., Eivers, E., Jirtle, R.L. and L. Byrnes (2006) 'Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish'. DEVELOPMENT GENES AND EVOLUTION, 216 :144-151. [DOI] [Details] |
| O'Boyle S, Bree RT, McLoughlin S, Grealy M, Byrnes L (2007) 'Identification of zygotic genes expressed at the midblastula transition in zebrafish'. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 358 :462-468. [Details] |
| Collins CM, Murray PG, Denman S, Morrissey JP, Byrnes L, Teeri TT, MG Tuohy (2007) 'Molecular cloning and expression analysis of two distinct b-glucosidase genes, bg1 and aven1, with very different biological roles from the thermophilic, saprophytic fungus Talaromyces emersonii'. MYCOLOGICAL RESEARCH, 111 :840-849. [DOI] [Details] |
| Geoghehan E Byrnes L (2008) 'Mouse induced pluripotent stem cells'. International Journal Of Developmental Biology, 52 :1015-1022. [Details] |
| Moriarty MA, Martin ED, Byrnes L, M Grealy (2008) 'Molecular cloning and developmental expression of plakophilin 2 in zebrafish'. Biochem Biophys Res Comm, 367 :124-129. [Details] |
| Tsalavouta M, Astudillo O, Byrnes L and Nolan CM (2009) 'Regulation of expression of zebrafish (Danio rerio) insulin-like growth factor 2 receptor: implications for evolution at the IGF2R locus'. Evol Dev, 11 :547-559. [DOI] [Details] |
| Martin, ED, Moriarty, MA, Byrnes, L and Grealy, M (2009) 'Plakoglobin has both structural and signalling roles in zebrafish development'. Developmental Biology, 327 :83-96. [Details] |
| Hartnett L, Glynn C, Nolan CM, Grealy M and Byrnes L (2010) 'Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos'. Int J Dev Biol, 54 :573-583. [Details] |
Book Chapters
| Wagner A Deryckere F Hardiman G Byrnes L Gannon F (1993) 'The isolation and structure of liver and globin genes from Atlantic salmon' In: Aquaculture: Fundamental and Applied Research. Washington: American Biophysical Union. [Details] |
| Byrnes L, Enenkel B, Gannon F and Smith T (1995) 'Preparation of DNA for use as probes' In: Hames, B.D.; Higgins, S.J (eds). Gene Probes 1: A Practical Approach. IRL Press. [Details] |
Conference Publications
| Abdul-Ahad W Byrnes L Gosling JP (1987) The use of Fab'-beta-lactamase conjugate in an enzyme-linked immunosorbent assay for bovine luteinizing hormone Biochem Soc Trans 15 277-278 [Details] |
| Powell R Byrnes L Gannon F (1990) Liver gene expression: cloning of abundant messenger RNA transcripts from the liver of Atlantic salmon (Salmo salar). Identification of salmon apolipoprotein A-1 gene Proc. 5th European Congress on Biotechnology 5 453-456 [Details] |
| Stenson C McNair A Byrnes L Gannon F (1996) Cloning of an Atlantic salmon transcription factor Biochem Soc Trans 24 1 106S [Details] |
| Ayaso E Nolan C Byrnes L (1999) Zebrafish IGF-1 receptor expression during development Growth hormone and IGF Research 9 347 [Details] |
| O'Connor D Byrnes L (1999) CCAAT/enhancer binding protein in zebrafish J Fish Biol 55A 247 [Details] |
| Kelly A Schmitz M Hill J Cutts C Adams C Byrnes L (1999) Molecular basis for variation in metabolic rate in juvenile charr J Fish Biol 55A 244-245 [Details] |
| O'Connor D Byrnes L (2001) ONECUT domain transcription factors in the zebrafish Biochem Soc Trans 29 135A [Details] |
| McLoughlin S Bree RT O'Boyle S Grealy M Byrnes L (2004) Gene expression at the midblastula transition in zebrafish Biochem Soc Trans 32 135A [Details] |
| McCarthy K Glynn C Hartnett L Grealy M Nolan C Byrnes L (2005) The role of insulin-like growth factor-2 (IGF-2) in zebrafish embryonic development Developmental Biology 283 620-621 [Details] |
Conference Poster
| Ayaso E, Nolan CM and L Byrnes (2000) Cloning and developmental expression of the zebrafish IGF-I receptor. Zebrafish Development & Genetics. Cold Spring Harbor, New York: Conference Poster [Details] |
| Brabazon ED, Byrnes L and M Grealy (2000) Expression and localization of cadherins and catenins during zebrafish embryo development. Zebrafish Development & Genetics. Cold Spring Harbor, New York: Conference Poster [Details] |
| D O'Connor and L Byrnes (2001) Isolation and expression of a ONECUT domain transcription factor from the zebrafish. 2nd European conference on Zebrafish Genetics and Development. University College London, UK: Conference Poster [Details] |
| E D Brabazon, R T Bree, M Grealy and L Byrnes (2001) Characterisation of Zebrafish Cyclin Dependent Kinase 8: cDNA Sequencing and Expression Studies. 2nd European conference on Zebrafish Genetics and Development. University College London, UK: Conference Poster [Details] |
| Collins C, Murray PG, Byrnes L and Tuohy M (2001) Molecular genetics of cellulase production in the filamentous fungus Talaromyces emersonii. 4th Carbohydrate Bioengineering Meeting. Stockholm, Sweden: Conference Poster [Details] |
| Brabazon ED, Byrnes L and M Grealy (2001) Cadherin and catenin expression and localization during early zebrafish embryo morphogenesis. Cell and Tissue Morphogenesis, British Societies for Cell and Developmental Biology Joint Spring Meeting. University of Sussex, Brighton, UK: Conference Poster [Details] |
| Brabazon ED, Byrnes L and Grealy M (2001) Cadherin and catenin expression and localisation during early zebrafish morphogenesis. Cell and Tissue Morphogenesis, British Societies for Cell and Developmental Biology Joint Spring Meeting. University of Sussex, Brighton, UK: Conference Poster [Details] |
| Bree RT, McMeel O, Brabazon ED, Cairns M, Smith T, Grealy M and L Byrnes (2001) Characterisation of the molecular events occurring at the mid-blastula transition during zebrafish embryo development. 2nd European conference on Zebrafish Genetics and Development. University College London, UK: Conference Poster [Details] |
| Nolan C, McCarthy K, Byrnes L and Jirtle R (2004) Evolution of the cation-independent mannose 6-phosphate receptor: the zebrafish receptor. Gordon Conference on Lysosomes and Endocytosis. New Hampshire, USA: Conference Poster [Details] |
| Nolan C, McCarthy K, Byrnes L and Jirtle R (2004) Evolution of the mannose 6-phosphate/IGF2 receptor: a novel regulatory element?. 69th Cold Spring Harbor Symposium on Quantitative Biology: Epigenetics. Cold Spring Harbor, New York, USA: Conference Poster [Details] |
| McLoughlin S, Bree RT, O'Boyle S, Grealy M, and Byrnes, L (2004) Gene expression at the midblastula transition in zebrafish. BioScience 2004 from molecules to organisms. Glasgow, UK: Conference Poster [Details] |
| Eivers E, McCarthy K, Glynn C, Nolan CM and Byrnes L (2004) IGF signalling and neural development in the zebrafish embryo. Zebrafish Development & Genetics. University of Wisconsin-Madison, USA: Conference Poster [Details] |
| McCarthy K, Eivers E, Nolan C and Byrnes L (2004) Molecular characterisation and expression analysis of the cation independent mannose 6-phosphate receptor (CI-M6PR) in zebrafish. Joint meeting of Genetics Society and British Society for Developmental Biology. University of Warwick, UK: Conference Poster [Details] |
| Hartnett L, McCarthy K, Glynn C, Grealy M, Nolan C and Byrnes L (2005) Insulin-like growth factors are involved in heart and somite development in zebrafish. 4th European zebrafish meeting. Dresden, Germany: Conference Poster [Details] |
| Ferg M, Lovas A, Bree R, O'Boyle S, Byrnes L and Muller F (2005) Regulation of differential gene expression during zebrafish development by alternative transcription initiation complexes. 4th European zebrafish meeting. Dresden, Germany: Conference Poster [Details] |
| Reynolds T and Byrnes L (2005) Embryonic development in Atlantic salmon (Salmo salar). British Societies for Cell and Developmental Biology Joint Spring Meeting. University of Warwick, U.K: Conference Poster [Details] |
| Astudillo A, McCarthy K, Byrnes L and Nolan C (2005) Evolution of an imprinted gene: the zebrafish mannose 6-phosphate/IGF2 receptor. 4th European zebrafish meeting. Dresden, Germany: Conference Poster [Details] |
| O'Boyle S, Bree RT, McLoughlin S, Schindler S, Muller F, Grealy M and Byrnes L (2005) A study of gene expression at the midblastula transition in zebrafish. 4th European zebrafish meeting. Dresden, Germany: Conference Poster [Details] |
| Nolan CM, Astudillo O, Callanan S, McCann A, Jirtle RL, Byrnes L and O'Sullivan F (2005) Evolution of an imprinted gene: the mannose 6-phosphate/IGF2 receptor. Environmental Epigenomics, Imprinting and Disease susceptibility. Durham, North Carolina, USA: Conference Poster [Details] |
| Hartnett L, McCarthy K, Glynn C, Grealy M and Byrnes L (2006) Targeted knockdown of IGF-2 disrupts cardiovascular development in zebrafish embryos. BSDB Autumn Meeting. Dundee, Scotland: Conference Poster [Details] |
| Collins C, Murray P, Morrissey J, Byrnes L and M Tuohy (2006) Evidence of a phytopathogenic gene in the thermophoilic, saprophytic fungus Talaromyces emersonii. 8th European Fungal Genetics meeting. Austria: Conference Poster [Details] |
| Tsalavouta M, Astudillo O, Byrnes L and Nolan C (2006) Complex regulation of expression of an evolutionarily important gene: the zebrafish CI-MPR/IGF2R. 7th International meeting: Zebrafish Development and Genetics. Madison, Wisconsin, USA: Conference Poster [Details] |
Associations
| Association: Irish Network of Developmental Biologists, Function/Role: Convener |
| Association: The Biochemical Society, Function/Role: Member |
| Association: British Society for Developmental Biology, Function/Role: Member |
Education
| Year 1991 Institution: UCG Qualification: Phd Subject: Molecular biology |
| Year 1986 Institution: UCG Qualification: Subject: Biochemistry |
Outreach Activities
| Judge, Young Scientists Exhibition, 2004-present |
Teaching Interests
| Course Director, 4th year Biochemistry |
Recent Postgraduates
| Miriam Moriarty (co-supervised with Maura Grealy), PhD (2006-2010) Lori Hartnett (co-supervised with Maura Grealy and Catherine Nolan, UCD), PhD (2004-2009) Shaun O'Boyle (co-supervised with Maura Grealy), PhD (2003-2008) Karena McCarthy (co-supervised with Catherine Nolan, UCD), PhD (2002-2007) Sarah McLoughlin (co-supervised with Maura Grealy), MSc (2002-2005) Ed Eivers (co-supervised with Catherine Nolan, UCD), PhD (1999-2004) Ronan Bree (co-supervised with Maura Grealy), PhD (1999-2003) Catherine Collins (co-supervised with Maria Tuohy), PhD (1999-2003) Audrey Kelly, PhD (1997-2002) Catherine Glynn (co-supervised with Afshin Samali and Adrienne Gorman), MSc (2001-2002) Deirdre O'Connor, PhD (1997-2002) Elena Ayaso (co-supervised with Catherine Nolan, UCD), PhD (1996-2001) Kathy Gately, PhD (1996-2001) |
Current Postgraduate Students
| Rebecca Ryan, Doctorate - Ph.D.(Science) - Supervisor |
Modules Taught
Internal Collaborators
| Dr. Maura Grealy, Pharmacology & Therapeutics |
External Collaborators
| Dr. Catherine Nolan, UCD Prof. Didier Stainier, UCSF |