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Dr Michael Carty B.Sc., Ph.D.
Contact Details
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Biography:
| Dr. Carty received his Ph.D. degree from the Department of Biochemistry at the National University of Ireland, Galway, in 1986. He then obtained a Fogarty International fellowship to carry out post-doctoral research at the National Institutes of Health at Bethesda, MD, in the area of DNA replication in mammalian cells. From 1991, at the Department of Environmental Health at the University of Cincinnati Medical School, Dr. Carty carried out research on cellular responses to agents that damage DNA, especially ultraviolet light, a major cause of skin cancer. Dr. Carty took up a position as a College Lecturer in the Department of Biochemistry at the National University of Ireland, Galway in 2000. He is currently Senior Lecturer and Head of Biochemistry, School of Natural Sciences, NUI Galway. Dr. Carty is head of the DNA Damage Response laboratory in the Centre for Chromosome Biology, NUI Galway. His research group focuses on how the loss of genome stability contributes to cancer development, and on the molecular responses of human cells to UV light, and to DNA damaging agents such as cisplatin that are used in cancer therapy. In collaboration with Prof. Frank Barry (Regenerative Medicine Institute) the responses of human mesenchymal stem cells to cisplatin and ionising radiation have also been characterised. In addition, the response of human cancer cell lines to novel mitomycin C-related chemical compounds is being investgated in an ongoing collaboration with Dr. Fawaz Aldabbagh (School of Chemistry, NUI Galway). |
Research Interests
| Responses of human cells to DNA damage, in particular following expousre to ultraviolet radiation and platinum-based chemotherapeutic drugs; Genome instability; the POLH gene and DNA polymerase eta; PIKK kinases and Replication protein A phosphorylation after DNA damage; DNA damage responses in mesenchymal stem cells; responses to long wavelength UVA radiation in melanocytes. |
Book Chapters
| Cruet-Hennequart, S, Gallagher, K, Sokol, AM, Villalan, S, Prendergast, AM, Carty, MP. (2010) 'DNA polymerase eta, a key protein in translesion synthesis in human cells. Subcell Biochem' In: Genome Stability and Human Diseases. London: Springer. [Details] |
Peer Reviewed Journals
| Fagan, V,Bonham, S,McArdle, P,Carty, MP,Aldabbagh, F (2012) 'Synthesis and Toxicity of New Ring-Fused Imidazo[5,4-f]benzimidazolequinones and Mechanism Using Amine N-Oxide Cyclizations'. European Journal Of Organic Chemistry, :1967-1975. [DOI] [Details] |
| Fagan, V,Bonham, S,Carty, MP,Saenz-Mendez, P,Eriksson, LA,Aldabbagh, F (2012) 'COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates'. Bioorgan Med Chem, 20 :3223-3232. [DOI] [Details] |
| Cuffe, S,Dowling, CM,Claffey, J,Pampillon, C,Hogan, M,Fitzpatrick, JM,Carty, MP,Tacke, M,Watson, RWG (2011) 'Effects of Titanocene Dichloride Derivatives on Prostate Cancer Cells, Specifically DNA Damage-Induced Apoptosis'. Prostate, 71 :111-124. [DOI] [Details] |
| Prendergast, AM,Cruet-Hennequart, S,Shaw, G,Barry, FP,Carty, MP (2011) 'Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or gamma-irradiation'. Cell Cycle, 10 :3768-3777. [DOI] [Details] |
| Bonham, S,O'Donovan, L,Carty, MP,Aldabbagh, F (2011) 'First synthesis of an aziridinyl fused pyrrolo[1,2-a]benzimidazole and toxicity evaluation towards normal and breast cancer cell lines'. Organic & Biomolecular Chemistry, 9 :6700-6706. [DOI] [Details] |
| Fagan, V,Bonham, S,Carty, MP,Aldabbagh, F (2010) 'One-pot double intramolecular homolytic aromatic substitution routes to dialicyclic ring fused imidazobenzimidazolequinones and preliminary analysis of anticancer activity'. Organic & Biomolecular Chemistry, 8 :3149-3156. [DOI] [Details] |
| Fahey, K,O'Donovan, L,Carr, M,Carty, MP,Aldabbagh, F (2010) 'The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells'. European Journal Of Medicinal Chemistry, 45 :1873-1879. [DOI] [Details] |
| Moriarty,E, Carr,M, Carty,M.P, Aldabbagh,F. (2010) 'Synthesis and Toxicity Towards Normal and Cancer Cell Lines of Benzimidazolequinones Containing Fused Aromatic Rings and 2-Aromatic Ring Substituents'. European Journal of Medicinal Chemistry, 45 (9):3762-3769. [Details] |
| Fahey,K., O'Donovan,L., Carr,M., Carty,M.P., Aldabbagh,F. (2010) 'The Influence of the Aziridinyl Substituent of Benzimidazoles and Benzimidazolequinones on Toxicity Towards Normal and Fanconi Anaemia Cells'. European Journal of Medicinal Chemistry, 45 :1873-1879. [Details] |
| O'Meara, E, Cruet-Hennequart, S, Carty, MP. (2010) 'Analysis of protein phosphorylation in cisplatin-treated human cells following annexin V-based separation and multi-antibody screening'. Cancer Genomics Proteomics, 7 (5):279-286. [Details] |
| Grzywa, R,Sokol, AM,Sienczyk, M,Radziszewicz, M,Kosciolek, B,Carty, MP,Oleksyszyn, J (2010) 'New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13'. Bioorgan Med Chem, 18 :2930-2936. [DOI] [Details] |
| Moriarty, E,Carr, M,Bonham, S,Carty, MP,Aldabbagh, F (2010) 'Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents'. European Journal Of Medicinal Chemistry, 45 :3762-3769. [DOI] [Details] |
| Cruet-Hennequart, S,Villalan, S,Kaczmarczyk, A,O'Meara, E,Sokol, AM,Carty, MP (2009) 'Characterization of the effects of cisplatin and carboplatin on cell cycle progression and DNA damage response activation in DNA polymerase eta-deficient human cells'. Cell Cycle, 8 :3039-3050. [Details] |
| Stephan, H,Concannon, C,Kremmer, E,Carty, MP,Nasheuer, HP (2009) 'Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis'. Nucleic Acids Research, 37 :6028-6041. [DOI] [Details] |
| Cruet-Hennequart, S,Glynn, MT,Murillo, LS,Coyne, S,Carty, MP (2008) 'Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin'. Dna Repair, 7 :582-596. [DOI] [Details] |
| O'Donovan, L,Carty, MP,Aldabbagh, F (2008) 'First synthesis of N-[(aziridin-2-yl)methyl]benzimidazolequinone and analysis of toxicity towards normal and Fanconi anemia cells'. Chemical Communications, :5592-5594. [DOI] [Details] |
| O'Donovan,L, Carty,M.P, Aldabbagh,F. (2008) 'RSC Prospect: First Synthesis of N-[Aziridinyl-2-yl)methyl]Benzimidazolequinone and Analysis of Toxicity Towards Normal and Fanconi Anemia Cells'. Chemical Communications, :5592-5594. [Details] |
| Hehir, S,O'Donovan, L,Carty, MP,Aldabbagh, F (2008) 'Synthesis of dimethyl substituted benzimidazoles containing cyclopropane fused onto five to eight membered [1,2-a]alicyclic rings and influence of methyl group substituents on cytotoxicity of benzimidazolequinones'. Tetrahedron, 64 :4196-4203. [DOI] [Details] |
| Flanagan, AM,Rafferty, G,O'Neill, A,Rynne, L,Kelly, J,McCann, J,Carty, MP (2007) 'The human POLH gene is not mutated, and is expressed in a cohort of patients with basal or squamous cell carcinoma of the skin'. International Journal Of Molecular Medicine, 19 :589-596. [Details] |
| Lynch, M,Hehir, S,Kavanagh, P,Leech, D,O'Shaughnessy, J,Carty, MP,Aldabbagh, F (2007) 'Synthesis by radical cyclization and cytotoxicity of highly potent bioreductive alicyclic ring fused [1,2-a]benzimidazolequinones'. Chemistry-A European Journal, 13 :3218-3226. [DOI] [Details] |
| Cruet-Hennequart, S,Coyne, S,Glynn, MT,Oakley, GG,Carty, MP (2006) 'UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK'. Dna Repair, 5 :491-504. [DOI] [Details] |
| Carty, M,Goodbody, R,Schroder, M,Stack, J,Moynagh, PN,Bowie, AG (2006) 'The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling'. Nature immunology, 7 :1074-1081. [DOI] [Details] |
| Carty MP, Glynn M, Maher M, Smith T, Yao J, Dixon K, McCann J, Rynn L, Flanagan A. (2003) 'The RAD30 cancer susceptibility gene'. Biochemical Society Transactions, 31 (1):252-256. [Details] |
| Oakely, G.G., Patrick, S.M., Yao, J., Carty, M.P., Turchi, J.J. and Dixon, K. (2003) 'RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions'. Biochemistry, 42 :3255-3264. [Details] |
| Miller, M.L., Andringa, A., Dixon, K. and Carty, M.P. (2002) 'Insights into UV-induced apoptosis: ultrastructure, trichrome stains and spectral imaging'. Micron, 37 :157-166. [Details] |
| Yao, J., Dixon, K. and Carty, M.P. A single (2001) '6-4 photoproduct inhibits plasmid DNA replication in xeroderma pigmentosum variant cell extracts Env'. Mol Mutagen, 38 :19-29. [Details] |
| King, N.M., Carty, M.P. and Dixon, K. (2001) 'In vitro replication and mutagenesis of a novel reversion vector with selective DNA damage in the SupF gene'. Mutation Res, 476 :21-28. [Details] |
| Yao, JQ,Dixon, K,Carty, MP (2001) 'A single (6-4) photoproduct inhibits plasmid DNA replication in xeroderma pigmentosum variant cell extracts'. Environmental And Molecular Mutagenesis, 38 :19-29. [Details] |
| Oakley, G.G., Loberg, L. I., Yao, J., Risinger, M.A., Yunker, R.L., Zernik-Kobak, M.,Khanna, K.K., Lavin, M.F., Carty, M.P. and Dixon, K. (2001) 'UV-induced hyperphosphorylation of replication protein A depends on DNA replication and expression of ATM protein'. Mol Biol Cell, 12 :1199-1213. [Details] |
| Li, Y., Carty, M.P. and Dixon, K. (2001) 'Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in double-strand break repair in nuclear extracts'. Env Mol Mutagen, 37 :128-140. [Details] |
| Borchers, M.T., Carty, M.P. and Leikauf, G.D. (1999) 'Lung Cell Mol Physiol 20, L549- L555 Regulation of human airway mucins by acrolein and inflammatory mediators'. Am J Physiol, 20 . [Details] |
| Miller, M.L., Andringa, A., Elliott, J., Conwell, K., Dixon, K., and Carty, M.P. (1998) 'The morphological and spectral phenotype of apoptosis in HeLa cells varies following exposure to UV-C and the addition of inhibitors of ICE and CPP32'. Cell Proliferation, 31 :17-33. [Details] |
| Carty, M. P., Lawrence, C. W. and Dixon, K. (1996) 'Complete replication of plasmid DNA containing a single UV-induced lesion in human cell extracts'. J Biol Chem, 271 :9637-9647. [Details] |
| Carty, M. P., El-Saleh, S., Zernik-Kobak, M. and Dixon, K. (1995) 'Analysis of sequence changes induced during replication of ultraviolet light-damaged DNA in extracts of human cells'. Env Mol Mutagen, 26 :139-146. [Details] |
| Carty, M. P., Zernik-Kobak, M., McGrath, S. and Dixon, K. (1994) 'Ultraviolet light-induced DNA synthesis arrest in HeLa cells is associated with changes in the phosphorylation state of a replication factor, human single-stranded DNA-binding protein'. EMBO J, 13 :2114-2123. [Details] |
| Carty, M. P., Hauser, J., Levine, A. S., and Dixon, K. (1993) 'Replication and mutagenesis of UV-damaged DNA templates in human cell extracts in vitro'. Mol Cell Biol, 13 :533-542. [Details] |
| Carty, M. P., Levine, A. S., and Dixon, K. (1992) 'HeLa cell single-stranded-DNA binding protein increases the accuracy of DNA synthesis by DNA polymerase alpha in vitro'. Mutation Res, 274 :29-43. [Details] |
| Carbone, M., Hauser, J., Carty, M. P., Rundell, K., Dixon, K., and Levine, A. S. (1992) 'Simian virus 40 small t antigen inhibits SV40 DNA replication in vitro'. J Virol, 66 :1804-1808. [Details] |
| Carty, M. P., Ishimi, Y., Levine, A. S., and Dixon, K. (1990) 'DNA polymerase alpha from HeLa cells synthesizes DNA with high fidelity in a reconstituted replication system'. Mutation Res, 232 :141-153. [Details] |
| Carty, M. P., Beirne, E., and Donlon, J. (1989) 'High protein diet and phenylalanine hydroxylase activities in rats'. Pteridines, 1 :235-238. [Details] |
| BEIRNE, E,CARTY, MP,DONLON, J (1985) 'EFFECT OF GLUCAGON ON HEPATIC PHENYLALANINE-HYDROXYLASE INVIVO'. Bioscience Reports, 5 :463-467. [Details] |
Conference Publications
| Carty, MP,Glynn, M,Maher, M,Smith, T,Yao, J,Dixon, K,McCann, J,Rynn, L,Flanagan, A (2003) BIOCHEMICAL SOCIETY TRANSACTIONS The RAD30 cancer susceptibility gene , pp.252-256 [Details] |
Abstract
| Cuffe, S,Dowling, C,Gill, C,Tacke, M,Fitzpatrick, JM,Carty, MP,Watson, RWG (2008) Novel titanocene analogues induce apoptosis in prostate cancer epithelial cells by initiating a DNA damage response. Abstract [Details] |
| Cruet-Hennequart, S,Villalan, S,O'Meara, E,Carty, MP (2008) ROLE OF LESION BYPASS BY DNA POLYMERASE ETA, AND PIK KINASE SIGNALLING, IN THE RESPONSE OF HUMAN CELLS TO PLATINUM-BASED CHEMOTHERAPEUTIC AGENTS. Abstract [Details] |
Conference Paper
| Flanagan, A., McCann, J., Rynne, L., Maher, M., Smith, T. & Carty, M.P. (2002) Analysis of sequence changes in the RAD30 cancer susceptibility gene, using glycosylase-mediated polymorphism detection (GMPD). Nature Genetics/American Association for Cancer Research (ACCR) Conference on oncogenomics, 2002 (Meeting Abstract). Dublin, Ireland: Conference Paper [Details] |
| Flanagan, A., Rynne, L., McCann, J., Maher, M., Smith, T. & Carty, M.P. (2002) Analysis of sequence changes associated with the RAD30 cancer susceptibility gene. Biochemical Society, Irish Area Section Meeting, 2002 (Meeting Abstract). Galway, Ireland: Conference Paper [Details] |
Reviews
| Cruet-Hennequart, S, Prendergast, AM, Barry, FP, Carty, MP. (2010) Human mesenchymal stem cells (hMSCs) as targets of DNA damaging agents in cancer therapy. Curr Cancer Drug Targets. Reviews [Details] |
| Cruet-Hennequart, S,Prendergast, AM,Barry, FP,Carty, MP (2010) Human Mesenchymal Stem Cells (hMSCs) as Targets of DNA Damaging Agents in Cancer Therapy. Reviews [Details] |
| Carty, M.P., Glynn, M., Maher, M., Smith, T., Yao, J., Dixon, K., McCann, J., Rynn, L., and Flanagan, A. (2003) The RAD30 cancer susceptibility gene. Biochem Soc Trans. Reviews [Details] |
| Miller, M.L., Andringa, A., Dixon, K. and Carty, M.P. (2002) Insights into UV-induced apoptosis: ultrastructure, trichrome stains and spectral imaging. Micron. Reviews [Details] |
| Miller, ML,Andringa, A,Dixon, K,Carty, MP (2002) Insights into UV-induced apoptosis: ultrastructure, trichrome stain and spectral imaging. Reviews [Details] |
Associations
| Association: Irish Association for Cancer Research, Function/Role: Committee member 2004-2008 |
| Association: Irish Area Section Biochemical Society (IASBS), Function/Role: Treasurer 2006-2009; Committee member 2004-2012 |
Conference Contributions
| Glynn MT, Cruet-Hennequart S, O'Meara EM, Coyne S, Carty MP (2006) Invited speaker. [Invited Oral Presentation], 11th World Congress on Advances in Oncology/9th International Symposium on Molecular Medicine, Crete, Greece , 09-OCT-06 - 11-OCT-06. |
| Cruet-Hennequart S, O'Meara, EM, Kaczmarczyk A, Villalan S, Glynn MT, Carty MP (2007) Invited speaker and Session chair. [Invited Oral Presentation], 12th World Congress on Advances in Oncology/10th International Symposium on Molecular Medicine, Crete, Greece , 10-OCT-07 - 13-OCT-07. |
| Cruet-Hennequart S, Villalan S, O'Meara EM, Carty MP (2008) Invited speaker and Session Chair. [Invited Oral Presentation], 8th International Conference of Anticancer Research, Kos, Greece , 17-OCT-08 - 22-OCT-08. |
| Carty MP (2008) Organiser, Biochemical Society Irish Area Section Focused meeting. [Conference Organising Committee Chairperson], Genome Instability and Cancer, NUI Galway, Ireland , 04-DEC-08 - 04-DEC-08. |
| Carty MP (2010) Speaker in session on 'Chromosomes and Chromatin'. [Invited Oral Presentation], Irish Association for Cancer Research Annual meeting 2010, Galway, Ireland , 03-MAR-10 - 05-MAR-10. |
| Sokol AM, Bianco J, Cruet-Hennequart S, Villalan S, Pasero P, Carty MP (2011) International DNA Repair conference. [Oral Presentation], Responses to DNA damage: from molecular mechanisms to human disease, Egmond-aan-Zee, Holland , 03-APR-11 - 08-APR-11. |
Education
| Year 1982 Institution: NUI Galway Qualification: BSc Subject: Biochemistry (honours) |
| Year 1986 Institution: NUI Galway Qualification: Phd Subject: Biochemistry |