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Prof. Terry Smith BA Mod, MA, D.PHIL
Contact Details
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Biography:
| Professor Terry Smith obtained a BA. Moderatorship Degree in Microbiology, from Trinity College Dublin, in 1981. He was employed as a research scientist in the R&D division of a multinational pharmaceutical company (G.D. Searle, High Wycombe, UK) from 1981 until 1984, where he worked on optimised recombinant protein production systems. In 1984, he undertook a Ph.D. degree at Oxford University, where his studies were focused on investigating the molecular basis of the devastating human genetic disease, Duchenne's Muscular Dystrophy (DMD). Prof. Smith was awarded a D. Phil. degree from Oxford University in 1988. Having completed a Muscular Dystrophy Society post-doctoral Fellowship at Oxford, Prof. Smith was awarded a European Molecular Biology Organisation (EMBO) Long-term Post-doctoral Fellowship to work in the laboratory of Professor Oliver Smithies, 2007 Nobel Laureate in Medicine, at the University of North Carolina (UNC), Chapel Hill. He spent two years at UNC, Chapel Hill, where he worked on the development of an animal model for human atherosclerosis using mouse embryonic stem cells. In 1990, Prof. Smith took up a Senior Research Scientist/Team Leader position at the National Diagnostics Centre (BioResearch Ireland) at NUI Galway, where he headed up the DNA Diagnostics laboratory. In 1994, Prof. Smith was appointed General Manager of the National Diagnostics Centre, a post he held until 2001. Prof. Smith was a founder member of the National Centre for Biomedical Engineering Science (NCBES), established at NUI Galway in 1999, and was appointed Professor of Biomedical Engineering Science and Director of the NCBES in January 2002. In that role, he led the development, growth and evolution of the Centre's research programmes in Biomedical Science and Engineering with the centre currently hosting over 100 academic members and afffiliates, over 350 researchers and support staff, with an annual research spend of over 20 million. Other major achievements, as NCBES Director include, playing a leadership role in the successful submission to the SFI CSET programme in 2003, leading to the establishment of the Regenerative Medicine Institute (REMEDI) with funding of 19 million from SFI and industry partners. He also played a key role in the establishment of the Network for Functional Biomaterials (NFB), in 2007, and the Alimentary Glycosciences Research Centre (AGRC) in 2009. He led the NUI Galway research team in the development of a collaborative bioanalytical sciences research programme in partnership with Bristol Myers Squibb company and Dublin City University leading to the establishment of the Centre for BioAnalytical Sciences (CBAS), with over 9.5 million in funding. He also led the negotiation of a four-year 7.3 million research collaboration in molecular diagnostics assay development and commercialisation, with Beckman Coulter Incorporated, which was launched in January 2008, and he is the Research Director of this programme. Professor Smith was appointed Vice President for Research at NUI Galway in July 2008. His responsibilities include providing leadership in research strategy and policy development to the entire NUI Galway academic research community, as well as representing NUI Galway's research strategy, priority areas and research community nationally and internationally. In this role, Professor Smith led the NUI Galway HEA PRTLI 5 Institutional submission in 2010, resulting in the University securing over 65 million from the HEA and private funders. This award, which includes
funding for three research buildings and a range of structured PhD programmes, represents the most successful Institutional award in NUI Galway's history. Prof. Smith has supervised 18 Ph.D. students to completion, he is the former Director of a taught Masters in Biomedical Science programme, while he led the design and development of a two year part-time distance-learning masters in Biomedical Science programme that was initiated in 2006. He is the author/co-author of over 110 peer-reviewed papers in international journals, as well as being co-inventor of two granted patents, with 12 other patent applications pending. |
Research Interests
| My research is primarily focused on the use of functional genomics approaches to understand the molecular basis of human disease. This work involves the identification of genes, whose expression patterns are altered under disease conditions, determining their disease-association and analysing their functional significance. My main research interests in which I have active programmes are:
1. Molecular and cellular basis of complications of pregnancy and labour. Investigation of the molecular and cellular basis of complications of pregnancy and parturition to understand the underlying mechanisms involved in the process of labour particularly during preterm birth in reproductive tissues, including in particular myometrium. 2. Cellular interactions between novel biomaterials and vascular cells. Investigation of the molecular and cellular interactions between novel biomaterials with vascular cells and tissues, which has as a major goal, understanding and modulating the body's response to implant materials. I have one patent application filed in the biomaterials area. 3. Nucleic acid-based diagnostics assays for infectious disease. I also have a long-standing and ongoing research interest related to the development of nucleic acid-based diagnostics assays for infectious disease, an area in which I have 2 granted patents and 12 filed patent applications. |
Book Chapters
| Maher, M., Glennon, M. Cormican, M., and Smith, T.J. (2000) 'The application of PCR to the detection of M. tuberculosis in sputum samples' In: Lo, Y.M.D (eds). Methods in molecular medicine, Vol. 16: Clinical applications of PCR. Humana Press Inc. [Details] |
| Maher, M., Glennon, M. Cormican, M., and Smith, T.J. (1998) 'The application of PCR to the detection of M. tuberculosis in sputum samples' In: Ed. Lo, Y.M.D (eds). Methods in molecular medicine, Vol. 16: Clinical applications of PCR. [Details] |
| Dawson, M.T., Gannon, F. and Smith, T.J. (1996) 'DNA diagnostics for fungi' In: Fungal Identification Techniques. [Details] |
| Ed. Sheridan , J.L., Buchanan, R.L., and Montville, T.J. (1996) 'The use of rapid DNA based pathogen detection methods in the development of HACCP systems' In: Ed. Sheridan , J.L., Buchanan, R.L., and Montville, T.J (eds). HACCP: An integrated approach to assuring the microbiological safety of meat and poultry. [Details] |
| Smith, T.J., Maher, M., Gannon, F. and Dawson, M.T. (1995) 'Development of bacterial species-specific DNA probes based on ribosomal RNA genes using PCR. Diagnostic Bacteriology Protocols' In: Walker, J (eds). Methods in Molecular Biology. [Details] |
| Byrnes, L., Enenkel, B., Gannon F., and Smith, T.J. (1995) 'Preparation of DNA probes' In: Eds. Higgins, S. and Hames, D (eds). Gene Probes: A Practical Approach. [Details] |
| Smith, T.J. and Gannon, F. (1992) 'DNA probes for microorganisms' In: Biotechnology International. [Details] |
| Davies, K.E., Ball, S., Dorkins, H., Forrest, S.M., Kenwrick, S.J., King, A.W., Lavenir, I., McGlade, S., Patterson, M.N., Smith, T.J., Wilson, L., Speer, A., Coutelle, Ch. (1986) 'Molecular analysis of human X-linked disease' In: Cold Spring Harbour Symposia on Quantitative Biology. [Details] |
| Davies, K.E., Dorkins, H.R., McGlade, S., Ball, S.P., Kenwrick, S., Smith, T.J., Forrest, S., Wilson, L., Lavenir, I., Speer, A., Coutelle, Ch. (1986) 'DNA analysis of Duchenne and Becker muscular dystrophies' In: eds Giuditta, A., Kaplan, B.B., Zomezely-Neurath, C (eds). Role of RNA and DNA in Brain. [Details] |
| Davies, K.E., Dorkins, H.R., McGlade, S., Ball, S.P., Kenwrick, S., Smith, T.J., Forrest, S., Wilson, L., Lavenir, I., Speer, A., Coutelle, Ch., Bundey, S., Schwartz, C. (1985) 'DNA analysis in Duchenne muscular dystrophy' In: eds Kowprowski, H., Ferrone, S. Albertini, A (eds). Symposia of the Giovanni Lorenzi Foundation: Biotechnology in Diagnostics. [Details] |
Peer Reviewed Journals
| Hanley, S,Smith, TI,Muller, F,Maclean, N,Uzbekova, S,Prunet, P,Breton, E (1998) 'Isolation and functional analysis of the histone H3 promoter from Atlantic salmon (Salmo salar L.)'. Molecular Marine Biology And Biotechnology, 7 :165-172. [Details] |
| Feeley, KM,Fullard, JF,Heneghan, MA,Smith, T,Maher, M,Murphy, RP,O'Gorman, TA (1999) 'Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis'. Journal Of Pathology, 188 :14-17. [Details] |
| Murphy, M,Harte, T,McInerney, J,Smith, TJ (2000) 'Molecular cloning of an Atlantic salmon nucleoside diphosphate kinase cDNA and its pattern of expression during embryogenesis'. Gene, 257 :139-148. [Details] |
| Govoroun, M,McMeel, OM,D'Cotta, H,Ricordel, MJ,Smith, T,Fostier, A,Guiguen, Y (2001) 'Steroid enzyme gene expressions during natural and androgen-induced gonadal differentiation in the rainbow trout, Oncorhynchus mykiss'. Journal Of Experimental Zoology, 290 :558-566. [Details] |
| Curley, M,Cairns, MT,Friel, AM,McMeel, OM,Morrison, JJ,Smith, TJ (2002) 'Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium'. Molecular Human Reproduction, 8 :941-945. [Details] |
| O'Doherty, A,O'Grady, D,O'Farrell, K,Smith, T,Egan, J (2002) 'Survey of Johne's disease in imported animals in the Republic of Ireland'. Veterinary Record, 150 :634-636. [Details] |
| Devaney, J,Glennon, M,Farrell, G,Ruttledge, M,Smith, T,Houghton, JA,Maher, M (2003) 'Cystic fibrosis mutation frequencies in an Irish population'. Clinical Genetics, 63 :121-125. [Details] |
| Devaney, J,Maher, M,Smith, T,Houghton, JA,Glennon, M (2003) 'HFE alleles in an Irish cystic fibrosis population'. Genetic Testing, 7 :155-158. [Details] |
| Mahony, S,McInerney, JO,Smith, TJ,Golden, A (2004) 'Gene prediction using the Self-Organizing Map: automatic generation of multiple gene models'. BMC Bioinformatics, 5 . [DOI] [Details] |
| Keating, AF,Davoren, P,Smith, TJ,Ross, RP,Cairns, MT (2007) 'Bovine kappa-casein gene promoter haplotypes with potential implications for milk protein expression'. Journal Of Dairy Science, 90 :4092-4099. [DOI] [Details] |
| O'Brien, M,Morrison, JJ,Smith, TJ (2008) 'Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor'. Reproductive Sciences, 15 :382-393. [DOI] [ARAN Link] [Details] |
| Glynn, B,Lacey, K,O'Grady, J,Barry, T,Smith, TJ,Maher, M (2008) 'Reusable surface plasmon resonance assay for the specific detection of Streptococcus pneumoniae tmRNA'. Journal Of Rapid Methods And Automation In Microbiology, 16 :210-221. [Details] |
| O' Grady, J,Sedano-Balbas, S,Maher, M,Smith, T,Barry, T (2008) 'Rapid real-time PCR detection of Listeria monocytogenes in enriched food samples based on the ssr A gene, a novel diagnostic target'. Food Microbiology, 25 :75-84. [DOI] [Details] |
| O'Brien, M,Flynn, D,Mullins, B,Morrison, JJ,Smith, TJ (2008) 'Expression of RHOGTPase regulators in human myometrium'. Reproductive Biology And Endocrinology, 6 . [DOI] [ARAN Link] [Details] |
| Dimov, IK,Garcia-Cordero, JL,O'Grady, J,Poulsen, CR,Viguier, C,Kent, L,Daly, P,Lincoln, B,Maher, M,O'Kennedy, R,Smith, TJ,Ricco, AJ,Lee, LP (2008) 'Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics'. Lab On A Chip, 8 :2071-2078. [DOI] [Details] |
| McLucas, E, Rochev, Y,Carroll, WM, Smith, TJ (2008) 'Analysis of the effects of surface treatments on nickel release from nitinol wires and their impact on candidate gene expression in endothelial cells'. Journal Of Materials Science-Materials In Medicine, 19 :975-980. [DOI] [Details] |
| O'Grady, J,Lacey, K,Glynn, B,Smith, TJ,Barry, T,Maher, M (2009) 'tmRNA - a novel high-copy-number RNA diagnostic target - its application for Staphylococcus aureus detection using real-time NASBA'. Fems Microbiology Letters, 301 :218-223. [DOI] [Details] |
| O'Grady, J,Ruttledge, M,Sedano-Balbas, S,Smith, TJ,Barry, T,Maher, M (2009) 'Rapid detection of Listeria monocytogenes in food using culture enrichment combined with real-time PCR'. Food Microbiology, 26 :4-7. [DOI] [Details] |
| Fitzgibbon, J,Morrison, JJ,Smith, TJ,O'Brien, M (2009) 'Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin'. Reproductive Biology And Endocrinology, 7 . [DOI] [Details] |
| O'Brien, M,Earley, P,Morrison, JJ,Smith, TJ (2010) 'Ghrelin in the human myometrium'. Reproductive Biology And Endocrinology, 8 . [DOI] [Details] |
| B.R. Prasad, M.A. Brook, T. Smith, S. Zhao, Y. Chen, H. Sheardown, R. D'souza, Y. Rochev (2010) 'Contolling Cellular activity by Manipulating Silicone surface roughness'. Colloids and Surfaces B: Biointerfaces, 78 :237-242. [DOI] [Details] |
| Friel, A.M., Hynes, P.G., Sexton, D.J., Smith, T.J., Morrison, J.J. (2008) 'Expression Levels of Rho A / Rho kinase and its role in isoprostane induced vasoconstriction of human placental and maternal resistance vessel'. REPRODUCTIVE SCIENCES, 15 (2):179-188. [Details] |
| Hynes PG, Friel AM, Smith TJ, Morrison JJ. (2008) 'b-Adrenoreceptor Subtype Expression in Human Placenta and Umbilical Arteries in Normal and Pre-Eclamptic Pregnancies'. HYPERTENSION IN PREGNANCY, 27 (2):169-181. [Details] |
| Glynn, B., Lacey, K., Reilly, J., Barry, T., Smith, T.J. and Maher, M. (2007) 'Quantification of Bacterial tmRNA using in vitro Transcribed RNA Standards and Two-Step qRT-PCR'. RESEARCH JOURNAL OF BIOLOGICAL SCIENCES, 2 (5):564-570. [Details] |
| S Mahony, PV Benos, TJ Smith, A Golden (2006) 'Self-organizing neural networks to support the discovery of DNA-binding motifs'. Neural Networks, 19 (6-7):950-962. [Details] |
| Moynihan, A.T., Hehir, M.P., Glavey, S.V., Smith, T.J., Morrison, J.J. (2006) 'Inhibitory Effect of Leptin on Human Uterine Contractility In Vitro'. AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, . [Details] |
| Sangrador-Vegas A, Smith T.J., Cairns M.T. (2005) 'Inhibitor of NF-kB in Rainbow Trout (Oncorhynchus Mykiss)'. VETERINARY IMMUNOLOGY AND IMMUNOOPATHOLOGY, 103 (01-Feb):1-7. [Details] |
| Keating, A.F., Cairns, M.T., Stanton, C., Murphy, JJ., Ross, R.P., and Smith, T.J. (2005) 'Variation in bovine milk cis-9, trans-11 CLA concentrations is not associated with the polymorphisms in the Stearoyl-CoA desaturase promoter region'. MAMM GENOME, 16 (3):184-193. [DOI] [Details] |
| Doheny H.C., Lynch C.M., Smith T.J., Morrison J.J. (2005) 'Functional Coupling of B3-adrenoceptors to Large Conductance Calcium-Activated K+ Channels in Human Uterine Myocytes'. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 90 (10):5786-96. [Details] |
| Mahony, S., Hendrix, D., Golden, A., Smith, T.J., Rokhsar, D.S. (2005) 'Transcription factor binding site identification using the Self-Organizing Map'. BIOINFORMATICS, 1 (21(9)):1807-14. [Details] |
| Mahony, S., Golden, A., Smith, T.J., Benos, P.V. (2005) 'Improved detection of DNA motifs using a self-organized clustering of familial binding profiles'. BIOINFORMATICS, 1 (21):283-291. [Details] |
| Curley, M., Morrison, J.J. and Smith, T.J. (2004) 'Analysis of Maxi-K a subunit splice variants in human myometrium'. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2 (1). [ARAN Link] [Details] |
| Stenson-Cox, C., Barron, V., Murphy, B., McHugh, P.E., Smith, T. (2004) 'Profiling the shear stress of atherosclerosis; a genomic view'. CURRENT GENOMICS, 5 (4):287-297. [Details] |
| Dennedy MC, Friel AM, Houlihan DD, Broderick VM, Smith T, Morrison JJ. (2004) 'Cannabinoids and the human uterus during pregnancy'. AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, 190 (1):2-9. [Details] |
| Carty MP, Glynn M, Maher M, Smith T, Yao J, Dixon K, McCann J, Rynn L, Flanagan A. (2003) 'The RAD30 cancer susceptibility gene'. Biochemical Society Transactions, 31 (1):252-256. [Details] |
| O'Doherty A., O'Grady D., Smith T., Egan J. (2002) 'Mycobacterium avium subsp. paratuberculosis in pasteurised and unpasteurised milk in the Republic of Ireland'. IRISH JOURNAL OF AGRICULTURE AND FOOD RESEARCH, 41 :117-121. [Details] |
| Fitzpatrick R, Casey OM, Morris D, Smith T, Powell R, Sreenan JM. (2002) 'Postmortem stability of RNA isolated from bovine reproductive tissues'. BIOCHEM. BIOPHYS. ACTA, 20 (1574(1)):10-4. [Details] |
| Friel, A., Houghton, J.A., Glennon, M., Smith, T.J., Nolan, A. and Maher, M. (2002) 'Using RT-PCR to detect DAZ, RBMY and USP9Y RNA in testicular biopsy samples from azoospermic men'. INTERNATIONAL JOURNAL OF ANDROLOGY, 25 :59-64. [Details] |
| Stenson, C., McNair, A., Curley, M., Smith, T., Gannon, F. (2002) 'A role for atlantic salmon HNF-3 in the regulation of Alantic salmon HNF-1'. MOLECULAR GENETICS AND GENOMICS, 266 :832-837. [DOI] [Details] |
| S. Lahiff, M. Glennon, J. Lyng, N. Shilton, T. Smith and M. Maher. (2002) 'Real-Time PCR assay for the detection of bovine material in meat and bone meal'. JOURNAL OF FOOD PROTECTION, 65 (7):1158-65. [Details] |
| Sangrador-Vegas, A., Lennington, J.B. and Smith, T.J. (2002) 'Molecular cloning of a novel CXC chemokine, RTCXC-1 and tissue factor in Rainbow Trout by use of suppression subtractive hybridisation'. CYTOKINE, 17 :66-70. [DOI] [Details] |
| Grennan, B., O'Sullivan N., Fallon R., Carroll C., Smith T.J., Glennon M., and Maher M. (2001) 'PCR-ELISA assays for the detection of Campylobacter jejuni and Campylobacter coli in poultry samples'. BIOTECHNIQUES, 30 . [Details] |
| Friel, A., Houghton, J.A., Maher, M., Smith, T., Noel, S., Nolan, A., Egan, D. and Glennon, M. (2001) 'Molecular detection of Y chromosome microdeletions: An Irish study'. INTERNATIONAL JOURNAL OF ANDROLOGY, 24 :31-36. [Details] |
| Collins E., Glennon, M., Hanley, S., Murray A-M., Cormican, M., Smith, T.J., and Maher M. (2001) 'Evaluation of a PCR/DNA probe colorimetric membrane assay for the identification of Campylobacter spp. directly from stool specimens'. JOURNAL OF CLINICAL MICROBIOLOGY, 39 (11):4163-65. [Details] |
| Lahiff, S., Glennon, M., O'Brien, L., Lyng, J., Smith, T.J., Maher, M. and Shilton, N. (2001) 'Species-specific PCR for the identification of bovine, ovine, porcine and poultry species in meat and bone meal (MBM)'. MOLECULAR AND CELLULAR PROBES, 15 :27-35. [Details] |
| Smith, T.J., O'Connor, L., Glennon, M., and Maher, M. (2000) 'Molecular diagnostics in food safety: rapid detection of food-borne pathogens'. JOURNAL OF AGRICULTURAL AND FOOD RESEARCH, 39 :309-319. [Details] |
| Liu, S., Govoroun. M., D'Cotta. H., Ricordel. M.J., Lareyre. J.J., McMeel. O.M., Smith. T.J., Nagahama, Y. and Guiguen, Y. (2000) 'Expression of cytochrome P450(11beta) (11beta-hydroxylase) gene during gonadal sex differentiation and spermatogenesis in rainbow trout, Oncorhynchus mykiss'. JOURNAL OF STEROID BIOCHEMISTRY, 75 :291-298. [Details] |
| Nolan, D., Martin, S., Kelly, Y., Glennon, K., Palmer, R., Smith, T.J., McCormack, G.P. & Powell, R. (2000) 'Development of microsatellite PCR typing methodology for the sea louse, Lepeophtheirus salmonis'. AQUACULTURE RESEARCH, 31 :1-8. [Details] |
| O'Sullivan, N.A., Fallon, R., Carroll, C., Smith, T., and Maher, M. (2000) 'Detection and differentiation of Campylobactor jejuni and Campylobacter coli in broiler chicken samples using a PCR/DNA probe membrane based colorimetric detection assay'. MOLECULAR AND CELLULAR PROBES, 14 :7-16. [Details] |
| O'Connor, L., J. Joy, M. Kane, T.J. Smith and M. Maher (2000) 'Rapid Polymerase Chain Reaction/DNA Probe Membrane-Based Assay for the Detection of Listeria and Listeria Monocytogenes in Food'. JOURNAL OF FOOD PROTECTION, 63 :337-342. [Details] |
| Martin, C., Roberts, D., van der Weide, M., Rosseau, R., Jannes, G., Smith, T.J. and Maher, M. (2000) 'Development of a PCR-based line probe assay for the identification of fungal pathogens'. JOURNAL OF CLINICAL MICROBIOLOGY, 38 :3735-3742. [Details] |
| McNair, A., Cereghini, S., Brand, H., Smith, T.J., Breillat, C., and Gannon, F. (2000) 'The Atlantic salmon HNF1 promoter displays a different structure and reactivity to orphan nuclear receptors than previously characterised vertebrate HNF1 promoters'. JOURNAL OF BIOCHEMISTRY, 352 :557-564. [Details] |
| Martin, S.A.M., Wallner, W., Youngson, A.F. and Smith, T.J (1999) 'Differential expression of Atlantic salmon thyrotropin beta subunit mRNA and its cDNA sequence'. J. FISH BIOL, 54 :757-766. [Details] |
| Highsmith,W.E., Burch, L.H., Zhou, Z., Olsen, J.C., Strong, T.V., Smith, T.J., Friedman, K.J., Silverman, L.M., Boucher, R.C., Collins, F.S., and Knowles, M.R. (1997) 'Identification of a Splice Site Mutation (2789+5 G>A) Associated With Small Amounts of Normal CFTR mRNA and Mild Cystic Fibrosis'. HUMAN MUTATION, 9 (4):332-338. [Details] |
| Glennon, M., Jager, B., Dowdall, D., Maher, M., Dawson, M., Quigley, F., Costello, E., and Smith, T.J. (1997) 'PCR based DNA fingerprinting of Mycobacterium bovis'. VETERINARY MICROBIOLOGY, 54 :235-245. [Details] |
| Maher, M., Glennon, M., Martinazzo, E., Turchetti, E., Marcolini, S., Smith, T.J. and Dawson, M.T. (1996) 'Evaluation of a novel PCR based diagnostic assay for the detection of Mycobacterium tuberculosis in sputum specimens'. JOURNAL OF CLINICAL MICROBIOLOGY, 34 (9):2307-2308. [Details] |
| Maher M., Dowdall D., Glennon M., Walshe S., Cormican M., Wiesner P., Gannon, F. and Smith, T.J. (1996) 'The sensitive detection of fluorescently labelled PCR products using an automated detection system'. MOLECULAR AND CELLULAR PROBES, 9 :265-276. [Details] |
| Toth, L.R., Smith, T.J., Jones,C., de Silva, H.V., Smithies, O., and Maeda, N. (1996) 'Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting'. GENE, 178 :161-168. [Details] |
| Glennon, M., Cormican, M., Ni Riain, U., Heginbotham, M., Gannon, F. and Smith, T.J. (1996) 'A Mycobacterium malmoense specific DNA probe from the 16S/23S rRNA intergenic region'. MOLECULAR AND CELLULAR PROBES, 10 :337-345. [Details] |
| Maher, M., Palmer, R., Gannon, F. and Smith, T.J. (1995) 'Relationship of a novel bacterial fish pathogen to Streptobacillus moliniformis and the Fusobacteria group based on 16S ribosomal RNA analysis'. SYSTEMATIC AND APPLIED MICROBIOLOGY, 18 :79-84. [Details] |
| Ni Riain, U., Cormican, M., Flynn,J., Smith, T.J., and Glennon, M. (1994) 'Polymerase Chain Reaction Based fingerprinting of Enterobacter cloacae'. JOURNAL OF HOSPITAL INFECTION, 27 :237-240. [Details] |
| Glennon, M., Smith, T.J., Cormican, M., Noone, D., Barry, T., Maher, M., Dawson, M., Gilmartin, J.J. and Gannon, F (1994) 'The ribosomal RNA intrergenic spacer region: a target for the PCR based diagnosis of tuberculosis'. TUBERCLE AND LUNG DISEASE, 75 :353-360. [Details] |
| Noone, D., Glennon, M., Gannon, F. and Smith, T.J. (1994) 'Important variables for Direct PCR Amplification from Blood'. THE GENETIC ENGINEER AND BIOTECHNOLOGIST, 14 :149-154. [Details] |
| Barry, T., Glennon, M., Smith, T.J. and Gannon, F. (1993) 'Detection of Mycobacterium bovis in bovine blood by combined PCR and DNA probe methods'. VETERINARY RECORD, 132 :66-67. [Details] |
| Homanics, G.E., Smith, T.J., Zhang, S. H., Lee, D., Oliver, P., Young, S.G. and Maeda, N (1993) 'Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 90 :2389-2393. [Details] |
| McCusker, J., Dawson, M., Noone, D., Gannon, F. and Smith, T.J. (1992) 'Improved method for direct PCR amplification from whole blood'. NUCLEIC ACIDS RESEARCH, 20 . [Details] |
| Love, D.R., England, S.B., Speer, A., Marsden, R.F., Bloomfield, J.F., Roche, A.L., Cross, G.S., Mountford, R.C., Smith, T.J., Davies, K.E. (1991) 'Sequences of Junction fragments in the deletion-prone region of the dystrophin gene'. GENOMICS, 10 :57-67. [Details] |
| Smith, T.J., Hautamaa, D., Maeda, N. (1990) 'Comparison of the sequence of the putative LDL receptor binding regions of Apolipoprotein B in human, pig, mouse and hamster'. GENE, 87 :309-310. [Details] |
| Love, D.R., Forrest, S.M., Smith, T.J., England, S., Flint, T., Davies, K.E. (1989) 'Molecular analysis of Duchenne and Becker muscular dystrophies'. BRITISH MEDICAL BULLETIN, 45 :659-680. [Details] |
| Davies, K.E., Smith, T.J., Bundey, S., Read, A.P., Flint, T., Bell, M. and Speer, A. (1988) 'Mild and severe muscular dystrophy associated with deletions in Xp21 of the human X chromosome'. JOURNAL OF MEDICAL GENETICS, 25 :9-13. [Details] |
| Kenwrick, S.J., Smith, T.J., England, S., Collins, F. and Davies, K.E. (1988) 'Localisation of the endpoints of deletions in the 5' region of the Duchenne gene using a sequence isolated by chromosome jumping'. NUCLEIC ACIDS RESEARCH, 16 :1305-1317. [Details] |
| Smith, T.J., Wilson, L., Kenwrick, S.J., Forrest, S.M., Speer, A., Coutelle, Ch. and Davies, K.E. (1987) 'Isolation of a conserved sequence deleted in Duchenne muscular dystrophy patients'. NUCLEIC ACIDS RESEARCH, 15 :2167-2174. [Details] |
| Cross, G.S., Speer, A., Rosenthal, A., Forrest, S.M., Smith, T.J., Edwards, Y., Flint, T., Hill, D. and Davies, K.E. (1987) 'Deletions of fetal and adult muscle cDNA in Duchenne and Becker muscular dystrophy patients'. EMBO JOURNAL, 6 :3277-3283. [Details] |
| Forrest, S.M., Smith, T.J., Cross, G.S., Read, A.P., Thomas, N.S.T., Mountford, R.C., Harper, P.S., Geirsson, R.T. and Davies, K.E. (1987) 'Effective strategy for prenatal prediction of Duchenne and Becker muscular dystrophy'. LANCET, 2 :1294-1297. [Details] |
| Smith, T.J., Forrest, S.M., Cross, G.S. and Davies, K.E. (1987) 'Duchenne and Becker muscular dystrophy mutations: analysis using 2.6kb of muscle cDNA from the 5' end of the gene'. NUCLEIC ACIDS RESEARCH, 15 :9761-9769. [Details] |
| Nugent, M.E., Smith, T.J., Tacon, W.C.A. (1986) 'Characterisation and incompatibility properties of ROM- derivatives of pBR322 based plasmids'. JOURNAL OF GENETIC MICROBIOLOGY, 132 :1021-1026. [Details] |
| Davies, K.E., Forrest, S.M., Smith, T.J., Kenwrick, S.J., Ball, S., Dorkins, H., Patterson, M.N. (1986) 'Molecular analysis of human muscular dystrophies'. Muscle And Nerve, 10 :191-199. [Details] |
| Fotheringham, I.G., Dacey, S.A., Taylor, P.P., Smith, T.J., Hunter, M.G., Finlay, M.E., Primrose, S.B., Parker, D.M., Edwards, R.M. (1986) 'The cloning and sequence analysis of the aspC and tyrB genes from Escherichia coli K12'. JOURNAL OF BIOCHEMISTRY, 234 :593-604. [Details] |
Conference Paper
| Friel, A.M., Smith, T.J., Morrison, J.J., (2004) Rho A / Rho Kinase mRNA and Protein levels in Human Myometrium during Pregnancy and Labour. J Soc Gynecol Investigation. Conference Paper [Details] |
| Friel, AM., Smith, TJ., Morrison, JJ (2004) Vasoconstrictor Effects of Isoprotanes in Human Umbilical Artery via Rho kinase pathway. Journal of Soc for Gynecologic Investigation. Conference Paper [Details] |
| Friel, AM., Sexton, DJ., O'Reilly, MW., Smith, TJ., Morrison, JJ (2004) Selectivity of Protein Kinase inhibition on Human Umbilical Artery Tone. Journal of Soc for Gynecologic Investigation. Conference Paper [Details] |
| Friel, A.M., Ravikumar, N., Smith, T.J., Morrison, J.J. (2004) Rho A and ROCK1 Protein Levels in Human Myometrium during Pregnancy. Journal of Soc for Gynecologic Investigation. Conference Paper [Details] |
| Doheny, H.C., O'Brien, M., Smith, T.J., Morrison, J.J. (2004) Modulation of potassium currents by human chorionic gonadotropin in cultured human myometrial smooth muscle cells. Journal of Soc for Gynecologic Investigation. Conference Paper [Details] |
| Doheny, H.C., Morrison, J.J., Smith, T.J. (2003) Modulation of large conductance potassium channel activity in pregnant human myometrium by a selective b3-adrenoreceptor agonist. J Society for Gynaecological Investigations. Washington DC, USA: Conference Paper [Details] |
| Cairns, M.T., Friel, A.M., McMeel, O.M., Morrison, J.J., Smith, T.J. (2003) FP Receptor mRNA levels in Human Pregnant and Non-Pregnant Myometrium. Journal for the Society for Gynaecological Investigations. Conference Paper [Details] |
| McMeel, O.M., Morrison, J.J., O'Brien, M., Smith, T.J. (2003) High Density microarray analysis of differentially expressed genes in human myometrium before and after the onset of labour. Journal for the Society for Gynaecologic Investigation. Conference Paper [Details] |
| Barron, V., Coghlan, K., McHugh, P.E., O'Brien, M., McLucas, E., Smith, T. (2003) Mechano-Biological Interactions of Tissue Engineered Arteries. Biomaterials: Biocompatibility/Tissue Engineering, Gordon Research Conference. Conference Paper [Details] |
| Flanagan, A., McCann, J., Rynne, L., Maher, M., Smith, T. & Carty, M.P. (2002) Analysis of sequence changes in the RAD30 cancer susceptibility gene, using glycosylase-mediated polymorphism detection (GMPD). Nature Genetics/American Association for Cancer Research (ACCR) Conference on oncogenomics, 2002 (Meeting Abstract). Dublin, Ireland: Conference Paper [Details] |
| Flanagan, A., Rynne, L., McCann, J., Maher, M., Smith, T. & Carty, M.P. (2002) Analysis of sequence changes associated with the RAD30 cancer susceptibility gene. Biochemical Society, Irish Area Section Meeting, 2002 (Meeting Abstract). Galway, Ireland: Conference Paper [Details] |
| Bree, R.T., McMeel, O., Brabazon, E., Cairns, M., Smith, T., Grealy, M & Byrnes, M. (2002) Molecular cloning and developmental expression of a novel gene upregulated at the midblastula transition in zebrafish. Biochemical Society Meeting. Galway: Conference Paper [Details] |
| Dennedy, M.C., Friel, A.M., McMeel, O., Smith, T.J., Morrison, J.J. (2001) Beta-3 versus Beta-2 adrenergic agonists and preterm labour. Irish Journal of Medical Science. Conference Paper [Details] |
| Bree, R.T., McMeel, O., Brabazon, E.D., Cairns, M., Smith, T., Grealy, M. & Byrnes, L. (2001) Characterisation of the molecular events occurring at the mid-blastula transition during zebrafish embryo development. 2nd European conference on zebrafish genetics and development. London: Conference Paper [Details] |
| Ryan, K.A., Moran, A.P., Little, C.L. Abukhadir, B, Smith, T. & Maher, M. (2000) Direct detection of Helicobacter pylori in stomach biopsies using the polymerase chain reaction - a preliminary study. Irish Journal of Medical Science. Conference Paper [Details] |
| Kelliher, F., Glynn, B., Smith, T. & Barry, T. (2000) tmRNA as an indicator of bacterial viability - A preliminary experimental analysis. SGM Irish Branch Meeting. Conference Paper [Details] |
| Ryan, K.A., Maher, M.A., Smith, T. & Moran, A.P. (2000) Poly-(C) tract lencth in the alpha (1,3)-fucosyltransfrase gene of Irish Helicobacter pylori is not a predictor of Lewis antigen phenotype. Gut. Conference Paper [Details] |
Reviews
| Stenson-Cox, C. Barron, V. Murphy, B., McHugh, P.E. and Smith, T.J. (2004) Profiling the Shear Stress of Atherosclerosis; A Genomic View.. CURRENT GENOMICS. Reviews [Details] |
| Walsh, S., Maher, M., Sullivan, R., Smith, T.J. and Mortimer, G. (1995) The spectrum of unexplained stillbirth and sudden infant death syndrome.. IRISH JOURNAL OF MEDICAL SCIENCE. Reviews [Details] |
| Smith, T.J. (1993) DNA in disease diagnosis.. THE IRISH DOCTOR, September. Reviews [Details] |
| Smith, T.J., Dawson, M., Forde, T. and Gannon, F. (1993) New methods for the diagnosis of disease.. TECHNOLOGY IRELAND. Reviews [Details] |
| Forrest, S.M., Smith, T.J., Cross, G.S., Kenwrick, S.J., England, S.E., Flint, T., Davies, K.E. (1988) Molecular analysis and diagnosis of Duchenne muscular dystrophy.. JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS. Reviews [Details] |
| Davies, K.E., Ball, S., Dorkins, H., Forrest, S.M., Kenwrick, S.J., Lavenir, I., McGlade, S., Smith, T.J., Wilson, L. (1985) The molecular analysis of Duchenne muscular dystrophy.. BULLETIN OF MOLECULAR BIOLOGY AND MEDICINE. Reviews [Details] |