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Prof. Malini Carolene Olivo B.Sc., Ph.D.
Contact Details
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Biography:
Research Interests · Biophotonics in Medicine and Biology · Nanoscale Biophotonics · Nanomedicine Research Background Prof. Malini Olivo is a pioneer in the area of clinical applications of Photomedicine in optical photodiagnostics and Phototherapeutics. The focus of my laboratory is to investigate minimally invasive novel optical methods for cancer detection and therapy using biophotonics and nanotechnology. The novel optical methods being investigated are Surface Enhanced Raman Spectroscopy and Imaging (SERS) for biosensing and bioimaging; SERS spectroscopy and imaging with nanophotonics is being investigated for protein and biomarker sensing and tracking in cells and tissues both in-vivo and in vitro. Endoscopic catheter based in vivo cellular imaging systems using in-vivo multiphoton confocal microscopy, Optical Coherence Tomography (OCT) and photothermal imaging are combined with novel bio-chemo-synthetic optical probes and their formulations. These novel optical methods are compared with currently used fluorescence and autofluorescence detection methods in translational medicine. Our major objective is to devise optical on-line real time imaging and therapeutic systems. We are also using image processing software and endomicroscopic approaches to develop an optical biopsy technique to stage cancer. Our ex-vivo methods in fluorescence based cytology of biofluids combines the use of multiphoton confocal microscopy and fluorescence life-time imaging to stage cancer histopathologically. This may prove to be a superior method to the current widely used gold standards i.e white light endoscopy and histopathology.
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Books
| Lin,F.,Olivo,M., Kung,S.Y. (2008) Biomedical Imaging Springer US editor. [Details] |
Peer Reviewed Journals
| Kah,J.C.,Wong,K.Y.,Neoh, K.G.,Song, J.H.,Fu,J.W.,Mhaisalkar, S.,Olivo, M.,Sheppard, C.J. (2008) 'Critical parameters in the pegylation of gold nanoshells for biomedical applications: An in vitro macrophage study'. J Drug Target, 17 (3):181-193. [Details] |
| OLIVO,M.C., Samanta,A.,Maiti, K., Kiat-Seng Soh, Xiaojun Liao., Vendrell,M., U. S. Dinish., Seong-Wook Yun., Bhuvaneswari,R.,Kim,H., Rautela,S.,Chung,J.,Olivo,M.,Chang,Y.T (2011) '“Ultrasensitive Near-Infrared Raman Reporters for SERS-based in vivo Cancer Imaging”'. Angewandte Chemie 2011 (in press), . [Details] |
| OLIVO,M.C. (2011) 'Mohamed Ali-Seyed, Ramaswamy Bhuvaneswari1, Khee Chee Soo, Malini Olivo , Photolon™. “Photosensitization induces apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes”'. International Journal of Oncology 2011 ( in press), . [Details] |
| Olivo,M., Bhuvaneswari,R., Keogh, I. (2011) 'Early detection of oral cancer using bio-optical imaging technologies'. Book Chapter in Biosensors and biodetection technologies for cancer detection, diagnostics and research Editors: Rasooly A and Herold K (In press 2011), . [Details] |
| OLIVO,M.C. (2011) '“Anti-angiogenesis agents Avastin and Erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model”'. Lasers in Surgery and Medicine 2011 (in press), . [Details] |
| OLIVO,M.C. (2011) 'Kiang Wei Kho, Chit Yaw Fu, US Dinish, Malini Olivo, Pre-clinical and Clinical Applications of SERS: A Review'. Journal of Biophotonics, . [Details] |
| OLIVO,M.C. (2011) 'Kho KW, Shen ZX, Olivo MC, “Sub-micron Free-standing Metal Slabs with Dielectric Nano-voids of Arbitrary Shapes Embedded beneath Atomically-Smooth Surface”'. Opt Exp 2011 (in press), . [Details] |
| Dinish,U. S.,Chit Yaw,F.,Agarwal,A.,Olivo,M. (2011) 'Development of Highly Reproducible Nanogap SERS Substrates: Comparative Performance Analysis and its Application for Glucose Sensing'. Biosensors Bioelectron, 26 :1987-1992. [DOI] [Details] |
| Upile,T.,Jerjes,W.,Sterenborg,H.,Wong,B.,El-Naggar,A.,Ilgner,J., Sandison,A.,Witjes,M.,Biel,M.,Van Veen,R., Zaid Hamdoon,Gillenwater,A.,Mosse,C.,Robinson,D.,Betz,C.,Stepp,H.,Bolotine,L.,McKenzie,G.,Barr,H, Zhongping Chen, Kristian Berg, Anil D'Cruz, Holger Sudhoff,Stone,N.,Kendall,C.,Fisher,S.,MacRobert,A.,Leunig,A., Olivo, M.,Richards-Kortum,R., Khee Soo,Bagnato,V., Lin-Ping Choo-Smith, Svanberg,K.,Tan,I.B.,Wilson,B., Wolfsen,H.,Bigio,I.,Yodh,A.,Hopper,C. (2011) 'At the Frontiers of Surgery: Review; Head & Neck Oncology'. 3 (7). [Details] |
| Kiang Wei Kho., ZeXiang,S.,Malini,O. (2011) '„Hyper-spectral confocal nano-imaging with a 2D super-lens”'. Optics Express, 19 (3):2502-2518. [Details] |
| Olivo, M., Bhuvaneswari,R., Keogh, I. (2011) '“Advances in bio-optical imaging for the diagnosis of early oral cancer”'. Pharmaceutics (Special issue: Molecular Imaging) 2011 (in press), . [Details] |
| Kumar Maiti,K., Samanta,A., Vendrell,M., Kiat-Seng Soh., Olivo,M.,Chang,Y.T. (2011) '“Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters”'. Chem Comm (in press 2011), . [Details] |
| OLIVO,M.C.,Xiaojing Mu, B, Winston Sun., Hanhua Feng.,Yu,A.,Sheng Chen,K.W., Chit Yaw Fu., Olivo, M. (2011) '“MEMS Micromirror Integrated Endoscopic Probe for Optical Coherence Tomography Bioimaging”'. Sensors and Actuators A (in press) 2011, . [Details] |
| Fan Hai Ming., Olivo, M. (2011) '“Magnetic nanorings and nanotubes for cancer detection and therapy”'. Book chapter In : Nanomedicine and Cancer, . [Details] |
| Kho,K.W., Shen, Z.X., Olivo, M.C. (2011) '“Broadband High-resolution Imaging via a 2D Plasmonic Super-lens Constructed with an Embedded Oblate Nanocavity” highlighted in'. Nature photonics, 5 . [Details] |
| Thong,P.S.P., Olivo,M., Seah,H.S.,Lin,F., Qian,K., Soo,K.C. (2011) '“Hypericin fluorescence imaging of oral cancer: From endoscopy to real-time 3-dimensional endomicroscopy”'. Journal of Medical Imaging and Health Informatics (in press 2011), . [Details] |
| OLIVO,M.C. (2011) 'Malini Olivo, Bhuvana R and Lucky S, “Nano-sensitizers for multi-modality optical diagnostic imaging and therapy of cancer”'. SPIE ( in press), . [Details] |
| Kho KW., Sheppard,C., Soo,K.C., Olivo,M.C. (2011) 'Broadband High-resolution Imaging via a 2D Plasmonic Super-lens Constructed with an Embedded Oblate Nanocavity'. Optics Express, 19 (3). [Details] |
| Fan,H.M.,Olivo,M.,Shuter,B., Bhuvaneswari,R., Yi,J.B., H. R. Tan.,G. C. Xing.,CT Ng.,L. Liu.,S. S. Lucky.,Bay,B.H.,Ding,J. (2010) '“Quantum. Dot Capped Magnetite Nanoring as high performance nanoprobe for Multiphoton Fluorescence and Magnetic Resonance Imaging”'. J Am Chem Soc (Epub ahead of print), . [Details] |
| Bhuvaneswari,R., Thong, P.S.P., Gan, Y.Y., Soo, K.C., Olivo, M. (2010) 'Evaluation of photodynamic therapy in combination with angiogenesis inhibitor bevacizumab using in vivo fluorescence confocal endomicroscopy'. J Biomedical Optics (In press), . [Details] |
| Han,W.,Chuang, K.H.,Chang, Y.T.,Olivo, M.,Velan, S.S.,Bhakoo, K.,Townsend, D.,Radda, G.K.I (2010) 'imaging metabolic syndrome. EMBO molecular medicine'. 2 (6):196-210. [Details] |
| Vasudevan,S.,Chen, G.C.,Andika,M.,Agarwal, S.,Chen, P.,Olivo M. (2010) 'Dynamic quantitative photothermal monitoring of cell death of individual human red blood cells upon glucose depletion'. J Biomed Opt 057001, 15 (5). [Details] |
| Maiti,K.K.,Dinish, U.S.,Fu, C.Y.,Jae-Jun Lee.,Soh Kiat Seng.,Ramaswamy,B., Olivo,M.,Chang, Y.T. (2010) '“Development of Biocompatible SERS Nanotag with Increased Stability by Chemisorption of Reporter Molecule for in vivo Cancer Detection'. Biosens Bioelectron, 26 (2):3998-403. [Details] |
| Chin,W.W.,Thoniyot, P.,Heng, P.W.S.,Olivo, M. (2010) '“Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization.”'. Eur J Pharm Biopharm 2010 Oct;Epub, 76 (2):245-252. [DOI] [Details] |
| Cho,S.J., Ahn, Y.H., Maiti, K.K.,Dinish, U.S., Fu, C.Y.,Thoniyot, P., Olivo, M., Chang, Y.T. (2010) 'Combinatorial synthesis of a triphenylmethine library and their application in the development of surface enhanced Raman scattering (SERS) probes'. Chem Commun (Camb), 7 (46(5)):722-724. [Details] |
| Olivo,M.,Swarnalatha Lucky,S.,Mancer, K.,Kam On Lau,W. (2010) 'Role of cell-adhesion molecules in the differential accumulation of hypericin in photodynamic diagnosis of bladder cancer. Urologic Oncology: Seminars and Original Investigations (In Press.)'. . [Details] |
OLIVO,M.C. (2010) 'Optical imaging in biomedicine'. Medical Imaging: Imaging Techniques for Pre-clinical and Clinical Applications, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London, .  [Details] |
| Dong,H.,Gong,Y.,Olivo,M. (2010) 'Measurement of stokes parameters of terahertz radiation in terahertz timedomain spectroscopy. Microwave and Optical Technology Letters'. 52 (10):2319-2324. [Details] |
| Y Xu., Wang,M.F.,Premachandran,C.S.,Chen, K.W.S.,Chen, N., Olivo,M. (2010) 'Platinum microheater integrated silicon optical bench assembly for endoscopic optical coherence tomography'. J of Micromechanics and Microengineering, 20 - 015008 :1-8. [Details] |
| Vasudevan,S.,Chung Kit Chen,G.,Andika,M.,Agarwal, S.,Chen,P.,Olivo,M. (2010) '. “Quantitative photothermal monitoring of the effect of glucose depletion on human red blood cells”'. Journal of Biomedical Optics (in press 2010), . [Details] |
| Lee,L.S.,Thong, P.S.,Olivo, M.,Chin, W.W.,Ramaswamy, B.,Kho, K.W.,Lim, P.L.,Lau, W.K. (2010) 'Chlorin e6-polyvinylpyrrolidone mediated photodynamic therapy-A potential bladder sparing option for high risk non-muscle invasive bladder cancer'. Photodiagnosis Photodyn Ther, 7 (4):213-220. [Details] |
| Dinish,U. S.,Yaw Fu,C.,Goh,D.,Olivo,M. (2010) 'Nanosphere Templated Optical Fiber for In-Vivo SERS Sensing Applications'. Photonics Global, . [Details] |
| OLIVO,M.C. (2010) 'Targeted Therapy of Cancer using Photodynamic Therapy in Combination with Multi-faceted Anti-tumor Modalities'. Pharmaceuticals, 3 (5):1507-1529. [Details] |
| Chin,W.W., Thong, P.S.P., Bhuvaneswari, R., Soo, K.C., Heng, P.W., Olivo, M. (2009) 'In-vivo optical detection of cancer using clorin e6-polyvinylpyrrolidone induced fluorescence imaging and spectroscopy'. BMC Medical Imaging, 9 (1). [Details] |
| Van Valin, C. C., Berresheim,H., Andreae,M.O.,Luria,M. (2009) 'The effect of photodynamic therapy on tumor angiogenesis'. Cellular and molecular life sciences, 66 (14):2275-2283. [Details] |
| Dinish,U. S.,Yaw Fu,C.,Wei Kho,K.,Thoniyot,P., Agarwal,A., Olivo,M. (2009) 'Fluctuation in Surface Enhanced Raman Scattering intensity due to plasmon related heating effect'. Proc of SPIE 73940T-1, 7394 . [Details] |
| Sing Cheong,L.,Lin,F.,Soon Seah,H.,Qian,K., Zhao,F.,Thong, P.S.P.,Chee Soo, K.,Olivo,M.,Sun-Yuan Kung. (2009) 'Embedded Computing for Fluorescence Confocal Endomicroscopy Imaging'. Journal of Signal Processing Systems, 55 :217-228. [Details] |
| Bhuvaneswari, R., Yuen Gan,Y., SP Thong,P., Wei Lim Chin, W., Chee Soo,K., Olivo,M. (2009) 'Combination of angiogenesis inhibitors increases the anti-tumor efficacy of photodynamic therapy in a human bladder tumor xenograft model'. SPIE Proceedings, 7380 . [Details] |
| Chit Yaw Fu.,Zhen Yu Koh.,Khiang Wei Kho.,Dinish,U.S.,Praveen,T., Olivo,M. (2009) 'The Effect of Design Parameters of Metallic Substrate on the Reproducibility of SERS Measurement for Biosensing'. Proc of SPIE 739717-1, 7397 . [Details] |
| Sasidharan,S.L., Lau, W.K.O., Mancer, K., Olivo, M. (2009) 'Loss of intercellular adhesion leads to differential accumulation of hypericin in bladder cancer'. SPIE Proceedings, 7380 . [Details] |
| Thong,P.S.P, Olivo,M.,Chin,W.W.L.,Bhuvaneswari,R.,Mancer,K., Khee-Chee Soo. (2009) 'Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions'. Br J Cancer, 101 (9):1580-1584. [Details] |
| OLIVO,M.C. (2009) 'Feng Lin & Malini Olivo. “The State-of-the-art Technologies for Medical and Biological Imaging, Guest Editors’ Comments”'. J Sign Process Syst, 54 :1-6. [Details] |
| Dong,H., Gong, Y.D., Paulose, V., Shum, P., Olivo, M. (2009) 'Optimum input states of polarization for Mueller matrix measurement in a system having finite polarization-dependent loss or gain'. Opt Express, 17 (25):23044-23057. [Details] |
| Chen Yong Kah,J., Hao Chow, T., Beng Koon Ng.,Gulam Razul,S., Olivo,M.,Sheppard,C.J.R. (2009) 'Concentration dependence of gold nanoshells on the enhancement of optical coherence tomography images: A quantitative study'. Applied Optics pp (epub ahead of print), 48 (10):D96-D108. [Details] |
| Dong,H.,Gong,Y.D., Paulose, V., Shum,P.,Olivo,M. (2009) 'Effect of input states of polarization on the measurement error of Mueller matrix in a system having small polarization-dependent loss or gain'. Optics Express, 17 (15):13017-13030. [Details] |
| Dinish,U. S.,Yaw Fu,C., Agarwal, A., Thoniyot,P., Olivo,M. (2009) 'Glucose sensing using 3D array of reproducible Surface Enhanced Raman Scattering substrates'. Proc of SPIE 73970C-1, 7397 . [Details] |
| Liu,J., Saw, C.L., Olivo, M., Sudhaharan, T., Ahmed,S., Heng, P.W., Wohland, T. (2009) 'Study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques'. J of Biomedical Optics, 14 (1). [Details] |
| Kah,J.C., Olivo,M., Chow, T.H., Song,K.S., Koh, K.Z., Mhaisalkar,S., Sheppard C.J. (2009) 'Control of optical contrast using gold nanoshells for optical coherence tomography imaging of mouse xenograft tumor model in vivo'. J Biomed Opt, 14 (5). [Details] |
| OLIVO,M.C. (2009) '“Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response'. Mol Cancer, 8 (1). [Details] |
| Hai-Ming Fan.,Jia-Bao Yi.,Yang, Y., Kiang-Wei Kho., Hui-Ru Tan.,Ze-Xiang Shen.,Jun Ding.,Xiao-Wei Sun.,Olivo,M.,Yuan-Ping Feng. (2009) 'Single-Crystalline MFe2O4 Nanotubes/Nanorings Synthesized by Thermal Transformation Process for Biological Applications'. ACS Nano, 3 (9):2798-2808. [Details] |
| PSP Thong.,Olivo,M., Lin,F.,Seah,H.S.,Tandjung,S.S.,Qian,K.,Chin,W.W.L., Bhuvaneswari, R.,Mancer,K., Soo,K.C. (2009) 'Detection and Diagnosis of Human Oral Cancer using Hypericin Fluorescence Endoscopic Imaging Interfaced with Embedded Computing'. SPIE Proceedings, 7380 . [Details] |
| C. S. Premachandran.,Khairyanto,A.,Chen Wei Sheng,K.,Singh,J.,Teo,J., Yingshun,X.,Nanguang, X.,Sheppard, C.,Olivo,M. (2009) 'Design, fabrication, and assembly of an optical biosensor probe package for OCT (Optical Coherence Tomography) application'. IEEE Transaction on Advanced Packaging, 32 (2):417-422. [Details] |
| Upile,T.,Jerjes, W., Henricus JCM Sterenborg, Adel K El-Naggar.,Sandison,A., Max JH Witjes, Merrill A Biel, Irving Bigio, Brian JF Wong, Ann Gillenwater.,MacRobert,A.J.,Robinson,D.J., Christian S Betz.,Stepp,H.,Bolotine, L.,McKenzie,G.,Mosse, A.C.,Barr,H., Zhongping Chen.,Berg,K., Anil K D'Cruz.,Stone,N.,Kendall,C.,Fisher,S.,Leunig, A.,Olivo,M., Richards-Kortum,R., Khee Chee Soo.,Bagnato,V., Lin-Ping Choo-Smith.,Svanberg,K., I Bing Tan, Brian C Wilson.,Wolfsen,H., Arjun G Yodh.,Hopper,C. (2009) 'Meeting Report - Head & neck optical diagnostics: vision of the future of surgery'. Head & Neck Oncology, 1 (25). [Details] |
| OLIVO,M.C. (2008) 'William Wei Lim Chin, Paul Wan Sia Heng, Patricia Soo Ping Thong, Ramaswamy Bhuvaneswari, Werner Hirt, Sebastian Kuenzel, Khee Chee Soo, Malini Olivo. “Improved formulation of photosensitizer chlorin e6-polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer.”'. Eur J Pharm Biopharm, 69 (3):1083-1093. [Details] |
| James, K.C., Olivo, M.C., Caroline Lee, S.G., Sheppard, C.J.R. (2008) 'Molecular contrast of EGFR expression using gold nanoparticles as a reflectance-based imaging probe'. Mol Cell Probes, 22 (1):14-33. [Details] |
| Chen Yong Kah,J., Weber Kam On Lau., Hoon Tan,P.,Richard Sheppard, C.J.,Olivo,M. (2008) 'Endoscopic image analysis of photosensitizer fluorescence as a promising noninvasive approach for pathological grading of bladder cancer in situ'. J Biomed Opt 054022, 13 (5). [Details] |
| Xu,Y.,Singh,J.,Premachandran,C.S.,Khairyanto,A.,Chen,K.W.S., Chen,N., Sheppard,C.J.R.,Olivo, M. (2008) 'Design and development of a 3D scanning MEMS OCT probe using a novel SiOB package assembly'. J of Micromechanics and Microengineering, 18 (125005):1-8. [Details] |
| Kah,J.C., Phonthammachai, N., Wan, R.C.Y., Song, J., White, T., Mhaisalkar, S., Ahmad, I., Sheppard, C., Olivo, M. (2008) 'Synthesis of gold nanoshells using precursor seed particles prepared from a deposition-precipitation process'. Gold Bulletin, 41 (1):23-36. [Details] |
| Kah, J.C., Wan, R.C., Wong, K.Y., Mhaisalkar, S.,Sheppard C.J., Olivo, M. (2008) 'Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: an in vitro study'. Lasers Surg Med, 40 (8):584-589. [Details] |
| Bhuvaneswari,R., Yuen Gan,Y.,Swarnalatha Lucky,S., Wei Lim Chin,W., Ali-Seyed,M., Chee Soo,K., Olivo,M. (2008) 'Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy'. Molecular Cancer, 7 (1). [Details] |
| Wei Lim Chin,W., Wan Sia Heng,P., Li Lim,P., Kam On Lau, W., Olivo,M. (2008) 'Membrane transport enhancement of chlorin e6-polyvinylpyrrolidone and its photodynamic efficacy on the chick chorioallantoic model'. Journal of Biophotonics, 1 (5):395-407. [Details] |
| OLIVO,M.C. (2008) 'Kah JC, Wong KY, Neoh KG, Song JH, Fu JW, Mhaisalkar S, Olivo M, Sheppard CJ., “Critical parameters in the pegylation of gold nanoshells for biomedical applications: An in vitro macrophage study”'. J Drug Target, 17 (3). [Details] |
| Phonthammachai, N.,Kah,J.C.Y.,Guo Jun.,Colin JR Sheppard.,Olivo,M.C.,Mhaisalkar, S..G.,White,T.J. (2008) 'Synthesis of Contiguous Silica-Gold Core-Shell Structures: Critical parameters and processes'. Langmuir, 24 (9):5109-5112. [Details] |
| Saw,C.L., Heng,P.W., Olivo, M. (2008) 'Potentiation of the Photodynamic Action of Hypericin'. Journal of Environmental Pathology, Toxicology and Oncology, 27 (1):23-33. [Details] |
| Kho,K.W., Qing, K.Z, Shen, Z.X., Ahmad, I.B., Lim, S.S.,Mhaisalkar, S., White, T.J., Watt, F., Soo, K.C.,Olivo, M. (2008) 'Polymer-based microfluidics with surface-enhanced Raman-spectroscopy-active periodic metal nanostructures for biofluid analysis'. J of Biomedical Optics 054026, 13 (5). [Details] |
| Singh,J.,Teo,J.H.S., Xu, Y., Premachandran,C.S., Chen,N., Kotlanka,R., Olivo,M., Sheppard,C.J.R. (2008) 'A two axes scanning SOI MEMS micromirror for endoscopic bioimaging'. J of Micromechanics and Microengineering, 18 (25001):1-9. [Details] |
| Thong,P.S.,Olivo, M.,Kho, K.W.,Bhuvaneswari,R.,Chin, W.W.,Ong, K.W.,Soo, K.C. (2008) 'Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy'. Journal of Enivronmental Pathology, Toxicology and Oncology, 27 (1):35-42. [Details] |
| Thong,P.S.P., Olivo,M., Kho,K.W., Zheng,W., Mancer,K., Harris, M., Soo, K.C. (2007) 'Laser confocal endomicroscopy as a novel technique for fluorescence diagnostic imaging of the oral cavity'. J Biomedical Optics 12(1): 014007, 12 (1). [Details] |
| Sing, C.L., Soon, S.H., Feng, L., Kenneth, Y.C.W., Kemao, Q., Soo,K.C., Thong, P., Olivo M. (2007) 'Towards in vivo navigational cellular imaging'. Proc SPIE 2007, . [Details] |
| Kah,J.C.Y.,Sheppard,C.J.R.,Lee,C.G.L., Olivo,M. (2007) 'Application of Antibody-conjugated gold nanoparticles for Optical Molecular Imaging of Epithelial Carcinoma Cells'. Proc SPIE 6095-04, . [Details] |
| Singh, J., Hoe, C.C., Jason,T.H.S., Chen,N., Premachandran,C.S., Sheppard,C.J.R., Olivo,M.. (2007) 'Optical coherent tomography (OCT) bioimaging using 3D scanning micromirror'. Photonic West - BIOS 2007 Proceedings of SPIE 1605-7422, 6432 :0C-1-0C-8. [Details] |
| Saw,C.L., Olivo,M., Chin, W.W., Soo,K.C., Heng,P.W. (2007) 'Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model'. J Photochem Photobiol B, 86 (3):207-218. [Details] |
| Kho,K.W., James CY Kah, Lee CGL, Sheppard, C.J.R., Shen, Z.X., Soo, K.C., Olivo, M. (2007) 'Applications of gold nanoparticles in the early detection of oral cancer'. Journal of Mechanics in Medicine and Biology, 7 (1):1-7. [Details] |
| Wei Lim Chin,W., Wan Sia Heng,P.,Olivo,M. (2007) 'Chlorin e6 - polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts'. BMC Pharmacology, 7 (1). [Details] |
| Thong,P.S.P., Kho, KW., Zheng, W., Mancer, K., Harris, M., Soo, K.C., Olivo, M. (2007) 'Development of a laser confocal endomicroscope for in vivo fluorescence imaging'. Journal of Mechanics in Medicine and Biology, 7 (1):1-7. [Details] |
| Chen Yong Kah, J.,Wei Kho,K.,Guat Leng Lee, C.,Sheppard,C.J.R.,Ze Xiang Shen.,Chee Soo, K.,Olivo,M.C. (2007) 'Early Diagnosis of Oral Cancer based on the Surface Plasmon Resonance of Gold Nanoparticles'. International Journal of Nanomedicine, 2 (4):785-798. [Details] |
| Bhuvaneswari,R.,Yik-Yuen Yap,G.,Yee Kar Lye,K.,Olivo,M. (2007) 'Effect of hypericin-mediated Photodynamic therapy on the expression of vascular endothelial growth factor (VEGF) in a human nasopharyngeal carcinoma'. International Journal of Molecular Medicine, 20 (4):421-428. [Details] |
| Fu,C.Y., Ng,B.K., Razul, S.G., Chin, W.W., Lau, W.K., Tan,P.H., Olivo, M. (2007) 'Fluorescence Diagnosis of Bladder Cancer using Urine Cytology'. International Journal of Oncology, 31 (3):525-530. [Details] |
| Bhuvaneswari,R.,Yik-Yuen Yap,G., Khee Chee,S., Olivo,M. (2007) 'Hypericin-mediated photodynamic therapy in combination with Avastin (Bevacizumab) improves tumor response by downregulating angiogenic proteins'. Photochem Photobiol Sci, 6 (12):1275-1283. [Details] |
| Saw,C.L.L., Olivo, M., Wohland, T., Fu, C.Y., Kho, K.W., Soo, K.C., Heng PWS. (2007) 'Effects of N-Methyl Pyrrolidone on the Uptake of Hypericin in Human Bladder Carcinoma and Co-staining with DAPI Investigated by Confocal Microscopy'. Technology in Cancer Research and Treatment, 6 (5):383-394. [Details] |
| OLIVO,M.C. (2007) 'William Wei Lim Chin, Paul Wan Sia Heng and Malini Olivo. “Chlorin e6 - polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts.”'. BMC Pharmacology, 7(1) (15). [Details] |
| Patricia Soo-Ping Thong.,Kong-Wee Ong.,Seng-Geok Goh,N., Kiang-Wei Kho.,Manivasager,V.,Ramaswamy, B.,Olivo,M.C., Khee-Chee Soo. (2007) 'Photodynamic Therapy-Activated Immune Response Against Distant Untreated Lesions In Recurrent Angiosarcoma'. Lancet Oncology, 8 (10):950-952. [Details] |
| Du,H.Y., Olivo,M., Mahendran, R.,Huang, Q., Shen, H-M., Ong, C-N.,Bay, B.H. (2007) 'Hypericin photoactivation triggers downregulation of Matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells'. Cellular and Molecular Life Sciences, 64 :979-988. [Details] |
| Kho,K.W.,Shen,Z.X., Lei,Z., Watt,F, Soo,K.C.,Olivo,M. (2007) 'Investigation into Surface Plasmon Related Heating Effect in Surface Enhanced Raman Spectroscopy'. Analytical Chemistry, 79 (23):8870-8882. [Details] |
| Olivo,M., Ali-Seyed,M. (2007) 'Apoptosis signaling mechanisms in human cancer cells induced by Calphostin - PDT'. Int J Oncol, 30 :537-548. [Details] |
| Chin,W.W., Heng,P.W., Lau, W.K., Bhuvaneswari,R., Olivo,M. (2006) 'The potential application of chlorin e6-PVP in photodynamic therapy'. Photochem Photobiol Sci, 5 :1031-1037. [Details] |
| Chin,W.W.L., Lau, W.K.O., Heng, P.W.S., Ramaswamy,B., Olivo, M. (2006) 'Chlorin e6-polyvinylpyrrolidone as a fluorescent marker for fluorescence diagnosis of human bladder cancer implanted on the chick chorioallantoic membrane model'. Cancer Lett, 245 (1~2):127-133. [Details] |
| OLIVO,M.C. (2006) 'Olivo M, “Cancer Diagnosis using the novel photosensitizer hypericin. In: Tan BKH, editor.”'. Novel Compounds from Natural Products in the New Millennium Potential and Challenges World Scientific, :227-236. [Details] |
| Kho,K.W., Shen, Z.X., Zhou,L., Watt,F., Soo, K.C., Olivo,M. (2006) 'Plasmon-Induced Heating Effect in Surface Enhanced Raman Scattering'. Proc SPIE 6095-09, 2006, . [Details] |
| Saw,L.L.C., Olivo,M, Soo,K.C., Heng,W.S.P. (2006) 'Spectroscopic characterization and photobleaching kinetics of hypericin-N-methyl pyrrolidone'. Photochem Photobiol Sci, 5 :1018-1023. [Details] |
| Olivo,M., Chin, W.W.L. (2006) 'Perelynequinone in photodynamic: Cellular versus vascular response'. J Environ Pathol Toxicol Oncol, 25 (1~2):223-227. [Details] |
| Olivo,M., Kho,K.W. (2006) 'Surface-plasmon heating and the study of biomolecules'. SPIE Newsroom, . [Details] |
| Yan, D.H., Bay,B.H., Mahendran,R., Olivo,M. (2006) 'Hypericin mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer'. Cancer Lett, 235 (2):202-208. [Details] |
| OLIVO,M.C. (2006) 'Saw LLC, Olivo M, Soo KC and Heng WSP. “Use of Hypericin in photodynamic applications.” In: Govil, J. N. (Eds.)'. Recent Progress in Medicinal Plants World Scientific Phytopharmacology and Therapeutic Values, 20 :249-275. [Details] |
| OLIVO,M.C. (2006) 'Li YH, Du HY, Bay BH and Olivo M. “St John’s Wort: a Precious Gift from the Saints? “ In: Tan BKH, editor'. Novel Compounds from Natural Products in the New Millennium Potential and Challenges, :290-301. [Details] |
| Olivo,M., Hong-Yan Du., Boon-Huat Bay. (2006) 'Hypericin lights up the way for the potential treatment of nasopharyngeal cancer by photodynamic therapy'. Curr Clin Pharmacol, 1 :217-222. [Details] |
| Saw,L.L.C., Heng, W.S.P., Chin, W.L.C., Soo, K.C., Olivo, M. (2006) 'Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model'. Cancer Lett, 238 (1):104-110. [Details] |
| Chin,W.W.L., Lau, W.K.O., Heng, P.W.S., Ramaswamy,B., Olivo. M. (2006) 'Fluorescence imaging and phototoxicity effects of new formulation of chlorin e6-polyvinypyrrolidone'. J Photochem Photobiol B, 84 (2):103-110. [Details] |
| Soo-Ping Thong,P., Watt,F.,Ren,M.Q., Tan,P.H., Soo,K,C., Olivo,M. (2006) 'Hypericin-photodynamic therapy (PDT) using an alternative treatment regime suitable for multi-fraction PDT'. J Photochem Photobiol B, 82 (1):1-8. [Details] |
| Saw,L.L.C.,Olivo, M.,Soo, K.C.,Heng, W.S.P. (2006) 'Delivery of hypericin for photodynamic applications'. Cancer Lett, 241 :23-30. [Details] |
| Du,H.Y., Li .Y.H., Olivo,M., Yip W.C.G., Bay, B. H. (2006) 'Differential up-regulation of metallothionein isoforms in well differentiated nasopharyngeal cancer cells in vitro by photoactivated hypericin'. Oncology Reports, 16 (6):1397-1402. [Details] |
| OLIVO,M.C. (2006) 'Pervaiz Shazib and Olivo M. “The Art and science of photodynamic therapy: A review.”'. Clin Exp Pharmacol Physiol, 33 :551-556. [Details] |
| Kho,K.W., Shen,Z.X., Zeng, H.C., Soo, K.C.,Olivo, M. (2005) 'Deposition Method for Preparing SERS-Active Gold Nanoparticle Substrates'. Anal Chem, 77 (22):7462-7471. [Details] |
| Du,H.Y.,Olivo, M.,Chen,Y.J.,Yip,G.,Tan,P.H.,Matsumoto,K., Tsujimoto,M.,Bay,B.H. (2005) 'Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well differentiated nasopharyngeal cancer in vivo'. Int J Mol Med, 16 (5):865-868. [Details] |
| Sim,H.G., Lau, W.K.O., Olivo, M., Tan, P.H., Cheng, C.W.S. (2005) 'Is photodynamic diagnosis using hypericin better then white light cystoscopy for the detection of superficial bladder carcinoma?'. Br J Urology, 95 (9):1215-1218. [Details] |
| Yee,K.K.L., Soo,K.C., Olivo, M. (2005) 'Anti-angiogenic effect of Hypericin-photodynamic therapy in combination with Celebrex® in the treatment of human nasopharyngeal carcinoma'. Int J Mol Med, 16 (6):993-1002. [Details] |
| Zhou,Q.Y., Olivo, M., Yee, K.K.L., Moore, S.X.L., Sharma, A., Chowbay, B. (2005) 'Enhancing the therapeutic responsiveness of photodynamic therapy with the anti-angiogenic agents SU 5416 and SU 6668 in murine nasopharyngeal carcinoma models'. Cancer Chemother Pharmacol, 56 (6):569-577. [Details] |
| Ramaswamy,B., Manivasager, V., Chin, W.W.L., Soo, K.C., Olivo, M. (2005) 'Photodynamic diagnosis of a human nasopharyngeal carcinoma xenograft model using the novel chlorin e6 photosensitizer Fotolon'. Int J Oncology, 26 (6):1501-1506. [Details] |
| Kho,K.W., Olivo, M., Shen, Z.X., Soo, K.C. (2005) 'Surface enhanced Raman spectroscopic (SERS) study of saliva in the early detection of cancer'. Proc SPIE-Optical Diagnostic and sensing, 5702 (13):84-91. [Details] |
| Saw,C.L., Olivo, M., Chin, W.W., Soo, K.C., Heng, P.W. (2005) 'Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment'. Biol Pharm Bull, 28 (6):1054-1060. [Details] |
| Thong,P.S.P.,Watt,F.,Ren,M.Q.,Soo,K.C.,Olivo,M. (2005) 'Investigating the role of calcium and biological trace elements in hypericin photodynamic therapy induced tumor cell death using nuclear microscopy'. Nuclear Instruments and Methods, B 231 ((1-4)):315-320. [Details] |
| Zheng,W., Olivo, M., Kho, K.W., Thong, P.S.P., Harris, M., Soo, K.C. (2005) 'Confocal fluorescence endomicroscopic imaging of the tongue'. Proc SPIE- Photonic Therapeutics and Diagnostic, 5686 :301-306. [Details] |
| Chin,W., Lau, W., Cheng, C., Olivo, M. (2004) 'Evaluation of Hypocrellin B in a human bladder tumor model in experimental photodynamic therapy: Biodistribution, light dose and drug-light interval effects'. Int J Oncol, 25 (3):623-629. [Details] |
| Du,H., Olivo, M., Mahendran, R., Bay, B.H. (2004) 'Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin'. Int J Oncol, 24 (3):657-662. [Details] |
| Olivo,M., Wilson, B.C. (2004) 'Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy'. Int J Oncol, 25 (1):37-45. [Details] |
| Tammilmani,V., Yee, K.K., Heng, P.W., Soo, K.C., Olivo, M. (2004) 'An Evaluation of Exogenous Application of Protoporphyrin IX and its Dimethyl Ester as a Photodynamic Diagnostic Agent in Poorly Differentiated Human Nasopharyngeal Carcinoma paragraph sign'. Photochem Photobiol, 80 (3):595-601. [Details] |
| Du,H.Y., Olivo, M., Tan, B.K., Bay, B.H. (2004) 'Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells'. Cancer Lett, 207 (2):175-181. [Details] |
| OLIVO,M.C. (2004) 'Du HY, Bay BH, Olivo M. “Modulation of Hypericin-Based Phototoxicity in Nasopharyngeal Cancer.” In: Zhu YZ, editor'. Novel Compounds from Natural Products in the New Millennium Potential and Challenges Singapore: World Scientific, :290-301. [Details] |
| Zheng,W., Harris, M., Kho, K.W., Thong, P.S.,Hibbs, A., Olivo, M., Soo, K.C. (2004) 'Confocal endomicroscopic imaging of normal and neoplastic human tongue tissue using ALA-induced-PPIX fluorescence: a preliminary study'. Oncol Rep, 12 (2):397-401. [Details] |
| Zheng,W., Olivo, M., Soo, K.C. (2004) 'The use of digitized endoscopic imaging of 5-ALA-induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo'. Int J Cancer, 110 (2):295-300. [Details] |
| Chin,W., Lau, W., Lay, S.L., Wei, K.K., Olivo, M. (2004) 'Photodynamic-induced vascular damage of the chick chorioallantoic membrane model using perylenequinones'. Int J Oncol, 25 (4):887-891. [Details] |
| Olivo,M. (2004) 'Cancer Diagnosis Using the Novel Photosensitizer, Hypericin. In: Tan BKH, editor. Novel Compounds from Natural Products in the New Millennium Potential and Challenges'. Singapore: World Scientific, :227-236. [Details] |
| Du,H.Y., Olivo, M., Tan, B.K., Bay, B.H. (2003) 'Hypericin-mediated photodynamic therapy induces lipid peroxidation and necrosis in nasopharyngeal cancer'. Int J Oncol, 23 (5):1401-1405. [Details] |
| Zheng,W., Lau, W., Cheng,C., Soo, K.C., Olivo, M. (2003) 'Optimal excitation-emission wavelengths for autofluorescence diagnosis of bladder tumors'. Int J Cancer, 104 (4):477-481. [Details] |
| Du,H.Y., Bay, B.H., Olivo, M. (2003) 'Biodistribution and photodynamic therapy with hypericin in a human NPC murine tumor model'. Int J Oncol, 22 (5):1019-1024. [Details] |
| Olivo,M., Lau, W., Manivasager, V., Tan, P.H.,Soo, K.C., Cheng, C. (2003) 'Macro-microscopic fluorescence of human bladder cancer using hypericin fluorescence cystoscopy and laser confocal microscopy'. Int J Cancer, 23 (4):983-990. [Details] |
| Olivo,M., Lau,W., Manivasager,V., Hoon,T.P., Christopher, C. (2003) 'Fluorescence confocal microscopy and image analysis of bladder cancer using 5-aminolevulinic acid'. Int J Oncol, 22 (3):523-528. [Details] |
| Manivasager,V., Heng,P.W., Hao,J., Zheng, W., Soo, K.C., Olivo, M. (2003) 'A study of 5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems of human bladder cancer'. Int J Cancer, 22 (2):313-318. [Details] |
| SM,A., Olivo, M. (2003) 'Nitric oxide mediated photo-induced cell death in human malignant cells'. Int J Cancer, 22 (4):751-756. [Details] |
| SM,A., Olivo, M. (2003) 'Mechanisms of action of phenanthroperylenequinones in photodynamic therapy (review)'. Int J Oncol, 22 (6):1181-1191. [Details] |
| Olivo,M., Lau,W., Manivasager, V., Bhuvaneswari, R., Wei,Z., Soo,K.C., Cheng, C.,Tan, P.H. (2003) 'Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin'. Int J Oncol, 23 (6):1501-1504. [Details] |
| Ali,S.M., Chee, S.K., Yuen, G.Y., Olivo, M. (2002) 'Photodynamic therapy induced Fas-mediated apoptosis in human carcinoma cells'. Int J Mol Med, 9 (3):257-270. [Details] |
| Ali,S.M., Olivo, M., Gan, Y.Y., Soo, K.C. (2002) 'Apoptosis Induced by Photosensitizers (Perylquinone Derivatives) in Human Carcinoma Cells: A Possible Relevance to Photodynamic Therapy'. Asian Journal of Surgery, 25 (1):18-26. [Details] |
| Ali,S.M., Olivo, M. (2002) 'Efficacy of hypocrellin pharmacokinetics in phototherapy'. Int J Oncol, 21 (6):1229-1239. [Details] |
| Zheng, W., Tay,S.K., Soo, K.C., Olivo, M. (2002) 'Development and clinical applications of digitized fluorescence endoscopic imaging system for the detection of early neoplasms in the oral cavity and uterine-cervix'. Proc of SPIE: Optical Biopsy IV, iv (4613):264-268. [Details] |
| Ali,S.M., Chee, S.K., Yuen, G.Y., Olivo, M. (2002) 'Hypericin induced death receptor-mediated apoptosis in photoactivated tumor cells'. Int J Mol Med, 9 (6):601-616. [Details] |
| Zheng,W., Soo, K.C., Sivanandan,R., Olivo, M. (2002) 'Detection of squamous cell carcinomas and pre-cancerous lesions in the oral cavity by quantification of 5-aminolevulinic acid induced fluorescence endoscopic images'. Lasers Surg Med, 31 (3):151-157. [Details] |
| Ali,S.M., Chee, S.K., Yuen, G.Y., Olivo, M. (2002) 'Hypocrellins and Hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide'. Int J Mol Med, 9 (5):461-472. [Details] |
| Ali,S.M., Olivo, M. (2002) 'Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells'. Int J Oncol, 21 (3):531-540. [Details] |
| Du,H.,Bay, B.H.,Mahendran, R.,Olivo, M. (2002) 'Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy'. Int J Mol Med, 10 (1):73-76. [Details] |
| Zheng,W., Olivo, M., Soo, K.C. (2001) 'Diagnosis of Oral Tumors Using Light-Induced Autofluorescence Spectra at Multiple Excitation Wavelengths'. Proc SPIE: Biophotonics Instrumentation and Analysis, (4597):133-138. [Details] |
| Zheng,W., Olivo, M., Sivanandan, R., Karuman,P., Lim, T.K., Soo,K.C. (2001) 'Endoscopy imaging of 5-ALA induced PpIX fluorescence for the detection of early neoplasms in the oral cavity'. Proc of SPIE: Biophotonics Instrumentation and Analysis, (4597):128-132. [Details] |
| Ali,S.M., Olivo, M., Yuen, G.Y., Chee, S.K. (2001) 'Photodynamic-induced apoptosis of human nasopharyngeal carcinoma cells using Hypocrellins'. Int J Oncol, 19 (3):633-643. [Details] |
| Ali,S.M., Olivo, M., Yuen, G.Y., Chee, S.K. (2001) 'Induction of apoptosis by Hypericin through activation of caspase-3 in human carcinoma cells'. Int J Mol Med, 8 (5):521-530. [Details] |
| Ali,S.M., Chee, S.K., Yuen, G.Y., Olivo, M. (2001) 'Hypericin and hypocrellin induced apoptosis in human mucosal carcinoma cells'. J Photochem Photobiol B, 65 (1):59-73. [Details] |
| Olivo,M., Soo, K.C. (2001) 'Photodynamic therapy comes of age'. SGH Proceedings, 9 (3):197-201. [Details] |
| Cheng,C.W., Lau, W.K., Tan, P.H., Olivo, M. (2000) 'Cystoscopic diagnosis of bladder cancer by intravesical instillation of 5-aminolevulinic acid induced porphyrin fluorescence--the Singapore experience'. Ann Acad Med Singapore, 29 (2):153-158. [Details] |
| Olivo,M., Ali, S.M., Soo, K. (2000) 'Photodynamic induced apoptosis of nasopharyngeal cells using novel photosensitizers Hypericin, Hypocrellin A and B'. Royal Australian and New Zealand Journal of Surgery, :123-156. [Details] |
| Farrell,T.J., Wilson, B.C., Patterson, M.S.,Olivo, M. (1998) 'Comparison of the in vivo photodynamic threshold dose for photofrin, mono- and tetrasulfonated aluminum phthalocyanine using a rat liver model'. Photochem Photobiol, 68 (3):394-399. [Details] |
| Wilson,B.C., Olivo, M., Singh, G. (1997) 'Subcellular localization of Photofrin and aminolevulinic acid and photodynamic cross-resistance in vitro in radiation-induced fibrosarcoma cells sensitive or resistant to photofrin-mediated photodynamic therapy'. Photochem Photobiol, 65 (1):166-176. [Details] |
| Hebeda,K.M., Saarnak,A.E., Olivo, M., Sterenborg, H.J., Wolbers, J.G. (1997) 'Aminolevulinic acid induced endogenous porphyrin fluorescence in 9L and C6 brain tumours and in the normal rat brain'. Acta Neurochir (Wien) 503-12; discussion 512-3, 1998, 140 (5). [Details] |
| Lilge, L.,Olivo, M.C.,Schatz, S.W.,MaGuire, J.A.,Patterson, M.S.,Wilson, B.C. (1996) 'The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy'. Br J Cancer, 73 (3):332-343. [Details] |
| Lilge, L., Olivo,M., Wilson, B.C. (1995) 'Distribution of photosensitizers in normal brain and VX2 tumor using confocal fluorescence microscopy'. Proc of SPIE: Biomedical optics, 3133 :305-310. [Details] |
| Wilson,B.C., Olivo, M., Moorehead, R., Singh, G. (1994) 'Studies of the significance of functional and structural changes in mitochondria in Photofrin-photodynamic therapy resistant cells'. Proc of SPIE: Biomedical optics, 2133 :200-207. [Details] |
| Lilge,L., Olivo, M., Schatz, S., Patterson, M.S., Farrell, T.J., Wilson, B.C. (1993) 'The photodynamic threshold for normal rabbit brain and for implanted VX2 tumors'. Proc of society of photo-optical instrumentation engineers' journal; 1882:, :60-72. [Details] |
| Lilge,L.L., Olivo, M., Schatz, S., Wilson, B.C. (1993) 'Determination of the photodynamic threshold for normal rabbit brain for the implanted VX2 tumor'. Laser-tissue interaction IV;SPIE 1882-07:60-72, . [Details] |
| Farrell,T.J., Olivo, M., Schatz, S., Patterson, M.S., Wilson, B.C. (1992) 'Investigation of the dependence of tissue necrosis on irradiation wavelength and time post injection using a photodynamic threshold dose model'. In Photodynamic therapy and biomedical lasers eds Spinnelli P, Dalfnate M and Marchesini 1992, :R 830-834. [Details] |
| Olivo,M., Low, K.S., Looi, L.M., Tan, B.C. (1989) 'Investigation of immediate photodynamic therapy for cancer treatment'. IRCS Medical Science, 17 (31). [Details] |
| Olivo,M., Low,K.S., Baskaran, G., Looi, L.M., Ng, K.H., Jayalakshmi P, Sam CK, Khor HT, Oo KC, Tan BC. (1986) 'Photoradiation therapy of carcinogen induced murine tumors using a simple light source'. IRCS Medical Science, 14 :1097-1102. [Details] |
Conference Paper
| Premachandran CS, Singh J, Sheng KCW, Teo J, Yingshun X, Nanguang C, Sheppard C, Olivo M. (2007) Design, fabrication and assembly of an optical biosensor probe package for OCT (Optical Coherence Tomography) application targeting for cancer detection.. Electronic Components and Technology Conference Organized by IEEE association http://wwwectcnet. Conference Paper [Details] |
| Singh J, Chan CH, Teo HS, Chen N, Premachandran CS, Sheppard C, Olivo M. (2007) Optical coherent tomography bio-imaging using 3D scanning micromirror.. SPIE Photonics West (BIOS) 2007. Conference Paper [Details] |
| Dinish,U. S.,Kiang Wei,K.,Agarwal,A., Chit Yaw Fu., Olivo,M. (2011) “Highly Ordered Sub-40nm Ultrasmall Nanogap SERS Substrates Fabricated by Deep UV Lithography and its Application in Biosensing”,. ICMAT. Singapore: Conference Paper [Details] |
| Bhuvaneswari,R.,Olivo,M. (2011) Photodynamic therapy and the suppression of tumor angiogenesis by monoclonal antibodies to improve treatment response,. International Photodynamic Association. Innsbruck, Austria: Conference Paper [Details] |
| Patricia S.P. Thong.,Olivo,M.,Movania, M.M.,Tandjung, S.S.,Bhuvaneswari,R., Hock-Soon Seah., Feng Lin4.,Qian,K., Khee-Chee Soo. (2011) Toward 3-dimensional virtual biopsy of oral lesions through the development of a confocal endomicroscope interfaced with embedded computing.. European Conferences on Biomedical Optics. Munich, Germany: Conference Paper [Details] |
| Chit Yaw Fu., Dinish,U. S.,Wei Kho,K.,Goh Wenda,D., Olivo,M. (2011) “Development of Bimetallic Substrate with Alternating Nanosphere Array for SERS-based Biosensing”,. SPIE/OSA European Conferences on Biomedical Optics. Munich, Germany: Conference Paper [Details] |
| Dinish,U. S.,Yaw Fu,C., Kiat Seng Soh., Bhuvaneswari, R.,Olivo,M. (2011) “Development of Photonic Crystal Fiber Based SERS platform for Biosensing Applications”,.. SPIE/OSA European Conferences on Biomedical Optics. Munich, Germany: Conference Paper [Details] |
| Swarnalatha Lucky,S., Mancer,K., Kam On Lau,W., Olivo,M. (2010) Altered expression of cell adhesion molecules leads to selective uptake of hypericin in bladder cancer.. Optics with in Life Sciences. Quebec, Canada: Conference Paper [Details] |
| Kho, K.W., Fu,C.Y., Dinish, U.S., Praveen, T., Olivo,M. (2010) “SERS-based Mechanical Nano-Sensor for Mutiplexed Protein Detection”. Optics with in Life Sciences. Quebec, Canada: Conference Paper [Details] |
| Kho,K.W., Fu, C.Y., Dinish, U.S., Praveen, T., Olivo, M. (2010) SERS-based Mechanical Nano-Sensor for Multiplexed Protein Detection. International Conference on Raman Spectroscopy (ICORS). Boston: Conference Paper [Details] |
| Chit Yaw Fu., Dinish, U.S.,Thoniyot,P., Olivo M., (2010) Multilayered Nanosphere Substrates for Surface Enhanced Raman Spectroscopy,. Optics with in Life Sciences. Quebec, Canada: Conference Paper [Details] |
| Dinish,U. S., Chit Yaw Fu.,Olivo, M. (2010) Development of Highly Sensitive Compact Raman Scanner for Mass Screening of Chemical Dyes. International Conference on Raman Spectroscopy (ICORS). Boston: Conference Paper [Details] |
| Bhuvaneswari,R.,Yik Yuen, G.,Thong, P.,Khee Chee, S., Malini,O. (2010) Antiangiogenic photodynamic therapy with targeted monoclonal antibodies.. Optics with in Life Sciences. Quebec, Canada: Conference Paper [Details] |
| Dinish,U. S.,Yaw Fu,C., Goh,D.,Olivo,M. (2010) “Nanosphere Templated Optical Fiber for In-Vivo SERS Sensing Applications”. Photonics Global Conference. Singapore: Conference Paper [Details] |
| Thong,P.S.P., Olivo,M.,Cheong, L.S.,Bhuvaneswari,R.,Swarnalatha Lucky,S.,Mancer, K.,Soo,K.C. (2010) Real-Time Clinical Fluorescence Diagnostic Imaging of Oral Lesions using an Endoscope Interfaced to a Matlab-based Image Processing System.. Optics with in Life Sciences. Quebec, Canada: Conference Paper [Details] |
| Dinish,U. S., Agarwal, A.,Yaw Fu, C.,Olivo,M. (2010) Comparison of the Performance of SERS Substrates Fabricated by Deep UV Lithography and Nanosphere Lithography. International Conference on Raman Spectroscopy (ICORS). Boston: Conference Paper [Details] |
| Fu,C.Y., Koh,Z.Y.,Dinish,U.S.,Kho,K.W., Praveen,T., Olivo,M. (2010) Fabrication of SERS Substrate by Multilayered Nanosphere Deposition Technique.. International Conference on Raman Spectroscopy (ICORS). Boston: Conference Paper [Details] |
| Dinish, U.S.,Thoniyot,P.,Yaw Fu, C.,Agarwal,A., Olivo,M., (2010) Nanogap SERS Substrates Fabricated using Deep UV lithography and its Applications in Biosensing. Optics with in Life Sciences. Quebec, Canada: Conference Paper [Details] |
| Nagamani,D., Praveen, T., Bhuvaneswari,R., Lucky, S. S.,Olivo, M. (2010) Multimodality optical imaging along with targeted photodynamic therapy for cancer using photosensitizer immobilized gold nanoparticles as novel theragnostic agents.. Optics with in Life Sciences. Quebec, Canada: Conference Paper [Details] |
| Ravi Kumar, K., Dinish,U. S., Chit Yaw Fu., Gopalkrishna Hegde.,Olivo,M.,Asundi,A. (2010) “Metal Enhanced Fluorescence on Silver Nano-Triangles”, .. Photonics Global Conference. Singapore: Conference Paper [Details] |
| Dinish, U. S.,Fu,C.Y.,Agarwal,A., Thoniyot,P.,Olivo,M. (2009) Glucose sensing using 3D array of reproducible Surface Enhanced Raman Scattering substrates.. SPIE conference. Conference Paper [Details] |
| Bhuvaneswari, R.,Yuen Gan,Y., Thong,P.S.P.,Wei Lim Chin,W., Chee Soo,K., Olivo,M. (2009) Combination of angiogenesis inhibitors increase the anti-tumor efficacy of photodynamic therapy in a human bladder tumor xenograft model.. International Photodynamic Association World Congress, Seattle. Conference Paper [Details] |
| Dong,H. ,Gong,Y.D.,Thong,P.S.P.,Bhuvaneswari,R.,Olivo,M. (2009) Measurement of Polarization Dependent Loss in Terahertz Time Domain Spectroscopy, . Presentation at the 34th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz 2009). Busan, Korea: Conference Paper [Details] |
| Thong,P.S.P., Olivo, M.,Chin,W.W.L., Bhuvaneswari, R.,Mancer, K.,Soo,K.C. (2009) Hypericin Fluorescence Endoscopy for Clinical Diagnostic Imaging of Oral Cavity Lesions. oral presentation at the First Congress of Asian Society of Head and Neck Oncology ASHNO 2009. Taipei, Taiwan: Conference Paper [Details] |
| Sasidharan, S.L., Lau, W.K.O., Mancer, K., Olivo, M. (2009) Loss of intercellular adhesion leads to differential accumulation of hypericin in bladder cancer.. International Photodynamic Association World Congress, Seattle. Conference Paper [Details] |
| Dinish,U.S., Yaw Fu,C., Wei Kho,K., Thoniyot,P., Olivo,M. (2009) Fluctualtion in Surface Enhanced Raman Scattering intensity due to Plasmon related heating effect.. SPIE conference. Conference Paper [Details] |
| Fu,C.Y.,Koh,K.Z.Y.,Dinish,U.S.,Kho,K.W.,Praveen,T.,Olivo,M. (2009) The effect of design parameters of metallic substrate on the reproducibility of SERS measurement for biosensing.. SPIE conference. Conference Paper [Details] |
| Gong,Y.D.,Dong,H.,Hong,M.H.,Olivo,M.,Thong,P.S.P., Bhuvaneswari,R. (2009) Polarization Effect in Liver Tissue in Terahertz Band. presentation at the 34th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz 2009). Busan, Korea: Conference Paper [Details] |
| Thong,P., Olivo, M.,Lin, F.,Seah, H.S., Tandjung, S.S., Qian, K., Chin, W.W.L., Bhuvaneswari, R., Mancer, K., Soo, K.C. (2009) Diagnosis of human oral cancer using hypericin fluorescence endoscopic imaging interfaced with embedded computing.. International Photodynamic Association World Congress. Seattle: Conference Paper [Details] |
| Kho,K.W., Qing,Z.M.,Shen, Z.X.,Iman, A., Lim,S.C.,Mhaisalkan,S.G.,Frank, W.,Mhaisalkar,S.G.,Soo, K.C.,Olivo,M. (2008) A report on a SERS-based polymer microfluidics incorporated with in-channel periodic metal nano-structures. XXIst International Conference on Raman Spectroscopy. Brunel University, London, UK: Conference Paper [Details] |
| Patricia S.P. Thong., Chin,W.W.L.,Bhuvaneswari,R., Kiang-Wei Kho.,Mancer,K.,Olivo,M., Khee-Chee Soo. (2008) Fluorescence Diagnostic Imaging of Lesions in the Human Oral Cavity using Hypericin.. 34th American Society for Photobiology (ASP). Burlingame, CA: Conference Paper [Details] |
| Kho,K.W.,Iman, A.,Koh,Z.Y.,Madhavi, S.,Shen,Z.X.,Sheppard, C.,Frank,W.,Mhaisalkar,S.G.,Timothy, J.W.,Olivo,M. (2008) Surface Enhanced Raman Spectroscopy using a smooth planar metal surface with embedded nano-cavities. XXIst International Conference on Raman Spectroscopy. Brunel University, London, UK: Conference Paper [Details] |
| Wei Kho,K.,Zhu Mei Qing,K., Xiang Shen,Z., Binte Ahmad,I., Sing Chin Lim,S.,Mhaisalkar,S., Timothy John White.,Watt,F.,Chee Soo, K.,Olivo,M. (2008) A Polymer-based Microfluidics with SERS-active Periodic Metal Nano-structures for Bio-fluid Analysis. Singapore Management University. Singapore: Conference Paper [Details] |
| Thong,P.S.P.,Lee Sing,C.,Olivo, M.,Feng, L.,Hock Soon,S.,Kemao, Q.,Khee-Chee Soo. (2008) Development of a Real-Time Image Processing and Analysis System for Real-Time Fluorescence Diagnostic Imaging of the Oral Cavity in the Clinic.. Optics Within Life Sciences -10 Biophotonics Asia. Singapore: Conference Paper [Details] |
| Gustavsson, N., Lu, J., Olivo,M. , Radda, G.K., Han, W. (2008) In vivo detection of insulin secretory events.. Abstract in 2008 World Molecular Imaging Congress. Nice, France: Conference Paper [Details] |
| Bhuvaneswari,R.,Yuen Gan,Y.,Swarnalatha Lucky,S.,Wei Lim Chin, W.,Ali-Seyed,M.,Chee Soo,K.,Olivo,M. (2008) Evaluation of angiogenic markers in vascular and cellular mediated photodynamic therapy using hypericin.. 34th American Society for Photobiology (ASP). Burlingame, CA: Conference Paper [Details] |
| Chin,W.W.,Thong,P.S.P.,Bhuvaneswari, R.,Soo,K.C., Heng, P.W.,Olivo, M. (2008) Chlorin e6-polyvinylpyrrolidone induced fluorescence endoscopy and spectroscopy for in vivo cancer diagnostics.. Optics Within Life Sciences -10 Biophotonics Asia. Singapore: Conference Paper [Details] |
| Chin, W.W.,Heng, P.W.,Lau, W.K.,Lim, P.L.,Bhuvaneswari, R.,Thong, P.S.P.,Olivo, M. (2008) Fluorescence kinetics and drug transport of chlorin e6 - polyvinylpyrrolidone for photodynamic applications of urological cancer.. 34th American Society for Photobiology (ASP). Burlingame, CA: Conference Paper [Details] |
| Bhuvaneswari,R., Yuen Gan,Y., Thong,P.S.P.,Wei Lim Chin, W.,Chee Soo, K.,Olivo,M. (2008) Targeted Therapy of Bladder Carcinoma by Combining Photodynamic Therapy and Angiogenesis Inhibitors.. Optics Within Life Sciences -10 Biophotonics Asia. Conference Paper [Details] |
| Bhuvaneswari,R.,Yap-Yik Yuen, G.,Khee Chee,S.,Olivo,M. (2007) Optimizing hypericin mediated photodynamic therapy downregulates the expression of angiogenic proteins in bladder carcinoma.. 12th European Society for Photobiology 2007 -. University of Bath, UK: Conference Paper [Details] |
| Kah,J.C.Y., Wan,R.C.Y., Tzu-Hao Chow.,Phonthammachai,N.,Olivo,M.,Mhaisalkar, S.,White,T.J., Sheppard,C.J.R. (2007) Exploiting the Optical Response of Metallodielectric core-shell particles for imaging and therapy of cancer. 4th Scientific Meeting of the Biomedical Engineering Society. Singapore: Conference Paper [Details] |
| Chen Yong Kah, J.,Wei Kho,K.,Guat Leng Lee,C.,James Richard Sheppard,C.,Xiang Shen,Z.,Chee Soo,K.,Olivo,M. (2007) Application of the surface plasmon resonance of gold nanoparticles in the photodetection of early oral cancers.. 11th World Congress of the International Photodynamic Association. Shanghai: Conference Paper [Details] |
| Thong,P.S.P.,Olivo,M., Kiang-Wei Kho.,Bhuvaneswari,R.,Khee-Chee Soo. (2007) Response of angiosarcoma to photodynamic therapy using various treatment regimes.. 11th World Congress of the International Photodynamic Association. Shanghai: Conference Paper [Details] |
| Bhuvaneswari,R., Gan, Y.Y., Soo, K.C., Olivo, M. (2007) Combination of bevacizumab (Avastin) and Hypericin-photodynamic therapy for the treatment of human bladder cancer xenografts.. 11th World Congress of the International Photodynamic Association. Shanghai: Conference Paper [Details] |
| Chin,W.W.L.,Paul WS. Heng.,Weber KO. Lau.,Dill,O.,Kuenzel,S.,Hirt,W.,Chee Soo,K.,Olivo,M. (2007) Effect of polyvinylpyrrolidone on the trisodium salt of chlorin e6 for in vitro and in vivo photodynamic application in human carcinoma cells.. 11th World Congress of the International Photodynamic Association. Conference Paper [Details] |
| Chin, W.W.,Heng, P.W.S.,Lau, W.K.,Lim, P.L.,Bhuvaneswari, R.,Gulam Razul, S.,Olivo, M. (2007) Chlorin e6 - polyvinylpyrrolidone selectively accumulates and causes photodynamic damage in human bladder carcinoma: From chick chorioallantoic membrane model to clinical patients.. 12th European Society for Photobiology 2007 -. University of Bath, UK: Conference Paper [Details] |
| Sing Cheong,L., Lin,F.,Soon Seah,H., Qian,K.,Chin-Wen Yu, K.,Soo-Ping Thong, P.,Olivo,M. (2007) Real-time Cellular Morphologic Analysis with Fine-grained Parallel Image Processing. 2nd IAPR Workshop on Pattern Recognition in Bioinformatics. Conference Paper [Details] |
| Xu,Y.,Singh, J., Jason,T.H.S., Ramakrishna, K.,Premachandran,C.S.,Kelvin,C.W.S.,Kuan,C.T., Chen,N.,Olivo,M.C.,Sheppard,C.J.R. (2007) MEMS based non rotatory circumferential scanning optical probe for endoscopic optical coherence tomography. SPIE European Conferences of Biomedical Optics - Optical Coherence Tomography and Coherence Techniques 17 to 21 Jun 2007, Munich, Germany, published in Proceedings of SPE -OSA Biomedical Optics. Conference Paper [Details] |
| Yong Kah,J.C.,Hao Chow,T., Olivo,M.,Koon Ng,B., Richard Sheppard,C.J. (2007) Improving the optical contrast of backscattering signal in reflectance-based imaging with gold nanoshells.. European Conferences on Biomedical Optics. Munich: Conference Paper [Details] |
| Premachandran,C.S.,Sheng, K.C.W.,J. Singh, T.H.S. Jason, X. Yinghsun, N. Chen, C. JR. Sheppard, M. Olivo (2007) Design, fabrication, and assembly of an optical biosensor probe package for OCT (optical coherence tomography) application. 2007 Electronic Components and Technology Conference. Conference Paper [Details] |
| Lee Sing,C.,Feng, L.,Hock Soon,S.,Kemao, Q.,Khee Chee, S.,Thong Soo-Ping,P.,Olivo,M. (2007) Coupling of Embedded Computing into Endoscopy Imaging.. 3rd Asian Conference on Computer Aided Surgery. Conference Paper [Details] |
| Saw,C.L.L.,Heng,P.W.S.,Fu,C.Y.,Kho,K.W.,Soo,K.C.,Wohland,T.,Olivo,M. (2007) Pharmaceutical development of hypericin for photodynamic applications by real-time 3D confocal microscopy.. 11th World Congress of the International Photodynamic Association. Shanghai: Conference Paper [Details] |
| Kho,K.W.,Olivo,M. (2007) . Colloguium Spectroscopium Internationale XXXV. Xiamen, China: Conference Paper [Details] |
| Olivo,M., Chen Yong Kah,J.,Hoon Tan, P., Weber KO. Lau. (2007) A Study of Hypericin as a Potential Fluorescence Marker for Detection and Pathological Grading of Transtitional Cell Bladder Carcinoma.. 11th World Congress of the International Photodynamic Association. Shanghai: Conference Paper [Details] |
| Kho,K.W., Shen,Z.X., Watt, F., Soo, K.C., Olivo, M. (2006) Plasmon-induced Heating effect in Surface Enhanced Raman Scattering.. In: International Symposium Photonic West. Conference Paper [Details] |
| Cheong Lee Sing.,Seah Hock Soon, Lin Feng, Yu Chin-Wen Kenneth, Qian Kemao, Soo Khee Chee, PSP Thong, Malini Olivo (2006) FPGA Implementation of Real-time Fluorescence Endoscopy Imaging Algorithms. The International Conference on Biomedical and Pharmaceutical Engineering 2006 (ICBPE06). Conference Paper [Details] |
| Saw,L.L.C.,Olivo, M.,Wohland, T.,Fu, C.Y.,Soo, K.C.,Heng,W.S.P. (2006) Effects of N-methyl pyrrolidone on cellular uptake of hypericin monitored by real-time 3D Confocal Microscopy.. Asian Pharmaceutics Graduate Congress - The science of product design and pharmaceutical Technology Best Poster Award. Conference Paper [Details] |
| Bhuvaneswari,R.,Gan, Y.Y.,Thong, P.S.P.,Ho, M.,Soo, K.C.,Olivo, M. (2006) Upregulation of Copper and Vascular Endothelial Growth Factor (VEGF) in Nasopharyngeal Carcinoma following Hypericin mediated Photodynamic Therapy (PDT).. The 33rd Meeting of the American Society for Photobiology and the Photostability of Drug and Drug Products Group. Rio Grande, Puerto Rico: Conference Paper [Details] |
| Cheong Lee Sing, Seah Hock Soon, Lin Feng, Yu Chin-Wen Kenneth, Qian Kemao, Soo Khee Chee, PSP Thong, Malini Olivo (2006) Towards In Vivo Navigational Cellular Imaging. Singaporean-French Biomedical Imaging Workshop (SFBI06). Conference Paper [Details] |
| Chin,W.W., Heng,P.W.S., Bhuvaneswari,R., Dill,O., Olivo,M. (2006) Investigation of antitumor efficacy using chlorin e6-polyvinylpyrrolidone in cancer models.. The 33rd Meeting of the American Society for Photobiology and the Photostability of Drug and Drug Products Group. Rio Grande, Puerto Rico: Conference Paper [Details] |
| Kah,J.C.Y.,Sheppard,C.J.R., Lee,C.G.L.,Olivo,M. (2006) Application of Antibody-Conjugated Gold Nanoparticles for Optical Molecular Imaging of Epithelial Carcinoma Cells. Photonics West BIOS 2006 Symposium on Biomedical Optics. San Jose: Conference Paper [Details] |
| Kah,J.C.Y., Olivo, M., Sheppard,C.J.R., Lau, W.K.O. (2005) Pathological diagnosis of bladder cancer by image analysis of hypericin induced fluorescence cystoscopic images.. In: SPIE-BIOS European Biophotonics meeting. Munich, Germany: Conference Paper [Details] |
| Thong,P.S.P., Goh,B.K.P., Kho, K.W., Olivo,M., Soo,K.C. (2005) Photodynamic therapy of recurrent angiosarcoma using the new chlorin compound Fotolon® - A case study.. In: 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Saw,C.L.L.,Olivo,M.,Soo,K.C.,Hen,P.W.S. (2005) Novel 3d-confocal microscopy and real-time uptake of hypericin visualized in human bladder carcinoma.. In: The 2nd Aasp Symposium & 2nd Apem Conference. Thailand: Conference Paper [Details] |
| Kho,K.W., Olivo, M., Shen,Z.X., Soo, K.C. (2005) Surface enhanced raman spectroscopic (SERS) study of saliva in the early detection of oral cancer.. In: SPIE international symposium photonic west. San Jose, California, USA: Conference Paper [Details] |
| Chin,W.L.W., Lau,K.O.W., Ramaswamy,B., Heng, W.S.P., Olivo,M. A. (2005) ssessment of fluorescence diagnosis and therapy of bladder cancer on the chick chorioallantoic membrane (CAM) using Fotolon®.. In: 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Du,H.Y., Olivo,M., Mahendran,R., Huang, Q., Shen, H.M., Ong, C.N., Bay, B.H. (2005) Hypericin-PDT downregulates matrix metalloproteinase 9 (MMP-9) expression via inhibiting NF-kB and AP-1 transcriptional activity in nasopharyngeal cancer (NPC).. In: 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Thong,P.S.P.,Goh,B.K.P,Kho K.W., Olivo,M., Soo, K.C. (2005) Photodynamic therapy as a promising alternative for palliative treatment of angiosarcoma.. In: Combined Scientific Meeting. Singapore: Conference Paper [Details] |
| Kah,J.C.Y., Lee, C.G.L.,Sheppard, C.J.R.,Olivo, M. (2005) Antibody-conjugated gold nanoparticlees and its interaction with epithelial carcinoma cells for optical imaging.. In: 7th annual NTU-SGH Symposium. Singapore: Conference Paper [Details] |
| Olivo,M. (2005) Is photodynamic diagnosis using ALA induced PPIX fluorescence better then white light for the detection of pre-malignant and malignant lesisons in the oral cavity?. 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Sim,H.G., Lau, W.K.,Olivo, M., Tan, P.H.,Cheng, C.W. (2005) Is photodynamic diagnosis using ALA induced PPIX fluorescence better then white light cystoscopy for the detection of superficial bladder carcinoma?. 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Thong,P.S.P.,Tammilmani, V.,Yee, K.K.L.,Ren, M.Q.,Bay, B.H.,Watt, F.,Tan, P.H.,Chin, W.W.L.,Soo, K.C.,Olivo, M. (2005) Novel treatment regime in Hypericin-mediated PDT to optimise apoptosis and VEGF levels.. In: 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Olivo,M.,Chin, W.L.W.,Ramaswamy, B.,Heng, W.S.P.,Lau, W. (2005) Therapeutic efficacy of chlorin e6 conjugated with polyvinyl pyrrolidone (Fotolon®) as a novel sensitizer for phototherapy.. In: 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Kho,K.W., Olivo, M., Shen, Z.X., Soo, K.C. (2005) Saliva analysis in the early detection of oral cancer using Surface Enhanced Raman Spectroscopy (SERS).. In: Combined Scientific Meeting. Singapore: Conference Paper [Details] |
| Goh,B.K.P.,Manivasager, V.,Hui, K.M.,Bay, B.H.,Tan, A.S.Z.,Olivo, M.,Soo, K.C. P (2005) hotoimmunotherapy of Murine Melanoma via Combination of Hypericin Photodynamic Therapy and in vivo stimulation of dendritic cells by pNGVL3-Flex Plasmid DNA.. 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Thong,P.S.P.,Olivo,M.,Kho,K.W., Harris,M.,Soo,K.C. (2005) Development of a laser confocal endomicroscope as a novel technique for in vivo fluorescence imaging of the oral cavity.. In: 7th annual NTU-SGH Symposium. Singapore: Conference Paper [Details] |
| Manivasager,V., Heng,W.S.P., Yee,K.K.L., Soo,K.C., Olivo, M. (2005) A comparison between 5-ALA and ALA methyl ester and exogenous PpIX and PpIX dimethyl ester in photodynamic diagnosis of epithelial cancers.. In: 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Lau,K.O.W., Kah, C.Y.J., Olivo, M. (2005) Image analysis of hypericin induced fluorescence used in pathological diagnosis of bladder cancer.. 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Kah,J.C.Y., Olivo, M., Lee, C.G.L., Sheppard, C.J.R. (2005) Antibody-conjugated gold nanoparticlees and its interaction with epithelial carcinoma cells for optical imaging.. In: Combined Scientific Meeting. Singapore: Conference Paper [Details] |
| Yee,K.K.L., Soo,K.C., Olivo, M. (2005) The effect of Hypericin-Photodynamic treatment in combination with Celebrex® evaluation in non-differentiated human nasopharyngeal carcinoma.. In: 10th World Congress of The International Photodynamic Association. Munich, Germany: Conference Paper [Details] |
| Du,H.Y., Olivo, M., Bay, B.H. (2004) Regulation of granulocyte-macrophage colony stimulating factor (GM-CSF), interleukine-6 (IL-6) and matrix metalloproteinase 9 (MMP-9) upon hypericin mediated photodynamic therapy (PDT) in vitro and in vivo.. In: 95th annual meeting of American association for cancer research (AACR) Orange county convention center. Orlando, Florida: Conference Paper [Details] |
| Soo,K.C., Thong, P.S.P., Kho, K.W., Olivo,M. (2004) Fotolon (TM) Photodynamic Therapy of Recurrent Angiosarcoma.. In: Singhealth Scientific Meeting - Medicine and Quality from Science to Practice. Singapore: Conference Paper [Details] |
| Ramaswamy,B., Chin, W.W.L., Olivo, M. (2004) Fotolon mediated photodynamic diagnosis and therapy.. In: China-Singapore Biomedical Science Conference. Kunming, Yunnan, China: Conference Paper [Details] |
| Chin,W.W.L., Lau, W., Cheng,C., Olivo, M. (2004) Evaluation of hypocrellin B in human bladder tumor model and its efficacy in photodynamic treatment (PDT).. In: Singapore urological association. Singapore: Conference Paper [Details] |
| Thong,P.S.P., Watt,F., Ren,M.Q., Soo, K.C., Olivo, M. (2004) Establishing the role of biological elements in Hypericin Photodynamic Therapy induced cell death using nuclear microscopy.. In: 9th International Conference on Nuclear Microprobe Technology and Applications. Conference Paper [Details] |
| Saw, L.L., Olivo,M., Soo, K.C., Heng, W.S.P. (2004) The photobleaching kinetics of hypericin in novel pharmaceutical formulations.. In: 5th international meeting on the photostability of drugs and drug products. London, UK;: Conference Paper [Details] |
| Ramaswamy, B., Soo, K.C., Manivasager, V.,Olivo, M. (2004) Photodynamic diagnosis and therapy studies on nasopharyngeal cells using novel photosensitizer Fotolon.. In: International symposium on new trends in PDT and PDD. Wroclaw, Poland: Conference Paper [Details] |
| Olivo,M., Lau, W., Manivasager, V., Bhuvaneswari, R., Cheng, C.,Tan, P.H. (2004) Ex-Vivo Fluorescence Cytology Using Hypericin, A Novel Agent.. In: Singapore Urological Association. Singapore: Conference Paper [Details] |
| Zheng,W.,Lau, W.,Cheng, C.,Soo, K.C.,Olivo, M. (2004) Autofluorescence excitation-emission spectroscopy for bladder cancer detection.. In: Singhealth scientific meeting - Medicine and Quality from Science to Practice Singapore. Conference Paper [Details] |
| Thong,P.S.P., Bay,B.H., Watt, F., Tan, P.H., Soo,K.C., Olivo M. (2004) A study on hypericin photodynamic therapy induced cell death: Novel complementary techniques used and initial results.. Acta Bio - Optica et Informatica Medica. Conference Paper [Details] |
| Zheng,W., Soo, K.C., Olivo, M. (2004) A combination of autofluorescence spectroscopy and diffuse reflectance spectroscopy detects subcutaneous tumors in mouse skin in vivo.. In: SPIE's Photonic West. San Jose, California, USA: Conference Paper [Details] |
| Lau,W.,Chin, W.W.L.,Saw, L.L.,Kho, K.W.,Olivo, M. (2004) Photodynamic induced vascular damage of the chick chorioallantoic membrane model using perylenequinones.. In: International symposium on new trends in PDT and PDD. Wroclaw, Poland: Conference Paper [Details] |
| Zheng,W., Soo, K.C., Olivo, M. (2004) Diagnosis of Oral neoplasia in vivo by digitized endoscopic imaging of 5 ALA-induced PpIX fluorescence.. In: SPIE's Photonic West. San Jose, California, USA: Conference Paper [Details] |
| Saw, L.L., Chin, W.W.L., Olivo, M., Soo, K.C.,Heng, W.S.P. (2004) Establishing a diffusion model for the development of topical pharmaceuticals in photodynamic therapy using hypericin in the chick chorioallantoic membrane model.. In: 31st Annual Meeting of the Controlled Release Society. Honolulu, Hawaii: Conference Paper [Details] |
| Sim,H.G., Lau, W., Olivo M., Tan P.H., Cheng,C. (2004) Is Photodynamic diagnosis using Hypericin better than white light cystoscopy in detection of superficial bladder carcinoma?. In: Singapore Urological Association. Singapore: Conference Paper [Details] |
| Olivo,M. (2004) Photodynamic diagnosis of cancer using fluorescence or autofluorescence.. In: International symposium on new trends in PDT and PDD Wroclaw. Poland: Conference Paper [Details] |
| Du,H.Y., Olivo, M., Bay, B.H. (2004) Hypericin mediated photodynamic therapy (PDT) on nasopharyngeal cancer (NPC) in vitro.. In: 8th Asia-pacific conference on electron microscopy. Kanazawa, Japan: Conference Paper [Details] |
| Tammilmani,V., Yee,K.K.L., Soo, K.C., Olivo, M. (2003) Cancer diagnosis using topical application of Protoporphyrin IX in head and neck xenografts.. In: 9th World Congress of the International Photodynamic Association. Miyazaki, Japan;: Conference Paper [Details] |
| Lau,W.K.O., Chin, W.W.L., Soo, K.C., Cheng, C., Olivo, M. (2003) In vivo biodistribution of hypocrellin B and its efficacy in photodynamic treatments (PDT).. In: SGH 14th annual scientific meeting. Conference Paper [Details] |
| Zheng, W., Soo, K.C., Olivo, M. (2003) Fluorescence excitation-emission spectroscopy for optical diagnosis of oral cancer.. In: 9th World Congress of the International Photodynamic Association. Miyazaki, Japan: Conference Paper [Details] |
| Chin,W.W.L., Lau, W., Cheng, C., Olivo, M. (2003) Biodistribution of hypocrellin B in a human bladder tumor model and its efficacy in photodynamic treatment.. In: 10th Congress of the European Society for Photobiology. Vienna, Austria: Conference Paper [Details] |
| Olivo,M., Ali,S.M., Soo, K.C. (2003) Photosensitization and mechanism of cell deaht induced by calphostin c.. In: 9th World Congress of the International Photodynamic Association. Miyazaki, Japan: Conference Paper [Details] |
| Lau,W., Chin, W.W.L., Cheng, C., Olivo, M. (2003) In Vivo Biodistribution of Hypocrellin B and its Efficacy in Photodynamic Treatments (PDT).. In: 12th Malaysian Urological Conference. Malaysia: Conference Paper [Details] |
| Yee,K.K,L.,Tammilmani, V., Soo, K.C., Bay, B.H., Olivo, M. (2003) A comparative study of PpIX and PpIX dimethyl ester effects in human nasopharyngeal carcinoma.. In: 10th Congress of the European Society for Photobiology. Vienna, Austria: Conference Paper [Details] |
| Du,H.Y., Olivo, M., Bay, B.H. (2003) Photodynamic therapy with hypericin downregulates matrix metalloproteinase 9 expression in nasopharyngeal carcinoma.. In: 2003 AACR Annual Meeting Washington Convention Center. Washington DC;: Conference Paper [Details] |
| Zheng, W., Lau, W., Cheng,C., Soo,K.C.,Olivo, M. (2003) Autofluorescence characteristics of normal and tumor. bladder tissue.. In: SPIE's Photonic West. San Jose, California, USA: Conference Paper [Details] |
| Du, HY., Olivo,M., Mahendran,R., Bay, B.H. (2003) Downregulation of matrix metalloproteinase-9 by hypericin-PDT in well-differentiated nasopharyngeal cancer cells (HK1).. In: 31st Annual Meeting of the American Society for Photobiology. Baltimore, Maryland, USA: Conference Paper [Details] |
| Yee,K.K.L., Moore,S.X.L., Soo, K.C., Olivo, M. (2003) Evaluation of Hypericin-PDT effects on human NPC/CNE-2 cell xenografts and its effects in angiogenesis.. In: 31st Annual Meeting of the American Society for Photobiology. Baltimore, Maryland, USA;: Conference Paper [Details] |
| Olivo,M.,Lau, W.,Manivasager,V.,Tan, P.H.,Soo,K.C.,Cheng, C. (2003) Macroscopic and microscopic fluorescence imaging of the human bladder cancer using hypericin as a photosensitizer.. In: 10th congress of the European Society for Photobiology. Vienna, Austria: Conference Paper [Details] |
| Lau,W., Chin, W.W.L., Cheng, C., Olivo, M. (2003) In vivo biodistribution of hypocrellin B and its efficacy in photodynamic treatment.. In: 9th World congress of The International Photodynamic Association. Miyazaki, Japan: Conference Paper [Details] |
| Lau,W., Chin, W.W.L., Cheng, C., Olivo, M. (2003) In Vivo Biodistribution of Hypocrellin B and its Efficacy in Photodynamic Treatments (PDT).. In: 2nd Asia-Pacific Society of Uro-Oncology Meeting. Hong Kong: Conference Paper [Details] |
| Zheng,W., Tay, S.K.,Soo, K.C., Olivo, M. (2002) Development and clinical applications of digitized fluorescence endoscopic imaging system for the detection of early neoplasms in the oral cavity and uterine-cervix.. In: SPIE The International Conference on Photonics West, Biomedical Optics. San Jose, California USA;: Conference Paper [Details] |
Invited papers
| Gustavsson,N., Lu, J, Olivo,M., Lee, P., Chuang, K-H., Golay, X., Radda, G.K., Han, W. (2008) In vivo detection of pancreatic ?-cell mass and insulin secretory events.. Abstract in The 7th International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2008), Wuhan, China, 2008 (Invited talk). Invited papers [Details] |
Workshops
| Olivo, M. (2010) Nanobiophotonics in Cancer. Dublin City University. Workshops [Details] |
| Olivo, M. (2010) Photodynamic Therapy-Mediated Anti-Tumor Immune Response. Invitation to speak at the 3rd World Cancer Congress Singapore. Workshops [Details] |
| Olivo, M. (2010) Nanophotonics in Photomedicine. Royal College of Surgeons Ireland (RCSI), -Biophotonics in Diagnostics and Therapeutics. Workshops [Details] |
| Olivo, M. (2010) Nanobiophotonics in Diagnostics and Therapeutics. Medical Devices Conference. Galway: Workshops [Details] |
| Olivo, M. (2009) Biophotonics for cancer detection.. Princess Margaret Cancer Center. University of Toronto, Canada: Workshops [Details] |
| Olivo, M. (2009) Nanoscale Biophotonics.. National Nanoscience Conference, Tyndall Institute. Cork, Ireland: Workshops [Details] |
| Olivo, M. (2008) In vivo Cellular imaging and optical molecular imaging.. Singapore Biomaging Consortium workshop on molecular imaging in cancer: cells to man. Workshops [Details] |
| Olivo, M. (2008) Photodetection of Cancer with Fluorescence and Non-Fluorescent.. Nano-Gold IEEE Photonics Global. Workshops [Details] |
| Olivo, M. (2008) MEMS optical probe for cancer disgnostics using optical coherence tomography.. Inaugural A star scientific conference. Workshops [Details] |
| Olivo, M. (2008) Trends in Biophotonics in cancer detection and therapy.. Wellman Center of Photomedicine. Harvard Medical School, USA: Workshops [Details] |
| Olivo, M. (2007) Photonics initiatives in novel cancer detection and photodynamic therapy.. NTU and Northwestern University Collaboration. Workshops [Details] |
| Olivo, M. (2006) Novel Strategies in Cancer Detection and Therapy using Light-induced Drugs and Bio-optical Imaging.. 8th Singapore Pharmacy Congress. Workshops [Details] |
| Olivo, M. (2005) Is photodynamic diagnosis using ALA induced PPIX fluorescence better then white light for the detection of pre-malignant and malignant lesions in the oral cavity?. PDT World Congress. Munich: Workshops [Details] |
| Olivo, M. (2004) Photodynamic diagnosis of cancer using fluorescence or autofluorescence.. International Symposium on new trends in photodynamic therapy and diagnosis Wroclaw Poland. Workshops [Details] |