Dr. Adrienne Gorman

BA (MOD) Biochemistry, PhD Biochemistry

Contact Details

Lecturer
Apoptosis Research Centre
Bioscience Research Building
Newcastle Road, Dangan
NUI Galway

T: Ext. 2417
E: adrienne.gorman@nuigalway.ie
 
researcher

Biography

Education and qualifications
BAMod Biochemistry Trinity College Dublin
PhD Biochemistry Trinity College Dublin

Appointments
Vice-Dean for Research in College of Science, since 2013
Lecturer, NUI Galway since 2000
Post-doctoral research fellow, Karolinska Institutet, Stockholm Sweden
Post-doctoral researcher, University College Cork, Ireland
Marie Curie Post-doctoral research fellow, University of St Andrews, Scotland

Research Interests
Cell stress and cell death; Cell survival mechanisms; Endoplasmic reticulum stress; Unfolded protein response; Heat shock proteins; Proteostasis 

Peer Reviewed Journals

  Year Publication
(2013) 'Current concepts in ER stress-induced apoptosis'
13. Logue SE, Gorman AM, Cleary P, Keogh N, Samali A (2013) 'Current concepts in ER stress-induced apoptosis'. Journal of Carcinogenesis & Mutagenesis, S6 :1-7 [DOI] [Details]
(2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'
Devisscher, L;Vieri, M;Logue, SE;Panse, J;Geerts, A;Van Vlierberghe, H;Chevet, E;Gorman, AM;Samali, A;Masouleh, BK (2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'. Pharmacology & Therapeutics, 167 :1-12 [DOI] [Details]
(2016) 'Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells'
Chakravarthy, R,Mnich, K,Gorman, AM (2016) 'Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells'. Biochemical And Biophysical Research Communications, 478 :1541-1547 [DOI] [Details]
(2016) 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)'
Klionsky DJ;Abdelmohsen K;Abe A et al. (2016) 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)'. Autophagy, 12 (1) [DOI] [Details]
(2016) 'Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells'
Chakravarthy R;Mnich K;Gorman AM; (2016) 'Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells'. Biochemical And Biophysical Research Communications, 478 (4) [DOI] [Details]
(2016) 'The integrated stress response'
Pakos-Zebrucka K;Koryga I;Mnich K;Ljujic M;Samali A;Gorman AM; (2016) 'The integrated stress response'. Embo Reports, 17 (10) [DOI] [ARAN Link] [Details]
(2016) 'Neurotrophins and B-cell malignancies'
Hillis, J,O'Dwyer, M,Gorman, AM (2016) 'Neurotrophins and B-cell malignancies'. Cell Mol Life Sci, 73 :41-56 [DOI] [Details]
(2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'
Devisscher L;Vieri M;Logue SE;Panse J;Geerts A;van Vlierberghe H;Chevet E;Gorman AM;Samali A;Kharabi Masouleh B; (2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'. Pharmacology & Therapeutics, [DOI] [Details]
(2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'
Deegan, S,Koryga, I,Glynn, SA,Gupta, S,Gorman, AM,Samali, A (2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'. Biochemical And Biophysical Research Communications, 456 :305-311 [DOI] [Details]
(2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'
Mnich, K,Carleton, LA,Kavanagh, ET,Doyle, KM,Samali, A,Gorman, AM (2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'. Cell Death & Disease, 5 [DOI] [ARAN Link] [Details]
(2014) 'Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease'
Moloney, TC,Hyland, R,O'Toole, D,Paucard, A,Kirik, D,O'Doherty, A,Gorman, AM,Dowd, E (2014) 'Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease'. Cns Neuroscience & Therapeutics, 20 :50-58 [DOI] [Details]
(2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'
Cawley K, Logue SE, Gorman AM, Zeng Q, Patterson J, Gupta S, Samali A (2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'. Plos One, 8 (8) [DOI] [Details]
(2013) 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'
Toner, AP;McLaughlin, F;Giles, FJ;Sullivan, FJ;O'Connell, E;Carleton, LA;Breen, L;Dunne, G;Gorman, AM;Lewis, JD;Glynn, SA (2013) 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'. British Journal Of Cancer, 109 :2131-2141 [DOI] [Details]
(2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'
Cawley K;Logue SE;Gorman AM;Zeng Q;Patterson J;Gupta S;Samali A; (2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'. Plos One, 8 (8) [DOI] [Details]
(2013) 'The eIF2 alpha kinases: their structures and functions'
Donnelly, N,Gorman, AM,Gupta, S,Samali, A (2013) 'The eIF2 alpha kinases: their structures and functions'. Cell Mol Life Sci, 70 :3493-3511 [DOI] [Details]
(2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'
Deegan S, Saveljeva S, Gorman AM, Samali A (2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'. Cellular And Molecular Life Sciences, 70 (14):2425-2441 [DOI] [Details]
(2013) 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'
Toner, AP,McLaughlin, F,Giles, FJ,Sullivan, FJ,O'Connell, E,Carleton, LA,Breen, L,Dunne, G,Gorman, AM,Lewis, JD,Glynn, SA (2013) 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'. British Journal Of Cancer, 109 :2131-2141 [DOI] [Details]
(2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'
Gorman AM, Healy SJ, Jäger R, Samali A (2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'. Pharmacology & therapeutics, 134 (3):306-316 [DOI] [Details]
(2012) 'The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress'
Jäger R, Bertrand MJ, Gorman AM, Vandenabeele P, Samali A (2012) 'The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress'. Biology of the Cell, 104 (5):259-270 [DOI] [Details]
(2011) 'Nerve growth factor in cancer cell death and survival'
Molloy NH, Read DE, Gorman AM (2011) 'Nerve growth factor in cancer cell death and survival'. Cancers, 3 :510-530 [ARAN Link] [Details]
(2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A (2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'. Journal Of Cellular And Molecular Medicine, 15 (10):2025-2039 [DOI] [Details]
(2010) 'Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat'
Walsh, S,Mnich, K,Mackie, K,Gorman, AM,Finn, DP,Dowd, E (2010) 'Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat'. Brain Research Bulletin, 81 :543-548 [DOI] [Details]
(2010) 'The effect of laminin gradient of enzymatically cross-linked collagen scaffold on neurite growth'
Yao L, Damodaran G, Nikolskaya N, Gorman AM, Windebank A, Pandit A (2010) 'The effect of laminin gradient of enzymatically cross-linked collagen scaffold on neurite growth'. J Biomedical Materials Res, 92 :484-492 [Details]
(2010) 'The Effect of Laminin Peptide Gradient in Enzymatically Cross-linked Collagen Scaffolds on Neurite Growth'
Yao, L,Damodaran, G,Nikolskaya, N,Gorman, AM,Windebank, A,Pandit, A (2010) 'The Effect of Laminin Peptide Gradient in Enzymatically Cross-linked Collagen Scaffolds on Neurite Growth'. Journal Of Biomedical Materials Research Part A, 92A :484-492 [DOI] [Details]
(2010) 'Cell stress and cell death'
Samali A, Fulda S, Gorman AM, Hori O, Srinivasula SM. (2010) 'Cell stress and cell death'. Int J Cell Biol, 2010 :245803-2pp [Details]
(2010) 'Cellular Stress Responses: cell survival and cell death'
Fulda S, Gorman AM, Hori O, Samali A. (2010) 'Cellular Stress Responses: cell survival and cell death'. Int J Cell Biol, [DOI] [Details]
(2010) 'Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells'
Mnich, K., Finn, D., Dowd, E., & Gorman, A. (2010) 'Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells'. International Journal Of Cell Biology, 818497 [ARAN Link] [Details]
(2009) 'Effect of Functionalised Micropatterned PLGA Scaffold on Guided Neurite Growth'
Yao, L., Wang, S., Cui, W., Sherlock, R., O'Connell, C., Damodaran, G., Gorman, A., Windebank, A. and Pandit, A. (2009) 'Effect of Functionalised Micropatterned PLGA Scaffold on Guided Neurite Growth'. ACTA BIOMATERIALIA, 5 (2):580-588 [DOI] [Details]
(2009) 'Heat shock protein 27 in neuronal survival and neurite outgrowth'
Read, D. E.,Gorman, A. M. (2009) 'Heat shock protein 27 in neuronal survival and neurite outgrowth'. Biochemical And Biomedical Research Communications, 382 (11):6-8 [Details]
(2009) 'Considerations and recent advances in neuroscience'
Gorman, A. M.,Doyle, K. M. (2009) 'Considerations and recent advances in neuroscience'. Biochemical Society Transactions, 37 :299-302 [Details]
(2009) 'Involvement of Akt in neurite outgrowth'
Read DE, Gorman AM (2009) 'Involvement of Akt in neurite outgrowth'. Cell Mol Life Sci, 66 :2975-2984 [Details]
(2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'
Healy, SJM,Gorman, AM,Mousavi-Shafaei, P,Gupta, S,Samali, A (2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'. European Journal Of Pharmacology, 625 :234-246 [DOI] [Details]
(2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'
Szegezdi E, Herbert KR, Kavanagh ET, Samali A, Gorman AM (2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'. Journal Of Cellular And Molecular Medicine, 12 (6A):2482-2496 [DOI] [Details]
(2008) 'Heat shock enhances NGF-induced neurite elongation which is not mediated by Hsp25 in PC12 cells'
Read DE, Reed Herbert K, Gorman AM (2008) 'Heat shock enhances NGF-induced neurite elongation which is not mediated by Hsp25 in PC12 cells'. Brain Research, 1221 :14-23 [Details]
(2008) 'Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling'
Gorman AM (2008) 'Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling'. J Cell Mol Med, 12 :2263-2280 [ARAN Link] [Details]
(2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'
Ni Chonghaile, T,Concannon, CG,Szegezdi, E,Gorman, AM,Samali, A (2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'. Apoptosis, 11 :1247-1255 [DOI] [Details]
(2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'
Kavanagh ET, Loughlin JP, Herbert KR, Dockery P, Samali A, Doyle KM, Gorman AM (2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'. Biochem, 351 (4):890-895 [DOI] [Details]
(2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'
Szegezdi E, Logue SE, Gorman AM, Samali A (2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'. Embo Reports, 7 (9):880-885 [DOI] [Details]
(2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochem. Biophys. Res. Commun, 327 :801-810 [Details]
(2005) 'Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells'
Gorman AM, Szegezdi E, Quigney DJ, Samali A (2005) 'Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells'. Biochem, 327 (3):801-810 [DOI] [Details]
(2005) 'Hypoxia induces neurite outgrowth in PC12 cells that is mediated through adenosine A2A receptors'
O'Driscoll, CM,Gorman, AM (2005) 'Hypoxia induces neurite outgrowth in PC12 cells that is mediated through adenosine A2A receptors'. Neuroscience, 131 :321-329 [Details]
(2003) 'Heat shock protects PC12 cells against MPP+ toxicity'
Quigney, DJ,Gorman, AM,Samali, A (2003) 'Heat shock protects PC12 cells against MPP+ toxicity'. Brain Research, 993 :133-139 [DOI] [Details]
(2003) 'On the role of Hsp27 in regulating apoptosis'
Concannon CG, Gorman AM, Samali A (2003) 'On the role of Hsp27 in regulating apoptosis'. Apoptosis, 8 :61-70 [Details]
(2002) 'Cellular longevity: role of apoptosis and replicative senescence'
Bree RT Stenson C Grealy M Byrnes L Gorman AM Samali A (2002) 'Cellular longevity: role of apoptosis and replicative senescence'. Biogerontology, 3 :195-206 [Details]
(2002) 'Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure'
Wu, JM,Gorman, A,Zhou, XH,Sandra, C,Chen, E (2002) 'Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure'. Investigative Ophthalmology & Visual Science, 43 :3349-3354 [Details]
(2001) 'Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons'
Daré E, Gorman AM, Ahlbom E, Götz M, Momoi T, Ceccatelli S (2001) 'Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons'. Neurotoxicity Research, 3 :501-514 [Details]
(2000) 'Role of mitochondria in neuronal apoptosis'
Gorman AM, Ceccatelli S, Orrenius S. (2000) 'Role of mitochondria in neuronal apoptosis'. Developmental Neuroscience, 22 :348-358 [ARAN Link] [Details]
(2000) 'Dexamethasone pre-treatment interferes with apoptotic death in glioma cells'
Gorman AM, Hirt UA, Orrenius S, Ceccatelli S. (2000) 'Dexamethasone pre-treatment interferes with apoptotic death in glioma cells'. Neurosci, 96 :417-425 [Details]
(1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'
Gorman, AM,Heavey, B,Creagh, E,Cotter, TG,Samali, A (1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'. Febs Letters, 445 :98-102 [Details]
(1999) 'Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells'
Gorman A, Bonfoco E, Zhivotovsky B, Orrenius S, Ceccatelli S. (1999) 'Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells'. Eur. J. Neurosci, 11 :1067-1073 [Details]
(1999) 'Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo'
Gorman AM, Hirt UA, Orrenius S, Ceccatelli S. (1999) 'Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo'. J. Immunol. Methods, 226 :43-48 [Details]
(1998) 'Apoptosis in neuronal cells: Role of caspases'
Gorman A, Orrenius S, Ceccatelli S. (1998) 'Apoptosis in neuronal cells: Role of caspases'. NeuroReport, 9 :R49-R55 [Details]
(1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'
Gorman, AM,Samali, A,McGowan, AJ,Cotter, TG (1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'. Cytometry, 29 :97-105 [Details]
(1997) 'Role of peroxide and superoxide anion during tumour cell apoptosis'
Gorman, A,McGowan, A,Cotter, TG (1997) 'Role of peroxide and superoxide anion during tumour cell apoptosis'. Febs Letters, 404 :27-33 [Details]
(1997) 'Role of peroxide and superoxide anion during tumour cell apoptosis'
Gorman A, McGowan A, Cotter TG. (1997) 'Role of peroxide and superoxide anion during tumour cell apoptosis'. FEBS Lett, 404 :27-33 [Details]
(1997) 'Role of Bcr-Abl kinase in resistance to apoptosis'
Samali A, Gorman AM, Cotter TG (1997) 'Role of Bcr-Abl kinase in resistance to apoptosis'. Advances in pharmacology (San Diego, Calif.), 41 :533-552 [Details]
(1996) 'Oxidative stress and apoptosis in neurodegeneration'
Gorman A, McGowan A, Cotter TG. (1996) 'Oxidative stress and apoptosis in neurodegeneration'. J. Neurol. Sci, 139 :45-52 [Details]
(1996) 'The role of proteases, PARP and free radicals during apoptosis of several leukemic cell lines'
McGowan A, Ruiz-Ruiz MC, Gorman A, Lopez-Rivas A, Cotter TG. (1996) 'The role of proteases, PARP and free radicals during apoptosis of several leukemic cell lines'. FEBS Lett, 392 :299-303 [Details]
(1996) 'Apoptosis -- the story so far'
Samali A, Gorman AM, Cotter TG (1996) 'Apoptosis -- the story so far'. Experientia, 52 (10-11):933-941 [Details]
(1996) 'Reactive oxygen intermediate(s) (ROI): Common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis'
McGowan, AJ,RuizRuiz, MC,Gorman, AM,LopezRivas, A,Cotter, TG (1996) 'Reactive oxygen intermediate(s) (ROI): Common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis'. Febs Letters, 392 :299-303 [Details]
(1996) 'The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia'
Fernandes RS, Gorman AM, McGahon A, Lawlor M, McCann S, Cotter TG. (1996) 'The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia'. Leukaemia, 10 :S17-S21 [Details]
(1995) 'Excitatory amino acid-induced cytotoxicity in primary cultures of mouse cerebellar granule cells correlates with elevated, sustained c-fos protooncogene expression'
Gorman A, Scott MP, Rumbsby PC, Meredith C, Griffiths R. (1995) 'Excitatory amino acid-induced cytotoxicity in primary cultures of mouse cerebellar granule cells correlates with elevated, sustained c-fos protooncogene expression'. Neurosci. Lett, 191 :116-120 [Details]
(1995) 'Modulation by ionotropic excitatory amino acids and K+ of trans-ACPD stimulated phosphoinositide hydrolysis in mouse cerebellar granule cells'
Gorman A, Grieve A, Griffiths R. (1995) 'Modulation by ionotropic excitatory amino acids and K+ of trans-ACPD stimulated phosphoinositide hydrolysis in mouse cerebellar granule cells'. J. Neurochem, 65 :2473-2483 [Details]
(1994) 'Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors'
Gorman A, Griffiths R. (1994) 'Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors'. Neuroscience, 59 :299-308 [Details]
(1994) 'L-Trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters'
Griffiths R, Dunlop J, Gorman A, Senior J, Grieve A. (1994) 'L-Trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters'. Biochem. Pharmacol, 47 :267-272 [Details]
(1992) 'The effects of the peripheral-type benzodiazepine acceptor ligands, Ro-5-4864 and PK-11195, on mitochondrial respiration'
Zisterer DM, Gorman A, Williams DC, Murphy MP. (1992) 'The effects of the peripheral-type benzodiazepine acceptor ligands, Ro-5-4864 and PK-11195, on mitochondrial respiration'. Methods and Findings in Experimental and Clinical Pharmacology, 14 :85-90 [Details]
(1990) 'In vitro screening for anticonvulsant-induced teratogenesis in neural primary cultures and cell lines. Preliminary observations'
Regan CM, Gorman A, Larsson OM, Maguire C, Martin ML, Schousboe A, Williams DC. (1990) 'In vitro screening for anticonvulsant-induced teratogenesis in neural primary cultures and cell lines. Preliminary observations'. Int. J. Devl. Neuroscience, 8 :143-150 [Details]
(1989) 'Antiproliferative actions of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor'
Gorman A, O'Beirne G, Regan C, Williams DC. (1989) 'Antiproliferative actions of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor'. J. Neurochem, 53 :849-855 [Details]

Book Chapters

  Year Publication
(2015) 'Induction of autophagy: Role of endoplasmic reticulum stress and unfolded protein response'
Yeganeh B, Jäger R, Gorman AM, Samali A, Ghavami S (2015) 'Induction of autophagy: Role of endoplasmic reticulum stress and unfolded protein response' In: AUTOPHAGY. CANCER, OTHER PATHOLOGIES, INFLAMMATION, IMMUNITY AND INFECTION. Netherlands: Elsevier Inc. [Details]
(2006) 'Heat shock proteins and the regulation of apoptosis'
Fitzgerald, U, Gorman AM, Samali A. (2006) 'Heat shock proteins and the regulation of apoptosis' In: Heat Shock Proteins in Neural Cells. TX, USA: Landes Bioscience. [Details]
(2006) 'The role of heat shock proteins in neuronal differentiation and development'
Reed Herbert K, Samali A, Gorman AM. (2006) 'The role of heat shock proteins in neuronal differentiation and development' In: Heat Shock Proteins in Neural Cells. TX, USA: Landes Bioscience. [Details]
(1996) 'Morphological assessment of apoptosis'
Gorman A, McCarthy J, Finucane D, Reville W, Cotter T. (1996) 'Morphological assessment of apoptosis' In: Techniques in Apoptosis: A User's Guide. [Details]

Conference Publications

  Year Publication
(2014) Irish Association for Cancer Research
Toner, AP; Giles, FJ; Carleton, LA; O’Connell, E; Harte, E; Breen, L; Dunne. G; Clynes, M; Lewis, JD; Gorman, AM; Sullivan, FJ; Glynn, SA. (2014) Characterisation of a new class of prostate cancer chemotherapeutics Irish Association for Cancer Research [Details]
(2013) British Association of Urological Surgeons AGM
Toner, AP; McLaughlin, F; Giles, FJ; Sullivan, FJ; O’Connell, E; Carleton, LA; Breen, L; Gorman , AM; Lewis, JD and Glynn, SA. (2013) Introducing Novel Toluidine Sulphonamide EL102: A Potential Chemotherapeutic In Prostate Cancer British Association of Urological Surgeons AGM [Details]
(2011) Irish Journal of Medical Science
Walsh S, Finn DP, Gorman AM and Dowd E. (2011) The effect of pharmacological activation or blockade of the endocannabinoid system on the development of levodopa-induced dyskinesias in a rat model Irish Journal of Medical Science , pp.180: 20-20 [Details]
(2011) Neuroscience Ireland 2011
Walsh S, Mnich K, Finn DP, Gorman AM, Mackie K, Dowd E. (2011) Expression of the cannabinoid CB1 receptor is decreased in the ipsilateral substantia nigra in hemi-parkinsonian rats Neuroscience Ireland 2011 , pp.S192-pp19 [Details]
(2011) Irish Journal of Medical Science
Hyland, R., A.M. Gorman, A. O'Doherty, and Dowd, E. (2011) HEAT SHOCK PROTEIN GENE THERAPY IN THE ALPHA-SYNUCLEIN VIRAL GENE TRANSFER RAT MODEL OF PARKINSON'S DISEASE Irish Journal of Medical Science , pp.180: 18-19 [Details]
(2010) Neuroscience Ireland 2010
Walsh S, Finn DP, Gorman AM and Dowd E. T (2010) The effect of pharmacological activation or blockade of the endocannabinoid system on the development of levodopa-induced dyskinesias in a rat model Neuroscience Ireland 2010 [Details]
(2009) Neuroscience Ireland 2009
Walsh S, Mnich K, Finn DP, Gorman AM, Mackie K, Dowd E (2009) Cannabinoid CB1 receptor expression is reduced following terminal lesion of the nigrostriatal pathway in the rat Neuroscience Ireland 2009 , pp.2-44 [Details]
(2009) Considerations and recent advances in neuroscience
Gorman, AM,Doyle, KM (2009) BIOCHEMICAL SOCIETY TRANSACTIONS Considerations and recent advances in neuroscience , pp.299-302 [DOI] [Details]
(2008) NeuroScience Ireland
Yao L., O'Brien N., O'Connell C., Sherlock R., Damodaran A., Gorman A., Wang S., Windebank A., Pandit A. (2008) The use of Biomaterials structural and functional cues for neural regeneration NeuroScience Ireland [Details]
(1996) Oxidative stress and apoptosis in neurodegeneration
Gorman, AM,McGowan, A,ONeill, C,Cotter, T (1996) JOURNAL OF THE NEUROLOGICAL SCIENCES Oxidative stress and apoptosis in neurodegeneration , pp.45-52 [Details]
(1996) The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia
Fernandes, RS,Gorman, AM,McGahon, A,Lawlor, M,McCann, S,Cotter, TG (1996) LEUKEMIA The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia , pp.17-21 [Details]

Other Journals

  Year Publication
(2009) 'Considerations and recent advances in neuroscience. Meeting report of 2nd Neuroscience Ireland Conference'
Doyle KM, Gorman AM (2009) 'Considerations and recent advances in neuroscience. Meeting report of 2nd Neuroscience Ireland Conference' Biochem Soc Trans, 37 :299-302. [Details]
(2008) 'Considerations and recent advances in neuroscience'
Doyle KM, Gorman AM (2008) 'Considerations and recent advances in neuroscience' Biochem Soc Trans, 37 :299-302. [Details]
(2006) 'Helping keep our neurons alive with neurotrophins'
Gorman AM (2006) 'Helping keep our neurons alive with neurotrophins' The Irish Scientist Yearbook, 14 . [Details]
(1999) 'Challenging the dogmas'
Gorman AM, Zhivotovsky B. (1999) 'Challenging the dogmas' Cell Death Diff, 6 :207-211. [Details]

Conference Contributions

  Year Publication
(2010) Apoptosis Symposium,
Gorman A, Szegezdi E, Samali A. (2010) A one day international meeting of researchers in Galway, 2010. [Conference Organising Committee Member], Apoptosis Symposium, Galway , 20-AUG-10 - 20-AUG-10. [Details]

Abstract

  Year Publication
(2014) Further preclinical assessment of compound EL102 in the treatment of prostate cancer.
Toner, AP,Giles, FJ,Sullivan, F,Harte, E,Carleton, LA,Gorman, AM,Lewis, J,Glynn, SA (2014) Further preclinical assessment of compound EL102 in the treatment of prostate cancer. Abstract [Details]
(2011) Expression of genes related to neurotrophin signalling in breast cancer - in search of novel therapeutic techniques.
Helen, E,Healy, N,Gorman, A,Miller, N,Kerin, MJ (2011) Expression of genes related to neurotrophin signalling in breast cancer - in search of novel therapeutic techniques. Abstract [Details]
(2011) NERVE GROWTH FACTOR MEDIATES ACTIVE CASPASE-3 TURNOVER IN APOPTOTIC PC12 CELLS.
Carleton, LA,Mnich, K,Kavanagh, ET,Doyle, K,Samali, A,Gorman, AM (2011) NERVE GROWTH FACTOR MEDIATES ACTIVE CASPASE-3 TURNOVER IN APOPTOTIC PC12 CELLS. Abstract [Details]
(2011) HEAT SHOCK PROTEIN GENE THERAPY IN THE ALPHA-SYNUCLEIN VIRAL GENE TRANSFER RAT MODEL OF PARKINSON'S DISEASE.
Hyland, R,Gorman, AM,O'Doherty, A,Dowd, E (2011) HEAT SHOCK PROTEIN GENE THERAPY IN THE ALPHA-SYNUCLEIN VIRAL GENE TRANSFER RAT MODEL OF PARKINSON'S DISEASE. Abstract [Details]
(2011) THE EFFECT OF PHARMACOLOGICAL ACTIVATION OR BLOCKADE OF THE ENDOCANNABINOID SYSTEM ON THE DEVELOPMENT OF LEVODOPA-INDUCED DYSKINESIAS IN A RAT MODEL.
Walsh, S,Finn, DP,Gorman, AM,Dowd, E (2011) THE EFFECT OF PHARMACOLOGICAL ACTIVATION OR BLOCKADE OF THE ENDOCANNABINOID SYSTEM ON THE DEVELOPMENT OF LEVODOPA-INDUCED DYSKINESIAS IN A RAT MODEL. Abstract [Details]
(2007) Laminin peptide gradient in a collagen scaffold shows guidance effect on neurite growth. Tissue Eng.
Yao L, Damodaran G, Natalia N, Gorman A, Windebank A, Pandit A. (2007) Laminin peptide gradient in a collagen scaffold shows guidance effect on neurite growth. Tissue Eng. Abstract [Details]
(2007) Laminin peptide gradient in a collagen scaffold shows guidance effect on neurite growth.
Yao, L,Damodaran, G,Natalia, N,Gorman, A,Windebank, A,Pandit, A (2007) Laminin peptide gradient in a collagen scaffold shows guidance effect on neurite growth. Abstract [Details]
(2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Gordon Research Conference on Signal Transduction by Engineered Extracellular Matrices.
Yao L, Damodaran G, Nikolskaya N, Gorman A, Windebank AJ, Pandit A. (2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Gordon Research Conference on Signal Transduction by Engineered Extracellular Matrices. Connecticut College, New London, CT: Abstract [Details]

Conference Paper

  Year Publication
(2007) Laminin Peptide Gradient in a Collagen Scaffold Shows Guidance Effect on Neurite Growth. Tissue Engineering and Regenerative Medicine International Society Meeting.
Yao, L., Damodaran, G., Natalia, N., Gorman, A., Windebank, A., and Pandit, A. (2007) Laminin Peptide Gradient in a Collagen Scaffold Shows Guidance Effect on Neurite Growth. Tissue Engineering and Regenerative Medicine International Society Meeting. London, U.K: Conference Paper [Details]

Conference Poster

  Year Publication
(2008) The Use of Biomaterials Structural and Functional Cues for Neural Regeneration. Neuroscience Ireland.
Yao, L., O'Brien, N., O'Connell, C., Sherlock, R., Damodaran, G., Gorman, A., Wang, S., Windebank, W. and Pandit, A. (2008) The Use of Biomaterials Structural and Functional Cues for Neural Regeneration. Neuroscience Ireland. Galway, Ireland: Conference Poster [Details]
(2008) Functionalised Biodegradable Polymer Scaffold for Nerve Regeneration. 5th Tissue Engineering Symposium.
O' Connell, C., Yao, L., Sherlock, R., Cui, C., Damodaron, G., Gorman, A., Windebank, A., Wang, S.G. and Pandit, A. (2008) Functionalised Biodegradable Polymer Scaffold for Nerve Regeneration. 5th Tissue Engineering Symposium. Tampere, Finland: Conference Poster [Details]
(2007) Functionalised Microchannels Guide Neurite Growth on a PLGA Scaffold. 21st European Conference on Biomaterials.
Yao, L., Cui, WJ., Sherlock, R., O'Connell, C., Damodaran, G., Gorman, A., Windebank, A., Wang, S.G., and Pandit, A. (2007) Functionalised Microchannels Guide Neurite Growth on a PLGA Scaffold. 21st European Conference on Biomaterials. Brighton, U.K: Conference Poster [Details]
(2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Gordon Research Conference on Signal Transduction through Engineered Matrices.
Yao, L., Damodaran, G., Nikolskaya, N., Gorman, A., Windebank, A., and Pandit, A. (2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Gordon Research Conference on Signal Transduction through Engineered Matrices. New London, Connecticut: Conference Poster [Details]
(2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Tissue Engineering and Regenerative Medicine International Society Meeting.
Yao, L., Damodaran, G., Nikolskaya, N., Gorman, A., Windebank, A.J., and Pandit, A. (2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Tissue Engineering and Regenerative Medicine International Society Meeting. Rotterdam: Conference Poster [Details]

Editorial

  Year Publication
(2010) Cell Stress and Cell Death. International Journal of Cell Biology.
Afshin Samali, Simone Fulda, Adrienne M. Gorman, Osamu Hori, and Srinivasa M. Srinivasula (2010) Cell Stress and Cell Death. International Journal of Cell Biology. Editorial [DOI] [Details]

Meeting

  Year Publication
(2013) HSP70 reduces alpha-synuclein-induced neuronal pathology in the alpha-synuclein viral gene transfer rat model of Parkinson's disease.
Moloney, T,Hyland, R,O'Toole, D,Paucard, A,Kirik, D,Doherty, AO,Gorman, A,Dowd, E (2013) HSP70 reduces alpha-synuclein-induced neuronal pathology in the alpha-synuclein viral gene transfer rat model of Parkinson's disease. Meeting [Details]
(2010) CANNABINOID CB1 RECEPTOR EXPRESSION IS REDUCED FOLLOWING TERMINAL LESION OF THE NIGROSTRIATAL PATHWAY IN THE RAT.
Walsh, S,Mnich, K,Finn, DP,Gorman, AM,Mackie, K,Dowd, E (2010) CANNABINOID CB1 RECEPTOR EXPRESSION IS REDUCED FOLLOWING TERMINAL LESION OF THE NIGROSTRIATAL PATHWAY IN THE RAT. Meeting [Details]
(2009) Analysis of cellular environment of spinal cord lesion following transplantation of neural stem cells into injured rat spinal cord.
Hynes, J,Bourke, E,Deering, EM,Doherty, G,Murray, A,Dockery, P,Doyle, K,Gorman, A,Barry, FP,McMahon, SS (2009) Analysis of cellular environment of spinal cord lesion following transplantation of neural stem cells into injured rat spinal cord. Meeting [Details]
(2001) Involvement of caspase-3 in photoreceptor apoptosis induced by blue light exposure.
Chen, E,Wu, J,Gorman, A,Zhou, X,Sandra, C (2001) Involvement of caspase-3 in photoreceptor apoptosis induced by blue light exposure. Meeting [Details]

Reviews

  Year Publication
(2013) Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress.
Deegan, S;Saveljeva, S;Gorman, AM;Samali, A (2013) Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress. BASEL: Reviews [DOI] [Details]
(2012) Stress management at the ER: Regulators of ER stress-induced apoptosis.
Gorman, AM,Healy, SJM,Jager, R,Samali, A (2012) Stress management at the ER: Regulators of ER stress-induced apoptosis. Reviews [DOI] [Details]
(2011) Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders.
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A. (2011) Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders. Reviews [Details]
(2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
Doyle, KM,Kennedy, D,Gorman, AM,Gupta, S,Healy, SJM,Samali, A (2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. Reviews [DOI] [Details]
(2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy.
Healy, SZ, Gorman, AM, Mousavi-Shafaei, P, Gupta, S, Samali, A. (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. Reviews [Details]
(2009) Heat shock protein 27 in neuronal survival and neurite outgrowth.
Read, DE,Gorman, AM (2009) Heat shock protein 27 in neuronal survival and neurite outgrowth. Reviews [DOI] [Details]
(2009) Involvement of Akt in neurite outgrowth.
Read, DE,Gorman, AM (2009) Involvement of Akt in neurite outgrowth. Reviews [DOI] [Details]
(2008) Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling.
Gorman, AM (2008) Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. Reviews [DOI] [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep.
Szegezdi E., Logue S.E., Gorman A.M., Samali A. (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. Reviews [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis.
Szegezdi, E,Logue, SE,Gorman, AM,Samali, A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. Reviews [DOI] [Details]
(2003) On the role of Hsp27 in regulating apoptosis.
Concannon, CG,Gorman, AM,Samalli, A (2003) On the role of Hsp27 in regulating apoptosis. Reviews [Details]
(2003) On the role of Hsp27 in regulating apoptosis. Apoptosis.
Concannon C.G., Gorman A.M., Samali A. (2003) On the role of Hsp27 in regulating apoptosis. Apoptosis. Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescence.
Bree, RT,Stenson-Cox, C,Grealy, M,Byrnes, L,Gorman, AM,Samali, A (2002) Cellular longevity: role of apoptosis and replicative senescence. Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescenece. Biogerontology.
Bree RT, Stenson C, Grealy M, Byrnes L, Gorman AM and Samali A (2002) Cellular longevity: role of apoptosis and replicative senescenece. Biogerontology. Reviews [Details]
(1996) Apoptosis - The story so far .
Samali, A,Gorman, AM,Cotter, TG (1996) Apoptosis - The story so far . Reviews [Details]