Dr Erica Burnell

BSc., PhD

Contact Details

Lecturer (Fixed Term)
E: ERICA.BURNELL@nuigalway.ie
 
researcher

Biography

2017 - present         Lecturer in Medicinal Chemistry, NUI Galway
2014 - 2017              Research Associate (Prof David Jane), University of Bristol
2009 - 2014              PhD in Organic Chemistry (Prof Jim Thomas), University of Manchester
2007 - 2008              Research Chemist (industrial placement), Boehringer Ingelheim, Germany 
2005 - 2009               BSc in Medicinal Chemistry, Queen's University Belfast

Research Interests

My research interests lie in the field of natural products and medicinal chemistry. I use organic synthesis and ligand-based drug design to develop natural products and other small organic molecules with promising biological activity into suitable lead candidates for drug development.




Peer Reviewed Journals

  Year Publication
(2018) 'Positive and Negative Allosteric Modulators of N-Methyl-D-aspartate (NMDA) Receptors: Structure–Activity Relationships and Mechanisms of Action'
Burnell, E. S., Irvine, M., Fang, G., Jane, D. E., Monaghan, D. T. (2018) 'Positive and Negative Allosteric Modulators of N-Methyl-D-aspartate (NMDA) Receptors: Structure–Activity Relationships and Mechanisms of Action'. Journal Of Medicinal Chemistry, 62 (1):3-23 [Details]
(2018) 'Synthetic approaches to phomactins: Late stage stereochemical and reactivity issues'
Burnell, E. S., Irshad, A., Lee, A. T. L., Thomas, E. J. (2018) 'Synthetic approaches to phomactins: Late stage stereochemical and reactivity issues'. Tetrahedron, 74 (47):6737-6748 [Details]
(2019) 'The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators'
Sapkota, K., Dore, K., Tang, K., Irvine, M., Fang, G., Burnell, E. S., Malinow, R., Jane, D. E., Monaghan, D. (2019) 'The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators'. Biochemical Pharmacology, 159 :140-153 [Details]
(2019) 'Investigation of the Stuctural Requirements for N-Methyl-D-Aspartate Receptor Positive and Negative Allosteric Modulators Based on 2-Naphthoic Acid'
Irvine, M. W., Fang, G., Sapkota, K., Burnell, E. S., Volianskis, A., Costa, B. M., Costa, V., Culley, G., Collingridge, G. L., Monaghan, D. T., Jane, D. E. (2019) 'Investigation of the Stuctural Requirements for N-Methyl-D-Aspartate Receptor Positive and Negative Allosteric Modulators Based on 2-Naphthoic Acid'. European Journal Of Medicinal Chemistry, 15 (164):471-498 [Details]
(2017) 'Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus'
France, G;Fernandez-Fernandez, D;Burnell, ES;Irvine, MW;Monaghan, DT;Jane, DE;Bortolotto, ZA;Collingridge, GL;Volianskis, A (2017) 'Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus'. Neuropharmacology, 112 :76-83 [DOI] [Details]
(2017) 'Risk to heroin users of polydrug use of pregabalin or gabapentin'
Lyndon, A;Audrey, S;Wells, C;Burnell, ES;Ingle, S;Hill, R;Hickman, M;Henderson, G (2017) 'Risk to heroin users of polydrug use of pregabalin or gabapentin'. Addiction, 112 :1580-1589 [DOI] [Details]
(2017) 'Mechanism and properties of positive allosteric modulation of N-methyl-D-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives'
Sapkota, K;Irvine, MW;Fang, GY;Burnell, ES;Bannister, N;Volianskis, A;Gulley, GR;Dravid, SM;Collingridge, GL;Jane, DE;Monaghan, DT (2017) 'Mechanism and properties of positive allosteric modulation of N-methyl-D-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives'. Neuropharmacology, 125 :64-79 [DOI] [Details]
(2016) 'Assessment of Methods for the Intracellular Blockade of GABA(A) Receptors'
Atherton, LA;Burnell, ES;Mellor, JR (2016) 'Assessment of Methods for the Intracellular Blockade of GABA(A) Receptors'. Plos One, 11 [DOI] [Details]
(2016) 'Stereoselective synthesis of oxazolidinonyl-fused piperidines of interest as selective muscarinic (M-1) receptor agonists: a novel M-1 allosteric modulator'
Broadley, KJ;Buffat, MGP;Burnell, E;Davies, RH;Moreau, X;Snee, S;Thomas, EJ (2016) 'Stereoselective synthesis of oxazolidinonyl-fused piperidines of interest as selective muscarinic (M-1) receptor agonists: a novel M-1 allosteric modulator'. Organic & Biomolecular Chemistry, 14 :2057-2089 [DOI] [Details]
(2016) 'The synthesis of a series of adenosine A(3) receptor agonists'
Broadley, KJ;Burnell, E;Davies, RH;Lee, ATL;Snee, S;Thomas, EJ (2016) 'The synthesis of a series of adenosine A(3) receptor agonists'. Organic & Biomolecular Chemistry, 14 :3765-3781 [DOI] [Details]
(2015) 'Approaches to phomactin A: unexpected late-stage observations'
Burnell, ES;Irshad, AR;Raftery, J;Thomas, EJ (2015) 'Approaches to phomactin A: unexpected late-stage observations'. Tetrahedron Letters, 56 :3255-3258 [DOI] [Details]
(2015) 'Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-D-aspartate Receptor Allosteric Modulators'
Irvine, MW;Fang, GY;Eaves, R;Mayo-Martin, MB;Burnell, ES;Costa, BM;Culley, GR;Volianskis, A;Collingridge, GL;Monaghan, DT;Jane, DE (2015) 'Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-D-aspartate Receptor Allosteric Modulators'. Synthesis-Stuttgart, 47 :1593-1610 [DOI] [Details]

Book Chapters

  Year Publication
(2016) 'Ligand-based Drug Design'
Erica S. Burnell, David E. Jane, Robert, J. Thatcher (2016) 'Ligand-based Drug Design' In: Textbook of Drug Design and Discovery. USA: CRC Press, Taylor & Francis Group. [Details]

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
Semester 2 Medicinal Chemistry CH2101