Prof Olivier Thomas

PhD

Contact Details

Marine Biodiscovery
Chemistry
room C212
School of Chemistry, https://www.nuigalway.ie/campus-map/
NUI Galway
University Road
Galway

T: +353 (0)91493563
M: +353 (0)894556289
E: olivier.thomas@nuigalway.ie
W: Skype: othomas1
 
researcher

Biography

2015-: Established Professor in Marine Biodiscovery at NUI Galway
2012: Professor in Marine Natural Product Chemistry at University Nice Sophia Antipolis, France
2004: Lecturer in Marine Natural Product Chemistry at University Nice Sophia Antipolis, France
2002: Post-Doctorate at CEA Saclay, France
2002: PhD in Organic Chemistry at University Paris Descartes, France
under the supervision of Henri-Philippe HUSSON
1999: Master Degree in Organic Chemistry from University Paris Descartes, France
1996-1998: Teacher at French School La Condamine Quito, Ecuador
1996: Agregation in Chemistry at Ecole Normale Superieure de Cachan, France

Research Interests

Our research focuses on the specialized metabolites, also called natural products, produced by marine organisms and especially marine invertebrates like sponges, zoantharians, soft corals but also algae, microalgae, or cyanobacteria. While our main playground for biodiscovery is the North-eastern Atlantic and especially the Irish waters from the seashore until the deep sea, through collaborations with local marine biologists and ecologists, we work in the Caribbean and Mediterranean Seas or the Atlantic and Pacific Oceans.
We have expertise in the purification by HPLC and structure elucidation by NMR and MS of all types of specialized metabolites. Such natural products may find applications in the pharmaceutical, the cosmetical or agri-food sectors. Through the establishment of a National Marine Biodiscovery Laboratory in Ireland we strive for a strong collaboration between marine biologists, taxonomists, microbiologists, and chemists to organize a biological and chemical repository of marine products. We are also engaged in several projects in marine chemical ecology first to understand their metabolic pathways but also their ecological role in the environment. Although omnipresent, the chemical mediation in the marine environment is still very poorly understood. We develop new tools to point out the key role of some chemical cues in the structure of ecosystems. These findings may also find applications in several sectors like the aquaculture sector. These approaches are of special interest in the field of marine biotoxins. Under the impacts of anthropogenic activities and global changes the proliferation of non-indigenous species and especially toxic dinoflagellates and cyanobacteria affect local ecosystems through the production and release of specialized metabolites. The marine seafood sector is frequently under the threat of such toxic contamination. To address these basic and applied questions we want to apply the recent technological and more global approach called marine environmental metabolomics by mass spectrometry but also nuclear magnetic resonance.

Keywords:  Natural Product Chemistry, Bioactive Natural Products, Chemical Ecology, Marine Invertebrates, Sponges, Microalgae, Metabolic Pathways, Metabolomics

Research Projects

  Project Start Date End Date
A NATIONAL MARINE BIODISCOVERY LABORATORY 09-DEC-16 28-FEB-20
Registrars Office 01-NOV-15 31-OCT-20
Marine microalgae for the cosmetic sector 01-JAN-17 30-JUN-17
OCEAN-15 04-JAN-16 31-DEC-19
TARA-PACIFIC 01-JUL-16 01-JUL-18

Contract Researchers

  Researcher Name Project Role Funding Body
Miriam REVERTER NMBLI Post-Doctorate in Marine Biodiscovery Marine Institute
Eva TERNON French ANR OCEAN-15 Post-Doctorate in Plankton Chemical Ecology International
Kevin CALABRO COSMO II Post-Doc in codirection with COSMO II at Nice France Industrial Contracts
Christine MORROW Integrative Taxonomy Marine Sponges Post-Doctorate in cosupervision with Grace McCormack NUIG Irish Research Council (IRC)
Sathees KUMAR Biology and Chemistry of Irish Marine Ascidians Post-Doctorate in cosupervision with Grace McCormack NUIG Irish Research Council (IRC)
Daria FIRSOVA Beaufort PhD Student for the chemistry of Irish marine sponges Marine Institute
Karla JARAMILLO Marine Biodiversity in Ecuador PhD student in codirection with Grace McCormack NUIG and Jenny Rodriguez CENAIM Ecuador Other Government
Anna ORANI Inorganic Contamination in the Marine Field PhD Student in codirection with Emilia VASILEVA at IAEA Monaco and Aurelie BARATS at Nice France and Monaco International
Hiren SOLANKI Marine Biodiscovery PhD Student in cosupervision with Christine MORROW (NUIG) and Mayalen ZUBIA (French Polynesia University) Other Government
Paul GUILLEN Natural Product Chemistry of Ecuadorian Cnidarians PhD student between NUI Galway and CENAIM Ecuador Other Government
Robert NESBITT Irish Deep Sea Marine Biodiscovery MSc Student in cosupervision with Louise Allcock NUIG working on sponges Science Foundation Ireland (SFI)
Daniel RODRIGUES NMBLI Research Assistant in Marine Biology Marine Institute
Navdeep KAUR NMBLI Research Assistant in Marine Natural Product Chemistry Marine Institute
Erika GARCIA Metabolic Pathways Haliclona Fulva PhD Student in codirection with Howard JUNCA in Bogota Colombia International
Julie GAUBERT Brown Algae Chemical Ecology PhD Student in codirection with Claude PAYRI at Noumea New Caledonia International
Siguara SILVA Science without Border Brazil, Biosynthesis of Sponge Alkaloids PhD Student in codirection with Erwan POUPON Paris 11 France International
Cesar RUIZ Taxonomy and Ecology of Homosleromorpha Sponges PhD Student in codirection with Thierry PEREZ at Marseille France International

Peer Reviewed Journals

  Year Publication
(2017) 'Terrazoanthines, 2-Aminoimidazole Alkaloids from the Tropical Eastern Pacific Zoantharian Terrazoanthus onoi'
Guillen, Paul O.,Jaramillo, Karla B.,Genta-Jouve, Gregory,Sinniger, Frederic,Rodriguez, Jenny,Thomas, Olivier P. (2017) 'Terrazoanthines, 2-Aminoimidazole Alkaloids from the Tropical Eastern Pacific Zoantharian Terrazoanthus onoi'. Organic Letters, [Details]
(2017) 'Discrimination of Four Marine Biofilm-Forming Bacteria by LC-MS Metabolomics and Influence of Culture Parameters'
Favre, Laurie,Ortalo-Magne, Annick,Greff, Stephane,Perez, Thierry,Thomas, Olivier Paul,Martin, Jean-Charles,Culioli, Gerald. (2017) 'Discrimination of Four Marine Biofilm-Forming Bacteria by LC-MS Metabolomics and Influence of Culture Parameters'. Journal of Proteome Research, [Details]
(2017) 'Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea'
Mahajan, Nipun,Chadda, Rekha,Calabro, Kevin,Solanki, Hiren,O'Connell, Enda,Murphy, Paul V.,Thomas, Olivier P. (2017) 'Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea'. Tetrahedron Letters, 58 (12):1237-1239 [Details]
(2017) 'The interaction between the proliferating macroalga Asparagopsis taxiformis and the coral Astroides calycularis induces changes in microbiome and metabolomic fingerprints'
Greff, Stephane,Aires, Tania,Serrao, Ester A.,Engelen, Aschwin H.,Thomas, Olivier P.,Perez, Thierry. (2017) 'The interaction between the proliferating macroalga Asparagopsis taxiformis and the coral Astroides calycularis induces changes in microbiome and metabolomic fingerprints'. Scientific Reports, 7 [Details]
(2017) 'Chemogeography of the red macroalgae Asparagopsis: metabolomics, bioactivity, and relation to invasiveness'
Greff, Stephane,Zubia, Mayalen,Payri, Claude,Thomas, Olivier P.,Perez, Thierry. (2017) 'Chemogeography of the red macroalgae Asparagopsis: metabolomics, bioactivity, and relation to invasiveness'. Metabolomics, 13 (4):1-13 [Details]
(2017) 'Biological activities associated to the chemodiversity of the brown algae belonging to genus Lobophora (Dictyotales, Phaeophyceae)'
Vieira, Christophe,Gaubert, Julie,De Clerck, Olivier,Payri, Claude,Culioli, Gerald,Thomas, Olivier P. (2017) 'Biological activities associated to the chemodiversity of the brown algae belonging to genus Lobophora (Dictyotales, Phaeophyceae)'. Phytochemistry Reviews, 16 :1-17 [Details]
(2017) 'Autumnalamide targeted proteins of the immunophilin family'
Sanchez, Jon Andoni,Alfonso, Amparo,Thomas, Olivier P.,Botana, Lui­s M. (2017) 'Autumnalamide targeted proteins of the immunophilin family'. Immunobiology, 222 (2):241-250 [DOI] [Details]
(2016) 'Spherulization as a process for the exudation of chemical cues by the encrusting sponge C. crambe'
Eva Ternon, Lina Zarate, Sandrine Chenesseau, Julie Croué, Rémi Dumollard, Marcelino T. Suzuki & Olivier P. Thomas (2016) 'Spherulization as a process for the exudation of chemical cues by the encrusting sponge C. crambe'. Scientific Reports, 6 [ARAN Link] [Details]
(2016) 'Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model'
María Roel, Juan A. Rubiolo, Jorge Guerra-Varela, Siguara B. L. Silva, Olivier P. Thomas, Pablo Cabezas-Sainz, Laura Sánchez, Rafael López, Luis M. Botana (2016) 'Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model'. Oncotarget, 7 (50):83071-83087 [DOI] [Details]
(2016) 'Does the Chemical Diversity of the Order Haplosclerida (Phylum Porifera: Class Demospongia) Fit with Current Taxonomic Classification?'
Tribalat, Marie-Aude,Marra, Maria V.,McCormack, Grace P.,Thomas, Olivier P. (2016) 'Does the Chemical Diversity of the Order Haplosclerida (Phylum Porifera: Class Demospongia) Fit with Current Taxonomic Classification?'. Planta Medica, 82 (9-10):843-856 [Details]
(2016) 'Metabolomics for the Authentication of Natural Extracts Used in Flavours and Fragrances: the Case Study of Violet Leaf Absolutes from Viola odorata'
Saint-Lary L;Roy C;Paris JP;Martin JF;Thomas OP;Fernandez X; (2016) 'Metabolomics for the Authentication of Natural Extracts Used in Flavours and Fragrances: the Case Study of Violet Leaf Absolutes from Viola odorata'. Chemistry & biodiversity, 13 (6):737-747 [DOI] [Details]
(2016) 'Allelopathic interactions between the brown algal genus Lobophora (Dictyotales, Phaeophyceae) and scleractinian corals'
Vieira, Christophe,Thomas, Olivier P.,Culioli, Gerald,Genta-Jouve, Gregory,Houlbreque, Fanny,Gaubert, Julie,De Clerck, Olivier,Payri, Claude E. (2016) 'Allelopathic interactions between the brown algal genus Lobophora (Dictyotales, Phaeophyceae) and scleractinian corals'. Scientific Reports, 6 [ARAN Link] [Details]
(2016) 'Metabolomics as a tool for the authentication of rose extracts used in flavour and fragrance area'
Saint-Lary, Laure,Roy, Celine,Paris, Jean-Philippe,Martin, Jean-Francois,Thomas, Olivier P.,Fernandez, Xavier. (2016) 'Metabolomics as a tool for the authentication of rose extracts used in flavour and fragrance area'. Metabolomics, 12 (3):1-11 [Details]
(2016) 'On the use of 31P NMR for the quantification of hydrosoluble phosphorus-containing compounds in coral host tissues and cultured zooxanthellae'
Godinot, Claire,Gaysinski, Marc,Thomas, Olivier P.,Ferrier-Pages, Christine,Grover, Renaud. (2016) 'On the use of 31P NMR for the quantification of hydrosoluble phosphorus-containing compounds in coral host tissues and cultured zooxanthellae'. Scientific Reports, 6 [ARAN Link] [Details]
(2016) 'Gersemiols A-“C and Eunicellol A, Diterpenoids from the Arctic Soft Coral Gersemia fruticosa'
Angulo-Preckler, Carlos,Genta-Jouve, Grégory,Mahajan, Nipun,de la Cruz, Mercedes,de Pedro, Nuria,Reyes, Fernando,Iken, Katrin,Avila, Conxita,Thomas, Olivier P. (2016) 'Gersemiols A-“C and Eunicellol A, Diterpenoids from the Arctic Soft Coral Gersemia fruticosa'. Journal Of Natural Products, 79 :1132-1139 [Details]
(2015) 'Speciation of americium in seawater and accumulation in the marine sponge Aplysina cavernicola'
Maloubier, Melody,Michel, Herve,Solari, Pier Lorenzo,Moisy, Philippe,Tribalat, Marie-Aude,Oberhaensli, Francois R.,Dechraoui Bottein, Marie Yasmine,Thomas, Olivier P.,Monfort, Marguerite,Moulin, Christophe,Den Auwer, Christophe. (2015) 'Speciation of americium in seawater and accumulation in the marine sponge Aplysina cavernicola'. Dalton Transactions, 44 (47):20584-20596 [Details]
(2015) 'Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells'
Fiorini, Laura,Sauvard, Lucy,Cazareth, Julie,Lalli, Enzo,Mus-Veteau, Isabelle,Tribalat, Marie-Aude,Sauvard, Lucy,Thomas, Olivier P.,Broutin, Isabelle,Thomas, Olivier P. (2015) 'Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells'. Oncotarget, 6 (26):22282-22297 [Details]
(2015) 'Extraction, Purification, and NMR Analysis of Terpenes from Brown Algae'
Gaysinski, Marc,Ortalo-Magne, Annick,Thomas, Olivier P.,Culioli, Gerald (2015) 'Extraction, Purification, and NMR Analysis of Terpenes from Brown Algae'. Methods in molecular biology (Clifton, N.J.), 1308 :207-23 [Details]
(2015) 'Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction'
Roel, Maria,Rubiolo, Juan A.,Botana, Luis M.,Ternon, Eva,Thomas, Olivier P.,Thomas, Olivier P.,Vieytes, Mercedes R. (2015) 'Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction'. Marine drugs, 13 (8):4633-53 [Details]
(2015) 'Indole alkaloids from the Marquesan plant Rauvolfia nukuhivensis and their effects on ion channels'
Martin, Nicolas J.,Ferreiro, Sara F.,Barbault, Florent,Nicolas, Mael,Lecellier, Gael,Paetz, Christian,Gaysinski, Marc,Alonso, Eva,Thomas, Olivier P.,Botana, Luis M.,Raharivelomanana, Phila. (2015) 'Indole alkaloids from the Marquesan plant Rauvolfia nukuhivensis and their effects on ion channels'. Phytochemistry (Elsevier), 109 :84-95 [Details]
(2015) 'Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius'
Rodrigues, Daniel,Alves, Celso,Horta, Andre,Pinteus, Susete,Silva, Joana,Culioli, Gerald,Thomas, Olivier P.,Pedrosa, Rui. (2015) 'Antitumor and antimicrobial potential of bromoditerpenes isolated from the red alga, Sphaerococcus coronopifolius'. Marine Drugs, 13 (2) [Details]
(2015) 'Gambierone, a Ladder-Shaped Polyether from the Dinoflagellate Gambierdiscus belizeanus'
Rodriguez, Ines,Genta-Jouve, Gregory,Alfonso, Carmen,Calabro, Kevin,Alonso, Eva,Sanchez, Jon A.,Alfonso, Amparo,Thomas, Olivier P.,Botana, Luis M. (2015) 'Gambierone, a Ladder-Shaped Polyether from the Dinoflagellate Gambierdiscus belizeanus'. Organic Letters, 17 (10):2392-2395 [Details]
(2015) 'Cystophloroketals A-E, unusual phloroglucinol-meroterpenoid hybrids from the brown alga Cystoseira tamariscifolia'
El Hattab, Mohamed,Genta-Jouve, Gregory,Bouzidi, Naima,Ortalo-Magne, Annick,Hellio, Claire,Marechal, Jean-Philippe,Piovetti, Louis,Thomas, Olivier P.,Culioli, Gerald. (2015) 'Cystophloroketals A-E, unusual phloroglucinol-meroterpenoid hybrids from the brown alga Cystoseira tamariscifolia'. Journal of Natural Products, 78 (7):1663-1670 [Details]
(2015) 'Metabolomic profiling reveals deep chemical divergence between two morphotypes of the zoanthid Parazoanthus axinellae'
Cachet, Nadja,Genta-Jouve, Gregory,Ivanisevic, Julijana,Chevaldonne, Pierre,Sinniger, Frederic,Culioli, Gerald,Perez, Thierry,Thomas, Olivier P. (2015) 'Metabolomic profiling reveals deep chemical divergence between two morphotypes of the zoanthid Parazoanthus axinellae'. Scientific Reports, 5 [Details]
(2015) 'Eryloside W, a triterpenoid saponin from the sponge Dictyonella marsilii'
Genta-Jouve, Gregory,Boughanem, Cecile,Ocana, Oscar,Perez, Thierry,Thomas, Olivier P. (2015) 'Eryloside W, a triterpenoid saponin from the sponge Dictyonella marsilii'. Phytochemistry Letters, 13 :252-255 [Details]
(2014) 'Autumnalamide, a Prenylated Cyclic Peptide from the Cyanobacterium Phormidium autumnale, Acts on SH-SY5Y Cells at the Mitochondrial Level'
Audoin, Coralie,Sanchez, Jon Andoni,Genta-Jouve, Gregory,Alfonso, Amparo,Rios, Laurent,Vale, Carmen,Thomas, Olivier P.,Botana, Luis M. (2014) 'Autumnalamide, a Prenylated Cyclic Peptide from the Cyanobacterium Phormidium autumnale, Acts on SH-SY5Y Cells at the Mitochondrial Level'. Journal of Natural Products, 77 (10):2196-2205 [Details]
(2014) 'Mahorones, highly brominated cyclopentenones from the red alga Asparagopsis taxiformis'
Greff, Stephane,Zubia, Mayalen,Genta-Jouve, Gregory,Massi, Lionel,Perez, Thierry,Thomas, Olivier P. (2014) 'Mahorones, highly brominated cyclopentenones from the red alga Asparagopsis taxiformis'. Journal of Natural Products, 77 (5):1150-1155 [Details]
(2014) 'Volatile Compounds of Viola odorata Absolutes: Identification of Odorant Active Markers to Distinguish Plants Originating from France and Egypt'
Saint-Lary, Laure,Roy, Celine,Paris, Jean-Philippe,Tournayre, Pascal,Berdague, Jean-Louis,Thomas, Olivier P.,Fernandez, Xavier. (2014) 'Volatile Compounds of Viola odorata Absolutes: Identification of Odorant Active Markers to Distinguish Plants Originating from France and Egypt'. Chemistry & Biodiversity, 11 (6):843-860 [Details]
(2014) 'Metabolome consistency: additional parazoanthines from the Mediterranean zoanthid Parazoanthus axinellae'
Audoin, Coralie,Cocandeau, Vincent,Thomas, Olivier P.,Bruschini, Adrien,Holderith, Serge,Genta-Jouve, Gregory. (2014) 'Metabolome consistency: additional parazoanthines from the Mediterranean zoanthid Parazoanthus axinellae'. Metabolites, 4 (2) [Details]
(2014) 'Further insights into brevetoxin metabolism by de Novo radiolabeling'
Calabro, Kevin,Guigonis, Jean-Marie,Teyssie, Jean-Louis,Oberhaensli, Francois,Goudour, Jean-Pierre,Warnau, Michel,Bottein, Marie-Yasmine Dechraoui,Thomas, Olivier P. (2014) 'Further insights into brevetoxin metabolism by de Novo radiolabeling'. Toxins, 6 (6) [Details]
(2014) 'Development of a work-flow for high-performance thin-layer chromatography data processing for untargeted metabolomics'
Audoin, Coralie,Holderith, Serge,Romari, Khadidja,Thomas, Olivier P.,Genta-Jouve, Gregory. (2014) 'Development of a work-flow for high-performance thin-layer chromatography data processing for untargeted metabolomics'. Journal of Planar Chromatography--Modern TLC, 27 (5):328-332 [Details]
(2014) 'Two-dimensional ultra high pressure liquid chromatography quadrupole/time-of-flight mass spectrometry for semi-targeted natural compounds identification'
Genta-Jouve, Gregory,Croue, Julie,Weinberg, Lionel,Cocandeau, Vincent,Holderith, Serge,Bontemps, Nataly,Suzuki, Marcelino,Thomas, Olivier P. (2014) 'Two-dimensional ultra high pressure liquid chromatography quadrupole/time-of-flight mass spectrometry for semi-targeted natural compounds identification'. Phytochemistry Letters, 10 :318-323 [Details]
(2014) 'Environmental solutions for the sustainable production of bioactive natural products from the marine sponge Crambe crambe'
Perez-Lopez, Paula,Ternon, Eva,Gonzalez-Garcia, Sara,Genta-Jouve, Gregory,Feijoo, Gumersindo,Thomas, Olivier P.,Moreira, Teresa. (2014) 'Environmental solutions for the sustainable production of bioactive natural products from the marine sponge Crambe crambe'. Science of the Total Environment, 475 :71-82 [Details]
(2014) 'In vitro antiplasmodial activity, cytotoxicity and chemical profiles of sponge species of Cuban coasts'
Mendiola, Judith,Regalado, Erik L.,Diaz-Garcia, Alexis,Thomas, Olivier P.,Fernandez-Calienes, Ayme,Rodriguez, Hermis,Laguna, Abilio,Valdes, Olga. (2014) 'In vitro antiplasmodial activity, cytotoxicity and chemical profiles of sponge species of Cuban coasts'. Natural Product Research, 28 (5):312-317 [Details]
(2013) 'Ulososides and urabosides - triterpenoid saponins from the Caribbean marine sponge Ectyoplasia ferox'
Colorado, Jhonny,Munoz, Diana,Marquez, Diana,Marquez, Maria Elena,Lopez, Juan,Thomas, Olivier P.,Martinez, Alejandro. (2013) 'Ulososides and urabosides - triterpenoid saponins from the Caribbean marine sponge Ectyoplasia ferox'. Molecules, 18 :2598-2610 [Details]
(2013) 'Sustainable production of biologically active molecules of marine based origin'
Murray, Patrick M.,Moane, Siobhan,Collins, Catherine,Beletskaya, Tanya,Thomas, Olivier P.,Duarte, Alysson W. F.,Nobre, Fernando S.,Owoyemi, Ifeloju O.,Pagnocca, Fernando C.,Sette, L. D.,McHugh, Edward,Causse, Eric,Perez-Lopez, Paula,Feijoo, Gumersindo,Moreira, .T.,Rubiolo, Juan,Leiros, Marta,Botana, Luis M.,Pinteus, Susete,Alves, Celso,Horta, Andre,Pedrosa, Rui,Jeffryes, Clayton,Agathos, Spiros N.,Allewaert, Celine,Verween, Annick,Vyverman, Wim,Laptev, Ivan,Sineoky, Sergei,Bisio, Angela,Manconi, Renata,Ledda, Fabio,Marchi, Mario,Pronzato, Roberto,Walsh, Daniel J. (2013) 'Sustainable production of biologically active molecules of marine based origin'. New Biotechnology, 30 (6):839-850 [Details]
(2013) 'Ligerin, an Antiproliferative Chlorinated Sesquiterpenoid from a Marine-Derived Penicillium Strain'
Vansteelandt, Marieke,Blanchet, Elodie,Egorov, Maxim,Petit, Fabien,Toupet, Loic,Bondon, Arnaud,Monteau, Fabrice,Le Bizec, Bruno,Thomas, Olivier P.,Pouchus, Yves Francois,Le Bot, Ronan,Grovel, Olivier. (2013) 'Ligerin, an Antiproliferative Chlorinated Sesquiterpenoid from a Marine-Derived Penicillium Strain'. Journal of Natural Products, 76 (2):297-301 [Details]
(2013) 'Absolute configuration of the new 3-epi-cladocroic acid from the Mediterranean sponge Haliclona fulva'
Genta-Jouve, Gregory,Thomas, Olivier P. (2013) 'Absolute configuration of the new 3-epi-cladocroic acid from the Mediterranean sponge Haliclona fulva'. Metabolites, 3 (1):24-32 [Details]
(2013) 'Differential Effects of Crambescins and Crambescidin 816 in Voltage-Gated Sodium, Potassium and Calcium Channels in Neurons'
Martin, Victor,Vale, Carmen,Bondu, Stephanie,Thomas, Olivier P.,Vieytes, Mercedes R.,Botana, Luis M. (2013) 'Differential Effects of Crambescins and Crambescidin 816 in Voltage-Gated Sodium, Potassium and Calcium Channels in Neurons'. Chemical Research in Toxicology, 26 (1):169-178 [Details]
(2013) 'Revising the Absolute Configurations of Coatlines via Density Functional Theory Calculations of Electronic Circular Dichroism Spectra'
Genta-Jouve, Gregory,Weinberg, Lionel,Cocandeau, Vincent,Maestro, Yannick,Thomas, Olivier Paul,Holderith, Serge. (2013) 'Revising the Absolute Configurations of Coatlines via Density Functional Theory Calculations of Electronic Circular Dichroism Spectra'. Chirality, 25 (3):180-184 [Details]
(2013) 'Balibalosides, an original family of glucosylated sesterterpenes produced by the Mediterranean sponge Oscarella balibaloi'
Audoin, Coralie,Bonhomme, Dominique,Ivanisevic, Julijana,de, la Cruz Mercedes,Cautain, Bastien,Monteiro, Maria Candida,Reyes, Fernando,Rios, Laurent,Perez, Thierry,Thomas, Olivier P. (2013) 'Balibalosides, an original family of glucosylated sesterterpenes produced by the Mediterranean sponge Oscarella balibaloi'. Marine drugs, 11 (5):1477-89 [Details]
(2013) 'Balibalosides, an original family of glycosylated sesterterpenes produced by the Mediterranean sponge Oscarella balibaloi'
Audoin, Coralie,Bonhomme, Dominique,Ivanisevic, Julijana,de la Cruz, Mercedes,Cautain, Bastien,Monteiro, Maria Candida,Reyes, Fernando,Rios, Laurent,Perez, Thierry,Thomas, Olivier P. (2013) 'Balibalosides, an original family of glycosylated sesterterpenes produced by the Mediterranean sponge Oscarella balibaloi'. Marine Drugs, 11 :1477-1489 [Details]
(2013) 'Additional Cytotoxic Pyridoacridine Alkaloids from the Ascidian Cystodytes violatinctus and Biogenetic Considerations'
Bontemps, Nataly,Gattacceca, Florence,Long, Christophe,Thomas, Olivier P.,Banaigs, Bernard. (2013) 'Additional Cytotoxic Pyridoacridine Alkaloids from the Ascidian Cystodytes violatinctus and Biogenetic Considerations'. Journal of Natural Products, 76 (9):1801-1805 [Details]
(2013) 'Biosynthesis in marine sponges: the radiolabelling strikes back'
Genta-Jouve, Gregory,Thomas, Olivier P. (2013) 'Biosynthesis in marine sponges: the radiolabelling strikes back'. Phytochemistry Reviews, 12 (3):425-434 [Details]
(2013) 'Crambescidin-816 acts as a fungicidal with more potency than crambescidin-800 and -830, inducing cell cycle arrest, increased cell size and apoptosis in Saccharomyces cerevisiae'
Rubiolo, Juan A.,Ternon, Eva,Lopez-Alonso, Henar,Thomas, Olivier P.,Vega, Felix V.,Vieytes, Mercedes R.,Botana, Luis M. (2013) 'Crambescidin-816 acts as a fungicidal with more potency than crambescidin-800 and -830, inducing cell cycle arrest, increased cell size and apoptosis in Saccharomyces cerevisiae'. Marine Drugs, 11 (11) [Details]
(2013) 'Chemical diversity in the scleractinian coral Astroides calycularis'
Cachet, Nadja,Loffredo, Loic,Vicente, Oscar Ocana,Thomas, Olivier P. (2013) 'Chemical diversity in the scleractinian coral Astroides calycularis'. Phytochemistry Letters, 6 (2):205-208 [Details]
(2012) 'Nukuhivensiums, indolo[2,3-a]quinoliziniums from the Marquesan plant Rauvolfia nukuhivensis'
Martin, Nicolas J.,Prado, Soizic,Lecellier, Gael,Thomas, Olivier P.,Raharivelomanana, Phila. (2012) 'Nukuhivensiums, indolo[2,3-a]quinoliziniums from the Marquesan plant Rauvolfia nukuhivensis'. Molecules, 17 :12015-12022 [Details]
(2012) 'Determination of the absolute configuration and evaluation of the in vitro antitumor activity of dilospirane B'
Genta-Jouve, Gregory,Ioannou, Efstathia,Mathieu, Veronique,Bruyere, Celine,Lefranc, Florence,Thomas, Olivier P.,Kiss, Robert,Roussis, Vassilios. (2012) 'Determination of the absolute configuration and evaluation of the in vitro antitumor activity of dilospirane B'. Phytochemistry Letters, 5 (4):747-751 [Details]
(2012) 'Antiparasitic bromotyrosine derivatives from the Caribbean marine sponge Aiolochroia crassa'
Galeano, Elkin,Martinez, Alejandro,Thomas, Olivier P.,Robledo, Sara,Munoz, Diana. (2012) 'Antiparasitic bromotyrosine derivatives from the Caribbean marine sponge Aiolochroia crassa'. Quimica Nova, 35 (6):1189-1193 [Details]
(2012) 'Comparative bioaccumulation kinetics of trace elements in Mediterranean marine sponges'
Genta-Jouve, Gregory,Cachet, Nadja,Oberhansli, Francois,Noyer, Charlotte,Teyssie, Jean-Louis,Thomas, Olivier P.,Lacoue-Labarthe, Thomas. (2012) 'Comparative bioaccumulation kinetics of trace elements in Mediterranean marine sponges'. Chemosphere, 89 (3):340-349 [Details]
(2012) 'Additional bioactive guanidine alkaloids from the Mediterranean sponge Crambe crambe'
Bondu, Stephanie,Genta-Jouve, Gregory,Leiros, Marta,Vale, Carmen,Guigonis, Jean-Marie,Botana, Luis M.,Thomas, Olivier P. (2012) 'Additional bioactive guanidine alkaloids from the Mediterranean sponge Crambe crambe'. RSC Advances, 2 (7):2828-2835 [Details]
(2012) 'Phytochemical analysis and antioxidant capacity of BM-21, a bioactive extract rich in polyphenolic metabolites from the sea grass Thalassia testudinum'
Regalado, Erik L.,Menendez, Roberto,Valdes, Olga,Morales, Ruth A.,Laguna, Abilio,Thomas, Olivier P.,Hernandez, Yasnay,Nogueiras, Clara,Kijjoa, Anake. (2012) 'Phytochemical analysis and antioxidant capacity of BM-21, a bioactive extract rich in polyphenolic metabolites from the sea grass Thalassia testudinum'. Natural Product Communications, 7 (1):47-50 [Details]
(2012) 'Sponge chemical diversity: from biosynthetic pathways to ecological roles'
Genta-Jouve, Gregory,Thomas, Olivier P. (2012) 'Sponge chemical diversity: from biosynthetic pathways to ecological roles'. Advances in marine biology, 62 :183-230 [Details]
(2011) 'Biochemical trade-offs: evidence for ecologically linked secondary metabolism of the sponge Oscarella balibaloi'
Ivanisevic, Julijana,Thomas, Olivier P.,Pedel, Laura,Penez, Nicolas,Ereskovsky, Alexander V.,Culioli, Gerald,Perez, Thierry. (2011) 'Biochemical trade-offs: evidence for ecologically linked secondary metabolism of the sponge Oscarella balibaloi'. PLoS One, 6 (11) [Details]
(2011) 'Acanthifoliosides, minor steroidal saponins from the Caribbean sponge Pandaros acanthifolium'
Regalado, Erik L.,Jimenez-Romero, Carlos,Genta-Jouve, Gregory,Tasdemir, Deniz,Amade, Philippe,Nogueiras, Clara,Thomas, Olivier P. (2011) 'Acanthifoliosides, minor steroidal saponins from the Caribbean sponge Pandaros acanthifolium'. Tetrahedron, 67 (5):1011-1018 [Details]
(2011) 'Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida'
Galeano, Elkin,Thomas, Olivier P.,Robledo, Sara,Munoz, Diana,Martinez, Alejandro. (2011) 'Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida'. Marine Drugs, 9 :1902-1913 [Details]
(2011) 'Photoprotecting action and phytochemical analysis of a multiple radical scavenger lipophilic fraction obtained from the leaf of the seagrass Thalassia testudinum'
Regalado, Erik L.,Rodriguez, Maria,Menendez, Roberto,Fernandez, Xavier,Hernandez, Ivones,Morales, Ruth A.,Fernandez, Miguel D.,Thomas, Olivier P.,Pino, Jorge A.,Concepcion, Angel R.,Laguna, Abilio. (2011) 'Photoprotecting action and phytochemical analysis of a multiple radical scavenger lipophilic fraction obtained from the leaf of the seagrass Thalassia testudinum'. Photochemistry and Photobiology, 87 (5):1058-1066 [Details]
(2011) 'New Insight into Marine Alkaloid Metabolic Pathways: Revisiting Oroidin Biosynthesis [Erratum to document cited in CA155:609335]'
Genta-Jouve, Gregory,Cachet, Nadja,Holderith, Serge,Oberhaensli, Francois,Teyssie, Jean-Louis,Jeffree, Ross,Al Mourabit, Ali,Thomas, Olivier P. (2011) 'New Insight into Marine Alkaloid Metabolic Pathways: Revisiting Oroidin Biosynthesis [Erratum to document cited in CA155:609335]'. ChemBioChem, 12 (15) [Details]
(2011) 'Antifouling Properties of Simple Indole and Purine Alkaloids from the Mediterranean Gorgonian Paramuricea clavata'
Penez, Nicolas,Culioli, Gerald,Perez, Thierry,Briand, Jean-Francois,Thomas, Olivier P.,Blache, Yves. (2011) 'Antifouling Properties of Simple Indole and Purine Alkaloids from the Mediterranean Gorgonian Paramuricea clavata'. Journal of Natural Products, 74 (10):2304-2308 [Details]
(2011) 'Cytotoxic and hemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium'
Regalado, Erik L.,Turk, Tom,Tasdemir, Deniz,Gorjanc, Manca,Kaiser, Marcel,Thomas, Olivier P.,Fernandez, Rogelio,Amade, Philippe. (2011) 'Cytotoxic and hemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium'. Steroids, 76 (12):1389-1396 [Details]
(2011) 'New Insight into Marine Alkaloid Metabolic Pathways: Revisiting Oroidin Biosynthesis'
Genta-Jouve, Gregory,Cachet, Nadja,Holderith, Serge,Oberhaensli, Francois,Teyssie, Jean-Louis,Jeffree, Ross,Al Mourabit, Ali,Thomas, Olivier P. (2011) 'New Insight into Marine Alkaloid Metabolic Pathways: Revisiting Oroidin Biosynthesis'. ChemBioChem, 12 (15):2298-2301 [Details]
(2011) 'Chemical composition and antioxidant activities of the essential oil from Tornabenea bischoffii (Apiaceae)'
Ortet, Risoleta,Regalado, Erik L.,Thomas, Olivier P.,Pino, Jorge A.,Fernandez, Miguel D. (2011) 'Chemical composition and antioxidant activities of the essential oil from Tornabenea bischoffii (Apiaceae)'. Natural Product Communications, 6 (8):1179-1182 [Details]
(2011) 'Structure elucidation of the new citharoxazole from the Mediterranean deep-sea sponge Latrunculia (Biannulata) citharistae'
Genta-Jouve, Gregory,Francezon, Nellie,Puissant, Alexandre,Auberger, Patrick,Vacelet, Jean,Perez, Thierry,Fontana, Angelo,Mourabit, Ali Al,Thomas, Olivier P. (2011) 'Structure elucidation of the new citharoxazole from the Mediterranean deep-sea sponge Latrunculia (Biannulata) citharistae'. Magnetic Resonance in Chemistry, 49 (8):533-536 [Details]
(2011) 'Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Uraba Gulf (Colombia)'
Marquez, Diana M.,Marquez, Maria E.,Martinez, Alejandro,Thomas, Olivier P. (2011) 'Isolation of a bromotyrosine derivative compound of a bioactive fraction from the marine sponge Iotrochota birotulata from the Uraba Gulf (Colombia)'. Latin American Journal of Pharmacy, 30 (2):392-396 [Details]
(2011) 'Patterns of chemical diversity in the Mediterranean sponge Spongia lamella'
Noyer, Charlotte,Thomas, Olivier P.,Becerro, Mikel A. (2011) 'Patterns of chemical diversity in the Mediterranean sponge Spongia lamella'. PLoS One, 6 (6) [Details]
(2011) 'Metabolic fingerprinting as an indicator of biodiversity: towards understanding inter-specific relationships among Homoscleromorpha sponges'
Ivanisevic, Julijana,Thomas, Olivier P.,Lejeusne, Christophe,Chevaldonne, Pierre,Perez, Thierry. (2011) 'Metabolic fingerprinting as an indicator of biodiversity: towards understanding inter-specific relationships among Homoscleromorpha sponges'. Metabolomics, 7 (2):289-304 [Details]
(2011) 'Lysophospholipids in the Mediterranean Sponge Oscarella tuberculata: Seasonal Variability and Putative Biological Role'
Ivanisevic, Julijana,Perez, Thierry,Ereskovsky, Alexander V.,Barnathan, Gilles,Thomas, Olivier P. (2011) 'Lysophospholipids in the Mediterranean Sponge Oscarella tuberculata: Seasonal Variability and Putative Biological Role'. Journal of Chemical Ecology, 37 (5):537-545 [Details]
(2011) 'Bromopyrrole alkaloids from the Caribbean sponge Agelas cerebrum'
Regalado, Erik L.,Laguna, Abilio,Mendiola, Judith,Thomas, Olivier P.,Nogueiras, Clara. (2011) 'Bromopyrrole alkaloids from the Caribbean sponge Agelas cerebrum'. Quimica Nova, 34 (2):289-291 [Details]
(2011) 'Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid-sensing ionic channels by the phenolic compound thalassiolin B'
Garateix, Anoland,Salceda, Emilio,Menendez, Roberto,Regalado, Erik L.,Lopez, Omar,Garcia, Teidy,Morales, Ruth A.,Laguna, Abilio,Thomas, Olivier P.,Soto, Enrique. (2011) 'Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid-sensing ionic channels by the phenolic compound thalassiolin B'. Molecular Pain, 7 [Details]
(2011) 'Dictyotadimer A, a new dissymmetric bis-diterpene from a brown alga of the genus Dictyota'
Viano, Yannick,Bonhomme, Dominique,Ortalo-Magne, Annick,Thomas, Olivier P.,El Hattab, Mohamed,Piovetti, Louis,Blache, Yves,Culioli, Gerald. (2011) 'Dictyotadimer A, a new dissymmetric bis-diterpene from a brown alga of the genus Dictyota'. Tetrahedron Letters, 52 (9):1031-1035 [Details]
(2011) 'Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum'
Ortet, Risoleta,Prado, Soizic,Regalado, Erik L.,Valeriote, Frederick A.,Media, Joseph,Mendiola, Judith,Thomas, Olivier P. (2011) 'Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum'. Journal of Ethnopharmacology, 138 (2):637-640 [Details]
(2010) 'Polar alkaloids from the Caribbean marine sponge Niphates digitalis'
Regalado, Erik L.,Mendiola, Judith,Laguna, Abilio,Nogueiras, Clara,Thomas, Olivier P. (2010) 'Polar alkaloids from the Caribbean marine sponge Niphates digitalis'. Natural Product Communications, 5 (8):1187-1190 [Details]
(2010) 'Composition and Biological Properties of the Volatile Oil of Artemisia gorgonum Webb'
Ortet, Risoleta,Thomas, Olivier P.,Regalado, Erik L.,Pino, Jorge A.,Filippi, Jean-Jacques,Fernandez, Miguel D. (2010) 'Composition and Biological Properties of the Volatile Oil of Artemisia gorgonum Webb'. Chemistry & Biodiversity, 7 (5):1325-1332 [Details]
(2010) 'Antiprotozoal Steroidal Saponins from the Marine Sponge Pandaros acanthifolium'
Regalado, Erik L.,Tasdemir, Deniz,Kaiser, Marcel,Cachet, Nadja,Amade, Philippe,Thomas, Olivier P. (2010) 'Antiprotozoal Steroidal Saponins from the Marine Sponge Pandaros acanthifolium'. Journal of Natural Products, 73 (8):1404-1410 [Details]
(2009) 'Njaoaminiums A, B, and C: cyclic 3-alkylpyridinium salts from the marine sponge Reniera sp'
Laville, Remi,Genta-Jouve, Gregory,Urda, Carlos,Fernandez, Rogelio,Thomas, Olivier P.,Reyes, Fernando,Amade, Philippe. (2009) 'Njaoaminiums A, B, and C: cyclic 3-alkylpyridinium salts from the marine sponge Reniera sp'. Molecules, 14 (11):4716-4724 [Details]
(2009) 'Composition and antioxidant properties of the essential oil of the endemic cape verdean Satureja forbesii'
Ortet, Risoleta,Regalado, Erik L.,Thomas, Olivier P.,Pino, Jorge A.,Fernandez, Miguel D.,Filippi, Jean-Jacques. (2009) 'Composition and antioxidant properties of the essential oil of the endemic cape verdean Satureja forbesii'. Natural Product Communications, 4 (9):1277-1280 [Details]
(2009) 'Bioactive Guanidine Alkaloids from two Caribbean Marine Sponges'
Laville, Remi,Thomas, Olivier P.,Berrue, Fabrice,Marquez, Diana,Vacelet, Jean,Amade, Philippe. (2009) 'Bioactive Guanidine Alkaloids from two Caribbean Marine Sponges'. Journal of Natural Products, 72 (9):1589-1594 [Details]
(2009) 'Parazoanthines A-E, Hydantoin Alkaloids from the Mediterranean Sea Anemone Parazoanthus axinellae'
Cachet, Nadja,Genta-Jouve, Gregory,Regalado, Erik L.,Mokrini, Redouane,Amade, Philippe,Culioli, Gerald,Thomas, Olivier P. (2009) 'Parazoanthines A-E, Hydantoin Alkaloids from the Mediterranean Sea Anemone Parazoanthus axinellae'. Journal of Natural Products, 72 (9):1612-1615 [Details]
(2009) 'Steroidal glycosides from the marine sponge Pandaros acanthifolium'
Cachet, Nadja,Regalado, Erik L.,Genta-Jouve, Gregory,Mehiri, Mohamed,Amade, Philippe,Thomas, Olivier P. (2009) 'Steroidal glycosides from the marine sponge Pandaros acanthifolium'. Steroids, 74 (9):746-750 [Details]
(2009) '3-Alkylpyridinium salts from Haplosclerida marine sponges: isolation, structure elucidations, and biosynthetic considerations'
Laville, Remi,Amade, Philippe,Thomas, Olivier P. (2009) '3-Alkylpyridinium salts from Haplosclerida marine sponges: isolation, structure elucidations, and biosynthetic considerations'. Pure and Applied Chemistry, 81 (6):1033-1040 [Details]

Book Chapters

  Year Publication
(2016) 'Metabolomic Contributions to Chemical Ecology'
Philippe Potin , Florence Nicolè, Olivier P. Thomas (2016) 'Metabolomic Contributions to Chemical Ecology' In: Chemical Ecology. Hoboken, NJ, USA: John Wiley & Sons, Inc.. [DOI] [Details]
(2014) 'Toxins from marine invertebrates'
Ternon, Eva,Thomas, Olivier P. (2014) 'Toxins from marine invertebrates' In: Seafood Freshwater Toxins (3rd Ed.). Boca Raton, FL: CRC Press. [Details]
(2011) 'Polyketide assembly mimics and biomimetic access to aromatic rings'
Genta-Jouve, Gregory,Antoniotti, Sylvain,Thomas, Olivier P. (2011) 'Polyketide assembly mimics and biomimetic access to aromatic rings' In: Biomimetic Organic Synthesis. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA. [Details]

Languages

  Language
Spanish
French
English

Reviews

  Journal Role
Journal Of Natural Products Reviewer
Polar Biology Reviewer
Scientific Reports Editoral Board
Tetrahedron Reviewer
Frontiers In Ecology And The Environment Editoral Board
Phytochemistry Reviewer
Planta Medica Reviewer
Organic Letters Reviewer
Plos One Reviewer
Journal of chemical ecology Reviewer

Current Postgraduate Students (Research)

  Student Degree Type Type
Nipun Mahajan Doctorate - Structured PhD (Science) Supervisor
Paul Guillen Mena Doctorate - Structured PhD (Science) Supervisor
Daria Firsova Doctorate - Structured PhD (Science) Supervisor

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
4th Year BSC and BPC Bioorganic Chemistry CH4108 and 4104 Structure Elucidation by NMR
3rd Year BSc Natural Products and Drugs CH332 Metabolic Pathways
2nd Year BSc Separation science and water chemistry CH205
2nd Year BSc Organic Chemistry CH202 Practicals
2nd Year BPS Plant Natural Products BPS3105 Isolation and purification

Internal Collaborators

  Name Description of Collaboration
Louise Allcock
SFI Grant
Grace McCormack
Common interest in the the application of metabolomic approaches to understand the systematics of Haliclona sponges
Paul MURPHY
Total synthesis of Marine natural products
Abhay PANDIT
CURAM-Biomaterials and medical devices

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Jeffrey FISHER Marine Institute IRELAND
Shellfish toxins and Marine Biodiscovery
Alan DOBSON UCC IRELAND
Marine microbes and metagenomics
Gregory Genta-Jouve University Paris Descartes FRANCE
Determination of the stereochemistry of natural products and environmental metabolomics
Erwan Poupon Universite Paris Sud FRANCE
Study of sponge metabolic pathways
Thierry Perez IMBE Marseille FRANCE
Multidiscilpinary approach in sponge ecology and chemical ecology
Luis Botana Universidad de Santiago de Compostella SPAIN
Biological applications of our marine natural compounds
Fernando REYES Fundacion Medina SPAIN
antimicrobial bioassays
Bassam Soussi Mabiotech OMAN
Omani sponge natural products for the pharmaceutical industry
Jenny Rodriguez CENAIM-ESPOL ECUADOR
Natural Product Chemistry
Howard JUNCA Microbiomas COLOMBIA
Omics for the classification of sponges and metabolic pathways
Mayalen Zubia University French Polynesia FRANCE
Chemical ecology of cyanobacteria from the Pacific
Claude Payri UMR Entropie, IRD New Caledonia FRANCE
Chemical ecology of Pacific macroalgae