Dr Patrick O'Leary BSc, PhD
Contact Details
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Biography:
| Patrick O'Leary is a native of Cork, Ireland and has been working in this department as a lecturer since September 2004. His Previous studies include a Bachelors of Science (B.Sc, 1995) degree and a Ph.D from University College Cork. His Ph.D Research concentrated on the Rhodium (II) Catalysed Buchner reaction. His research consisted of both catalyst study as well as preparation and study of multi-componant dynamic interconverting products. On completion of his Ph.D he was awarded the inaugural Post Doctoral Fellowship in The Sciences from the National University of Ireland in 1999. This Fellowship is awarded after an open competition among scientists throughout Ireland and only one is awarded every two years. This fellowship allowed Patrick to study the use of the Buchner as the key step in a challenging natural product synthesis. On completion of the NUI-postdoctoral fellowship Patrick moved to Utrecht to work in the Department of Metal Mediated Synthesis with Prof. Gerard van Koten and Dr. Bert Klein Gebbink. During the following two years he worked on immobilisation and recycling techniques for chiral homogeneous catalysts. This was achieved via the non-covalent immobilisation of homogeneous transition metal to silica materials. |
Research Interests
| ARABOX A Novel Ligand for Asymmetric Catalysis
We have recently reported the synthesis of a novel 4,4' Bisoxazoline ligand ARABOX. This novel ligand was synthesised using a tandem deprotection, activation, ring closure (DARC) reaction. We will shortly report on the catalytic activity of a range of catalytic complexes derived from this ligand
Catalyst immobilisation
We have published a number of reports of our efforts to develop a facile immobilisation method for oxazoline based catalysts. These catalysts are easily immobilised on silica and typically maintain their activity. A number of instances of unusual benefits on immobilisation have also been found.
Chiral Amide Ligand Design
We are currently involved in the design and development of a number of new ligand classes and their corresponding transition metal catalysts. Catalysts are also being tested in a number of key test reactions
We have recently reported on the synthesis of new bisamide ligands and the use of their palladium complexes as catalysts.
We are developing many other 'families' of catalysts for a wide variety of key organic transformations |
Book Chapters
| Patrick O'Leary (2007) 'Arenediazonium salts' In: C.A. Ramsden (eds). Science of Synthesis 31b. Stuttgart: George Thieme Verlag. [Details] |
Edited Books
| Patrick O'Leary (Ed.). (2008) Analytical Chemistry. Galway: Modular Programme in Science and Technology Studies. [Details] |
Peer Reviewed Journals
| Maguire, AR,Buckley, NR,O'Leary, P,Ferguson, G (1996) 'Excellent stereocontrol in intramolecular Buchner cyclisations and subsequent cycloadditions; Stereospecific construction of polycyclic systems'. Chemical Communications, :2595-2596. [Details] |
| Maguire, AR,O'Leary, P,Harrington, F,Lawrence, SE,Blake, AJ (2001) 'Dynamic equilibria in the products of intramolecular Buchner additions of diazoketones to aryl rings bearing methoxy substituents'. Journal Of Organic Chemistry, 66 :7166-7177. [Details] |
| McDonagh, C,O'Conghaile, P,Gebbink, RJMK,O'Leary, P (2007) 'Electrostatic immobilisation of copper(I) and copper(II) bis(oxazolinyl)pyridine catalysts on silica: application to the synthesis of propargylamines via direct addition of terminal alkynes to imines'. Tetrahedron Letters, 48 :4387-4390. [DOI] [Details] |
| Bateman, L,Breeden, SW,O'Leary, P (2008) 'New chiral diamide ligands: synthesis and application in allylic alkylation'. Tetrahedron-Asymmetry, 19 :391-396. [DOI] [Details] |
| McDonagh, C,O'Leary, P (2009) 'Electrostatically immobilised BOX and PYBOX metal catalysts: application to ene reactions'. Tetrahedron Letters, 50 :979-982. [DOI] [Details] |
| Frain, D,Kirby, F,McArdle, P,O'Leary, P (2009) 'The Synthesis of AraBOX, a New 4,4 '-Bis(oxazoline), from Novel Pentitol-Derived Bis-beta-amino Alcohols'. Synlett, :1261-1264. [DOI] [Details] |
| Geoghegan, P,O'Leary, P (2010) 'Pyroglutamate-derived hydroxyamide ligands: synthesis and application to asymmetric catalysis'. Tetrahedron-Asymmetry, 21 :867-870. [DOI] [Details] |
| Kirby, F,Frain, D,McArdle, P,O'Leary, P (2010) '4,4 ' BOX based catalysts: Synthesis, structure and catalytic application'. Catalysis Communications, 11 :1012-1016. [DOI] [Details] |
| Frain, D,Kirby, F,McArdle, P,O'Leary, P (2010) 'Preparation, structure and catalytic activity of copper(II) complexes of novel 4,4 '-BOX ligands'. Tetrahedron Letters, 51 :4103-4106. [DOI] [Details] |
| McDowell, PA,Foley, DA,O'Leary, P,Ford, A,Maguire, AR (2012) 'Asymmetric Synthesis of cis-7-Methoxycalamenene via the Intramolecular Buchner Reaction of an alpha-Diazoketone'. Journal Of Organic Chemistry, 77 :2035-2040. [DOI] [Details] |
| Maguire,A.R.,Buckley, N.R.,O'Leary, P.,Ferguson, G. (1998) 'Stereocontrol in the intramolecular Buchner reaction of diazoketones'. Journal of the Chemical Society - Perkin Transactions 1, (24). [Details] |
| O'Leary,P.,Krosveld, N.P.,De Jong, K.P.,Van Koten, G.,Klein Gebbink, R.J.M. (2004) 'Facile and rapid immobilization of copper(II) bis(oxazoline) catalysts on silica: Application to Diels-Alder reactions, recycling, and unexpected effects on enantioselectivity'. Tetrahedron Letters, 45 (16). [Details] |
| O'Leary, P.,Van Walree, C.A.,Mehendale, N.C.,Sumerel, J.,Morse, D.E.,Kaska, W.C.,Van Koten, G.,Klein Gebbink, R.J.M. (2009) 'Enzymatic immobilization of organometallic species: Biosilification of NCN- and PCP-pincer metal species using demosponge axial filaments'. Dalton Transactions, (22). [Details] |
| O'Leary,P.,Maguire, A.R. (2009) 'Efficient construction of novel carbocyclic frameworks via intramolecular aromatic addition of diazoketones followed by Diels-Alder cycloaddition'. Arkivoc, 2009 (11). [Details] |
| Frain,D, Kirby,F, McArdle,P, O'Leary,P. (2009) 'The Synthesis of AraBOX, a New 4,4’-bisoxazoline), from Novel Pentitol-Derived Bis ß-Aminoalcohol'. Synlett, . [Details] |
| Paul Geoghegan, Patrick O'Leary (2012) 'Hydroxyamide-Based Ligands and Their Use in the Asymmetric'. ACS Catalysis, . [Details] |
Other Journals
| Patrick O'Leary (2005) 'Researching metal catalysts in the Department of Chemistry' The Irish Scientist . [Details] |
Published Reports
| Patrick O'Leary (2005) Activity Report 1999-2001 COST CHEMISTRY ACTION D8-D29. COST Brussels, COST Brussels. [Details] |
Honours and Awards
| Year: 1999. Title: NUI-postdoctoral Fellowship in Sciences |
Associations
| Association: Royal Society of Chemistry , Function/Role: Republic of Ireland Committee member |
| Association: Royal Society of chemistry, Function/Role: Member |
Conference Contributions
| Patrick O'Leary (2006) Universities Chemistry research colloquium for chemistry postgrads in Ireland. [Conference Organising Committee Member], Universities Chemistry research colloquium, NUI Galway , 14-JUN-06 - 16-FEB-07. |
| Patrick O'Leary (2007) One day conference on the chemistry of metals. [Invited Oral Presentation], Magic of Metals, NUI Maynooth , 08-NOV-07 - 08-NOV-07. |
| Patrick O'Leary (2008) One day conference to mark the retirement of Prof Butler NUI Galway. [Conference Organising Committee Chairperson], Adventures in Heterocyclic and Nitrogen Chemistry, NUI Galway , 07-MAY-08 - 07-MAY-08. |
| Prof. Corrado Santocanale National University of Ireland, Galway Prof. Karl J. HaleQueens University Belfast Prof. Ian Paterson FRS (2009) One-Day Cancer Chemistry Symposium concentratin on chemistry and biology of cancer. [Conference Organising Committee Member], One-Day Cancer Chemistry Symposium, NUI Galway , 03-JUL-09 - 03-JUL-09. |
| Patrick O'Leary and others as below (2012) Meeting at which 3 awardees of RSC medals presented their work and were presented with their awards. [Conference Organising Committee Chairperson], Royal Society of Chemistry Awards meeting, NU Galway , 12-APR-12 - 12-APR-12. |
Committees
| Committee : School of chemistry Safety Subcommittee |
| Committee : Academic Council standing Committee |
| Committee : Royal Society of Chemistry,Ireland Section |
| Committee : University Safety Working group (formerly Safety Committee) |
| Committee : Academic Council |
Languages
| German: |
| French: |
| Dutch: |
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| English: |