Chemistry

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Prof. Paul Murphy B.Sc.,Ph.D.

Contact Details

Title	Prof. of Chemistry
Address	School of Chemistry Room 236 Arts/Science Building Nui Galway
Telephone:	Ext. 2465
Email:	ei.yawlagiun@yhprum.v.luap

Biography:

Peer Reviewed Journals

Andre, S,Jarikote, DV,Yan, DD,Vincenz, L,Wang, GN,Kaltner, H,Murphy, PV,Gabius, HJ (2012) 'Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons'. Bioorganic & Medicinal Chemistry Letters, 22 :313-318. [DOI] [Details]

Napolitano, C,Palwai, VR,Eriksson, LA,Murphy, PV (2012) 'Synthesis, kinase activity and molecular modeling of a resorcylic acid lactone incorporating an amide and a trans-enone in the macrocycle'. Tetrahedron, 68 :5533-5540. [DOI] [Details]

Zhou, J,Matos, MC,Murphy, PV (2011) 'Synthesis of a Benzomacrolactone-Based Somatostatin Mimetic'. Organic Letters, 13 :5716-5719. [DOI] [Details]

Zhao, YX,Liu, M,Chagnault, V,Wang, JY,Zhang, XM,Murphy, PV (2011) 'Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold'. Bioorganic & Medicinal Chemistry Letters, 21 :824-828. [DOI] [Details]

O'Brien, C,Murphy, PV (2011) 'Synthesis of 1-Deoxynojirimycin Derivatives from L-Sorbose via Wittig Reactions'. Journal Of Carbohydrate Chemistry, 30 :626-640. [DOI] [Details]

Napolitano, C,Natoni, A,Santocanale, C,Evensen, L,Lorens, JB,Murphy, PV (2011) 'Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation'. Bioorganic & Medicinal Chemistry Letters, 21 :1167-1170. [DOI] [Details]

Jarikote,D.V., Li,W., Jiang,T.,Eriksson,L.A.., Murphy,P.V. (2011) 'Towards Econimycin Mimetics via Grafting Quinoxaline Residues on Glycophane Scaffolds'. Bioorgan Med Chem, 19 (2):826-835. [Details]

Jarikote,D.V., Li W., Jiang T., Eriksson L.A., Murphy P.V. (2011) 'Towards echinomycin mimetics by grafting quinoxaline residues on glycophane scaffolds'. Bioorganic and Medicinal Chemistry, 19 (2):826-835. [DOI] [Details]

O'Reilly, C,Murphy, PV (2011) 'Synthesis of alpha-S-Glycosphingolipids Based on Uronic Acids'. Organic Letters, 13 :5168-5171. [DOI] [Details]

Zhao, Y,Liu, W,Zhou, Y,Zhang, X,Murphy, PV (2010) 'N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells'. Bioorganic & Medicinal Chemistry Letters, 20 :7540-7543. [DOI] [Details]

Napolitano, C,McArdle, P,Murphy, PV (2010) 'Access to Resorcylic Acid Lactones via Phosphonate Based Intramolecular Olefination'. Journal Of Organic Chemistry, 75 :7404-7407. [DOI] [Details]

Zhao, YX,Zhou, Y,Boyle, KMO,Murphy, PV (2010) 'Biological study of the Angiogenesis Inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin'. Chemical Biology & Drug Design, 75 :570-577. [DOI] [Details]

Zhou, Y,Murphy, PV (2010) 'Synthesis of congeners of migrastatin and dorrigocin A from D-xylose'. Tetrahedron Letters, 51 :5262-5264. [DOI] [Details]

Pilgrim, W,Murphy, PV (2010) 'SnCl4- and TiCl4-Catalyzed Anomerization of Acylated O- and S-Glycosides: Analysis of Factors That Lead to Higher alpha:beta Anomer Ratios and Reaction Rates'. Journal Of Organic Chemistry, 75 :6747-6755. [DOI] [Details]

Jarikote, DV,O'Reilly, C,Murphy, PV (2010) 'Ultrasound-assisted synthesis of C-glycosides'. Tetrahedron Letters, 51 :6776-6778. [DOI] [Details]

Zhou,Y., Murphy,P.V. (2010) 'Synthesis of congeners of the migrastatin and dorrigocin: A core structures from D-xylose'. Tetrahedron Letters, 51 :5262-5264. [Details]

Napolitano,C, McArdle,P, Murphy,P.V. (2010) 'Rapid Access to Resorcylic Acid Lactones using Cross Metathesis and Phosphonate Based Intramolecular Olefination'. Journal Of Organic Chemistry, 75 :7404-7407. [DOI] [Details]

Jarikote,D.V, Murphy,P.V. (2010) 'Metathesis and macrocycles with embedded carbohydrates'. European Journal of Organic Chemistry Microreview), :4959-4970. [Details]

Leyden,R., Velasco-Torrijos,T., ré,S., Gouin,S.G., Gabius,H.J., Murphy,P.V. (2010) 'Synthesis of bivalent lactosides based on terephthalamide, N,N' diglucosylterephthalamide and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins'. Journal of Organic Chemistry, 74 :9010-9026. [DOI] [Details]

Andre, S,Velasco-Torrijos, T,Leyden, R,Gouin, S,Tosin, M,Murphy, PV,Gabius, HJ (2009) 'Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles'. Organic & Biomolecular Chemistry, 7 :4715-4725. [DOI] [Details]

Leyden, R,Velasco-Torrijos, T,Andre, S,Gouin, S,Gabius, HJ,Murphy, PV (2009) 'Synthesis of Bivalent Lactosides Based on Terephthalamide, N,N '-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins'. Journal Of Organic Chemistry, 74 :9010-9026. [DOI] [Details]

Leyden, R,Murphy, PV (2009) 'Glycotriazolophane Synthesis via Click Chemistry'. Synlett, :1949-1950. [DOI] [Details]

Pilgrim, W,Murphy, PV (2009) 'alpha-Glycosphingolipids via Chelation-Induced Anomerization of O- and S-Glucuronic and Galacturonic Acid Derivatives'. Organic Letters, 11 :939-942. [DOI] [Details]

O'Reilly, C,O'Brien, C,Murphy, PV (2009) 'Synthesis of a constrained polyfunctional bicyclic iminocyclitol scaffold from L-sorbose via a tandem sequence including stereoselective intramolecular Huisgen cycloaddition'. Tetrahedron Letters, 50 :4427-4429. [DOI] [Details]

Rountree, JSS,Murphy, PV (2009) 'Synthesis of a Novel Polyhydroxylated Salicylic Acid Lactone Framework'. Organic Letters, 11 :871-874. [DOI] [Details]

Leyden,R., Velasco-Torrijos,T., ré,S., Gouin,S.G., Gabius,H.J., Murphy,P.V. (2009) 'Synthesis of bivalent lactosides based on terephthalamide, N,N’ diglucosylterephthalamide and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins'. Journal of Organic Chemistry, 74 :9010-9026. [DOI] [Details]

Rountree, J.S.S.,Murphy, P.V. (2009) 'Synthesis of a novel polyhydroxylated salicylic acid lactone framework'. Organic Letters, 11 (4):871-874. [DOI] [Details]

Chagnault, V.,Lalot, J.,Murphy, P.V. (2008) 'Synthesis of somatostatin mimetics based on 1-deoxynojirimycin'. ChemMedChem, 3 (7). [Details]

Murphy,P.V., Velasco-Torrijos,T. (2008) 'Monosaccharide scaffolds for the synthesis of novel compounds'. Glycoscience-Chemistry and Chemical Biology, :997-1027. [DOI] [Details]

Zhou, Y.,Zhao,Y.,O' Boyle,K.M.,Murphy,P.V. (2008) 'Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds comprised of 1-deoxynojirimycin and 5-aryl-1,2,3-triazoles'. Bioorganic and Medicinal Chemistry Letters, 18 :954-958. [DOI] [Details]

Anquetin,G, Horgan,G, Rawe,S, Murray,D, Madden,A, MacMathuna,P, Doran,P, Murphy,P.V. (2008) 'Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin from D-Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener is a Potent Inhibitor of Gastric Cancer Cell Migration'. European Journal of Organic Chemistry, 11 :1953-1958. [Details]

Anqueti,G.,Rawe, S.L.,McMahon, K.,Murphy, E.P.,Murphy, P.V. (2008) 'Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal'. Chemistry (Weinheim an der Bergstrasse, Germany), 14 (5). [Details]

Anquetin, G.,Rawe, S.L.,McMahon, K.,Murphy, E.P.,Murphy, P.V. (2008) 'Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal'. Chemistry - A European Journal, 14 (5). [Details]

Zhao,Y.,Zhou,Y.,O'Boyle, K.M.,Murphy, P.V. (2008) 'Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis'. Bioorganic and Medicinal Chemistry, 16 (12). [Details]

Zhou, Y.,Murphy, P.V. (2008) 'New access to 1-deoxynojirimycin derivatives via azide-alkene cycloaddition'. Organic Letters, 10 (17). [Details]

Doyle,D.,Murphy, P.V. (2008) 'Synthesis of novel glycophanes derived from glucuronic acid by ring closing alkene and alkyne metathesis'. Carbohydrate Research, 343 (15). [Details]

Loukou,C..,Tosin, M.,Muller-Bunz, H.,Murphy, P.V. (2008) 'Corrigendum to Synthesis of sugar-lactams from azides of glucuronic acid. [Carbohydr. Res. 342 (2007) 1953] (DOI:10.1016/j.carres.2007.04.003)'. Carbohydrate Research, 343 (2). [Details]

Murphy, P.V. (2007) 'Peptidomimetics, glycomimetics and scaffolds from carbohydrate building blocks'. European Journal of Organic Chemistry, (25). [Details]

Loukou, C, Tosin,M, Müller-Bunz,H, Murphy,P.V. (2007) 'Synthesis of sugar-lactams from azides of glucuronic acid'. Carbohydrate Research Special issue-Glycomimetics, 342 :1953-1959. [DOI] [Details]

Matos,M.C., Murphy,P.V. (2007) 'Synthesis of macrolide-saccharide hybrids by ring closing metathesis of precursors derived from glycitols and benzoic acids'. J. Org. Chem, 72 :1803-1806. [DOI] [Details]

O' Brien,C, Poláková,M, Pitt,N, Tosin,M, Murphy,P.V. (2007) 'Glycosidation-Anomerisation Reactions of 6,1-Anhydroglucopyranuronic Acid and Anomerisation of -D-Glucopyranosiduronic Acids Promoted by SnCl4'. Chem. Eur. J, 13 :902-909. [Details]

Danieli,E.,Lalot, J.,Murphy, P.V. (2007) 'Selective protecting group manipulations on the 1-deoxynojirimycin scaffold'. Tetrahedron, 63 (29). [Details]

Cronin,L., Tosin,M., Müller-Bunz,H., Murphy,P.V. (2007) 'The synthesis of cyclic imidates from glucuronic acid amides and glycosidation reactions'. Carbohydr. Res, 342 :111-118. [Details]

Zaric,V., Doyle,D., Murphy,P.V., O' Boyle,K.M. (2007) 'Inhibition of endothelial cell proliferation by N- -D-mannopyranosyl-thiophene-2-carboxamides'. Anticancer Research, 27 :1331-1336. [Details]

Cronin,L.,Tosin, M.,Muller-Bunz, H.,Murphy, P.V. (2007) 'The synthesis of cyclic imidates from amides of glucuronic acid and investigation of glycosidation reactions'. Carbohydrate Research, 342 (1). [Details]

Zaric,V., Doyle, D., Murphy, P.V., O'Boyle, K.M. (2007) 'Inhibition of endothelial cell proliferation by per-O-acetylated mannose conjugates'. Anticancer Research, 27 (3 A). [Details]

Murphy,P.V., Dunne,J.L. (2006) 'Syntheses of peptidomimetics based on pyranose and polyhydroxylated piperidine scaffolds'. Curr. Org. Synth, 3 :403-437. [Details]

Rawe,S.L., Doyle,D., Zaric,V., Rozas,I., McMahon,K., Tosin, M., Murphy,E., O' Boyle,K.M., Murphy,P.V. (2006) 'N-Glycosyl-thiophene-2-carboxamides Synthesis, structure and effects on growth of diverse cell types in presence and absence of bFGF'. Carbohydr. Res. special issue - Synthesis, (341):1370-1390. [Details]

Breen,E.P.,Gouin, S.G.,Murphy, A.F.,Haines, L.R.,Jackson, A.M.,Pearson, T.W.,Murphy, P.V.,Porter, R.K. (2006) 'On the mechanism of mitochondrial uncoupling protein 1 function'. Journal of Biological Chemistry, 281 (4). [Details]

Murphy,P.V., Rutledge,P.J. (2006) 'Symbiosis in Chemistry and Biology'. Nature Chem. Biol, 2 :59-62. [Details]

Rawe,S.L., Zaric,V., O' Boyle,K.M., Murphy,P.V. (2006) 'N-Glycosyl-thiophene-2-carboxamides Effects on endothelial cell growth in the presence and absence of bFGF A significant increase in potency using per-O-acetylated sugar analogues , Bioorg Med'. Chem. Lett, 16 :1316-1319. [Details]

Rawe, S.L.,Murphy, P.V.,Doyle, D.,Zaric, V.,Rozas, I.,McMahon, K.,Tosin, M.,Bunz, H.M.,Murphy, E.P.,O' Boyle, K.M. (2006) 'N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types'. Carbohydrate Research, 341 (10). [Details]

Rawe, SL,Zaric, V,O'Boyle, KM,Murphy, PV (2006) 'N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF - A significant increase in potency using per-O-acetylated sugar analogues'. Bioorganic & Medicinal Chemistry Letters, 16 :1316-1319. [DOI] [Details]

Cronin, L,Murphy, PV (2005) 'Novel synthesis of castanospermine and 1-epicastanospermine'. Organic Letters, 7 :2691-2693. [DOI] [Details]

Velasco-Torrijos, T,Murphy, PV (2005) 'Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a beta-cyclodextrin mimic'. Tetrahedron-Asymmetry, 16 :261-272. [DOI] [Details]

Tosin,M.,Murphy, P.V. (2005) 'Synthesis of structurally defined scaffolds for bivalent ligand display based on glucuronic acid anilides. The degree of tertiary amide isomerism and folding depends on the configuration of a glycosyl azide'. Journal of Organic Chemistry, 70 (10). [Details]

Gouin,S.G.,Pilgrim, W.,Porter, R.K.,Murphy, P.V. (2005) 'Synthesis of a glycolipid for studying mechanisms of mitochondrial uncoupling proteins'. Carbohydrate Research, 340 (8). [Details]

Gouin, S.G.,Murphy, P.V. (2005) 'Synthesis of somatostatin mimetics based on the 1-deoxymannojirimycin scaffold'. Journal of Organic Chemistry, 70 (21). [Details]

Killoran, J.,Gallagher, J.F.,Murphy, P.V.,O'Shea, D.F. (2005) 'A study of the effects of subunit pre-orientation for diarylpyrrole esters; design of new aryl-heteroaryl fluorescent sensors'. New Journal of Chemistry, 29 (10). [Details]

Murphy, P.V.,Muller-Bunz, H.,Velasco-Torrijos, T. (2005) 'The crystal structure of a cyclic glycolipid reveals a carbohydrate- carbohydrate interaction interface'. Carbohydrate Research, 340 (7). [Details]

Tosin,M., O' Brien,C., Fitzpatrick,G.M., Müller-Bunz,H., Glass,W.K., Murphy,P.V. (2005) 'Synthesis and structural analysis of anilides of glucuronic acid and orientation of groups on carbohydrate scaffolding'. J. Org. Chem, 70 :4096-4106. [Details]

Tosin,M., Gouin, S.G., Murphy,P.V. (2005) 'Synthesis of structurally diverse and defined bivalent mannosides on saccharide scaffolding'. Org. Lett, (7):211-214. [Details]

Tosin, M,Muller-Bunz, H,Murphy, PV (2004) 'Synthesis and X-ray single crystal structure of a bivalent glycocluster'. Chemical Communications, :494-495. [DOI] [Details]

McDonnell, C, Cronin,L, O' Brien,J.L, Murphy,P.V. (2004) 'A general synthesis of iminosugars'. J. Org. Chem, 69 :3565-3568. [Details]

Polakova,M.,Pitt, N.,Tosin, M.,Murphy, P.V. (2004) 'Glycosidation reactions of silyl ethers with conformationally inverted donors derived from glucuronic acid: Stereoselective synthesis of glycosides and 2-deoxyglycosides'. Angewandte Chemie - International Edition, 43 (19). [Details]

McDonnell, C.,Lopez, O.,Murphy, P.,Fernandez Bolanos, J.G.,Hazell, R.,Bols, M. (2004) 'Conformational effects on glycoside reactivity: Study of the high reactive conformer of glucose'. Journal of the American Chemical Society, 126 (39). [Details]

McDonnell,C.,Cronin, L.,O'Brien, J.L.,Murphy, P.V. (2004) 'A General Synthesis of Iminosugars'. Journal of Organic Chemistry, 69 (10). [Details]

Poláková,M., Pitt, N., Tosin,M., Murphy,P.V. (2004) 'Glycosidation reactions of silyl ethers with conformationally inverted donors derived from glucuronic acid Stereoselective glycoside and 2-deoxyglycoside synthesis'. Angew. Chem. Int. Ed, 43 :2518-2521. [Details]

Chery, F, Cronin,L, O' Brien,J, Murphy,P.V. (2004) 'Synthesis of peptidomimetics based on an iminosugar and -D-glucopyranoside and inhibition of HIV-protease'. Tetrahedron, 60 :6597-6608. [Details]

Pitt,N.,Duane,R.M.,O' Brien, A.,Bradley,H.,O' Boyle,K.M.,Murphy,P.V. (2004) 'Synthesis of glucuronic acid and glucose conjugates and effects on endothelial cell growth'. Carbohydr. Res, (339):1873-1887. [Details]

Velasco-Torrijos,T.,Murphy, P.V. (2004) 'Metathesis of structurally preorganized bivalent carbohydrates. Synthesis of macrocyclic and oligomeric scaffolds'. Organic Letters, 6 (22). [Details]

Pitt,N.,Duane, R.M.,O' Brien, A.,Bradley, H.,Wilson, S.J.,O' Boyle, K.M.,Murphy, P.V. (2004) 'Synthesis of a glucuronic acid and glucose conjugate library and evaluation of effects on endothelial cell growth'. Carbohydrate Research, 339 (11). [Details]

O' Brien, A.,Lynch, C.,O' Boyle, K.M.,Murphy, P.V. (2004) 'Synthesis of disaccharides derived from heparin and evaluation of effects on endothelial cell growth and on binding of heparin to FGF-2'. Carbohydrate Research, 339 (14). [Details]

Tosin,M., Müller-Bunz,H., Murphy,P.V. (2004) 'Synthesis and X-ray single crystal structure of a novel bivalent glycocluster'. Chem. Commun, :494-495. [Details]

Chery,F, Murphy,P.V. (2004) 'Synthesis of an iminosugar based peptidomimetic analogue'. Tetrahedron Lett, 45 :2067-2069. [Details]

O' Brien,A,Lynch,c,O' Boyle,K.M, Murphy,P.V. (2004) 'Synthesis of disaccharides derived from heparin Effects on endothelial cell proliferation and on binding of heparin to FGF-2'. Carbohydr. Res, 339 :2343-2354. [Details]

Murphy, P.V.,McDonnell, C.,Hamig,L.,Paterson, D.E.,Taylor, R.J.K. (2003) 'Confirmation of the structure of a glucono-1,4-lactone derivative obtained from silylation of glucono-1,5-lactone'. Tetrahedron Asymmetry, 14 (1). [Details]

Murphy, P.V., Bradley,H., Tosin,M., Pitt,N., Fitzpatrick,G.M., Glass,W.K. (2003) 'Development of carbohydrate based scaffolds for restricted presentation of recognition groups Extension to divalent ligands and implications for the structure of dimerized receptors'. J. Org. Chem, 68 :5693-5704. [Details]

Murphy, PV,O'Brien, JL,Gorey-Feret, LJ,Smith, AB (2003) 'Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds'. Tetrahedron, 59 :2259-2271. [DOI] [Details]

Enright, PM,Tosin, M,Nieuwenhuyzen, M,Cronin, L,Murphy, PV (2002) 'A study of the epoxidation of 6-deoxyhex-5-enopyranosides. 1,5-dicarbonyl derivatives and novel synthetic routes to D-xylo-hexos-5-ulose and D-lyxo-hexos-5-ulose'. Journal Of Organic Chemistry, 67 :3733-3741. [DOI] [Details]

Griffin, F.K.,Paterson, D.E.,Murphy, P.V.,Taylor, R.J.K. (2002) 'A new route to exo-glycals using the Ramberg-Bäcklund rearrangement'. European Journal of Organic Chemistry, (7). [Details]

Enright, P.M., Tosin,M., Nieuwenhuyzen,M., Cronin,L., Murphy,P.V. (2002) 'A study of the epoxidation of 6-deoxyhex-5-enopyranosides Formation, reactions and structure of 1,5-dicarbonyl derivatives and novel synthetic routes to D-xylo-hexos-5-ulose and D-lyxo-hexos-5-ulose'. J. Org. Chem, 67 :3733-3741. [Details]

Murphy, P.V., Pitt,N.,O' Brien,A., Enright,P.M., Dunne,A., Wilson,S.J., Duane,R.M., O' Boyle,K.M. (2002) 'Identification of novel inhibitors of Fibroblast Growth Factor FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library'. Bioorg. Med. Chem. Lett, 12 :3287-3290. [Details]

Murphy,P.V., O' Brien, J., Gorey-Feret,L.J., Smith,A.B. (2002) 'Structure based design, synthesis and evaluation of inhibitors of HIV-1 protease based on -D-mannopyranoside scaffolds'. Bioorg. Med. Chem. Lett, 12 :1763-1766. [Details]

Tosin,M., Murphy,P.V. (2002) 'Synthesis of -glucuronic acid and amide derivatives in the presence of a participating 2-acyl protecting group'. Org. Lett, 4 :3675-3678. [Details]

Murphy,P.V.,O'Brien, J.L.,Gorey-Feret, L.J.,Smith, III A.B. (2002) 'Structure-based design and synthesis of HIV-1 protease inhibitors employing ?-D-mannopyranoside scaffolds'. Bioorganic and Medicinal Chemistry Letters, 12 (13). [Details]

Bradley, H., Fitzpatrick, G.,Glass, W.K.,Kunz, H.,Murphy, P.V. (2001) 'Application of Ugi reactions in synthesis of divalent neoglycoconjugates: Evidence that the sugars are presented in restricted conformation'. Organic Letters, 3 (17). [Details]

O'Brien, JL,Tosin, M,Murphy, PV (2001) 'Novel synthesis of the glycosidase inhibitor deoxymannojirimycin and of a synthetic precursor D-lyxo-hexos-5-ulose'. Organic Letters, 3 :3353-3356. [DOI] [Details]

Murphy, PV,O'Brien, JL,Smith, AB (2001) 'Stereospecific synthesis of beta-D-allopyrano sides by dihydroxylation of beta-D-erythro-2,3-dideoxyhex-2-enopyranosides'. Carbohydrate Research, 334 :327-335. [Details]

Murphy, PV,O'Sullivan, TJ,Kennedy, BD,Geraghty, NWA (2000) 'The reactions of diazo compounds with lactones. Part 2. The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with diketene: benzofuran formation'. Journal Of The Chemical Society-Perkin Transactions 1, :2121-2126. [DOI] [Details]

Murphy,P.V., O'Sullivan,T.J., Geraghty,N.W.A. (2000) 'The Reactions of Diazo Compounds with Lactones Part 1 Cyclopropanespiro- -lactones from Diketene: Synthesis and Reactions'. J. Chem. Soc. Perkin Trans. 1, :2109-2119. [DOI] [Details]

Geraghty, N., Murphy,P.V., O'Sullivan,T.J., Kennedy,B.D.. (2000) 'The reactions of diazo compounds with lLactones II The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with diketene: benzofuran formation'. J. Chem. Soc. Perkin Trans, (2121). [Details]

Enright, PM,O'Boyle, KM,Murphy, PV (2000) 'Synthesis of D-hexos-5-uloses by novel in situ hydrolysis of epoxides derived from 6-deoxyhex-5-enopyranosides'. Organic Letters, 2 :3929-3932. [DOI] [Details]

Geraghty, N.,Murphy,P.V., O' Sullivan,T.J., Cunningham,P.D., McArdle,P.J. (2000) 'The reactions of diazocompounds with lactones I Cyclopropanespiro-?-lactones from diketene: synthesis and reactions'. J. Chem. Soc. Perkin Trans, (2109). [Details]

Murphy,P.V., O'Sullivan,T.J.,Kennedy,B.D., Geraghty,N.W.A. (2000) 'The Reactions of Diazo Compounds with Lactones Part 2 The Reaction of Cyclic 2-Diazo-1,3-dicarbonyl Compounds with Diketene: Benzofuran Formation'. J. Chem. Soc. Perkin Trans. 1, :2121-2126. [Details]

Murphy, PV,O'Sullivan, TJ,Geraghty, NWA (2000) 'The reactions of diazo compounds with lactones. Part 1. Cyclopropanespiro-beta-lactones from diketene: synthesis and reactions'. Journal Of The Chemical Society-Perkin Transactions 1, :2109-2119. [DOI] [Details]

Manallack,D.T, Montana,J.G, Murphy, P.V, Hubbard,R.E, Taylor,R.J.K, (1998) 'Design, Synthesis and Testing of Novel Inhibitors of Cell Adhesion'. Proceedings of the European Symposium on Quantitative Structure Activity Relationships: Molecular Modelling and Prediction of Bioactivity, 12th, Copenhagen, Denmark 1998 2000), :371-372. [Details]

Murphy P.V.,Hubbard, R.E.,Manallack, D.T.,Montana, J.G.,Taylor, R.J.K. (1998) 'The synthesis of novel structural analogues of sialyl Lewis(x)'. Tetrahedron Letters, 39 (20). [Details]

Murphy,P.V.,Hubbard, R.E.,Manallack, D.T.,Wills, R.E.,Montana, J.G.,Taylor, R.J.K. (1998) 'The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x)'. Bioorganic and Medicinal Chemistry, 6 (12). [Details]

Griffin,F.K.,Murphy, P.V.,Paterson D.E., Taylor R.J.K. (1998) 'A Ramberg-Backlund approach to exo-glycals'. Tetrahedron Letters, 39 (44). [Details]

Cunningham,P.D., McArdle,P.A., Geraghty,N.W.A., Murphy,P.V., O' Sullivan,T.J. (1997) 'The Reactions of Cyclic 2-Diazo-1,3-dicarbonyl Compounds with - and -Lactones: the Formation of Benzofurans, Benzodioxepins and Benzodioxecins'. J. Chem. Soc.; Perkin Trans 1, :1-4. [Details]

Cunningham, PD,Geraghty, NWA,McArdle, PJ,Murphy, PV,OSullivan, TJ (1997) 'The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with beta- and gamma-lactones: Formation of benzodioxepinones, benzodioxecinones and benzofurans'. Journal Of The Chemical Society-Perkin Transactions 1, :1-4. [Details]

Geraghty, N.,Cunningham, P.D.,McArdle,P.J.,Murphy,P.V.,O'Sullivan,T.J. (1997) 'The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with - and -lactones: formation of benzodioxepinones, benzodioxecinones and benzofurans'. J. Chem. Soc. Perkin Trans I, 1 . [Details]

Murphy, P.V., Hubbard,R.E., Montana,J.G., Taylor,R.J.K. (1996) 'Glycosylation Reactions of 2,3,4-Tri-O-chlorosulfonyl- -L-fucopyranosyl chloride and 2,3,4-Tri-O-chlorosulfonyl- -D-xylopyranosyl chloride'. Carbohydr. Res, (287):247-253. [Details]

Geraghty,N.W.A., Murphy,P.V. (1994) 'Metal Catalysed Rearrangement of Cyclopropanespiro- -lactones to 2-Furanones'. Tetrahedron Lett, (6737). [Details]

Abstract

Zhou, J,Murphy, PV (2011) Synthesis of macrocycles with embedded carbohydrates for peptidomimetic research. Abstract [Details]

Field-Corbett, C,Torrijos, TV,Murphy, PV,Callaghan, M,McClean, S (2009) ADHERENCE OF BURKHOLDERIA MULTIVORANS TO LUNG EPITHELIAL CELLS VIA SUGAR RECEPTORS: QUANTIFICATION OF ADHESION BY A NOVEL METHOD USING REAL TIME PCR. Abstract [Details]

Editorial

Murphy, PV,Rutledge, PJ (2006) Symbiosis in chemistry and biology. Editorial [DOI] [Details]

Reviews

Jarikote, DV,Murphy, PV (2010) Metathesis and Macrocycles with Embedded Carbohydrates. Reviews [DOI] [Details]

Workshops

Murphy,P.V. Novel Analogues of Sialyl Lewis X. 10th European Carbohydrate Symposium. Workshops [Details]

Murphy,P.V. Problems in Glycosylation Reactions of Fucose. Workshops [Details]

Zhou,Y.,Murphy,P.V. Synthesis of Novel Migrastatin and Dorrigocin A analogues from D-Xylose. 41st National Organic Chemistry Symposium Poster presentation: A27. Workshops [Details]

Jarikote,D.V, Li,W , Murphy,P.V. (2009) Novel Echinomycin Analogues: Biophysical Study of Quinoxaline labelled Glycophanes . 15th European Carbohydrate Symposium Poster presentation: PC94:. Workshops [Details]

Field-Corbett, C., Torrijos-Velasco T., Murphy P.V., Callaghan, M., McClean, S. (2009) Adherence of Burkholderia Multivorans to Lung Epithelial Cells via Sugar Receptors: Quantification of Adhesion by a Novel Method using Real Time PCR . Pediatric Pulmonology Meeting Abstract. Workshops [Details]

Cheriyan, M, Tosetto, D, Murray, G, Anquetin, Y, Zhou, P,Doran, O'Donoghue, D, Mulcahy, H, Murphy, P.V, O'Sullivan, J. (2009) The Effect of Dorrigocin and Migrastatin Analogs on Angiogenic and Pro-inflammatory Cytokine Secretion in a Human Colorectal Cancer Tumour Explant Model. Cost Action CM0602: 3rd Workshop: Inhibitors of angiogenesis: design, synthesis and biological exploitation ANGIOKEM. Workshops [Details]

Cheriyan,D, Tosetto,M, Murray,D, Anquetin,G, Zhou,Y, Doran,P, O'Donoghue, D, Mulcahy,H, Murphy,P.V, O'Sullivan,J. (2009) The effect of dorrigocin and migrastatin analogues on angiogenic marker secretions and cellular processes using a human tumour explant model. COST Action Angiokem) Scientific Meeting. Workshops [Details]

Rountree,J.S.S.,Murphy,P.V. (2008) Synthesis of apicularen A and related salicylic acid macrolide structures as novel antiangiogenic compounds against cancer . Ninth Tetrahedron Symposium: Challenges in Organic and Bioorganic Chemistry, Berkeley,CA, USA. Poster Number: P1.35. Workshops [Details]

Murphy,P.V. (2007) Synthesis of compounds of medicinal interest based on carbohydrates. RSC-SCI-ICI Synthesis III Conference. Workshops [Details]

Astudillo,O.,Alvarez,Y.,Waghorne, N.,Murphy,P.V.,Fearon,U.,Kennedy,B. (2007) Identification of novel genetic and chemical determinants of the retinal/hyaloid vasculature development in zebrafish using genetic and chemical screening approaches . Irish Network of Developmental Biology INDB) meeting. Workshops [Details]

Horgan,G.,Murray,D.W.,Anquetin,G.,Murphy,P.V.,MacMathuna, P.,Doran,P. (2007) Novel migrastatin analogues reduce gastric tumour cell migration via cytoskeletal rearrangement. 15th United European Gastroenterology Week, Le Palais des Congrès de Paris. Workshops [Details]

Murphy,P.V. (2006) Carbohydrates in synthesis of bioactive molecules. Ocean University of China. Workshops [Details]

Loukou,C, Murphy,P.V. (2006) New approaches towards stereoselective glycoside synthesis. 1st European Chemistry Congress. Workshops [Details]

Murphy,P.V. (2006) Carbohydrate Guided Synthesis of Bioactive Molecules,' . Queens University Belfast, Symposium on Synthesis, chemical biology and drug design. Workshops [Details]

Murphy,P.V. (2006) Carbohydrates in Therapeutics: The role of sugars in drug delivery and drug discovery'. Carbohydrate Guided Synthesis of Bioactive Molecules at the Royal Sociaty of Chemistry Carbohydrate Group Autumn Meeting Biocity. Workshops [Details]

Zaric,V.,Rawe,S.L.,Doyle,D.,Murphy,P.V.,O'Boyle,K. (2006) Antiproliferative activity of thiophene sugar conjugates in endothelial cells, ,b Global mRNA and Protein Expression Analysis. Research applications in cancer and other diseases and in biopharmaceutical production, Dublin City University. Workshops [Details]

Murphy,P.V. (2006) Carbohydrate Guided Bioactive Molecule Synthesis. Arrhenius Laboratories. Workshops [Details]

Murphy,P.V. (2006) Sugars as renewable materials for the synthesis of compounds of biological interest' . EU Workshop,CEDNETS, Insitute of Organic Chemistry, Polish Academy of Sciences. Workshops [Details]

Murphy,P.V. (2006) Carbohydrates in synthesis of bioactive molecules. University of Florence, Italy. Workshops [Details]

Murphy,P.V. (2006) Carbohydrates in synthesis of bioactive molecules. Shanghai Institute of Organic Chemistry. Workshops [Details]

Murphy,P.V. (2006) Pyranoside and iminosugar scaffolding as a basis for the development of peptidomimetics. ERA Chemistry Workshop on 'Stereo-controlled chemistry related to the solution of major biological problems'. Workshops [Details]

Anquetin,G.,Rawe,S.L.,Murphy,P.V. (2006) Synthesis and anticancer activity of new migrastatin analogs . Abstracts of Papers, 234th ACS National Meeting MEDI-459. Workshops [Details]

Rawe,S.L.,Murphy,P.V. (2006) Natural Product Agents for Angiogenesis and Cancer, Guillaume Anquetin, 1st European Chemistry Congress. Workshops [Details]

Murphy,P.V. (2006) Carbohydrates in synthesis of bioactive molecules. Medical School, Peking University. Workshops [Details]

Murphy,P.V. (2006) Gordon Research Conference, Angiogenesis and Microcirculation. Workshops [Details]

Rawe,S.L., Zaric,V.,O' Boyle,K.M.,Murphy,P.V. (2005) Synthetic approaches to cell proliferation inhibitors. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, CARB-66 MEDI 453. Workshops [Details]

Gouin,S.G.,Murphy,P.V. (2005) Synthesis of peptidomimetics based on 1-deoxymannojirimycin. Abstracts of Papers, 230th ACS National Meeting CARB-87 Oral contribution). Workshops [Details]

Rawe,S.L.,Murphy,P.V. (2005) Structural analysis of thiophenecarboxamides showing intramolecular NH-acetylene interaction . Abstracts of Papers, 230th ACS National Meeting ORGN 511. Workshops [Details]

Murphy,P.V. (2005) Bioactive molecules derived from Carbohydrates. University of Virginia, Charlottesville, USA. Workshops [Details]

Gouin,S.G.,Murphy,P.V. (2005) Synthesis of peptidomimetics based on 1-deoxymannojirimycin. FEBS Summer School, Chemistry meets Biology. Workshops [Details]

Murphy,P.V.,Cronin,L. (2005) Synthesis of castanospermine and related iminosugars. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, August 2005, CARB-86 Oral presentation). Workshops [Details]

Murphy,P.V. (2005) Carbohydrates and natural products of biomedical interest. National Centre for Biomedical Engineering and Science. Workshops [Details]

Murphy,P.V. (2005) Saccharides: New Synthesis, Structure and Bioactive Molecules . Organic Chemistry Symposium. Workshops [Details]

Lalot,J.,Murphy,P.V. (2005) New approaches to polyhydroxylated indolizidines. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, CARB-66 Poster presentation. Workshops [Details]

Murphy,P.V.,Cronin,L. (2005) Synthesis of castanospermine and related iminosugars. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, CARB-86. Workshops [Details]

Velasco-Torrijos,T.,Murphy,P.V. (2005) Synthesis of bivalent ligands for lattice formation. FEBS Summer School, Chemistry meets Biology. Workshops [Details]

Duane, R. M., O'Brien A., Lynch, C., Murphy, P. V., O' Boyle, K. M., (2004) The biological evaluation of disaccharides derived from heparin,. Glycobiology. Workshops [Details]

Murphy,P.V. (2004) Glycosidation reactions of silyl ethers with conformationally inverted donors . Stereoselective glycoside and 2-deoxyglycoside synthesis, 22nd International Carbohydrate Symposium. Workshops [Details]

Murphy,P.V. (2004) Novel syntheses and structure in carbohydrate chemistry. Department of Chemistry and Chemical Biology. Workshops [Details]

Murphy,P.V. (2003) Stereoselective Synthesis and Modulators of Cellular Behaviour Based on Glucuronic Acid. Universität Mainz, Germany. Workshops [Details]

Murphy,P.V. (2003) Synthesis of 1,2-cis glycosides in the presence of a 2-acyl group Introduction of 6,1-lactones as glycosyl donors' . Eurotron Glycosciences Conference, EGC-5 on Synthesis of biologically important carbohydrates and analogues. Workshops

[Details]

Murphy,P.V. (2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Konstanz, Germany. Workshops [Details]

Tosin, M., Murphy, P. V. (2003) The synthesis and structural evaluation of restricted divalent carbohydrates . Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, CARB-073. Workshops [Details]

Murphy,P.V. (2003) The synthesis of restricted glycoclusters. Chemical Biology Workshop, Centre for Synthesis and Chemical Biology, UCD. Workshops [Details]

Murphy,P.V. (2003) New approaches to glycoside synthesis and multivalent ligand design . University of Aarhus, Denmark. Workshops [Details]

Murphy, P. V., Tosin, M., Poláková, M., Pitt, N. (2003) Application of 6,1-lactones in glycoside synthesis . Abstracts of Papers, 226th ACS National Meeting CARB-002. Oral Contribution. Workshops [Details]

Murphy,P.V. (2003) Development of glycoconjugate based inhibitors of endothelial cell proliferation. Conway Institute Cancer Biology Group Meeting. Workshops [Details]

Murphy,P.V. (2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Hannover, Germany. Workshops [Details]

Murphy,P.V. (2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Regensburg, Germany. Workshops [Details]

Murphy,P.V. (2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Bayreuth, Germany. Workshops [Details]

Brien, A , Pitt, N , Duane, R, Wilson, S, Dunne, A , O'Boyle, K.M, Murphy, P. V. (2002) Synthesis of novel glucuronic acid conjugates and the evaluation of their effects on heparin/heparan sulfate binding to FGF . Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, MEDI-191. Workshops [Details]

Murphy,P.V. (2002) Novel Modulators of Proteoglycan Mediated Signal Transduction, Enzyme Inhibitors and Conformationally Restricted Divalent Ligands for Receptor Clustering. University of York. Workshops [Details]

Murphy,P.V. (2002) Progress in the Design, Synthesis and Biological Evaluation of Small Heparan Sulfate Mimetics and a New Synthesis of Aza-Sugars . Royal Society of Chemistry, Drugs from Natural Products Symposium. Workshops [Details]

McDonnell, C, Cronin, L, O'Brien, J.L., Murphy, P. V. (2002) Progress in the synthesis of five- and six-membered ring azasugars . Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, MEDI-397. Workshops [Details]

Murphy,P.V. (2002) Carbohydrates and Glycoconjugates in Chemistry and Biology. Conway Institute Festival of Research. Workshops [Details]

Murphy,P.V. (2002) Natural Products-Lead Structures'. Graduiertenkolleg Medicinal Chemistry DFG) and the International Quality Network Medicinal Chemistry Summer School, Universität Regensburg, Germany. Workshops [Details]

Murphy,P.V. (2001) Use of glycals and glycosyl azides in synthesis of bioactive carbohydrates . Workshops [Details]

Murphy,P.V. (2001) Towards regulation of GAG binding proteins, novel enzyme inhibitors and topographically restricted multivalent ligands. Trinity College Dublin. Workshops [Details]

Murphy,P.V. (2001) Novel glycoconjugates, interesting structures, and effects on binding of heparin to fibroblast growth factor. Joint Meeting Between the Section of Clinical Immunology and Allergy and the Education and Research Centre. Workshops [Details]

Murphy,P.V. (2001) Toward synthesis of monvalent and multivalent glyconjugate Libraries Eurocarb XI). 11th European Carbohydrate Symposium. Workshops [Details]

Murphy,P.V. (2000) Novel Synthesis of Divalent Glycoconjugates. 20th International Carbohydrate Symposium. Workshops [Details]

Murphy,P.V. (2000) Glasscyclics EU Network Meeting, Methods for the synthesis of bioactive carbohydrates. Workshops [Details]

Murphy,P.V. (1999) Euchem Conference III, Synthesis of Bioactive Molecules. Workshops [Details]

Murphy,P.V. (1999) Synthesis of Sialyl Lewis X Mimetics as Potential Anti-inflammatory Agents . Dublin City University. Workshops [Details]

Murphy,P.V. (1999) Synthesis of Novel Sialyl Lewis X mimetics. Royal Society of Chemistry Carbohydrate Group Spring Meeting Carbohydrates as the Basis for Therapeutic Agents) University of York. Workshops [Details]

Murphy,P.V. (1998) Carbohydrates and Medicinal Chemistry. University College Galway. Workshops [Details]

Murphy,P.V. (1998) CERC III, Young Chemists Meeting. Workshops [Details]

Murphy,P.V. (1997) CERC III, Young Chemists Meeting. Workshops [Details]

Murphy,P.V. (1997) Formation and Rearrangement of Cyclopropanespiro- -lactones from Diketene. Royal Society of Chemistry, Autumn Meeting, Pre-doctoral Symposium, September 1992. Workshops [Details]

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